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Article ; Online: Bilateral great toe deformities in a young child.

Reuter, Andrew M / Teigen, Luke C / Daniel, Jared W / Erie, Andrew J

2024

Language	English
Publishing date	2024-01-18
Publishing country	Germany
Document type	Editorial
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04577-8
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Article ; Online: Bilateral great toe deformities in a young child.

Reuter, Andrew M / Teigen, Luke C / Daniel, Jared W / Erie, Andrew J

Skeletal radiology

2024

Language	English
Publishing date	2024-01-13
Publishing country	Germany
Document type	Editorial
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04578-7
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Article ; Conference proceedings: Intraoperative Hemolysis during Left Ventricular Assist Device Implantation in Pigs

Meissner, F. / Reuter, J. / Büchsel, M. / Straky, HC. / Galbas, M.C. / Czerny, M. / Bothe, W.

The Thoracic and Cardiovascular Surgeon

2024 Volume 72, Issue S 01

Event/congress	53rd Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG), Congress Center Hamburg, 2024-02-17
Language	English
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0044-1780607
Database	Thieme publisher's database

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Uk I Zs.186: Show issues

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Article ; Online: A systematic methodology for epicardial and epiaortic echocardiography in swine research models.

Galbas, Michelle C / Meissner, Florian / Asmussen, Alexander / Straky, Hendrik C / Schimmel, Marius / Reuter, Johanna / Grundmann, Sebastian / Czerny, Martin / Bothe, Wolfgang

Health science reports

2024 Volume 7, Issue 1, Page(s) e1777

Abstract: Background: Perioperative echocardiography is of paramount importance during cardiac surgery. Nonetheless, in the experimental large-animal setting, it might be challenging obtaining optimal imaging when using conventional imaging acquisition techniques, ...

Abstract	Background: Perioperative echocardiography is of paramount importance during cardiac surgery. Nonetheless, in the experimental large-animal setting, it might be challenging obtaining optimal imaging when using conventional imaging acquisition techniques, such as transthoracic and transesophageal screenings. Open-chest surgery allows epicardial echocardiographic assessment with direct contact between probe and heart, thus providing superior quality. Standard protocols regarding the use of epicardial ultrasound in swine for research purposes are lacking. Methods: Epicardial echocardiography was performed in 10 female German Landrace pigs undergoing cardiac surgery. A structured and comprehensive protocol for epicardial echocardiography was elaborated including apical, ventricular long and short axis, as well as epiaortic planes. All experiments were approved by the local board for animal welfare and conducted in accordance with the German animal protection law (TierSchG) and the ARRIVE guidelines. Conclusions: Systematic protocols using epicardial echocardiography may serve as an additional tool to assess cardiac dimensions and function in experimental scenarios with swine models.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1777
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Article: Nanolithographic Fabrication Technologies for Network-Based Biocomputation Devices.

Meinecke, Christoph R / Heldt, Georg / Blaudeck, Thomas / Lindberg, Frida W / van Delft, Falco C M J M / Rahman, Mohammad Ashikur / Salhotra, Aseem / Månsson, Alf / Linke, Heiner / Korten, Till / Diez, Stefan / Reuter, Danny / Schulz, Stefan E

Materials (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: Network-based biocomputation (NBC) relies on accurate guiding of biological agents through nanofabricated channels produced by lithographic patterning techniques. Here, we report on the large-scale, wafer-level fabrication of optimized microfluidic ... ...

Abstract	Network-based biocomputation (NBC) relies on accurate guiding of biological agents through nanofabricated channels produced by lithographic patterning techniques. Here, we report on the large-scale, wafer-level fabrication of optimized microfluidic channel networks (NBC networks) using electron-beam lithography as the central method. To confirm the functionality of these NBC networks, we solve an instance of a classical non-deterministic-polynomial-time complete ("NP-complete") problem, the subset-sum problem. The propagation of cytoskeletal filaments, e.g., molecular motor-propelled microtubules or actin filaments, relies on a combination of physical and chemical guiding along the channels of an NBC network. Therefore, the nanofabricated channels have to fulfill specific requirements with respect to the biochemical treatment as well as the geometrical confienement, with walls surrounding the floors where functional molecular motors attach. We show how the material stack used for the NBC network can be optimized so that the motor-proteins attach themselves in functional form only to the floor of the channels. Further optimizations in the nanolithographic fabrication processes greatly improve the smoothness of the channel walls and floors, while optimizations in motor-protein expression and purification improve the activity of the motor proteins, and therefore, the motility of the filaments. Together, these optimizations provide us with the opportunity to increase the reliability of our NBC devices. In the future, we expect that these nanolithographic fabrication technologies will enable production of large-scale NBC networks intended to solve substantially larger combinatorial problems that are currently outside the capabilities of conventional software-based solvers.
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16031046
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Article ; Online: Resting-state brain signal complexity discriminates young healthy APOE e4 carriers from non-e4 carriers.

Li, Xiaojing / Kaur, Yadwinder / Wilhelm, Oliver / Reuter, Martin / Montag, Christian / Sommer, Werner / Zhou, Changsong / Hildebrandt, Andrea

The European journal of neuroscience

2023 Volume 57, Issue 5, Page(s) 854–866

Abstract: It is well established that the e4 allele of the APOE gene is associated with impaired brain functionality and cognitive decline in humans at elder age. However, it is controversial whether and how the APOE e4 allele is associated with superior brain ... ...

Abstract	It is well established that the e4 allele of the APOE gene is associated with impaired brain functionality and cognitive decline in humans at elder age. However, it is controversial whether and how the APOE e4 allele is associated with superior brain function among young healthy individuals, thus indicates a case of antagonistic pleiotropy of APOE e4 allele. Signal complexity is a critical aspect of brain activity that has been associated with brain function. In this study, the multiscale entropy (MSE) of resting-state EEG signals among a sample of young healthy adults (N = 260) as an indicator of brain signal complexity was investigated. It was of interest whether MSE differs across APOE genotype groups while age and education level were controlled for and whether the APOE genotype effect on MSE interacts with MSE time scale, as well as EEG recording condition. Results of linear mixed models indicate overall larger MSE in APOE e4 carriers. This genotype-dependent difference is larger at high as compared with low time scales. The interaction effect between APOE genotype and recording condition indicates increased between-state MSE change in young healthy APOE e4 carriers as compared with non-carriers. Because higher complexity is commonly taken to be associated with better cognitive functioning, the present results complement previous findings and therefore point to a pleiotropic spectrum of the APOE gene polymorphism.
MeSH term(s)	Adult ; Aged ; Humans ; Aging/genetics ; Aging/pathology ; Apolipoprotein E4/genetics ; Brain/pathology ; Electroencephalography/methods ; Genotype ; Heterozygote
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2023-02-01
Publishing country	France
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15915
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Zs.A 2548: Show issues

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Article: Spirituality and anxiety in pastoral care workers and physicians in the first wave of the COVID-19 pandemic.

Culmann, Anna C / Baranowski, Andreas M / Matthias, Julia-K / Tüttenberg, Simone C / Belschner, Wilfried / Erim, Yesim / Morawa, Eva / Beschoner, Petra / Jerg-Bretzke, Lucia / Albus, Christian / Steudte-Schmiedgen, Susann / Reuter, Martin / Geiser, Franziska

Frontiers in psychiatry

2024 Volume 15, Page(s) 1354044

Abstract: Background: The COVID-19 pandemic had serious impact on the well-being of health care workers and highlighted the need for resources to help hospital staff to cope with psychologically negative consequences. The purpose of this study was to investigate ... ...

Abstract	Background: The COVID-19 pandemic had serious impact on the well-being of health care workers and highlighted the need for resources to help hospital staff to cope with psychologically negative consequences. The purpose of this study was to investigate the potentially protective effect of spirituality, as measured by the construct of transpersonal trust, against anxiety in physicians and in hospital pastoral care workers. In addition, transpersonal trust was compared to the effects of other potential resources, namely sense of coherence, optimism, and resilience. We also explored the relationship between transpersonal trust and anxiety and how it was moderated by sense of coherence and expected a significant effect. Method: The sample included Results: There was no statistically significant negative relationship between transpersonal trust and anxiety in either profession or broken down by occupational group. Multiple regression analysis revealed that sense of coherence inversely predicted generalized anxiety, while transpersonal trust, resilience, and optimism did not. As hypothesized, the association between transpersonal trust and anxiety was moderated by sense of coherence. However, we could not confirm our hypothesis of a protective effect of transpersonal trust against anxiety. Conclusion: Our results point to the significant role of sense of coherence as a protective factor against anxiety and highlight the complexity of the relationship among spirituality, transpersonal trust, and anxiety.
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2024.1354044
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Article ; Online: Extraction and analysis of free amino acids and 5'-nucleotides, the key contributors to the umami taste of seaweed.

Moerdijk-Poortvliet, Tanja C W / de Jong, Dylan L C / Fremouw, Roy / de Reu, Sandra / de Winter, Jose M / Timmermans, Klaas / Mol, Geert / Reuter, Norbert / Derksen, Goverdina C H

Food chemistry

2021 Volume 370, Page(s) 131352

Abstract: ... respectively. Of multiple mouth emulating solvents, extracting in Milli-Q at 35 °C was found most suitable ...

Abstract	Assessing the umami taste of seaweed on a chemical level can inform the use and selection of seaweed in European cuisine. Accordingly, we developed a method for the simultaneous extraction, separate clean-up and analysis of 21 free amino acids and 10 free nucleotides by reversed phase and mixed-mode HPLC respectively. Of multiple mouth emulating solvents, extracting in Milli-Q at 35 °C was found most suitable. This method showed good linearity (R
MeSH term(s)	Amino Acids ; Glutamic Acid ; Nucleotides ; Seaweed ; Taste
Chemical Substances	Amino Acids ; Nucleotides ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2021-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131352
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Article ; Online: Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia.

Broome, Catherine M / Röth, Alexander / Kuter, David J / Scully, Marie / Smith, Roy / Wang, Jennifer / Reuter, Caroline / Hobbs, William / Daak, Ahmed

Blood advances

2022 Volume 7, Issue 6, Page(s) 987–996

Abstract: Chronic/refractory immune thrombocytopenia (ITP) is a rare and pathophysiologically heterogeneous disorder with variable responsiveness to available treatments. Sutimlimab, a first-in-class humanized monoclonal anti-C1s IgG4 antibody, selectively ... ...

Abstract	Chronic/refractory immune thrombocytopenia (ITP) is a rare and pathophysiologically heterogeneous disorder with variable responsiveness to available treatments. Sutimlimab, a first-in-class humanized monoclonal anti-C1s IgG4 antibody, selectively inhibits the classical pathway. This phase 1 study (NCT03275454) assessed the safety, efficacy, pharmacokinetics, and pharmacodynamics of biweekly sutimlimab in patients with chronic/refractory ITP with an inadequate response to ≥2 therapies (platelet count ≤ 30 × 109/L). Twelve patients (median age 42 years) received sutimlimab for a median of 20.5 weeks followed by a median 2-week washout period (part A). In part B, 7 of the 12 eligible patients received sutimlimab retreatment for a median of 113 weeks. In part A, the mean (standard deviation) platelet count increased from 25 × 109/L (17) to 54 × 109/L (60) 24 hours after starting sutimlimab, maintaining ≥50 × 109/L throughout part A. Five patients (42%) achieved durable platelet count responses (≥50 × 109/L in ≥50% of follow-up visits) and 4 achieved complete response (platelet count ≥100 × 109/L). The mean platelet count returned to baseline during washout and increased upon retreatment in part B. The mean platelet count improvements accompanied the rapid inhibition of the classical pathway. There were 74 treatment-emergent adverse events in part A (n = 10) and 70 in part B (n = 6). Five serious adverse events were observed; 1 event (migraine) was assessed by the investigator as related to sutimlimab. These results demonstrated that in some patients with ITP, autoantibodies activate the classical complement pathway, accelerating platelet destruction or impairing platelet production and contributing to treatment failure. Thus, C1s inhibition may be a safe and beneficial therapeutic approach for patients with chronic/refractory ITP.
MeSH term(s)	Humans ; Adult ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Complement Pathway, Classical ; Platelet Count ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	sutimlimab (GNWE7KJ995) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021006864
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Article: The Hypertension Paradox: Survival Benefit After ST-Elevation Myocardial Infarction in Patients With History of Hypertension. A Prospective Cohort- and Risk-Analysis.

Hoffmann, Fabian / Fassbender, Patricia / Zander, Wilhelm / Ulbrich, Lisa / Kuhr, Kathrin / Adler, Christoph / Halbach, Marcel / Reuter, Hannes

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 785657

Abstract: Background: Mortality after ST-elevation myocardial infarction (STEMI) is dependent from best-medical treatment after initial event.: Objectives: Determining the impact of prescription of guideline-recommended therapy after STEMI in two cohorts, ... ...

Abstract	Background: Mortality after ST-elevation myocardial infarction (STEMI) is dependent from best-medical treatment after initial event. Objectives: Determining the impact of prescription of guideline-recommended therapy after STEMI in two cohorts, patients with and without history of arterial hypertension, on survival. Methods: 1,025 patients of the Cologne Infarction Model registry with invasively adjudicated STEMI were dichotomized according to their history of arterial hypertension. We recorded prescription rates and dosing of RAS-inhibitors, β-blockers and statins in all patients. The primary outcome was all-cause death. Mean follow-up was 2.5 years. Results: Mean age was 64 ± 13 years, 246 (25%) were women. 749 (76%) patients had a history of hypertension. All-cause mortality was 24.2%, 30-day and 1-year mortality was 11.3% and 16.6%, respectively. History of hypertension correlated with lower mortality (hazard ratio [HR], @30 days: 0.41 [0.27-0.62], @1 year: 0.37 [0.26-0.53]). After adjusting for age, sex, Killip-class, diabetes mellitus, body-mass index, kidney function and statin prescription at discharge 1-year mortality HR was 0.24 (0.12-0.48). At discharge, prescription rates for RAS-inhibitors, β-blockers and statins, as well as individual dosing and long-term persistence of RAS-inhibitors were higher in patients with history of hypertension. On the same lines, prescription rates for RAS-inhibitors, β-blockers and statins at discharge correlated significantly with lower mortality regardless of history of hypertension. Conclusion: Patients with history of hypertension show higher penetration of guideline recommended drug therapy after STEMI, which may contribute to better survival. Better tolerance of β-blockers and RAS-inhibitors in patients with history of hypertension, not hypertension itself, likely explains these differences in prescription and dosing.
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.785657
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