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Article: A Retrospective Study of Correlation between Radiological and Intra-Operative Findings in FESS: A Case Series.

Minnu P, Fathima / K, Priya / D, Balaji / Shree C, Ramya

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 2, Page(s) 1626–1629

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2023-12-02
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04371-3
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Article ; Online: Wound healing mechanisms of

Vasanthakumari, Kumaraguru / Sharmila, Chelladurai / Jaya Priya, Shree / Vadivel, Vellingiri

Natural product research

2023 Volume 38, Issue 4, Page(s) 634–638

Abstract: In connection to search for safe and alternative plant-based drugs, the wound healing mechanisms of an Indian ... ...

Abstract	In connection to search for safe and alternative plant-based drugs, the wound healing mechanisms of an Indian ethnomedicine
MeSH term(s)	Humans ; Plant Extracts/chemistry ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/chemistry ; Methanol/chemistry ; Traditional Medicine Practitioners ; Antioxidants/pharmacology ; Fruit/chemistry ; Leukocytes, Mononuclear ; Wound Healing ; Microbial Sensitivity Tests ; Medicine, Traditional
Chemical Substances	Plant Extracts ; Anti-Bacterial Agents ; Methanol (Y4S76JWI15) ; Antioxidants
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2180636
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Article ; Online: Efficacy of photobiomodulation in the management of oral Lichen Planus in comparison to topical corticosteroids: Systematic review, meta-analysis, and GRADE-based assessment of certainty of evidence.

Mahuli, Simpy Amit / Rai, Arpita / Shree, Priya / Ul Haque, Zeya / Mahuli, Amit Vasant

Journal of stomatology, oral and maxillofacial surgery

2024 , Page(s) 101798

Abstract: Background: There is an urgent need to update the evidence available on the efficacy of photobiomodulation (PBM) in comparison to topical corticosteroids in the management of Oral Lichen Planus (OLP).: Methods: Cochrane Oral Health's Trials Register, ...

Abstract	Background: There is an urgent need to update the evidence available on the efficacy of photobiomodulation (PBM) in comparison to topical corticosteroids in the management of Oral Lichen Planus (OLP). Methods: Cochrane Oral Health's Trials Register, Cochrane Central Register of Controlled Trials in the Cochrane Library, MEDLINE Pubmed, SCOPUS, Lilacs and Google Scholar were searched. Other sources included US National Institutes of Health Ongoing Trials Register, World Health Organization International Clinical Trials Registry Platform and Clinical Trial Registry - India were searched using variations of the keywords "Laser" and "Oral Lichen Planus". Randomized controlled trials comparing PBM and topical corticosteroids in the resolution of pain among OLP patients were included. The studies were assessed using the Cochrane Risk-of-Bias assessment tool. Publication bias was assessed using a funnel plot, and the certainty of evidence was evaluated according to the GRADE guidelines. Results: Ten studies were included for qualitative assessment and of these eight were included in the meta-analysis. The included studies used laser parameters of varying strengths and duration. Meta-analysis favoured PBM (n = 274, MD =-0.48, CI -0.66- -0.30) for pain score. No adverse effects were reported for laser therapy. There was high heterogeneity and moderate certainty of evidence, and most studies had a high risk of bias. Conclusion: There is improvement in the clinical parameters of OLP when treated with PBM in comparison to topical corticosteroids. However, the strength of the evidence for these findings in limited. It is recommended to conduct better long-term trials with large sample size.
Language	English
Publishing date	2024-02-21
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2024.101798
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Article ; Online: In silico network pharmacology analysis and molecular docking validation of Swasa Kudori tablet for screening druggable phytoconstituents of asthma.

Sekaran, Karthik / Varghese, Rinku Polachirakkal / Karthik, Ashwini / Sasikumar, K / Shree Devi, M S / Sathiyarajeswaran, P / George Priya Doss, C

Advances in protein chemistry and structural biology

2023 Volume 138, Page(s) 257–274

Abstract: Traditional medicines are impactful in treating a cluster of respiratory-related illnesses. This paper demonstrates screening active, druggable phytoconstituents from a classical Siddha-based poly-herbal formulation called Swasa Kudori Tablet to treat ... ...

Abstract	Traditional medicines are impactful in treating a cluster of respiratory-related illnesses. This paper demonstrates screening active, druggable phytoconstituents from a classical Siddha-based poly-herbal formulation called Swasa Kudori Tablet to treat asthma. The phytoconstituents of Swasa Kudori are identified as Calotropis gigantea, Piper nigrum, and (Co-drug) Abies webbiana. Active chemical compounds are extracted with the Chemical Entities of Biological Interest (ChEBI) database. The gene targets of each compound are identified based on the pharmacological activity using the DIGEP-Pred database. Thirty-two genes showing P
MeSH term(s)	Humans ; Molecular Docking Simulation ; Network Pharmacology ; Asthma/drug therapy ; Computer Simulation ; Databases, Factual
Language	English
Publishing date	2023-08-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2473077-4
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2023.07.001
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Article ; Online: In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19.

Sekaran, Karthik / Karthik, Ashwini / Varghese, Rinku Polachirakkal / Sathiyarajeswaran, P / Shree Devi, M S / Siva, R / George Priya Doss, C

Advances in protein chemistry and structural biology

2023 Volume 138, Page(s) 233–255

Abstract: Immunosenescence is a pertinent factor in the mortality rate caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The changes in the immune system are strongly associated with age and provoke the deterioration of the individual's ... ...

Abstract	Immunosenescence is a pertinent factor in the mortality rate caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The changes in the immune system are strongly associated with age and provoke the deterioration of the individual's health. Traditional medical practices in ancient India effectively deal with COVID-19 by boosting natural immunity through medicinal plants. The anti-inflammatory and antiviral properties of Glycyrrhiza glabra are potent in fighting against COVID-19 and promote immunity boost against the severity of the infection. Athimadhura Chooranam, a polyherbal formulation containing Glycyrrhiza glabra as the main ingredient, is recommended as an antiviral Siddha herb by the Ministry of AYUSH. This paper is intended to identify the phytoconstituents of Glycyrrhiza glabra that are actively involved in preventing individuals from COVID-19 transmission. The modulated pathways, enrichment study, and drug-likeness are calculated from the target proteins of the phytoconstituents at the pharmacological activity (Pa) of more than 0.7. Liquiritigenin and Isoliquiritin, the natural compounds in Glycyrrhiza glabra, belong to the flavonoid class and exhibit ameliorative effects against COVID-19. The latter compound displays a higher protein interaction to a maximum of six, out of which HMOX1, PLAU, and PGR are top-hub genes. ADMET screening further confirms the significance of the abovementioned components containing better drug-likeness. The molecular docking and molecular dynamics method identified liquiritigenin as a possible lead molecule capable of inhibiting the activity of the major protease protein of SARS-CoV-2. The findings emphasize the importance of in silico network pharmacological assessments in delivering cost-effective, time-bound clinical drugs.
MeSH term(s)	Humans ; Plants, Medicinal ; Network Pharmacology ; Molecular Docking Simulation ; COVID-19 ; SARS-CoV-2 ; Glycyrrhiza/chemistry ; Glycyrrhiza/genetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use
Chemical Substances	Antiviral Agents ; Phytochemicals
Language	English
Publishing date	2023-06-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2473077-4
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2023.04.003
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Article: Colchicine in the Management of Oral Submucous Fibrosis: A Systematic Review, Meta-analysis, and GRADE-Based Assessment of Certainty of Evidence.

Rai, Arpita / Kumar, Ansul / Shree, Priya / Haque, Zeya Ul / Kumari, Sneha / Yadav, Satyendra Prasad / Mahuli, Simpy Amit / Shamsi, Shoa

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 4, Page(s) 4125–4136

Abstract: ... ...

Abstract	Purpose
Language	English
Publishing date	2023-05-17
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03876-1
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Article: Oxidative Stress Enzyme as Markers in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma Patients.

Shamsi, Shoa / Rai, Arpita / Manjhi, Lakhan / Mahuli, Simpy Amit / Shree, Priya / Haque, Zeya Ul / Kumari, Sneha

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 4, Page(s) 3757–3764

Abstract: Oxidative stress is a recognized factor that poses a significant risk for the development of Oral Squamous Cell Carcinoma (OSCC) and Oral Submucous Fibrosis (OSMF), as it leads to the generation of Reactive Oxygen Species. In recent years, there has been ...

Abstract	Oxidative stress is a recognized factor that poses a significant risk for the development of Oral Squamous Cell Carcinoma (OSCC) and Oral Submucous Fibrosis (OSMF), as it leads to the generation of Reactive Oxygen Species. In recent years, there has been significant research on the enzymes MDA (malondialdehyde) and SOD (superoxide dismutase), investigating their potential role in the development of OPMD and OSCC. These enzymes have emerged as promising biomarkers due to their ability to provide a less invasive, cost-effective, and objective diagnostic method. Furthermore, they can be used to monitor disease progression and assess the effectiveness of therapy. The aim of this study was to assess the levels of MDA and SOD in the serum of patients diagnosed with OSCC and OSMF. Study group comprised of 60 patients, out of which 20 cases of clinically diagnosed OSCC patients and 20 cases of OSMF and 20 cases pf control comprising of healthy patients were recruited. Estimation MDA and SOD was done by ELISA. The statistical analysis was done using SPSS analysis. When comparing the levels of MDA and SOD between the OSCC and OSMF groups and the control group, statistically significant findings indicated elevated levels of malondialdehyde and reduced levels of superoxide dismutase in both the OSCC and OSMF groups. In this study, the assessment of lipid peroxidation through MDA levels revealed elevated concentrations in both the OSCC and OSMF groups when compared to the control group. Specifically, the order of MDA levels was observed as OSCC > OSMF > Control. Conversely, antioxidant enzyme levels, such as SOD, exhibited decreased concentrations in the OSCC and OSMF groups compared to the control group, with the order of SOD levels being Control > OSMF > OSCC. Consequently, the findings suggest that MDA and SOD can be considered potential biomarkers for identifying and monitoring OSCC and OSMF diseases.
Language	English
Publishing date	2023-07-21
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04076-7
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Article ; Online: Salivary transforming growth factor beta in oral submucous fibrosis: A diagnostic and predictive marker.

Rai, Arpita / Parveen, Shama / Shree, Priya / Ahmed, Tanveer / Ali, Sher / Kaur, Mandeep / Sircar, Keya / Sybil, Debora / Chandra, Akhilesh

Journal of cancer research and therapeutics

2023 Volume 20, Issue 1, Page(s) 275–280

Abstract: Context: Growth factors and cytokines like transforming growth factor beta (TGF-β) play a key role in the pathogenesis of oral submucous fibrosis.: Aims: To elucidate the role of Salivary TGF-β isoforms as a predictive and diagnostic marker for oral ... ...

Abstract	Context: Growth factors and cytokines like transforming growth factor beta (TGF-β) play a key role in the pathogenesis of oral submucous fibrosis. Aims: To elucidate the role of Salivary TGF-β isoforms as a predictive and diagnostic marker for oral submucous fibrosis. Settings and design: A total of 30 OSMF and 10 control patients were included in this study, and their clinic-epidemiological data was recorded. Methodology: The expression of TGF-β genes-TGF-β1, TGF-β2, TGF-β3-was studied by a real-time polymerase chain reaction in tissue and saliva. Patients were given medicinal intervention for 12 weeks along with jaw-opening exercises. Expression of salivary TGF-β genes was studied at 12 weeks. Statistical analysis used: SPSS software version 20. Result: Expression of salivary TGF beta isoforms in OSMF was more than in the control group. There was an increase in salivary TGF-β1, β2, β3 expressions with increasing clinical grades of OSMF and advancing the stage of the disease. Expression of all the TGF beta isoforms was decreased after treatment with statistically significant results. Statistically significant correlations were found between the mean difference of TGF-β1 and the mean difference between mouth opening and tongue protrusion. Conclusion: Salivary TGF-β isoforms may be used in diagnosis, risk assessment, and screening of the entire population at risk of OSMF after its clinical validation. However, adequate sample size and segmental assessment of the expression of TGF-β isoforms are needed for further evaluation.
MeSH term(s)	Humans ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta1/genetics ; Oral Submucous Fibrosis/diagnosis ; Oral Submucous Fibrosis/genetics ; Oral Submucous Fibrosis/pathology ; Transforming Growth Factor beta3/genetics ; Protein Isoforms
Chemical Substances	Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Transforming Growth Factor beta3 ; Protein Isoforms
Language	English
Publishing date	2023-05-02
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_1929_22
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Article ; Online: Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (M

Naidu, Sreus A G / Tripathi, Yamini B / Shree, Priya / Clemens, Roger A / Naidu, A Satyanarayan

Journal of dietary supplements

2021 Volume 20, Issue 2, Page(s) 284–311

Abstract: The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2 pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control. Targeting the highly conserved viral genes and/or gene-encoded viral ... ...

Abstract	The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2 pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control. Targeting the highly conserved viral genes and/or gene-encoded viral proteins such as main proteinase (M
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Quercetin/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry ; Peptide Hydrolases/pharmacology ; Phytochemicals/pharmacology
Chemical Substances	Quercetin (9IKM0I5T1E) ; Antiviral Agents ; Peptide Hydrolases (EC 3.4.-) ; Phytochemicals
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2021.2006388
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Article ; Online: Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mᵖʳᵒ) Autocleavage Enzyme Critical for COVID-19 Pathogenesis

Naidu, Sreus A. G. / Tripathi, Yamini B. / Shree, Priya / Clemens, Roger A. / Naidu, A. Satyanarayan

Journal of Dietary Supplements. 2023 Mar. 4, v. 20, no. 2 p.284-311

2023

Abstract	The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2 pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control. Targeting the highly conserved viral genes and/or gene-encoded viral proteins such as main proteinase (Mᵖʳᵒ), RNA-dependent RNA polymerase (RdRp) and helicases are plausible antiviral approaches to prevent replication and propagation of the SARS-CoV-2 infection. Coronaviruses (CoVs) are prone to extensive mutagenesis; however, any genetic alteration to its highly conserved Mᵖʳᵒ enzyme is often detrimental to the viral pathogen. Therefore, inhibitors that target the Mᵖʳᵒ enzyme could reduce the risk of mutation-mediated drug resistance and provide effective antiviral protection. Several existing antiviral drugs and dietary bioactives are currently repurposed to treat COVID-19. Dietary bioactives from three ayurvedic medicinal herbs, 18 β-glycyrrhetinic acid (ΔG = 8.86 kcal/mol), Solanocapsine (ΔG = 8.59 kcal/mol), and Vasicoline (ΔG = 7.34 kcal/mol), showed high-affinity binding to Mᵖʳᵒ enzyme than the native N3 inhibitor (ΔG = 5.41 kcal/mol). Flavonoids strongly inhibited SARS-CoV-2 Mᵖʳᵒ with comparable or higher potency than the antiviral drug, remdesivir. Several tannin hydrolysates avidly bound to the receptor-binding domain and catalytic dyad (His₄₁ and Cys₁₄₅) of SARS‐CoV‐2 Mᵖʳᵒ through H-bonding forces. Quercetin binding to Mᵖʳᵒ altered the thermostability of the viral protein through redox-based mechanism and inhibited the viral enzymatic activity. Interaction of quercetin-derivatives with the Mᵖʳᵒ seem to be influenced by the 7-OH group and the acetoxylation of sugar moiety on the ligand molecule. Based on pharmacokinetic and ADMET profiles, several phytonutrients could serve as a promising redox nutraceutical for COVID-19 management.
Keywords	COVID-19 infection ; RNA-directed RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; antiviral agents ; dietary supplements ; drug resistance ; enzyme activity ; genomics ; hydrogen bonding ; ligands ; moieties ; mutagenesis ; mutagenicity ; pathogenesis ; pathogens ; pharmacokinetics ; phytonutrients ; proteinases ; quercetin ; risk reduction ; sugars ; thermal stability ; Antiviral ; Ayurvedic Medicine ; COVID-19 ; Mpro ; Redox nutraceutical ; SARS-CoV-2
Language	English
Dates of publication	2023-0304
Size	p. 284-311.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2021.2006388
Database	NAL-Catalogue (AGRICOLA)

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