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  1. Article ; Online: Strategies towards Fully Recyclable Commercial Epoxy Resins: Diels-Alder Structures in Sustainable Composites.

    Vidal, Julio / Hornero, Carlos / De la Flor, Silvia / Vilanova, Anna / Dieste, Jose Antonio / Castell, Pere

    Polymers

    2024  Volume 16, Issue 8

    Abstract: The Diels-Alder equilibrium is a widely known process in chemistry that can be used to provide a thermoset structure with recyclability and reprocessability mechanisms. In this study, a commercial epoxy resin is modified through the integration of ... ...

    Abstract The Diels-Alder equilibrium is a widely known process in chemistry that can be used to provide a thermoset structure with recyclability and reprocessability mechanisms. In this study, a commercial epoxy resin is modified through the integration of functional groups into the network structure to provide superior performance. The present study has demonstrated that it is possible to adapt the curing process to efficiently incorporate these moieties in the final structure of commercial epoxy-based resins. It also evaluates the impact that they have on the final properties of the cured composites. In addition, different approaches have been studied for the incorporation of the functional group, adjusting and adapting the stoichiometry of the system components due to the differences in reactivity caused by the presence of the incorporated reactive groups, with the objective of maintaining comparable ratios of epoxy/amine groups in the formulation. Finally, it has been demonstrated that although the Diels-Alder equilibrium responds under external conditions, such as temperature, different sets of parameters and behaviors are to be expected as the structures are integrated into the thermoset, generating new equilibrium temperatures. In this way, the present research has explored sustainable strategies to enable the recyclability of commercial thermoset systems through crosslinking control and its modification.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16081024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Percutaneous Left Atrial Appendage Closure in Patients with Non-Valvular Atrial Fibrillation and End-Stage Renal Disease on Hemodialysis: A Case Series.

    Basabe, Elena / De La Flor, José C / López de la Manzanara, Virginia / Nombela-Franco, Luis / Narváez-Mejía, Carlos / Cruzado, Leónidas / Villa, Daniel / Zamora, Rocío / Tapia, Manuel / Sastre, Miguel Ángel / López Soberón, Edurne / Herrero Calvo, José A / Suárez, Alfonso / Martí Sánchez, David

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 2

    Abstract: Non-valvular atrial fibrillation (NVAF) is the most common cardiac arrhythmia in the general population, and its prevalence increases among patients with chronic kidney disease (CKD) undergoing hemodialysis. This population presents high risk of both ... ...

    Abstract Non-valvular atrial fibrillation (NVAF) is the most common cardiac arrhythmia in the general population, and its prevalence increases among patients with chronic kidney disease (CKD) undergoing hemodialysis. This population presents high risk of both hemorrhagic and thrombotic events, with little evidence regarding the use of oral anticoagulation treatment (OAT) and multiple complications arising from it; however, stroke prevention with percutaneous left atrial appendage closure (LAAC) is an alternative to be considered. We retrospectively describe the safety and efficacy of percutaneous LAAC in eight patients with NVAF and CKD on hemodialysis during a 12-month follow-up. The mean age was 78.8 years (range 64-86; SD ± 6.7), and seven patients were male. The mean CHA
    MeSH term(s) Humans ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Stroke/etiology ; Stroke/prevention & control ; Stroke/epidemiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Left Atrial Appendage Closure ; Retrospective Studies ; Treatment Outcome ; Hemorrhage/complications ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic/complications ; Anticoagulants/therapeutic use ; Renal Dialysis/adverse effects ; Atrial Appendage/surgery
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020231
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Efficacy and safety of semaglutide in a diabetic and obese patient on incremental hemodialysis. Does it also contribute to preserving residual renal function?

    de la Flor, José Carlos / Deira, Javier / Monzón, Tania / Valga, Francisco / Albarracín, Cristina / Ruiz, Elisa / Rodeles, Miguel

    Nefrologia

    2023  Volume 43, Issue 4, Page(s) 501–503

    MeSH term(s) Humans ; Renal Dialysis ; Glucagon-Like Peptides/therapeutic use ; Kidney/physiology ; Diabetes Mellitus
    Chemical Substances semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8)
    Language English
    Publishing date 2023-08-30
    Publishing country Spain
    Document type Letter
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2023.08.005
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  4. Article: Evaluation of factors leading to poor outcomes for pediatric acute lymphoblastic leukemia in Mexico: a multi-institutional report of 2,116 patients.

    Moreira, Daniel C / González-Ramella, Oscar / Echavarría Valenzuela, Maite / Carrillo, Angela K / Faughnan, Lane / Job, Godwin / Chen, Yichen / Villegas, Cesar / Ellis Irigoyen, Andrea / Barra Urbays, Rosario / Ramírez Martinez, Maribel / Altamirano Alvarez, Eduardo / León Espitia, José Antonio / López Facundo, Norma Araceli / Colunga Pedraza, Julia Esther / Reyes Gutierrez, Flor de María / Aguilar Román, Ana Berenice / Tamez Gómez, Edna Liliana / Portillo Zavala, Claudia Selene /
    Negroe Ocampo, Natalia Del Carmen / Pulido Sanchez, Sandra Guadalupe / Cortés Alva, Deyanira / Casillas Toral, Paola / Salas Villa, Karime / Mendoza Sánchez, Patricia Judith / Pérez Alvarado, Carlos / Tamayo Pedraza, Gabriela / González Zamorano, Margarita / Ávila Alba, José Manuel Ricardo / Becerril Becerril, Jocelyn / Ramírez Durán, Hernán / Sandoval Cabrera, Antonio / Pineda Gordillo, Adolfo / de la Rosa Alonso, Dora Iveth / Mejía Marín, Leonardo Javier / Benítez Can, Leslie de Los Ángeles / Gutiérrez Martinez, Itzel / Jiménez Osorio, Mariana Isabel / Echeandia, Naomi / Casillas, Erika / Guerrero-Gomez, Karla / Devidas, Meenakshi / Friedrich, Paola

    Frontiers in oncology

    2023  Volume 13, Page(s) 1255555

    Abstract: ... Adopting comprehensive risk-stratification strategies, evidence-informed de-intensification for favorable ...

    Abstract Background and aims: Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- and middle-income countries are lower due to deficiencies in multilevel factors, including access to timely diagnosis, risk-stratified therapy, and comprehensive supportive care. This retrospective study aimed to analyze outcomes for pediatric ALL at 16 centers in Mexico.
    Methods: Patients <18 years of age with newly diagnosed B- and T-cell ALL treated between January 2011 and December 2019 were included. Clinical and biological characteristics and their association with outcomes were examined.
    Results: Overall, 2,116 patients with a median age of 6.3 years were included. B-cell immunophenotype was identified in 1,889 (89.3%) patients. The median white blood cells at diagnosis were 11.2.5 × 10
    Conclusion: Outcomes in this multi-institutional cohort describe poor outcomes, influenced by incomplete and inconsistent risk stratification, early toxic death, high on-treatment mortality, and high CNS relapse rate. Adopting comprehensive risk-stratification strategies, evidence-informed de-intensification for favorable-risk patients and optimized supportive care could improve outcomes.
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1255555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy and Safety of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist in Real-Life: A Case Series of Patients in Maintenance Incremental Hemodialysis.

    De la Flor, José C / Lorenzo, Javier Deira / Marschall, Alexander / Valga, Francisco / Vázquez, Tania Monzón / Cícero, Elisa Ruiz

    Case reports in nephrology and dialysis

    2022  Volume 12, Issue 3, Page(s) 238–247

    Abstract: The glucagon-like peptide-1 receptor agonists (GLP-1RA) are among the newest treatment options available for managing of type 2 diabetes mellitus and slowing the progression of diabetes kidney disease (DKD). Subcutaneous (SC) semaglutide ( ... ...

    Abstract The glucagon-like peptide-1 receptor agonists (GLP-1RA) are among the newest treatment options available for managing of type 2 diabetes mellitus and slowing the progression of diabetes kidney disease (DKD). Subcutaneous (SC) semaglutide (Ozempic
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2809879-1
    ISSN 2296-9705
    ISSN 2296-9705
    DOI 10.1159/000527919
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  6. Article ; Online: Electromyographic Activity of the Pelvic Floor Muscles and Internal Oblique Muscles in Women during Running with Traditional and Minimalist Shoes: A Cross-Over Clinical Trial.

    García-Arrabé, María / García-Fernandez, Pablo / Díaz-Arribas, María José / López-Marcos, Jose Javier / González-de-la-Flor, Ángel / Estrada-Barranco, Cecilia / Roy, Jean-Sébastien

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 14

    Abstract: The study aimed to investigate the effects of footwear on the electromyographic (EMG) activity of pelvic floor muscles (PFMs) and internal oblique (IO) muscles during running at different speeds. The study also aimed to explore the correlation between ... ...

    Abstract The study aimed to investigate the effects of footwear on the electromyographic (EMG) activity of pelvic floor muscles (PFMs) and internal oblique (IO) muscles during running at different speeds. The study also aimed to explore the correlation between EMG activity of PFMs and IO muscles and participants' morphological characteristics. Ten nulliparous female runners were included in the study. The participants ran for 90 s at speeds of 9, 11, and 13 km/h wearing both traditional and minimalist shoes. EMG outcomes were presented as a percentage of maximum voluntary contraction (%MVC). Comparative analysis was conducted using the Wilcoxon rank test. Correlational analysis was performed using the Rho-Spearman correlation coefficient. The %MVC for the IO muscles was significantly lower when using minimalist shoes compared to traditional shoes (
    MeSH term(s) Humans ; Female ; Foot/physiology ; Abdominal Oblique Muscles ; Shoes ; Pelvic Floor ; Running/physiology ; Biomechanical Phenomena/physiology
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23146496
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  7. Article ; Online: Waldenström's Macroglobulinemia and Cryoglobulinemic Glomerulonephritis: An Unusual Case of Monoclonal Gammopathy of Renal Significance.

    De La Flor, José C / Sulca, Jesús de María / Rodríguez, Pablo / Villa, Daniel / Sandoval, Edna / Zamora, Rocío / Monroy-Condori, Maribel / Lipa, Roxana / Perez, Henry / Cieza, Michael

    Medical sciences (Basel, Switzerland)

    2023  Volume 11, Issue 4

    Abstract: Cryoglobulins are immunoglobulins that precipitate at temperatures below 37 °C and dissolve ...

    Abstract Cryoglobulins are immunoglobulins that precipitate at temperatures below 37 °C and dissolve upon reheating. They can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation that occurs in patients with monoclonal gammopathy, specifically Waldenström's macroglobulinemia. We present the case of a 52-year-old patient with a history of cutaneous vasculitis and hypothyroidism, who presented with generalized edema, moderate anemia, hypercholesterolemia, nephrotic range proteinuria of 12.69 g/day, microhematuria, arterial hypertension, and hypocomplementemia via the classical pathway, without acute kidney injury and with negative serological studies and positive cryoglobulins in the second determination. Serum and urine protein electrophoresis and immunofixation studies showed a monoclonal band of IgM and kappa light chain. Renal biopsy was consistent with cryoglobulinemic glomerulonephritis. In the context of dysproteinemia and cryoglobulinemic glomerulonephritis, bone-marrow aspiration and biopsy were performed, leading to the diagnosis of Waldenström's macroglobulinemia. Monoclonal gammopathies have been described in association with type I cryoglobulinemias. This described association is uncommon, which is why we present this case, along with a review of the literature.
    MeSH term(s) Humans ; Middle Aged ; Cryoglobulins ; Glomerulonephritis/complications ; Glomerulonephritis/diagnosis ; Monoclonal Gammopathy of Undetermined Significance/complications ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Paraproteinemias/complications ; Paraproteinemias/diagnosis ; Waldenstrom Macroglobulinemia/complications ; Waldenstrom Macroglobulinemia/diagnosis
    Chemical Substances Cryoglobulins
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci11040077
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  8. Article: Monoclonal Gammopathy of Renal Significance with Deposits of Infrequent Morphology: Two Case Reports of Light and Heavy Chain Deposition Disease with Atypical Presentation and Literature Review.

    De La Flor, José C / Monroy-Condori, Maribel / Apaza-Chavez, Jacqueline / Arenas-Moncaleano, Iván / Díaz, Francisco / Guerra-Torres, Xavier E / Morales-Montoya, Jorge L / Lerma-Verdejo, Ana / Sandoval, Edna / Villa, Daniel / Vieru, Coca-Mihaela

    Medicines (Basel, Switzerland)

    2023  Volume 10, Issue 10

    Abstract: Background: Monoclonal immunoglobulin deposition disease (MIDD) includes three entities: light chain deposition disease (LCDD), heavy chain deposition disease (HCDD) and light and heavy chain deposition disease (LHCDD). The renal presentation can ... ...

    Abstract Background: Monoclonal immunoglobulin deposition disease (MIDD) includes three entities: light chain deposition disease (LCDD), heavy chain deposition disease (HCDD) and light and heavy chain deposition disease (LHCDD). The renal presentation can manifest with varying degrees of proteinuria and/or nephrotic syndrome, microhematuria, and often leads to end-stage renal disease. Given the rarity of LHCDD, therapeutic approaches for this condition remain inconclusive, as clinical trials are limited.
    Case presentation: We report two male patients with underlying monoclonal gammopathy of renal significance (MGRS) associated with LHCDD lesions. Both cases had non-nephrotic proteinuria, moderately impaired renal function, and normal levels of C3 and C4. Light microscopy of the renal biopsies in both patients did not show lesions of nodular glomerulosclerosis. Immunofluorescence showed a staining pattern with interrupted linear IgA-κ in patient #1 and IgA-λ in patient #2 only along the glomerular basement membrane (GBM). Electron microscopy of patient #1 revealed electrodense deposits in the subendothelial and mesangial areas only along the GBM.
    Discussion: In this case series, we discuss the clinical, analytical, and histopathological findings of two rare cases of LHCDD. Both patients exhibited IgA monoclonality and were diagnosed with monoclonal gammopathy of undetermined significance (MGUS) by the hematology department at the time of renal biopsy. Treatment with steroids and cytotoxic agents targeting the clone cells responsible for the deposition disease resulted in a favorable renal and hematologic response.
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2777965-8
    ISSN 2305-6320
    ISSN 2305-6320
    DOI 10.3390/medicines10100055
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  9. Article ; Online: A case of acute interstitial nephritis following the Pfizer-BioNTech COVID-19 vaccine.

    de la Flor Merino, José Carlos / Linares Gravalos, Tania / Alonso-Riaño, Marina / Segura Cebollada, Pilar / Albarracin Serra, Cristina / Ruiz Cicero, Elisa / Gallegos Bayas, Gioconda / Rodeles Del Pozoa, Miguel

    Nefrologia

    2023  Volume 42, Issue 5, Page(s) 617–620

    MeSH term(s) Humans ; BNT162 Vaccine ; COVID-19/prevention & control ; Nephritis, Interstitial/chemically induced
    Chemical Substances BNT162 Vaccine
    Language English
    Publishing date 2023-01-19
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2021.05.007
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  10. Article: Efficacy and Safety of the Use of SGLT2 Inhibitors in Patients on Incremental Hemodialysis: Maximizing Residual Renal Function, Is There a Role for SGLT2 Inhibitors?

    De La Flor, José C / Villa, Daniel / Cruzado, Leónidas / Apaza, Jacqueline / Valga, Francisco / Zamora, Rocío / Marschall, Alexander / Cieza, Michael / Deira, Javier / Rodeles, Miguel

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: SGLT-2i are the new standard of care for diabetic kidney disease (DKD), but previous studies have not included patients on kidney replacement therapy (KRT). Due to their high risk of cardiovascular, renal complications, and mortality, these patients ... ...

    Abstract SGLT-2i are the new standard of care for diabetic kidney disease (DKD), but previous studies have not included patients on kidney replacement therapy (KRT). Due to their high risk of cardiovascular, renal complications, and mortality, these patients would benefit the most from this therapy. Residual kidney function (RKF) conveys a survival benefit and cardiovascular health among hemodialysis (HD) patients, especially those on incremental hemodialysis (iHD). We retrospectively describe the safety and efficacy of SGLT2i regarding RKF preservation in seven diabetic patients with different clinical backgrounds who underwent iHD (one or two sessions per week) during a 12-month follow-up. All patients preserved RKF, measured as residual kidney urea clearance (KrU) in 24 h after the introduction of SGLT2i. KrU levels improved significantly from 4.91 ± 1.14 mL/min to 7.28 ± 1.68 mL/min at 12 months (
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071908
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