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  1. Book: Zhong yi xing wei yi xue

    Jiang, Yong

    2008  

    Author's details zhu bian Jiang Yong
    MeSH term(s) Mental Disorders/therapy ; Medicine, Chinese Traditional
    Language Chinese
    Size 5, 336 p. :, ill.
    Edition Di 1 ban.
    Publisher Zhongguo zhong yi yao chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787802314764 ; 7802314763
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book: Mian yi xing ji bing de Zhong yi zhi liao

    Jiang, Guofeng

    (Zhi yin Zhongjing cong shu ; 12)

    2004  

    Author's details zhu bian: Jiang Guofeng, Geng Yun ; fu zhu bian: Liao Xinhua, Yang Ning ; bian wei: Wang Hongdi ... [et al.]
    Series title Zhi yin Zhongjing cong shu ; 12
    MeSH term(s) Immune System Diseases/diagnosis ; Immune System Diseases/therapy ; Medicine, Chinese Traditional
    Language Chinese
    Size 6, 322 p. :, ill. ;, 22 cm.
    Edition Chu ban.
    Publisher Zhi yin chu ban she
    Publishing place Taibei Shi
    Document type Book
    ISBN 9789867825247 ; 9867825241
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: TBAF-Mediated [3+1] Cycloaddition of Difluorocarbene to Access

    Mao, Yuyin / Li, Na / Liu, Jie / Jiang, Zhong-Xing / Yang, Zhigang

    Organic letters

    2023  Volume 25, Issue 41, Page(s) 7567–7572

    Abstract: The facile synthesis ... ...

    Abstract The facile synthesis of
    MeSH term(s) Cycloaddition Reaction ; Metals ; Hydrocarbons, Fluorinated/pharmacology ; Antineoplastic Agents/pharmacology
    Chemical Substances difluorocarbene ; Metals ; Hydrocarbons, Fluorinated ; Antineoplastic Agents
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Jellyfish-inspired smart tetraphenylethene lipids with unique AIE fluorescence, thermal response, and cell membrane interaction.

    Zheng, Yujie / Li, Yu / Ke, Changsheng / Duan, Mojie / Zhu, Lijun / Zhou, Xin / Yang, Minghui / Jiang, Zhong-Xing / Chen, Shizhen

    Journal of materials chemistry. B

    2024  Volume 12, Issue 9, Page(s) 2373–2383

    Abstract: Smart lipids with fluorescence emission, thermal response, and polyethylene glycolation (PEGylation) functions can be highly valuable for formulation, image-traceable delivery, and targeted release of payloads. Herein, a series of jellyfish-shaped ... ...

    Abstract Smart lipids with fluorescence emission, thermal response, and polyethylene glycolation (PEGylation) functions can be highly valuable for formulation, image-traceable delivery, and targeted release of payloads. Herein, a series of jellyfish-shaped amphiphiles with a tetraphenylethene (TPE) core and four symmetrical amphiphilic side chains were conveniently synthesized and systematically investigated as smart lipids. Compared with regular amphiphilic TPE lipids and phospholipids, the unprecedented jellyfish-shaped molecular geometry was found to enable a series of valuable capabilities, including sensitive and responsive aggregation-induced emission of fluorescence (AIE FL) and real-time FL monitoring of drug uptake. Furthermore, the jellyfish-shaped geometry facilitated the concentration-dependent aggregation from unimolecular micelles at low concentrations to "side-by-side" spherical aggregates at high concentrations and a unique mode of AIE. In addition, the size and the arrangement of the amphiphilic side chains were found to dominate the aggregate stability, cell uptake, and thus the cytotoxicity of the amphiphiles. This study has unprecedentedly developed versatile smart TPE lipids with precise structures, and unique physicochemical and biological properties while the peculiar structure-property relationship may shed new light on the design and application of AIE fluorophores and functional lipids in biomedicine and materials science.
    MeSH term(s) Fluorescence ; Micelles ; Cell Membrane ; Fluorescent Dyes/chemistry ; Lipids
    Chemical Substances Micelles ; Fluorescent Dyes ; Lipids
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02068a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: One-Pot Assembly of Dual-Site-Specific Antibody-Drug Conjugates via Glycan Remodeling and Affinity-Directed Traceless Conjugation.

    Tang, Caihong / Zeng, Yue / Zhang, Jianxin / Zheng, Xing / Tang, Feng / Yao, Xu / Jiang, Zhong-Xing / Shi, Wei / Huang, Wei

    Bioconjugate chemistry

    2023  

    Abstract: The drug-to-antibody ratio (DAR) value and dual-drug combination greatly influence the therapeutic index of antibody-drug conjugates (ADCs). The reported approaches usually require multifunctional branched linkers, a combination of complicated ... ...

    Abstract The drug-to-antibody ratio (DAR) value and dual-drug combination greatly influence the therapeutic index of antibody-drug conjugates (ADCs). The reported approaches usually require multifunctional branched linkers, a combination of complicated technologies, or protein-protein ligation, which may incorporate multihydrophobic fragments or result in low coupling efficiency. Herein, we developed a facile and efficient one-pot method to assemble dual-site-specific ADCs with defined DARs at both the N-glycosylation site and K248 site, either with the same payloads or with two types of payloads. The constructed dual-site ADCs showed acceptable homogeneity, excellent buffer stability, and enhanced
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.3c00048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Monitoring ROS Responsive Fe

    Zhang, Lei / Qiu, Maosong / Wang, Ruifang / Li, Sha / Liu, Xiaoxun / Xu, Qiuyi / Xiao, Long / Jiang, Zhong-Xing / Zhou, Xin / Chen, Shizhen

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202403771

    Abstract: The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, the low immune response rate limits the immunotherapy efficiency. Here, we report a ROS-responsive ... ...

    Abstract The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, the low immune response rate limits the immunotherapy efficiency. Here, we report a ROS-responsive Fe
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202403771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: 

    Li, Yu-Jian / Jiang, Li-Na / Li, Zi-Zhong / Xing, Ji-Chun

    ZooKeys

    2023  Volume 1138, Page(s) 175–182

    Abstract: ... ...

    Abstract Parathlasia
    Language English
    Publishing date 2023-01-06
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.1138.82224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Using endogenous glycogen as relaxation agent for imaging liver metabolism by MRI

    Shizhen Chen / Mou Jiang / Yaping Yuan / Baolong Wang / Yu Li / Lei Zhang / Zhong-Xing Jiang / Chaohui Ye / Xin Zhou

    Fundamental Research, Vol 3, Iss 4, Pp 481-

    2023  Volume 487

    Abstract: Glycogen plays essential roles in glucose metabolism. Imaging glycogen in the liver, the major glycogen reservoir in the body, may shed new light on many metabolic disorders. 13C magnetic resonance spectroscopy (MRS) has become the mainstream method for ... ...

    Abstract Glycogen plays essential roles in glucose metabolism. Imaging glycogen in the liver, the major glycogen reservoir in the body, may shed new light on many metabolic disorders. 13C magnetic resonance spectroscopy (MRS) has become the mainstream method for monitoring glycogen in the body. However, the equipment of special hardware to standard clinical magnetic resonance imaging (MRI) scanners limits its clinical applications. Herein, we utilized endogenous glycogen as a T2-based relaxation contrast agent for imaging glycogen metabolism in the liver in vivo. The in vitro results demonstrated that the transverse relaxation rate of glycogen strongly correlates with the concentration, pH, and field strength. Based on the Swift-Connick theory, we characterized the exchange property of glycogen and measured the exchange rate of glycogen as 31,847 Hz at 37 °C. Besides, the viscosity and echo spacing showed no apparent effect on the transverse relaxation rate. This unique feature enables visualization of glycogen signaling in vivo through T2-weighted MRI. Two hours-post intraperitoneal injection of glucagon, a clinical drug to promote glycogenolysis and gluconeogenesis, the signal intensity of the mice's liver increased by 1.8 times from the T2-weighted imaging experiment due to the decomposition of glycogen. This study provides a convenient imaging strategy to non-invasively investigate glycogen metabolism in the liver, which may find clinical applications in metabolic diseases.
    Keywords Glycogen ; Magnetic resonance imaging ; Liver ; T2-weighted imaging ; Transverse relaxation ; Science (General) ; Q1-390
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher KeAi Communications Co. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Characterisation of an IncX4 plasmid harbouring mcr-1 from Escherichia fergusonii from chicken meat in China.

    Mei, Cai-Yue / Zhang, Xing-Xing / Jiang, Yue / Ma, Qin-Chun / Wang, Zhen-Yu / Jiao, Xinan / Zhong, Fa-Gang / Wang, Jing

    Journal of global antimicrobial resistance

    2024  Volume 37, Page(s) 8–10

    Language English
    Publishing date 2024-02-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2024.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Factors Influencing Copulation Duration in

    Zhong, Hui-Hui / Li, Chao-Qun / Zhang, Jiang-Tao / Wei, Li-Feng / Liu, Xing-Ping

    Insects

    2024  Volume 15, Issue 2

    Abstract: The gregarious ectoparasitic ... ...

    Abstract The gregarious ectoparasitic beetle
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects15020104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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