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  1. Article ; Online: Venetoclax in myeloma: to B, or not to B.

    Raab, Marc S

    Blood

    2024  Volume 143, Issue 1, Page(s) 4–5

    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Epigenesis, Genetic ; Proto-Oncogene Proteins c-bcl-2
    Chemical Substances venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic ; Proto-Oncogene Proteins c-bcl-2 ; BCL2 protein, human
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of Clonal Heterogeneity in Multiple Myeloma.

    Schinke, Carolina / Rasche, Leo / Raab, Marc S / Weinhold, Niels

    Hematology/oncology clinics of North America

    2024  Volume 38, Issue 2, Page(s) 461–476

    Abstract: Multiple myeloma is characterized by a highly heterogeneous disease distribution within the bone marrow-containing skeletal system. In this review, we introduce the molecular mechanisms underlying clonal heterogeneity and the spatio-temporal evolution of ...

    Abstract Multiple myeloma is characterized by a highly heterogeneous disease distribution within the bone marrow-containing skeletal system. In this review, we introduce the molecular mechanisms underlying clonal heterogeneity and the spatio-temporal evolution of myeloma. We discuss the clinical impact of clonal heterogeneity, which is thought to be one of the biggest obstacles to overcome therapy resistance and to achieve cure.
    MeSH term(s) Humans ; Multiple Myeloma/genetics ; Multiple Myeloma/therapy ; Bone Marrow ; Clonal Evolution/genetics
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2023.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Das immunogene Glykoprotein des humanen Herpesvirus 8 (HHV-8)

    Raab, Marc-Steffen

    ein neues serologisches Nachweisverfahren

    2002  

    Author's details vorgelegt von Marc-Steffen Raab
    Language German
    Size 68 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2002
    HBZ-ID HT013453322
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 E 3803 order for loan Magazin

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  4. Article ; Online: Oxygen bubbles to predict sensitivity to IMiDs.

    Raab, Marc S

    Blood

    2017  Volume 129, Issue 8, Page(s) 923–925

    MeSH term(s) Humans ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-01-760512
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  5. Article ; Online: Difficult-to-treat patients with relapsed/refractory multiple myeloma: A review of clinical trial results.

    Raab, Marc S / Zamagni, Elena / Manier, Salomon / Rodriguez-Otero, Paula / Schjesvold, Fredrik / Broijl, Annemiek

    EJHaem

    2023  Volume 4, Issue 4, Page(s) 1117–1131

    Abstract: Overall outcomes for multiple myeloma have improved due to the availability of new therapies, but patients with relapsed/refractory multiple myeloma harbouring certain factors continue to pose a therapeutic challenge. These challenging features include ... ...

    Abstract Overall outcomes for multiple myeloma have improved due to the availability of new therapies, but patients with relapsed/refractory multiple myeloma harbouring certain factors continue to pose a therapeutic challenge. These challenging features include high-risk cytogenetics, renal impairment, patient characteristics such as age and frailty, and extramedullary disease. Prior refractory status and number of prior lines add further complexity to the treatment of these patients. While newer regimens are available and have suggested efficacy in these patient populations through subgroup analyses, differences in trial definitions and cut-offs make meaningful comparisons difficult. This review aims to examine the available clinical trial data for patients with high-risk cytogenetics, renal impairment, age and frailty and extramedullary disease.
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.743
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  6. Article ; Online: Treatment in AL Amyloidosis

    Ute Hegenbart / Marc S. Raab / Stefan O. Schönland

    Hemato, Vol 2, Iss 50, Pp 739-

    Moving towards Individualized and Clone-Directed Therapy

    2021  Volume 747

    Abstract: ... monoclonal gammopathy of clinical significance, smoldering or symptomatic myeloma) or B cell non-Hodgkin’s lymphoma (e.g ... Waldenstrom’s disease or marginal zone lymphoma) with secretory activity. It is crucial to characterize ...

    Abstract Systemic amyloid light chain (AL) amyloidosis is a rare protein deposition disease caused by a clonal B cell disorder of the bone marrow. The underlying diseases can be plasma cell disorders (monoclonal gammopathy of clinical significance, smoldering or symptomatic myeloma) or B cell non-Hodgkin’s lymphoma (e.g., Waldenstrom’s disease or marginal zone lymphoma) with secretory activity. It is crucial to characterize the underlying disease very precisely as the treatment of AL amyloidosis is directed against the (often small) B cell clone. Finally, the detection of cytogenetic aberrations of the plasma cell clone will likely play an important role for choosing an effective drug in the near future.
    Keywords amyloidosis ; monoclonal B and plasma cells ; t(11 ; 14) ; Medicine ; R
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.

    Schreiner, Sarah / Berghaus, Natalie / Poos, Alexandra M / Raab, Marc S / Besemer, Britta / Fenk, Roland / Goldschmidt, Hartmut / Mai, Elias K / Müller-Tidow, Carsten / Weinhold, Niels / Hegenbart, Ute / Huhn, Stefanie / Schönland, Stefan O

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

    2024  , Page(s) 1–9

    Abstract: Background: AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM).: Objective: We ... ...

    Abstract Background: AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM).
    Objective: We analysed
    Material and methods: cDNA and bulk RNA sequencing of the LCs of AL and MM patients.
    Results: We studied 41 AL and 83 MM patients showing that
    Conclusion: This study confirmed that germline usage has an influence on AL amyloidosis risk and organ involvement.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1205246-2
    ISSN 1744-2818 ; 1350-6129
    ISSN (online) 1744-2818
    ISSN 1350-6129
    DOI 10.1080/13506129.2023.2295221
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    Zs.A 4114: Show issues Location:
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  8. Article ; Online: Treatment pattern and outcomes of re-induction therapy prior to stem cell transplantation in patients with relapsed/refractory multiple myeloma in Germany.

    Sauer, Sandra / Engelhardt, Monika / Trautmann-Grill, Karolin / Kimmich, Christoph / Hänel, Mathias / Schmidt-Hieber, Martin / Salwender, Hans / Flossmann, Carmen / Heckmann, Hiltrud / Ertel, Franziska / Friederich, Andrea / Patel, Sachin / Thun, Barbara / Raab, Marc S

    Bone marrow transplantation

    2024  

    Abstract: There are limited data guiding choice of re-induction therapies for patients with relapsed/refractory multiple myeloma (RRMM) prior to stem cell transplantation (SCT). We performed a retrospective medical chart review of 171 patients with RRMM in Germany ...

    Abstract There are limited data guiding choice of re-induction therapies for patients with relapsed/refractory multiple myeloma (RRMM) prior to stem cell transplantation (SCT). We performed a retrospective medical chart review of 171 patients with RRMM in Germany who received re-induction therapy in second line (78%; n = 134) or third line (22%; n = 37) prior to re-SCT. Index therapy was defined as first completed re-induction therapy for planned myeloablative conditioning and SCT in second/third line within the eligibility period (1/2016-12/2019). Most common pre-index first line and maintenance therapy used were bortezomib-based combinations (91%; n = 155/171) and lenalidomide (55%; n = 29/53), respectively. Median duration of index therapy line was 9 months; carfilzomib-based combinations were the most widely used in second/third line re-induction therapy (49%; n = 83/171), followed by daratumumab-based combinations (21%; n = 36/171). Overall response rates in second/third line were 87% after re-induction and 96% after SCT; median time to next treatment line after start of index therapy was 31 months; median progression-free survival (PFS) was 29 months; and median overall survival after index date was not reached. Based on these data, re-induction therapy with salvage SCT appears to be beneficial in selected patients with RRMM in clinical practice in Germany, translating into deep responses, long PFS and prolonged time to next treatment.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02208-3
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    Zs.A 2168: Show issues Location:
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  9. Article ; Online: Detection of inorganic arsenic in rice using a field-deployable method with Cola extraction.

    Wehmeier, Silvia / Preihs, Marc / Dressler, Julia / Raab, Andrea / Feldmann, Jörg

    Analytical and bioanalytical chemistry

    2023  Volume 416, Issue 11, Page(s) 2677–2682

    Abstract: Rice is a staple food and known to accumulate inorganic arsenic (iAs), which is a class 1 carcinogen to humans. Arsenic field-deployable method kits, designed for water testing, are able to screen iAs in rice, to assure food safety and quick decision- ... ...

    Abstract Rice is a staple food and known to accumulate inorganic arsenic (iAs), which is a class 1 carcinogen to humans. Arsenic field-deployable method kits, designed for water testing, are able to screen iAs in rice, to assure food safety and quick decision-making without the need for laboratory analysis. For the arsenic extraction within the field method, nitric acid is used. To make the field method on-site safer, cost-effective and easier to handle, the method was adapted using a Cola in the extraction process. The adapted field-deployable method was tested by screening a total of 30 rice and rice products from the Austrian market. To verify the results obtained by the Cola extraction field-deployable method, the obtained iAs concentration was compared to HPLC-ICP-MS results. The Cola extraction field method obtained an LOD of 39 µg iAs kg
    MeSH term(s) Humans ; Arsenic/analysis ; Oryza ; Reproducibility of Results ; Food Contamination/analysis ; Arsenicals/analysis
    Chemical Substances Arsenic (N712M78A8G) ; Arsenicals
    Language English
    Publishing date 2023-11-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-05041-7
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  10. Article ; Online: Artificial intelligence-based, volumetric assessment of the bone marrow metabolic activity in [

    Sachpekidis, Christos / Enqvist, Olof / Ulén, Johannes / Kopp-Schneider, Annette / Pan, Leyun / Mai, Elias K / Hajiyianni, Marina / Merz, Maximilian / Raab, Marc S / Jauch, Anna / Goldschmidt, Hartmut / Edenbrandt, Lars / Dimitrakopoulou-Strauss, Antonia

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Purpose: Multiple myeloma (MM) is a highly heterogeneous disease with wide variations in patient outcome. [: Materials and methods: Forty-four, previously untreated MM patients underwent whole-body [: Results: Median follow-up [95% CI] of the ... ...

    Abstract Purpose: Multiple myeloma (MM) is a highly heterogeneous disease with wide variations in patient outcome. [
    Materials and methods: Forty-four, previously untreated MM patients underwent whole-body [
    Results: Median follow-up [95% CI] of the patient cohort was 110 months [105-123 months]. AI-based BM segmentation and calculation of MTV and TLG were feasible in all patients. A significant, positive, moderate correlation was observed between the automated quantitative whole-body PET/CT parameters, MTV and TLG, and BM plasma cell infiltration for all ten [
    Conclusions: The AI-based, whole-body calculations of BM metabolism via the parameters MTV and TLG not only correlate with the degree of BM plasma cell infiltration, but also predict patient survival in MM. In particular, the parameter MTV, using the liver uptake as reference for BM segmentation, provides solid prognostic information for disease progression. In addition to highlighting the prognostic significance of automated, global volumetric estimation of metabolic tumor burden, these data open up new perspectives towards solving the complex problem of interpreting PET scans in MM with a simple, fast, and robust method that is not affected by operator-dependent interventions.
    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06668-z
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