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Article: Vitamin D and its association with severity and control of childhood bronchial asthma.

Bhat, Kamalakshi G / Mahalingam, Soundarya / Soumya, V C

2023 Volume 67, Issue 1, Page(s) 3–7

Abstract: Background: Bronchial asthma is a common disease in childhood. Vitamin D deficiency is a common ... well understood.: Objectives: Our study aimed to determine serum Vitamin D levels among asthmatic ... use. Serum Vitamin D levels were estimated using an enzyme-linked immunosorbent assay and classified ...

Abstract	Background: Bronchial asthma is a common disease in childhood. Vitamin D deficiency is a common unidentified nutritional deficiency. In spite of high prevalence, an association between the two has not been well understood. Objectives: Our study aimed to determine serum Vitamin D levels among asthmatic children and its association with clinical severity and level of control. Methods: A hospital-based cross-sectional study was conducted from 2017 to 2019 where 64 recurrent wheezers, classified into 6-15 years and the under 5 wheezers as per Global Initiative for Asthma guidelines, were included. The group of asthmatic children was comparable with respect to their demographic profiles with good adherence and proper inhaler use. Serum Vitamin D levels were estimated using an enzyme-linked immunosorbent assay and classified using the US Endocrine Society classification. Association between Vitamin D status and outcome variables was analyzed using Chi-square test, Fisher's exact test, unpaired t-test, and ANOVA. Results: Among the 64 wheezers, 29 (45.3%) had intermittent symptoms and 35 (54.7%) had persistent symptoms. Mean Vitamin D levels in the entire study population were in deficiency range (18.96 ng/ml ± 2.23). Persistent asthmatics had significantly lower Vitamin D levels (13.75 ng/ml) as compared to intermittent asthmatics (28.52 ng/ml). Those asthmatics who had hypovitaminosis D had higher rates of hospitalization (P = 0.048), increased use of rescue medications (P = 0.008), and poor symptom control (P = 0.001). Conclusions: Asthmatic children had a higher incidence of reduced Vitamin D levels showing a statistically significant association. There is also a significant association between Vitamin D level and poor symptom control, hospitalization for exacerbations, and requirement of rescue medication in asthmatic children.
MeSH term(s)	Child ; Humans ; Vitamin D ; Cross-Sectional Studies ; India/epidemiology ; Asthma/epidemiology ; Vitamin D Deficiency/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-01-10
Publishing country	India
Document type	Journal Article
ZDB-ID	800737-8
ISSN	2229-7693 ; 0019-557X
ISSN (online)	2229-7693
ISSN	0019-557X
DOI	10.4103/ijph.ijph_1507_21
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Article ; Online: α-bisabolol β-d-fucopyranoside (ABFP) ameliorates scopolamine-induced memory deficits through cholinesterase inhibition and attenuation of oxidative stress in zebrafish (Danio rerio).

Jeyakumar, Mahalingam / Jaya Balan, Devasahayam / Kiruthiga, Chandramohan / Jafni, Sakthivel / Pandima Devi, Kasi

Journal of biochemical and molecular toxicology

2023 Volume 38, Issue 1, Page(s) e23580

Abstract: ... In the present study, the neuroprotective ability of α-bisabolol β-d-fucopyranoside (ABFP) was assessed via ...

Abstract	Alzheimer's disease (AD) is one of the major devastating neurodegenerative disorders associated with the gradual decline of an individual's memory, cognition, and ability to carry out day-to-day activities. In the present study, the neuroprotective ability of α-bisabolol β-d-fucopyranoside (ABFP) was assessed via measurement of antioxidant parameters like lipid peroxidation, glutathione peroxidation, glutathione, protein carbonyl content assays, and caspase-3 activity estimation. Moreover, the acute toxicity of ABFP was estimated in the zebrafish larval model. The results showed that ABFP exhibits little to no toxicity at lower concentrations in the acute toxicity test. ABFP-pretreated and scopolamine-exposed fish exhibited more exploratory behavior in the behavior assay than scopolamine-only induced groups. Additionally, the results of antioxidant enzyme assays revealed reduced oxidative stress and damage in ABFP-treated fish, while enzyme activity experiments carried out with brain homogenate from ABFP-treated fish showed decreased acetylcholinesterase enzyme activity. Overall, it can be concluded that ABFP has the potential to be a promising agent for the treatment of AD in the future.
MeSH term(s)	Animals ; Zebrafish/metabolism ; Scopolamine/adverse effects ; Antioxidants/metabolism ; Acetylcholinesterase/metabolism ; Protein Carbonylation ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Oxidative Stress ; Alzheimer Disease/chemically induced ; Glutathione/metabolism ; Monocyclic Sesquiterpenes
Chemical Substances	Scopolamine (DL48G20X8X) ; Antioxidants ; bisabolol (24WE03BX2T) ; Acetylcholinesterase (EC 3.1.1.7) ; Glutathione (GAN16C9B8O) ; Monocyclic Sesquiterpenes
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.23580
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Article ; Online: Vitamin D and its association with severity and control of childhood bronchial asthma

Kamalakshi G Bhat / Soundarya Mahalingam / V C Soumya

Indian Journal of Public Health, Vol 67, Iss 1, Pp 3-

2023 Volume 7

Abstract: Background: Bronchial asthma is a common disease in childhood. Vitamin D deficiency is a common ... well understood. Objectives: Our study aimed to determine serum Vitamin D levels among asthmatic ... use. Serum Vitamin D levels were estimated using an enzyme-linked immunosorbent assay and classified ...

Abstract	Background: Bronchial asthma is a common disease in childhood. Vitamin D deficiency is a common unidentified nutritional deficiency. In spite of high prevalence, an association between the two has not been well understood. Objectives: Our study aimed to determine serum Vitamin D levels among asthmatic children and its association with clinical severity and level of control. Methods: A hospital-based cross-sectional study was conducted from 2017 to 2019 where 64 recurrent wheezers, classified into 6–15 years and the under 5 wheezers as per Global Initiative for Asthma guidelines, were included. The group of asthmatic children was comparable with respect to their demographic profiles with good adherence and proper inhaler use. Serum Vitamin D levels were estimated using an enzyme-linked immunosorbent assay and classified using the US Endocrine Society classification. Association between Vitamin D status and outcome variables was analyzed using Chi-square test, Fisher's exact test, unpaired t-test, and ANOVA. Results: Among the 64 wheezers, 29 (45.3%) had intermittent symptoms and 35 (54.7%) had persistent symptoms. Mean Vitamin D levels in the entire study population were in deficiency range (18.96 ng/ml ± 2.23). Persistent asthmatics had significantly lower Vitamin D levels (13.75 ng/ml) as compared to intermittent asthmatics (28.52 ng/ml). Those asthmatics who had hypovitaminosis D had higher rates of hospitalization (P = 0.048), increased use of rescue medications (P = 0.008), and poor symptom control (P = 0.001). Conclusions: Asthmatic children had a higher incidence of reduced Vitamin D levels showing a statistically significant association. There is also a significant association between Vitamin D level and poor symptom control, hospitalization for exacerbations, and requirement of rescue medication in asthmatic children.
Keywords	bronchial asthma ; use of rescue medication ; vitamin d ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Donald H. Gilden, M.D.

Owens, Gregory P / Nagel, Maria A / Mahalingam, Ravi / Cohrs, Randall J

Journal of neuroimmunology

2017 Volume 308, Page(s) 2–5

Language	English
Publishing date	2017-01-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2017.01.002
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Article ; Online: Vitamin D status among postmenopausal osteoporotic women

Navaneethakrishnan Suganthan / Thirunavukarasu Kumanan / Vithegi Kesavan / Mahalingam Aravinthan / Nadarajah Rajeshkannan

BMC Nutrition, Vol 6, Iss 1, Pp 1-

a hospital based cross-sectional study from Northern Sri Lanka

2020 Volume 8

Abstract: Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important ... to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies ... examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date ...

Abstract	Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis in Sri Lanka. This is the first study in Sri Lanka of such kind conducted to evaluate the serum vitamin D levels among postmenopausal women. Methods Cross-sectional study was conducted at the Endocrine Unit, Teaching Hospital Jaffna from January to December 2018. During this period 105 postmenopausal women who registered for bone density assessment were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nurses and total 25-Hydroxy Vitamin D level (25(OH)-Vit D) was measured by competitive immunoassay with enhanced chemiluminiscence technique, levels were categorized and analysis was done using SPSS 26. Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean total 25(OH)-Vit D was 27.5 (range11.7–52.5 ng/mL). 25(OH)-Vit D levels were adequate in only 36.2% (95%CI: 27–45), 44% had insufficient levels and deficiency was present in 19% (95%CI: 12–27) of postmenopausal women. Among total study participants 20% were vegetarian, 53, 76.2 and 64.8% were consuming milk, fish and egg respectively and 71.4% reported adequate level of sun exposure (> 30 min/day). Commonly reported vitamin D deficiency symptoms include paraesthesia (57.1%), bone-pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%). Nevertheless, comparison of musculoskeletal symptoms between group with sufficient level and group with insufficient and deficient level showed no significant difference (P > 0.05). Among 71 participants (66.7%) who completed bone density assessment, 38% (95%CI: 27–49) showed osteoporosis. Vertebral ...
Keywords	Vitamin D deficiency ; Post-menopausal women ; Osteoporosis ; Nutrition. Foods and food supply ; TX341-641 ; Food processing and manufacture ; TP368-456 ; Medicine (General) ; R5-920
Subject code	150
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

Suganthan, Navaneethakrishnan / Kumanan, Thirunavukarasu / Kesavan, Vithegi / Aravinthan, Mahalingam / Rajeshkannan, Nadarajah

BMC nutrition

2020 Volume 6, Page(s) 15

Abstract: Background: Vitamin D deficiency is common among post-menopausal women and it is important ... to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies ... examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date ...

Abstract	Background: Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis in Sri Lanka. This is the first study in Sri Lanka of such kind conducted to evaluate the serum vitamin D levels among postmenopausal women. Methods: Cross-sectional study was conducted at the Endocrine Unit, Teaching Hospital Jaffna from January to December 2018. During this period 105 postmenopausal women who registered for bone density assessment were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nurses and total 25-Hydroxy Vitamin D level (25(OH)-Vit D) was measured by competitive immunoassay with enhanced chemiluminiscence technique, levels were categorized and analysis was done using SPSS 26. Results: Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean total 25(OH)-Vit D was 27.5 (range11.7-52.5 ng/mL). 25(OH)-Vit D levels were adequate in only 36.2% (95%CI: 27-45), 44% had insufficient levels and deficiency was present in 19% (95%CI: 12-27) of postmenopausal women. Among total study participants 20% were vegetarian, 53, 76.2 and 64.8% were consuming milk, fish and egg respectively and 71.4% reported adequate level of sun exposure (> 30 min/day). Commonly reported vitamin D deficiency symptoms include paraesthesia (57.1%), bone-pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%). Nevertheless, comparison of musculoskeletal symptoms between group with sufficient level and group with insufficient and deficient level showed no significant difference ( Conclusion: Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to consider vitamin D supplementation when initiating treatment for osteoporosis. Hence, Vitamin D testing is desirable in decision making to treat or not to treat.
Language	English
Publishing date	2020-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2809847-X
ISSN	2055-0928 ; 2055-0928
ISSN (online)	2055-0928
ISSN	2055-0928
DOI	10.1186/s40795-020-00341-y
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Article ; Online: L-edge sum rule analysis on 3d transition metal sites: from d

Wang, Hongxin / Friedrich, Stephan / Li, Lei / Mao, Ziliang / Ge, Pinghua / Balasubramanian, Mahalingam / Patil, Daulat S

Physical chemistry chemical physics : PCCP

2018 Volume 20, Issue 12, Page(s) 8166–8176

Abstract: According to L-edge sum rules, the number of 3d vacancies at a transition metal site is directly proportional to the integrated intensity of the L-edge X-ray absorption spectrum (XAS) for the corresponding metal complex. In this study, the numbers of 3d ... ...

Abstract	According to L-edge sum rules, the number of 3d vacancies at a transition metal site is directly proportional to the integrated intensity of the L-edge X-ray absorption spectrum (XAS) for the corresponding metal complex. In this study, the numbers of 3d holes are characterized quantitatively or semi-quantitatively for a series of manganese (Mn) and nickel (Ni) complexes, including the electron configurations 3d
Language	English
Publishing date	2018-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c7cp06624d
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Article: α-bisabolol β-D-fucopyranoside inhibits β-amyloid (Aβ)25-35 induced oxidative stress in Neuro-2a cells via antioxidant approaches

Jeyakumar, Mahalingam / Sathya, Sethuraman / Gandhi, Soniya / Tharra, Prabhakararao / Aarthy, Murali / Balan, Devasahayam Jaya / Kiruthiga, Chandramohan / Baire, Beeraiah / Singh, Sanjeev Kumar / Devi, Kasi Pandima

Process biochemistry. 2022 July 23,

2022

Abstract: ... for the development of Alzheimer’s disease (AD). In the present study, α-bisabolol β-D-fucopyranoside (ABFP) was ...

Abstract	β-amyloid (Aβ)₂₅₋₃₅ peptide-induced oxidative stress is one of the primary reasons for the development of Alzheimer’s disease (AD). In the present study, α-bisabolol β-D-fucopyranoside (ABFP) was evaluated for its protective effect against β-amyloid (Aβ)₂₅₋₃₅ peptide-induced toxicity in Neuro-2a cells. The results of the current study revealed that ABFP inhibits acetylcholinesterase, apart from reducing the formation of lipid peroxides, protein carbonyls, and nitric oxides in Neuro-2a cells during the treatment of β-amyloid (Aβ)₂₅₋₃₅ peptide. Additionally, ABFP effectively prevented the mitochondrial membrane damage induced by the β-amyloid (Aβ)₂₅₋₃₅ peptide in Neuro-2a cells. Furthermore, ABFP was found to significantly inhibit caspase 3 production in Neuro-2a cells, which was confirmed through AO/EtBr, Annexin-V/FITC, and PI fluorescent microscopic images, indicating that ABFP has anti-apoptotic properties. In addition, ABFP also increased the anti-apoptotic protein expression and protected the Neuro-2a cell from β-amyloid (Aβ)₂₅₋₃₅ peptide-induced toxicity. The in silico molecular docking analysis of ABFP with GSK-3beta showed that it was able to bind with Asn 186, Asp 200, and Lys 183 residues of the enzyme. Overall, the results suggest that ABFP acts as a potent drug against oxidative stress-mediated cell death in AD.
Keywords	acetylcholinesterase ; caspase-3 ; cell death ; computer simulation ; drugs ; fluorescence ; mitochondrial membrane ; oxidative stress ; pro-apoptotic proteins ; protective effect ; protein synthesis ; toxicity
Language	English
Dates of publication	2022-0723
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ISSN	1359-5113
DOI	10.1016/j.procbio.2022.07.026
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Article ; Online: α-bisabolol β-D-fucopyranoside as a potential modulator of β-amyloid peptide induced neurotoxicity: An in vitro &in silico study.

Jeyakumar, Mahalingam / Sathya, Sethuraman / Gandhi, Soniya / Tharra, Prabhakarrao / Suryanarayanan, Venkatesan / Singh, Sanjeev Kumar / Baire, Beeraiah / Pandima Devi, Kasi

Bioorganic chemistry

2019 Volume 88, Page(s) 102935

Abstract: ... neuroprotective ability of the sesquiterpene glycoside α-bisabolol β-D-fucopyranoside (ABFP) against multiple ...

Abstract	Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder affecting the elderly people. For the AD treatment, there is inefficiency in the existing medication, as these drugs reduce only the symptoms of the disease. Since multiple pathological proteins are involved in the development of AD, searching for a single molecule targeting multiple AD proteins will be a new strategy for the management of AD. In view of this, the present study was designed to synthesize and evaluate the multifunctional neuroprotective ability of the sesquiterpene glycoside α-bisabolol β-D-fucopyranoside (ABFP) against multiple targets like acetylcholinesterase, oxidative stress and β-amyloid peptide aggregation induced cytotoxicity. In silico computational docking and simulation studies of ABFP with acetylcholinesterase (AChE) showed that it can interact with Asp74 and Thr75 residues of the enzyme. The in vitro studies showed that the compound possess significant ability to inhibit the AChE enzyme apart from exhibiting antioxidant, anti-aggregation and disaggregation properties. In addition, molecular dynamics simulation studies proved that the interacting residue between Aβ peptide and ABFP was found to be involved in Leu34 and Ile31. Furthermore, the compound was able to protect the Neuro2 a cells against Aβ
MeSH term(s)	Acetylcholinesterase/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Biphenyl Compounds/antagonists & inhibitors ; Biphenyl Compounds/metabolism ; Cell Line ; Cell Survival/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; Fucose/analogs & derivatives ; Fucose/chemistry ; Fucose/pharmacology ; Mice ; Models, Molecular ; Molecular Structure ; Monocyclic Sesquiterpenes/chemical synthesis ; Monocyclic Sesquiterpenes/chemistry ; Monocyclic Sesquiterpenes/pharmacology ; Picrates/antagonists & inhibitors ; Picrates/metabolism ; Protein Aggregates/drug effects ; Structure-Activity Relationship
Chemical Substances	Amyloid beta-Peptides ; Biphenyl Compounds ; Cholinesterase Inhibitors ; Monocyclic Sesquiterpenes ; Picrates ; Protein Aggregates ; bisabolol (24WE03BX2T) ; Fucose (28RYY2IV3F) ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2019-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2019.102935
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Article: Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka

Suganthan, Navaneethakrishnan / Kumanan, Thirunavukarasu / Kesavan, Vithegi / Aravinthan, Mahalingam / Rajeshkannan, Nadarajah

BMC nutrition. 2020 Dec., v. 6, no. 1

2020

Abstract: BACKGROUND: Vitamin D deficiency is common among post-menopausal women and it is important to treat ... vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined ... the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done ...

Abstract	BACKGROUND: Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis in Sri Lanka. This is the first study in Sri Lanka of such kind conducted to evaluate the serum vitamin D levels among postmenopausal women. METHODS: Cross-sectional study was conducted at the Endocrine Unit, Teaching Hospital Jaffna from January to December 2018. During this period 105 postmenopausal women who registered for bone density assessment were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nurses and total 25-Hydroxy Vitamin D level (25(OH)-Vit D) was measured by competitive immunoassay with enhanced chemiluminiscence technique, levels were categorized and analysis was done using SPSS 26. RESULTS: Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean total 25(OH)-Vit D was 27.5 (range11.7–52.5 ng/mL). 25(OH)-Vit D levels were adequate in only 36.2% (95%CI: 27–45), 44% had insufficient levels and deficiency was present in 19% (95%CI: 12–27) of postmenopausal women. Among total study participants 20% were vegetarian, 53, 76.2 and 64.8% were consuming milk, fish and egg respectively and 71.4% reported adequate level of sun exposure (> 30 min/day). Commonly reported vitamin D deficiency symptoms include paraesthesia (57.1%), bone-pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%). Nevertheless, comparison of musculoskeletal symptoms between group with sufficient level and group with insufficient and deficient level showed no significant difference (P > 0.05). Among 71 participants (66.7%) who completed bone density assessment, 38% (95%CI: 27–49) showed osteoporosis. Vertebral Z score showed a significant correlation with 25(OH)-Vit D level (r-0.252, P-0.03). CONCLUSION: Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to consider vitamin D supplementation when initiating treatment for osteoporosis. Hence, Vitamin D testing is desirable in decision making to treat or not to treat.
Keywords	blood sampling ; blood serum ; bone density ; cross-sectional studies ; data collection ; decision making ; eggs ; fish ; hospitals ; immunoassays ; milk ; muscles ; muscular diseases ; nurses ; osteoporosis ; patients ; postmenopause ; vegetarian diet ; vitamin D ; vitamin D deficiency ; vitamin status ; women ; Sri Lanka
Language	English
Dates of publication	2020-12
Size	p. 15.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2809847-X
ISSN	2055-0928
ISSN	2055-0928
DOI	10.1186/s40795-020-00341-y
Database	NAL-Catalogue (AGRICOLA)

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