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  1. Article ; Online: Microenvironment Is a Key Determinant of Immune Checkpoint Inhibitor Response.

    Cho, Shih-Feng / Anderson, Kenneth C / Tai, Yu-Tzu

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 8, Page(s) 1479–1481

    Abstract: Utilizing advanced RNA-sequencing techniques and rigorous bioinformatics analysis, this study identified gene signatures predicting responsiveness to pembrolizumab monotherapy. T-cell-inflamed gene expression profile was predictive for better treatment ... ...

    Abstract Utilizing advanced RNA-sequencing techniques and rigorous bioinformatics analysis, this study identified gene signatures predicting responsiveness to pembrolizumab monotherapy. T-cell-inflamed gene expression profile was predictive for better treatment response, while angiogenesis, monocytic myeloid-derived suppressor cell, and stroma/epithelial-mesenchymal transition/TGFβ gene signatures were associated with lower treatment response. See related article by Cristescu et al., p. 1680.
    MeSH term(s) Epithelial-Mesenchymal Transition/genetics ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Myeloid-Derived Suppressor Cells ; Sequence Analysis, RNA ; Tumor Microenvironment/genetics
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  2. Article ; Online: Correction to: Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors.

    Bae, Jooeun / Hideshima, Teru / Tai, Yu-Tzu / Song, Yan / Richardson, Paul / Raje, Noopur / Munshi, Nikhil C / Anderson, Kenneth C

    Leukemia

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Published Erratum
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02185-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Privacy-Preserved Image Protection Supporting Different Access Rights

    Ya-Fen Chang / Wei-Liang Tai / Yu-Tzu Huang

    Applied Sciences, Vol 12, Iss 12335, p

    2022  Volume 12335

    Abstract: The boom in cloud computing and social networking has led to a large number of online users in the networks. It is necessary to use appropriate privacy protection mechanisms to prevent personal privacy leakage. In general, image privacy protection ... ...

    Abstract The boom in cloud computing and social networking has led to a large number of online users in the networks. It is necessary to use appropriate privacy protection mechanisms to prevent personal privacy leakage. In general, image privacy protection techniques proceed with the whole image. However, the image may contain multiple users’ information, and different people’s data may require different privacy protection. In addition, cloud servers are semi-trusted instead of trusted service providers due to unknown security vulnerabilities and the possibility of grabbing sensitive data from the cloud server. In order to provide image protection with different privacy-preserved access rights and to prevent the cloud server from retrieving sensitive information from the image, we propose a privacy-preserved scheme that supports different privacy-preserved access rights in a single image based on the difficulty of solving the factorization problem and the discrete logarithm problem. The cloud server performed the image management method without knowing the privacy information contained in the protected images. By working out the proposed scheme in detail, we experimentally validate the scheme and discuss various options of access rights in practice.
    Keywords privacy protection ; cloud computing ; factoring problem ; discrete logarithm problem ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 303
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: B cell maturation antigen (BCMA)-based immunotherapy for multiple myeloma.

    Tai, Yu-Tzu / Anderson, Kenneth C

    Expert opinion on biological therapy

    2019  Volume 19, Issue 11, Page(s) 1143–1156

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; B-Cell Maturation Antigen/immunology ; Humans ; Immunoconjugates/therapeutic use ; Immunotherapy ; Multiple Myeloma/therapy ; Receptors, Chimeric Antigen/metabolism ; Single-Chain Antibodies/chemistry ; Single-Chain Antibodies/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances Antibodies, Monoclonal ; B-Cell Maturation Antigen ; Immunoconjugates ; Receptors, Chimeric Antigen ; Single-Chain Antibodies
    Language English
    Publishing date 2019-07-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2019.1641196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6094: Show issues Location:
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  5. Article: Bispecific antibodies in multiple myeloma treatment: A journey in progress.

    Cho, Shih-Feng / Yeh, Tsung-Jang / Anderson, Kenneth C / Tai, Yu-Tzu

    Frontiers in oncology

    2022  Volume 12, Page(s) 1032775

    Abstract: The incorporation of novel agents and monoclonal antibody-based therapies into the treatment of multiple myeloma (MM) has significantly improved long-term patient survival. However, the disease is still largely incurable, with high-risk patients ... ...

    Abstract The incorporation of novel agents and monoclonal antibody-based therapies into the treatment of multiple myeloma (MM) has significantly improved long-term patient survival. However, the disease is still largely incurable, with high-risk patients suffering shorter survival times, partly due to weakened immune systems. Bispecific molecules, including bispecific antibodies (BisAbs) and bispecific T-cell engagers (BiTEs), encourage immune cells to lyse MM cells by simultaneously binding antigens on MM cells and immune effector cells, bringing those cells into close proximity. BisAbs that target B-cell maturation antigen (BCMA) and GPRC5D have shown impressive clinical activity, and the results of early-phase clinical trials targeting FcRH5 in patients with relapsed/refractory MM (RRMM) are also promising. Furthermore, the safety profile of these agents is favorable, including mainly low-grade cytokine release syndrome (CRS). These off-the-shelf bispecific molecules will likely become an essential part of the MM treatment paradigm. Here, we summarize and highlight various bispecific immunotherapies under development in MM treatment, as well as the utility of combining them with current standard-of-care treatments and new strategies. With the advancement of novel combination treatment approaches, these bispecific molecules may lead the way to a cure for MM.
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1032775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Retraction: Cytokines Modulate Telomerase Activity in a Human Multiple Myeloma Cell Line.

    Akiyama, Masaharu / Hideshima, Teru / Hayashi, Toshiaki / Tai, Yu-Tzu / Mitsiades, Constantine S / Mitsiades, Nicholas / Chauhan, Dharminder / Richardson, Paul / Munshi, Nikhil C / Anderson, Kenneth C

    Cancer research

    2024  Volume 84, Issue 6, Page(s) 940

    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Retraction: Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage.

    Tai, Yu-Tzu / Teoh, Gerrard / Lin, Boris / Davies, Faith E / Chauhan, Dharminder / Treon, Steven P / Raje, Noopur / Hideshima, Teru / Shima, Yoshihito / Podar, Klaus / Anderson, Kenneth C

    Journal of immunology (Baltimore, Md. : 1950)

    2024  Volume 212, Issue 8, Page(s) 1392

    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2400070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Retraction: Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein.

    Akiyama, Masaharu / Hideshima, Teru / Hayashi, Toshiaki / Tai, Yu-Tzu / Mitsiades, Constantine S / Mitsiades, Nicholas / Chauhan, Dharminder / Richardson, Paul / Munshi, Nikhil C / Anderson, Kenneth C

    Cancer research

    2024  Volume 84, Issue 6, Page(s) 939

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retraction: Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications.

    Tai, Yu-Tzu / Catley, Laurence P / Mitsiades, Constantine S / Burger, Renate / Podar, Klaus / Shringpaure, Reshma / Hideshima, Teru / Chauhan, Dharminder / Hamasaki, Makoto / Ishitsuka, Kenji / Richardson, Paul / Treon, Steven P / Munshi, Nikhil C / Anderson, Kenneth C

    Cancer research

    2024  Volume 84, Issue 6, Page(s) 936

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retraction: Effects of Oligonucleotide N3'→P5' Thio-phosphoramidate (GRN163) Targeting Telomerase RNA in Human Multiple Myeloma Cells.

    Akiyama, Masaharu / Hideshima, Teru / Shammas, Masood A / Hayashi, Toshiaki / Hamasaki, Makoto / Tai, Yu-Tzu / Richardson, Paul / Gryaznov, Sergei / Munshi, Nikhil C / Anderson, Kenneth C

    Cancer research

    2024  Volume 84, Issue 6, Page(s) 937

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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