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Article ; Online: Crosstalk of Autophagy and Apoptosis.

Sorice, Maurizio

2022 Volume 11, Issue 9

Abstract: Autophagy and apoptosis represent two fundamental pathophysiological mechanisms of cell fate regulation. However, the signaling pathways of these processes are significantly interconnected through various mechanisms of crosstalk. Indeed, autophagy/ ... ...

Abstract	Autophagy and apoptosis represent two fundamental pathophysiological mechanisms of cell fate regulation. However, the signaling pathways of these processes are significantly interconnected through various mechanisms of crosstalk. Indeed, autophagy/apoptosis crosstalk is still an emerging field, in which an increasing number of molecules are involved, including, for example, PINK1 and ERLINs. On the other hand, this crosstalk involves signal transduction pathways which are strongly dependent on Ca
MeSH term(s)	Apoptosis/physiology ; Autophagy/physiology ; Humans ; Neoplasms/pathology ; Signal Transduction
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11091479
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Crosstalk of Autophagy and Apoptosis

Maurizio Sorice

Cells, Vol 11, Iss 1479, p

2022 Volume 1479

Abstract	Autophagy and apoptosis represent two fundamental pathophysiological mechanisms of cell fate regulation. However, the signaling pathways of these processes are significantly interconnected through various mechanisms of crosstalk. Indeed, autophagy/apoptosis crosstalk is still an emerging field, in which an increasing number of molecules are involved, including, for example, PINK1 and ERLINs. On the other hand, this crosstalk involves signal transduction pathways which are strongly dependent on Ca 2+ . Interestingly, crosstalk between autophagy and apoptosis impacts several pathologies, including multiple rheumatic diseases. The purpose of this Special Issue is also to investigate the bioactive properties of drugs with antitumor activity, focusing particularly on the role of anthraquinone derivatives in the regulation of cell death and autophagy crosstalk. This Special Issue of Cells brings together the most recent advances in understanding the various aspects of crosstalk between autophagy and apoptosis and the interconnected signaling pathways, implying therapeutic perspectives for the utility of its modulation in an anti-cancer setting.
Keywords	autophagy ; apoptosis ; cell signaling ; lipid rafts ; calcium ; PINK1 ; Biology (General) ; QH301-705.5
Subject code	571 ; 610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Different domains of β

Sorice, Maurizio / Misasi, Roberta

Cellular & molecular immunology

2018 Volume 17, Issue 11, Page(s) 1210–1211

MeSH term(s)	Autoimmune Diseases ; Epitopes, T-Lymphocyte ; Humans ; Lupus Erythematosus, Systemic ; T-Lymphocytes ; beta 2-Glycoprotein I
Chemical Substances	Epitopes, T-Lymphocyte ; beta 2-Glycoprotein I
Language	English
Publishing date	2018-06-19
Publishing country	China
Document type	Journal Article ; Comment
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-018-0060-9
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Article: Advances in the Pathophysiology of Thrombosis in Antiphospholipid Syndrome: Molecular Mechanisms and Signaling through Lipid Rafts.

Capozzi, Antonella / Manganelli, Valeria / Riitano, Gloria / Caissutti, Daniela / Longo, Agostina / Garofalo, Tina / Sorice, Maurizio / Misasi, Roberta

Journal of clinical medicine

2023 Volume 12, Issue 3

Abstract: The pathological features of antiphospholipid syndrome (APS) are related to the activity of circulating antiphospholipid antibodies (aPLs) associated with vascular thrombosis and obstetric complications. Indeed, aPLs are not only disease markers, but ... ...

Abstract	The pathological features of antiphospholipid syndrome (APS) are related to the activity of circulating antiphospholipid antibodies (aPLs) associated with vascular thrombosis and obstetric complications. Indeed, aPLs are not only disease markers, but also play a determining pathogenetic role in APS and exert their effects through the activation of cells and coagulation factors and inflammatory mediators for the materialization of the thromboinflammatory pathogenetic mechanism. Cellular activation in APS necessarily involves the interaction of aPLs with target receptors on the cell membrane, capable of triggering the signal transduction pathway(s). This interaction occurs at specific microdomains of the cell plasma membrane called lipid rafts. In this review, we focus on the key role of lipid rafts as signaling platforms in the pathogenesis of APS, and propose this pathogenetic step as a strategic target of new therapies in order to improve classical anti-thrombotic approaches with "new" immunomodulatory drugs.
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12030891
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Article: Role of Lipid Rafts on LRP8 Signaling Triggered by Anti-β2-GPI Antibodies in Endothelial Cells.

Riitano, Gloria / Capozzi, Antonella / Recalchi, Serena / Augusto, Mariaconcetta / Conti, Fabrizio / Misasi, Roberta / Garofalo, Tina / Sorice, Maurizio / Manganelli, Valeria

Biomedicines

2023 Volume 11, Issue 12

Abstract: Antiphospholipid antibody syndrome is an autoimmune disease characterized by thrombosis and/or pregnancy morbidity in association with circulating antiphospholipid antibodies, mainly anti-β2 glycoprotein 1 antibodies (anti-β2-GPI antibodies). Previous ... ...

Abstract	Antiphospholipid antibody syndrome is an autoimmune disease characterized by thrombosis and/or pregnancy morbidity in association with circulating antiphospholipid antibodies, mainly anti-β2 glycoprotein 1 antibodies (anti-β2-GPI antibodies). Previous studies demonstrated that the signaling pathway may involve lipid rafts, plasma membrane microdomains enriched in glycosphingolipid and cholesterol. In this study, we analyzed the signaling pathway of LRP8/ApoER2, a putative receptor of anti-β2-GPI antibodies, through lipid rafts in human endothelial cells. LRP8, Dab2 and endothelial nitric oxide synthase (e-NOS) phosphorylation were evaluated using Western blot, Nitric Oxide (NO) production with cytofluorimetric analysis, LRP8 enrichment in lipid rafts via sucrose gradient fractionation, and scanning confocal microscopy analysis of its association with ganglioside GM1 was also conducted. The analyses demonstrated that affinity-purified anti-β2-GPI antibodies induced LRP8 and Dab-2 phosphorylation, together with a significant decrease in e-NOS phosphorylation, with consequent decrease in NO intracellular production. These effects were almost completely prevented by Methyl-β-cyclodextrin (MβCD), indicating the involvement of lipid rafts. It was supported with the observation of LRP8 enrichment in lipid raft fractions and its association with ganglioside GM1, detected with scanning confocal microscopy. These findings demonstrate that LRP8 signaling triggered by anti-β2-GPI antibodies in endothelial cells occurs through lipid rafts. It represents a new task for valuable therapeutic approaches, such as raft-targeted therapy, including cyclodextrins and statins.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11123135
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Article ; Online: The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis.

Riitano, Gloria / Recalchi, Serena / Capozzi, Antonella / Manganelli, Valeria / Misasi, Roberta / Garofalo, Tina / Sorice, Maurizio / Longo, Agostina

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by persistent joint inflammation, leading to cartilage and bone destruction. Autoantibody production is directed to post-translational modified (PTM) proteins, i.e., ... ...

Abstract	Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by persistent joint inflammation, leading to cartilage and bone destruction. Autoantibody production is directed to post-translational modified (PTM) proteins, i.e., citrullinated or carbamylated. Autophagy may be the common feature in several types of stress (smoking, joint injury, and infections) and may be involved in post-translational modifications (PTMs) in proteins and the generation of citrullinated and carbamylated peptides recognized by the immune system in RA patients, with a consequent breakage of tolerance. Interestingly, autophagy actively provides information to neighboring cells via a process called secretory autophagy. Secretory autophagy combines the autophagy machinery with the secretion of cellular content via extracellular vesicles (EVs). A role for exosomes in RA pathogenesis has been recently demonstrated. Exosomes are involved in intercellular communications, and upregulated proteins and RNAs may contribute to the development of inflammatory arthritis and the progression of RA. In RA, most of the exosomes are produced by leukocytes and synoviocytes, which are loaded with PTM proteins, mainly citrullinated proteins, inflammatory molecules, and enzymes that are implicated in RA pathogenesis. Microvesicles derived from cell plasma membrane may also be loaded with PTM proteins, playing a role in the immunopathogenesis of RA. An analysis of changes in EV profiles, including PTM proteins, could be a useful tool for the prevention of inflammation in RA patients and help in the discovery of personalized medicine.
MeSH term(s)	Humans ; Arthritis, Rheumatoid/etiology ; Extracellular Vesicles ; Exosomes ; Autophagy ; Inflammation
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612764
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Article ; Online: Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway.

Sorice, Maurizio / Profumo, Elisabetta / Capozzi, Antonella / Recalchi, Serena / Riitano, Gloria / Di Veroli, Benedetta / Saso, Luciano / Buttari, Brigitta

Biomolecules

2023 Volume 13, Issue 8

Abstract: Oxidative stress is a well-known hallmark of Antiphospholipid Antibody Syndrome (APS), a systemic autoimmune disease characterized by arterial and venous thrombosis and/or pregnancy morbidity. Oxidative stress may affect various signaling pathways and ... ...

Abstract	Oxidative stress is a well-known hallmark of Antiphospholipid Antibody Syndrome (APS), a systemic autoimmune disease characterized by arterial and venous thrombosis and/or pregnancy morbidity. Oxidative stress may affect various signaling pathways and biological processes, promoting dysfunctional immune responses and inflammation, inducing apoptosis, deregulating autophagy and impairing mitochondrial function. The chronic oxidative stress and the dysregulation of the immune system leads to the loss of tolerance, which drives autoantibody production and inflammation with the development of endothelial dysfunction. In particular, anti-phospholipid antibodies (aPL), which target phospholipids and/or phospholipid binding proteins, mainly β-glycoprotein I (β-GPI), play a functional role in the cell signal transduction pathway(s), thus contributing to oxidative stress and thrombotic events. An oxidation-antioxidant imbalance may be detected in the blood of patients with APS as a reflection of disease progression. This review focuses on functional evidence highlighting the role of oxidative stress in the initiation and progression of APS. The protective role of food supplements and Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) activators in APS patients will be summarized to point out the potential of these therapeutic approaches to reduce APS-related clinical complications.
MeSH term(s)	Female ; Pregnancy ; Humans ; Antibodies, Antiphospholipid ; NF-E2-Related Factor 2 ; Oxidative Stress ; Phospholipids ; Antioxidants
Chemical Substances	Antibodies, Antiphospholipid ; NF-E2-Related Factor 2 ; Phospholipids ; Antioxidants
Language	English
Publishing date	2023-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13081221
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Article ; Online: Gender-affirming hormone therapy and autoimmunity: new insights from a three-year follow-up study.

Marconi, Matteo / Riitano, Gloria / Fisher, Alessandra Daphne / Cocchetti, Carlotta / Pagano, Maria Teresa / Capozzi, Antonella / Longo, Agostina / D'Arienzo, Sara / Vignozzi, Linda / Sorice, Maurizio / Ortona, Elena / Pierdominici, Marina

Clinical and experimental immunology

2023

Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1093/cei/uxad122
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Article ; Online: Combined Use of Noblestitch EL System and Amplatzer Device to Close a Patent Foramen Ovale With Complex Anatomy.

Gaio, Gianpiero / Giordano, Mario / Fusco, Flavia / Scognamiglio, Giancarlo / Bigazzi, Maurizio Cappelli / Marzullo, Raffaella / Sorice, Davide / Golino, Paolo / Russo, Maria Giovanna / Sarubbi, Berardo

The Canadian journal of cardiology

2023 Volume 39, Issue 5, Page(s) 700–702

MeSH term(s)	Humans ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/surgery ; Treatment Outcome ; Septal Occluder Device ; Cardiac Catheterization ; Stroke
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Case Reports
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2023.02.009
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Article ; Online: Advances in the Pathophysiology of Thrombosis in Antiphospholipid Syndrome

Antonella Capozzi / Valeria Manganelli / Gloria Riitano / Daniela Caissutti / Agostina Longo / Tina Garofalo / Maurizio Sorice / Roberta Misasi

Journal of Clinical Medicine, Vol 12, Iss 891, p

Molecular Mechanisms and Signaling through Lipid Rafts

2023 Volume 891

Abstract	The pathological features of antiphospholipid syndrome (APS) are related to the activity of circulating antiphospholipid antibodies (aPLs) associated with vascular thrombosis and obstetric complications. Indeed, aPLs are not only disease markers, but also play a determining pathogenetic role in APS and exert their effects through the activation of cells and coagulation factors and inflammatory mediators for the materialization of the thromboinflammatory pathogenetic mechanism. Cellular activation in APS necessarily involves the interaction of aPLs with target receptors on the cell membrane, capable of triggering the signal transduction pathway(s). This interaction occurs at specific microdomains of the cell plasma membrane called lipid rafts. In this review, we focus on the key role of lipid rafts as signaling platforms in the pathogenesis of APS, and propose this pathogenetic step as a strategic target of new therapies in order to improve classical anti-thrombotic approaches with “new” immunomodulatory drugs.
Keywords	APS ; β2-GPI ; aPLs ; lipid rafts ; TLR4 pathways ; therapeutic targets ; Medicine ; R
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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