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Article ; Online: Targeting TRIM29 As a Negative Regulator of CAR-NK Cell Effector Function to Improve Antitumor Efficacy of These Cells: A Perspective.

Saleh, Zahra / Noroozi, Maryam / Eshkevar Vakili, Mahsa / Kabelitz, Dieter / Nasrolahi, Hamid / Kalantar, Kurosh

2023

Abstract: Natural killer (NK) cells are among the most important cells in innate immune defense. In contrast to T cells, the effector function of NK cells does not require prior stimulation and is not MHC restricted. Therefore, chimeric antigen receptor (CAR)-NK ... ...

Abstract	Natural killer (NK) cells are among the most important cells in innate immune defense. In contrast to T cells, the effector function of NK cells does not require prior stimulation and is not MHC restricted. Therefore, chimeric antigen receptor (CAR)-NK cells are superior to CAR-T cells. The complexity of the tumor microenvironment (TME) makes it necessary to explore various pathways involved in NK cell negative regulation. CAR-NK cell effector function can be improved by inhibiting the negative regulatory mechanisms. In this respect, the E3 ubiquitin ligase tripartite motif containing 29 (TRIM29) is known to be involved in reducing NK cell cytotoxicity and cytokine production. Also, targeting TRIM29 may enhance the antitumor efficacy of CAR-NK cells. The present study discusses the negative effects of TRIM29 on NK cell activity and genomic deletion or suppression of the expression of TRIM29 as a novel approach to optimize CAR-NK cell-based immunotherapy.
Language	English
Publishing date	2023-05-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/1566524023666230510101525
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Zs.A 5580: Show issues

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Article ; Online: Immune responses in mildly versus critically ill COVID-19 patients.

Nasrollahi, Hamid / Talepoor, Atefe Ghamar / Saleh, Zahra / Eshkevar Vakili, Mahsa / Heydarinezhad, Paria / Karami, Narges / Noroozi, Maryam / Meri, Seppo / Kalantar, Kurosh

Frontiers in immunology

2023 Volume 14, Page(s) 1077236

Abstract: The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had devastating effects on the global health and economic system. The cellular and molecular mediators of both the innate and adaptive immune systems are critical in controlling SARS- ... ...

Abstract	The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had devastating effects on the global health and economic system. The cellular and molecular mediators of both the innate and adaptive immune systems are critical in controlling SARS-CoV-2 infections. However, dysregulated inflammatory responses and imbalanced adaptive immunity may contribute to tissue destruction and pathogenesis of the disease. Important mechanisms in severe forms of COVID-19 include overproduction of inflammatory cytokines, impairment of type I IFN response, overactivation of neutrophils and macrophages, decreased frequencies of DC cells, NK cells and ILCs, complement activation, lymphopenia, Th1 and Treg hypoactivation, Th2 and Th17 hyperactivation, as well as decreased clonal diversity and dysregulated B lymphocyte function. Given the relationship between disease severity and an imbalanced immune system, scientists have been led to manipulate the immune system as a therapeutic approach. For example, anti-cytokine, cell, and IVIG therapies have received attention in the treatment of severe COVID-19. In this review, the role of immunity in the development and progression of COVID-19 is discussed, focusing on molecular and cellular aspects of the immune system in mild vs. severe forms of the disease. Moreover, some immune- based therapeutic approaches to COVID-19 are being investigated. Understanding key processes involved in the disease progression is critical in developing therapeutic agents and optimizing related strategies.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Critical Illness ; Cytokines ; Immunity
Chemical Substances	Cytokines
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1077236
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Article ; Online: Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel Metabolic Approach in COVID-19 Patients: A Perspective.

Vakili, Mahsa Eshkevar / Saleh, Zahra / Kabelitz, Dieter / Kalantar, Kurosh

Endocrine, metabolic & immune disorders drug targets

2022 Volume 22, Issue 12, Page(s) 1149–1153

Abstract: Coronavirus disease-19 (COVID-19) can be a fatal disease and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). SARS-CoV2 is an enveloped virus that belongs to the Beta coronavirus subfamily. After entering into the target cells, ... ...

Abstract	Coronavirus disease-19 (COVID-19) can be a fatal disease and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). SARS-CoV2 is an enveloped virus that belongs to the Beta coronavirus subfamily. After entering into the target cells, this virus replicates rapidly and leads to cellular damage and uncontrolled pulmonary inflammation. Huge amounts of inflammatory cytokines and chemokines are produced by infected lung cells and are associated with monocyte recruitment and accumulation of inflammatory macrophages at the site of infection. Mitochondrial citrate carrier (CIC) expression increases in these macrophages, which results in elevated levels of cytosolic citrate and the production of inflammatory mediators. In this perspective article, we discuss the role of mitochondrial CIC in the metabolism of inflammatory macrophages and we propose that inhibition of this carrier might be a novel therapeutic approach for COVID-19 patients.
MeSH term(s)	Humans ; COVID-19/drug therapy ; SARS-CoV-2 ; RNA, Viral ; Macrophages ; Cytokines ; Chemokines ; Citrates
Chemical Substances	citrate-binding transport protein ; RNA, Viral ; Cytokines ; Chemokines ; Citrates
Language	English
Publishing date	2022-10-26
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530321666210909165757
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Zs.A 5824: Show issues

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Article ; Online: Th-1, Th-2, Th-9, Th-17, Th-22 type cytokine concentrations of critical COVID-19 patients after treatment with Remdesivir.

Kalantar, Kurosh / Ghamar Talepoor, Atefe / Eshkevar Vakili, Mahsa / Karami, Narges / Kalani, Mehdi / Ghandehari, Farzad / Kabelitz, Dieter / Meri, Seppo / Moattari, Afagh

Immunobiology

2023 Volume 228, Issue 3, Page(s) 152378

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the world causing a pandemic known as coronavirus disease 2019 (COVID-19). Cytokine storm was directly correlated with severity of COVID-19 syndromes. We evaluated the ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the world causing a pandemic known as coronavirus disease 2019 (COVID-19). Cytokine storm was directly correlated with severity of COVID-19 syndromes. We evaluated the levels of 13 cytokines in ICU hospitalized COVID-19 patients (n = 29) before, and after treatment with Remdesivir as well as in healthy controls (n = 29). Blood samples were obtained from ICU patients during ICU admission (before treatment) and 5 days after treatment with Remdesivir. A group of 29 age- and gender-matched healthy controls was also studied. Cytokine levels were evaluated by multiplex immunoassay method using a fluorescence labeled cytokine panel. In comparison to cytokine levels measured at ICU admission, serum levels were reduced of IL-6 (134.75 pg/mL vs. 20.73 pg/mL, P < 0.0001), TNF-α (121.67 pg/mL vs. 10.15 pg/mL, P < 0.0001) and IFN-γ (29.69 pg/mL vs. 22.27 pg/mL, P = 0.005), whereas serum level was increased of IL-4 (8.47 pg/mL vs. 12.44 pg/mL, P = 0.002) within 5 days after Remdesivir treatment. Comparing with before treatment, Remdesivir significantly reduced the levels of inflammatory (258.98 pg/mL vs. 37.43 pg/mL, P < 0.0001), Th1-type (31.24 pg/mL vs. 24.46 pg/mL, P = 0.007), and Th17-type (36.79 pg/mL vs. 26.22 pg/mL, P < 0.0001) cytokines in critical COVID-19 patients. However, after Remdesivir treatment, the concentrations of Th2-type cytokines were significantly higher than before treatment (52.69 pg/mL vs. 37.09 pg/mL, P < 0.0001). In conclusion, Remdesivir led to decrease levels of Th1-type and Th17-type cytokines and increase Th2-type cytokines in critical COVID-19 patients 5 days after treatment.
MeSH term(s)	Humans ; Cytokines ; COVID-19 ; Th1 Cells ; Th2 Cells ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Cytokines ; remdesivir (3QKI37EEHE)
Language	English
Publishing date	2023-03-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	563292-4
ISSN	1878-3279 ; 0171-2985
ISSN (online)	1878-3279
ISSN	0171-2985
DOI	10.1016/j.imbio.2023.152378
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Article ; Online: Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders.

Vakili, Mahsa Eshkevar / Faghih, Zahra / Sarvari, Jamal / Doroudchi, Mehrnoosh / Hosseini, Seyed Nezamedin / Kabelitz, Dieter / Kalantar, Kurosh

Immunologic research

2022 Volume 70, Issue 4, Page(s) 469–480

Abstract: Despite the availability of an effective vaccine and antiviral treatments, hepatitis B is still a global public health problem. Hepatitis B vaccination can prevent the disease. Vaccination induces long-lasting protective immune memory, and the ... ...

Abstract	Despite the availability of an effective vaccine and antiviral treatments, hepatitis B is still a global public health problem. Hepatitis B vaccination can prevent the disease. Vaccination induces long-lasting protective immune memory, and the identification of memory cell subsets can indicate the effectiveness of vaccines. Here, we compared the frequency of CD4
MeSH term(s)	CD4-Positive T-Lymphocytes ; Hepatitis B ; Hepatitis B Vaccines ; Humans ; Immunologic Memory ; Leukocytes, Mononuclear ; Stem Cells
Chemical Substances	Hepatitis B Vaccines
Language	English
Publishing date	2022-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-022-09278-9
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Zs.A 1755: Show issues

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Article ; Online: Targeting T Cell Metabolism as a Novel Approach for Treatment of MS: With a Focus on PFKFB3 Inhibitors.

Vakili, Mahsa Eshkevar / Shah Mohammadi, Fateme Nezhad / Ataollahi, Mohammad Reza / Shams, Keivan / Eklund, Kari K / Daryabor, Gholamreza / Kalantar, Kurosh

Endocrine, metabolic & immune disorders drug targets

2022 Volume 23, Issue 4, Page(s) 417–422

Abstract: Multiple sclerosis (MS) is one of the organ-specific autoimmune diseases in which immune cells invade the neurons in the central nervous system (CNS) due to loss of tolerance to self-antigens. Consequently, inflammation and demyelination occur in the ... ...

Abstract	Multiple sclerosis (MS) is one of the organ-specific autoimmune diseases in which immune cells invade the neurons in the central nervous system (CNS) due to loss of tolerance to self-antigens. Consequently, inflammation and demyelination occur in the central nervous system. The pathogenesis of MS is not completely understood. However, it seems that T cells, especially Th17 cells, have an important role in disease development. In recent years, studies on the manipulation of metabolic pathways with therapeutic targets have received increasing attention and have had promising results in some diseases, such as cancers. Glycolysis is a central metabolic pathway and plays an important role in the differentiation of T CD4+ cells to their subsets, especially Th17 cells. This suggests that manipulation of glycolysis, for example, using appropriate safe inhibitors of this pathway can represent a means to affect the differentiation of T CD4+, thus reducing inflammation and disease activity in MS patients. Hence, in this study, we aimed to discuss evidence showing that using inhibitors of 6-phosphofructo-2- kinase/fructose-2,6-biphosphatase 3(PFKFB3) as the main regulator of glycolysis may exert beneficial therapeutic effects on MS patients.
MeSH term(s)	Humans ; Autoimmune Diseases ; CD4-Positive T-Lymphocytes ; Inflammation ; Multiple Sclerosis/drug therapy ; Neoplasms ; Phosphofructokinase-2/metabolism
Chemical Substances	PFKFB3 protein, human (EC 2.7.1.105) ; Phosphofructokinase-2 (EC 2.7.1.105)
Language	English
Publishing date	2022-09-21
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530322666220921160930
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Article ; Online: Comparison of the Antibody Responses Following Vaccination with AstraZeneca and Sinopharm.

Anvari, Enayat / Ghamar Talepoor, Atefe / Eshkevar Vakili, Mahsa / Karimi, Narges / Ataollahi, MohammadReza / Najafi, Gelareh / Kabelitz, Dieter / Ahmadi, Iraj / Kalantar, Kurosh

Iranian journal of immunology : IJI

2022 Volume 19, Issue 3, Page(s) 321–329

Abstract: Background: Vaccines are the most effective way to prevent Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2).: Objectives: To compare the antibody response of healthy individuals vaccinated with either the AstraZeneca (ChAdOx1 nCoV-19) or ... ...

Abstract	Background: Vaccines are the most effective way to prevent Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2). Objectives: To compare the antibody response of healthy individuals vaccinated with either the AstraZeneca (ChAdOx1 nCoV-19) or the Sinopharm (BBIBP-CorV) vaccine, in those who had no prior infection with SARS-CoV-2. Methods: Thirty seven participants were included, of which 17 were administered the AstraZeneca (ChAdOx1 nCoV-19) vaccine, while 20 were given the Sinopharm (BBIBP-CorV) vaccine. SARS-CoV-2 neutralizing antibody and anti-receptor-binding domain (RBD) IgG levels were checked 4 weeks after giving the first and the second dose of either vaccine using the enzyme-linked immunosorbent assay (ELISA) technique. Results: The AstraZeneca (ChAdOx1 nCoV-19) vaccine exhibited a higher levels of anti-(RBD) IgG compared with the Sinopharm (BBIBP-CorV) in both the first (14.51 μg/ml vs. 1.160 μg/ml) and the second (46.68 μg/ml vs. 11.43 μg/ml) doses. About neutralizing Abs, the titer of the antibody was higher in the AstraZeneca (ChAdOx1 nCoV-19) recipients than in the Sinopharm (BBIBP-CorV) subjects after the first (7.77 μg/ml vs. 1.79 μg/ml, p < 0.0001) and the second dose (10. 36 μg/ml vs. 4.88 μg/ml, p < 0.0001). Conclusions: Recipients vaccinated with two doses of the AstraZeneca (ChAdOx1 nCoV-19) had superior quantitative antibody levels than Sinopharm (BBIBP-CorV)-vaccinated subjects. These data suggest that a booster dose may be needed for the Sinopharm (BBIBP-CorV) recipients, to control the COVID-19 pandemic.
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; Antibody Formation ; COVID-19/prevention & control ; ChAdOx1 nCoV-19 ; Humans ; Immunoglobulin G ; Pandemics/prevention & control ; SARS-CoV-2 ; Vaccination ; Viral Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Viral Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2022-10-18
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2616647-1
ISSN	1735-367X ; 1735-367X
ISSN (online)	1735-367X
ISSN	1735-367X
DOI	10.22034/iji.2022.94298.2300
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Article: Prevalence of

Afrakhteh, Narges / Marhaba, Zahra / Mahdavi, Seif Ali / Garoosian, Sahar / Mirnezhad, Reyhaneh / Vakili, Mahsa Eshkevar / Shahraj, Haniye Ahmadi / Javadian, Behzad / Rezaei, Rozita / Moosazadeh, Mahmood

Journal of parasitic diseases : official organ of the Indian Society for Parasitology

2015 Volume 40, Issue 4, Page(s) 1332–1336

Abstract: Enterobiasis (oxyuriasis) is probably the most common helminth, which infects humans. Amongst different age groups, prevalence ... ...

Abstract	Enterobiasis (oxyuriasis) is probably the most common helminth, which infects humans. Amongst different age groups, prevalence of
Language	English
Publishing date	2015-04-03
Publishing country	India
Document type	Journal Article
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-015-0683-z
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Article: Prevalence of Enterobius vermicularis amongst kindergartens and preschool children in Mazandaran Province, North of Iran

Afrakhteh, Narges / Zahra Marhaba / Seif Ali Mahdavi / Sahar Garoosian / Reyhaneh Mirnezhad / Mahsa Eshkevar Vakili / Haniye Ahmadi Shahraj / Behzad Javadian / Rozita Rezaei / Mahmood Moosazadeh

Journal of parasitic diseases. 2016 Dec., v. 40, no. 4

2016

Abstract: Enterobiasis (oxyuriasis) is probably the most common helminth, which infects humans. Amongst different age groups, prevalence of Enterobius vermicularis in children is high compared to adults. Oxyuriasis is one of the most significant parasitic diseases ...

Abstract	Enterobiasis (oxyuriasis) is probably the most common helminth, which infects humans. Amongst different age groups, prevalence of Enterobius vermicularis in children is high compared to adults. Oxyuriasis is one of the most significant parasitic diseases of children. This nematode in children can result in loss of appetite, insomnia, grinding of the teeth, restlessness, endometritis, abdominal cramps, diarrhea and etc. Due to important complications of this parasite, the objective of the current study was to determine the prevalence of enterobiasis in kindergarten and preschool children of Amol, Mazandaran Province, North of Iran. A total number of 462 children from 32 kindergartens of Amol were examined for the prevalence of E. vermicularis infection, 2013. Adhesive cello-tape anal swab method was trained to parents for sampling. In addition, a questionnaire was designed and filled out to collect demographic information for each individual. Data were analyzed using Chi square test and multivariate logistic regression for each risk factor. The overall prevalence of E. vermicularis infection was 7.1Â % (33). Although infection with E. vermicularis in girls 7.9Â % was higher compared to boys 6.3Â %, there was no significant difference between gender and age (pÂ >Â 0.05) whereas binary logistic regression showed significant difference between enterobiasis and age (pÂ <Â 0.05). The findings indicated that the prevalence of E. vermicularis in kindergarten and preschool children is relatively high and still is an important health problem and should not be underestimated due to being highly contagious infection. Therefore, educational programs and mass treatment should be carried out in order to reduce infection incidence in this area and regular parasitological test and attention to personal hygiene in kindergarten and preschool is of great importance.
Keywords	Enterobius vermicularis ; adults ; anorexia ; boys ; chi-square distribution ; diarrhea ; education programs ; endometritis ; girls ; grinding ; helminths ; humans ; hygiene ; kindergarten ; parasitoses ; parents ; preschool children ; questionnaires ; regression analysis ; risk factors ; sleep disorders ; teeth ; Iran
Language	English
Dates of publication	2016-12
Size	p. 1332-1336.
Publishing place	Springer India
Document type	Article
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-015-0683-z
Database	NAL-Catalogue (AGRICOLA)

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