LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 198

Search options

  1. Article ; Online: Quality Improvement Metrics and Methods for Neurohospitalists.

    Kvam, Kathryn A / Bernier, Eric / Gold, Carl A

    Neurologic clinics

    2021  Volume 40, Issue 1, Page(s) 211–230

    Abstract: Measurement of clinical performance is largely driven by the requirements of the Centers for Medicare and Medicaid Services and accrediting bodies like The Joint Commission. Performance measures include length of stay, readmission rate, mortality rate, ... ...

    Abstract Measurement of clinical performance is largely driven by the requirements of the Centers for Medicare and Medicaid Services and accrediting bodies like The Joint Commission. Performance measures include length of stay, readmission rate, mortality rate, hospital-acquired complications, and stroke core measures. Hospital rankings also depend heavily on quality and patient safety indicators. Becoming facile with these measures can aid neurohospitalists in understanding their value and garnering resources to support improvement projects. Neurohospitalists can apply a structured A3-based method to define a clinical problem, perform systematic analysis, then design and test solutions to drive improved outcomes for patients with neurologic disease.
    MeSH term(s) Aged ; Benchmarking ; Centers for Medicare and Medicaid Services, U.S. ; Hospitals ; Humans ; Medicare ; Quality Improvement ; United States
    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2021.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 854: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: ROS1--targeting the one percent in lung cancer.

    Gold, Kathryn A

    The New England journal of medicine

    2014  Volume 371, Issue 21, Page(s) 2030–2031

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Female ; Humans ; Lung Neoplasms/drug therapy ; Male ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use
    Chemical Substances Protein Kinase Inhibitors ; Proto-Oncogene Proteins ; Pyrazoles ; Pyridines ; crizotinib (53AH36668S) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; ROS1 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2014-11-20
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1411319
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Biotin-induced thyroid stimulating hormone aberrations in the setting of immunotherapy.

    N Ridgway, Forrest / A Gold, Kathryn / C Barnachea, Linda

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2021  Volume 27, Issue 8, Page(s) 2057–2060

    Abstract: Introduction: Immune checkpoint inhibitors are associated with immune-mediated thyroid disease and other endocrinopathies. Biotin is an over-the-counter supplement known to interfere with lab assays, including thyroid function tests. Biotin-induced ... ...

    Abstract Introduction: Immune checkpoint inhibitors are associated with immune-mediated thyroid disease and other endocrinopathies. Biotin is an over-the-counter supplement known to interfere with lab assays, including thyroid function tests. Biotin-induced complications with lab monitoring during immunotherapy have not been previously reported.
    Case report: We present a case of a 68-year old woman with hypothyroidism after initiating immune checkpoint blockade therapy and abnormal laboratory monitoring values while concurrently taking biotin supplements.
    Discussion: The purpose of this report is to provide the first known incidence of biotin complicating the routine monitoring of immune checkpoint inhibitors with elevated TSH levels and to alert providers to elicit accurate medication histories regarding over-the-counter supplements.
    MeSH term(s) Aged ; Biotin/adverse effects ; Female ; Humans ; Immunotherapy/adverse effects ; Thyroid Function Tests ; Thyrotropin ; Thyroxine
    Chemical Substances Biotin (6SO6U10H04) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/10781552211017960
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Outcomes of a Neurohospitalist Program at an Academic Medical Center.

    Gold, Carl A / Scott, Brian J / Weng, Yingjie / Bernier, Eric / Kvam, Kathryn A

    The Neurohospitalist

    2022  Volume 12, Issue 3, Page(s) 453–462

    Abstract: Background and purpose: The purpose is to determine the impact of an academic neurohospitalist service on clinical outcomes.: Methods: We performed a retrospective, quasi-experimental study of patients discharged from the general neurology service ... ...

    Abstract Background and purpose: The purpose is to determine the impact of an academic neurohospitalist service on clinical outcomes.
    Methods: We performed a retrospective, quasi-experimental study of patients discharged from the general neurology service before (August 2010-July 2014) and after implementation of a full-time neurohospitalist service (August 2016-July 2018) compared to a control group of stroke patients. Primary outcomes were length of stay and 30-day readmission. Using the difference-in-difference approach, the impact of introducing a neurohospitalist service compared to controls was assessed with adjustment of patients' characteristics. Secondary outcomes included mortality, in-hospital complications, and cost.
    Results: There were 2706 neurology admissions (1648 general; 1058 stroke) over the study period. The neurohospitalist service was associated with a trend in reduced 30-day readmissions (ratio of ORs: .52 [.27, .98],
    Conclusions: Implementation of a neurohospitalist service at an academic medical center is feasible and associated with a significant increase in patient complexity and acuity and a trend toward reduced readmissions.
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/19418744221083182
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Comparison of Early- and Late-Stage Breast and Colorectal Cancer Diagnoses During vs Before the COVID-19 Pandemic.

    Zhou, Jade Zifei / Kane, Shelly / Ramsey, Celia / Akhondzadeh, Melody / Banerjee, Ananya / Shatsky, Rebecca / Gold, Kathryn Ann

    JAMA network open

    2022  Volume 5, Issue 2, Page(s) e2148581

    MeSH term(s) Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; COVID-19/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer ; Female ; Humans ; Mass Screening ; Middle Aged ; Neoplasm Staging ; Pandemics ; Quality Improvement ; SARS-CoV-2
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.48581
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Immunotherapeutic Approaches to the Management of Head and Neck Cancer.

    Nan, Xinyu / Gold, Kathryn A / Cohen, Ezra

    Oncology (Williston Park, N.Y.)

    2019  Volume 32, Issue 12, Page(s) 617–9, 625–6

    Abstract: The two programmed death 1 checkpoint inhibitors nivolumab and pembrolizumab are approved by the US Food and Drug Administration as second-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Based on the existing ... ...

    Abstract The two programmed death 1 checkpoint inhibitors nivolumab and pembrolizumab are approved by the US Food and Drug Administration as second-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Based on the existing data, the effectiveness of these two drugs is similar in this setting. When choosing between them, the decision should be individualized and can be determined by patient and provider preferences, as well as scheduling. Testing for tumor programmed death ligand 1 (PD-L1) and human papillomavirus status is not required for use of these checkpoint inhibitors in the second-line setting, but the level of tumor PD-L1 expression can be useful for decision making in special situations. There are many ongoing trials that are studying immunotherapy as frontline treatment for recurrent or metastatic HNSCC, as well as trials combining immunotherapy with definitive chemoradiation in locally advanced disease. Based on the updated results of the KEYNOTE-048 trial, checkpoint inhibitors will likely be a part of first-line therapy in the near future.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Humans ; Immunotherapy/methods ; Nivolumab/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN) ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 372: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A framework and road map for rapid start-up and completion of a COVID-19 vaccine trial: A single clinical trial site experience.

    Rojas, Carlos / Spector, Stephen A / Cale, Bernadette / Loughran, Megan / Lazaro, Leander / Mah, Eric / Firestein, Gary S / Gold, Kathryn A / Wallace, Mark

    Journal of clinical and translational science

    2022  Volume 6, Issue 1, Page(s) e21

    Abstract: The COVID-19 global pandemic required the rapid development of vaccines with a quick start up of phase 1-3 studies with large enrollment targets. The University of California San Diego was identified as a site for the phase 3 trial of the mRNA-1273-SARS- ... ...

    Abstract The COVID-19 global pandemic required the rapid development of vaccines with a quick start up of phase 1-3 studies with large enrollment targets. The University of California San Diego was identified as a site for the phase 3 trial of the mRNA-1273-SARS-CoV-2 vaccine. There were many challenges with scaling up a large-scale clinical trial in such a short time. This report describes the processes and procedures that were implemented to successfully complete the enrollment target in under 10 weeks. This required the team to identify existing tools that could rapidly be accessed to develop a database, scheduling system, effective communication, document management, staff time tracking/efficiency, subject scheduling/tracking, project management, and accrual/study performance. The outcome of these efforts resulted in rapid enrollment and study completion in a short time. The lessons learned from this experience can be used by other clinical trial sites faced with similar challenges.
    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Case Reports
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2022.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: The subthalamic nucleus contributes causally to perceptual decision-making in monkeys.

    Rogers, Kathryn / Gold, Joshua I / Ding, Long

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The subthalamic nucleus (STN) plays critical roles in the motor and cognitive function of the basal ganglia (BG), but the exact nature of these roles is not fully understood, especially in the context of decision-making based on uncertain evidence. ... ...

    Abstract The subthalamic nucleus (STN) plays critical roles in the motor and cognitive function of the basal ganglia (BG), but the exact nature of these roles is not fully understood, especially in the context of decision-making based on uncertain evidence. Guided by theoretical predictions of specific STN contributions, we used single-unit recording and electrical microstimulation in the STN of healthy monkeys to assess its causal, computational roles in visual-saccadic decisions based on noisy evidence. The recordings identified subpopulations of STN neurons with distinct task-related activity patterns that related to different theoretically predicted functions. Microstimulation caused changes in behavioral choices and response times that reflected multiple contributions to an "accumulate-to-bound"-like decision process, including modulation of decision bounds and evidence accumulation, and to non-perceptual processes. These results provide new insights into the multiple ways that the STN can support higher brain function.
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.09.588715
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Scirrhous carcinoma: A previously undescribed tumor of the oral cavity.

    DeVries, Jacquelyn / Finegersh, Andrey / Gold, Kathryn A / Sharabi, Andrew B / Hu, Jingjing / Orosco, Ryan K

    Clinical case reports

    2021  Volume 9, Issue 5, Page(s) e03864

    Abstract: This patient was found to have a scirrhous carcinoma with extensive perineural invasion and without any evidence of minor salivary gland carcinoma. To our knowledge, this is the first report of isolated scirrhous carcinoma of the oral cavity. Treatment ... ...

    Abstract This patient was found to have a scirrhous carcinoma with extensive perineural invasion and without any evidence of minor salivary gland carcinoma. To our knowledge, this is the first report of isolated scirrhous carcinoma of the oral cavity. Treatment was surgery and adjuvant chemoradiation, and there was complete disease response.
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.3864
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online: COVID-19/Emergency 14-Day Meal Kit for Rural Grocery Stores

    Draeger, Kathryn / Gold, Abby / Olive, Ren

    2020  

    Abstract: This fact sheet provides guidance on 14-day meal kits that can be deployed from rural grocery stores to community members who need to isolate themselves in the face of COVID-19. ... UMN Extension Regional Sustainable Development Partnerships, UMN Extension ...

    Abstract This fact sheet provides guidance on 14-day meal kits that can be deployed from rural grocery stores to community members who need to isolate themselves in the face of COVID-19.

    UMN Extension Regional Sustainable Development Partnerships, UMN Extension Family Development, Bonnie's Hometown Grocery, Graceville Country Market, Mason Brothers Wholesale, Clinton Civic Club, Trinity Lutheran Church.
    Keywords Statewide ; Food ; covid19
    Language English
    Publishing date 2020-03-19
    Publisher UMN Extension Regional Sustainable Development Partnerships
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top