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  1. Book: Nutritional signaling pathway activities in obesity and diabetes

    Cheng, Zhiyong

    (Food chemistry, function and analysis ; 24)

    2020  

    Author's details edited by Zhiyong Cheng
    Series title Food chemistry, function and analysis ; 24
    Collection
    Keywords Obesity/Nutritional aspects ; Obesity/Molecular aspects ; Diabetes/Nutritional aspects ; Diabetes/Molecular aspects ; Cellular signal transduction
    Subject code 616.398
    Language English
    Size xiv, 338 Seiten, 24 cm
    Publisher Royal Society of Chemistry
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT020577554
    ISBN 978-1-78801-557-8 ; 9781839160615 ; 9781839160608 ; 1-78801-557-6 ; 1839160616 ; 1839160608
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1296 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: FoxO transcription factors in mitochondrial homeostasis.

    Cheng, Zhiyong

    The Biochemical journal

    2022  Volume 479, Issue 4, Page(s) 525–536

    Abstract: Mitochondria play essential roles in cellular energetics, biosynthesis, and signaling transduction. Dysfunctional mitochondria have been implicated in different diseases such as obesity, diabetes, cardiovascular disease, nonalcoholic fatty liver disease, ...

    Abstract Mitochondria play essential roles in cellular energetics, biosynthesis, and signaling transduction. Dysfunctional mitochondria have been implicated in different diseases such as obesity, diabetes, cardiovascular disease, nonalcoholic fatty liver disease, neurodegenerative disease, and cancer. Mitochondrial homeostasis is controlled by a triad of mitochondrial biogenesis, dynamics (fusion and fission), and autophagy (mitophagy). Studies have underscored FoxO transcription factors as key mitochondrial regulators. Specifically, FoxOs regulate mitochondrial biogenesis by dampening NRF1-Tfam and c-Myc-Tfam cascades directly, and inhibiting NAD-Sirt1-Pgc1α cascade indirectly by inducing Hmox1 or repressing Fxn and Urod. In addition, FoxOs mediate mitochondrial fusion (via Mfn1 and Mfn2) and fission (via Drp1, Fis1, and MIEF2), during which FoxOs elicit regulatory mechanisms at transcriptional, posttranscriptional (e.g. via miR-484/Fis1), and posttranslational (e.g. via Bnip3-calcineurin mediated Drp1 dephosphorylation) levels. Furthermore, FoxOs control mitochondrial autophagy in the stages of autophagosome formation and maturation (e.g. initiation, nucleation, and elongation), mitochondria connected to and engulfed by autophagosome (e.g. via PINK1 and Bnip3 pathways), and autophagosome-lysosome fusion to form autolysosome for cargo degradation (e.g. via Tfeb and cathepsin proteins). This article provides an up-to-date view of FoxOs regulating mitochondrial homeostasis and discusses the potential of targeting FoxOs for therapeutics.
    MeSH term(s) Homeostasis ; Humans ; Mitochondria/genetics ; Mitochondrial Dynamics ; Mitochondrial Proteins/genetics ; Neurodegenerative Diseases ; Peptide Elongation Factors ; Transcription Factors
    Chemical Substances MIEF2 protein, human ; Mitochondrial Proteins ; Peptide Elongation Factors ; Transcription Factors
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20210777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen.

    Tao, Zhipeng / Cheng, Zhiyong

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 6, Page(s) 415–434

    Abstract: Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated evidence has revealed a great deal of insulin and estrogen signaling pathways and their interplays in the regulation of mitochondrial, cellular remodeling, and ... ...

    Abstract Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated evidence has revealed a great deal of insulin and estrogen signaling pathways and their interplays in the regulation of mitochondrial, cellular remodeling, and macronutrient metabolism. Insulin signaling regulates nutrient and mitochondrial metabolism by targeting the IRS-PI3K-Akt-FoxOs signaling cascade and PGC1α. Estrogen signaling fine-tunes protein turnover and mitochondrial metabolism through its receptors (ERα, ERβ, and GPER). Insulin and estrogen signaling converge on Sirt1, mTOR, and PI3K in the joint regulation of autophagy and mitochondrial metabolism. Dysregulated insulin and estrogen signaling lead to metabolic diseases. This article reviews the up-to-date evidence that depicts the pathways of insulin signaling and estrogen-ER signaling in the regulation of metabolism. In addition, we discuss the cross-talk between estrogen signaling and insulin signaling via Sirt1, mTOR, and PI3K, as well as new therapeutic options such as agonists of GLP1 receptor, GIP receptor, and β3-AR. Mapping the molecular pathways of insulin signaling, estrogen signaling, and their interplays advances our understanding of metabolism and discovery of new therapeutic options for metabolic disorders.
    MeSH term(s) Insulin ; Sirtuin 1 ; Phosphatidylinositol 3-Kinases ; Estrogens ; TOR Serine-Threonine Kinases
    Chemical Substances Insulin ; Sirtuin 1 (EC 3.5.1.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Estrogens ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20210519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Band Gap Engineering of Mo

    Zhou, Zhonghao / Zhang, Xingchen / Chen, Xinya / Cheng, Zhihai / Wang, Zhiyong

    Inorganic chemistry

    2024  Volume 63, Issue 17, Page(s) 7714–7724

    Abstract: Modulating the band gap of two-dimensional (2D) transition metal dichalcogenide (TMDC) semiconductors is critical for their application in a wider spectral range. Alloying has been demonstrated as an effective method for regulating the band gap of 2D ... ...

    Abstract Modulating the band gap of two-dimensional (2D) transition metal dichalcogenide (TMDC) semiconductors is critical for their application in a wider spectral range. Alloying has been demonstrated as an effective method for regulating the band gap of 2D TMDC semiconductors. The fabrication of large-area 2D TMDC alloy films with centimeter-scale uniformity is fundamental to the application of integrated devices. Herein, we report a liquid-phase precursor one-step chemical vapor deposition (CVD) method for fabricating a Mo
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c04644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The FoxO-Autophagy Axis in Health and Disease.

    Cheng, Zhiyong

    Trends in endocrinology and metabolism: TEM

    2019  Volume 30, Issue 9, Page(s) 658–671

    Abstract: Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed ... ...

    Abstract Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear FoxOs transactivate genes that control the formation of autophagosomes and their fusion with lysosomes. Independently of transactivation, cytosolic FoxO proteins induce autophagy by directly interacting with autophagy proteins. Autophagy is also controlled by FoxOs through epigenetic mechanisms. Moreover, FoxO proteins can be degraded directly or indirectly by autophagy. Cutting-edge evidence is reviewed that the FoxO-autophagy axis plays a crucial role in health and disease.
    MeSH term(s) Animals ; Autophagy/genetics ; Autophagy/physiology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Humans ; Neoplasms/metabolism ; Neoplasms/physiopathology ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Forkhead Transcription Factors ; Transcription Factors
    Language English
    Publishing date 2019-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2019.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Medium-temperature calcination and acid pressure leaching extract the Al

    Yang, Zhiyong / Zheng, Yunsheng / Ma, Zhijun / Cheng, Liang / Wang, Guangming / Qin, Ying

    RSC advances

    2024  Volume 14, Issue 16, Page(s) 11266–11275

    Abstract: Bauxite is an important strategic resource, and it is facing with the problem of balance between high demand of bauxite ore and low resource of bauxite reserves in China. This research takes the Fuxin coal gangue as the object and extracts ... ...

    Abstract Bauxite is an important strategic resource, and it is facing with the problem of balance between high demand of bauxite ore and low resource of bauxite reserves in China. This research takes the Fuxin coal gangue as the object and extracts Al
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08901k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A wireless fluorescent sensing device for on-site closed-loop detection of hydrazine levels in the environment.

    Zhu, Zihao / Song, Ke / Li, Xiaobai / Chen, Yu / Kong, Fanwei / Mo, Wanqi / Cheng, Zhiyong / Yang, Shilong / Ma, Hongwei

    Journal of hazardous materials

    2024  Volume 468, Page(s) 133809

    Abstract: Given the extensive need for the detection of hydrazine ( ... ...

    Abstract Given the extensive need for the detection of hydrazine (N
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Research Progress and Prospect of Stimuli-Responsive Lignin Functional Materials.

    Li, Xiaobai / Meng, Yunhui / Cheng, Zhiyong / Li, Bin

    Polymers

    2023  Volume 15, Issue 16

    Abstract: As the world's second most abundant renewable natural phenolic polymer after cellulose, lignin is an extremely complex, amorphous, highly cross-linked class of aromatic polyphenolic macromolecules. Due to its special aromatic structure, lignin is ... ...

    Abstract As the world's second most abundant renewable natural phenolic polymer after cellulose, lignin is an extremely complex, amorphous, highly cross-linked class of aromatic polyphenolic macromolecules. Due to its special aromatic structure, lignin is considered to be one of the most suitable candidates to replace fossil materials, thus the research on lignin functional materials has received extensive attention. Because lignin has stimuli-sensitive groups such as phenolic hydroxyl, hydroxyl, and carboxyl, the preparation of stimuli-responsive lignin-based functional materials by combining lignin with some stimuli-responsive polymers is a current research hotspot. Therefore, this article will review the research progress of stimuli-responsive lignin-based functional materials in order to guide the subsequent work. Firstly, we elaborate the source and preparation of lignin and various types of lignin pretreatment methods. We then sort out and discuss the preparation of lignin stimulus-responsive functional materials according to different stimuli (pH, light, temperature, ions, etc.). Finally, we further envision the scope and potential value of lignin stimulus-responsive functional materials for applications in actuators, optical coding, optical switches, solar photothermal converters, tissue engineering, and biomedicine.
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15163372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficient photohydrogen production by edge-modified carbon nitride with nonmetallic group.

    Cheng, Jingsai / Li, Chunmei / Yu, Zhiyong / Liu, Hanxing

    Journal of colloid and interface science

    2022  Volume 629, Issue Pt B, Page(s) 739–749

    Abstract: As an efficient photocatalyst, graphitic carbon nitride (g- ... ...

    Abstract As an efficient photocatalyst, graphitic carbon nitride (g-C
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.09.121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  10. Article ; Online: Photo-gated polymer mechanochromism from excited-state intramolecular proton transfer.

    Cheng, Xin / Hu, Huan / Wu, Yu / Ma, Zhimin / Ma, Zhiyong

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 47, Page(s) 7236–7239

    Abstract: Controlled polymer mechanochromism has large potential for new applications. We design a novel ESIPT mechanophore (HBIA-2OH) by three-step synthesis. Connected to polyurethane, it shows unique photo-gated mechanochromism from excited-state intramolecular ...

    Abstract Controlled polymer mechanochromism has large potential for new applications. We design a novel ESIPT mechanophore (HBIA-2OH) by three-step synthesis. Connected to polyurethane, it shows unique photo-gated mechanochromism from excited-state intramolecular proton transfer (ESIPT)
    MeSH term(s) Models, Molecular ; Protons ; Hydrogen Bonding
    Chemical Substances Protons
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01900d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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