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  1. Article: From supramolecular porphyrin tweezers to dynamic A(n)B(m)C(l)D(k) multiporphyrin arrangements through orthogonal coordination.

    Kishore, Ravuri S K / Paululat, Thomas / Schmittel, Michael

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2006  Volume 12, Issue 31, Page(s) 8136–8149

    Abstract: ... three structurally different, still dynamic, four-component A(n)B(m)C(l)D(k) assemblies were cleanly ... A dynamic, supramolecular, three-component A(n)B(m)C(l) bis(zinc porphyrin) tweezer has been ... of nitrogenous spacers of different length, namely, the extended bipyridine 3 a, 4,4'-bipyridine (3 b), and 1,4 ...

    Abstract A dynamic, supramolecular, three-component A(n)B(m)C(l) bis(zinc porphyrin) tweezer has been prepared quantitatively using the heteroleptic bisphenanthroline (HETPHEN) concept. Upon addition of nitrogenous spacers of different length, namely, the extended bipyridine 3 a, 4,4'-bipyridine (3 b), and 1,4-diazabicyclo[2.2.2]octane (DABCO; 3 c), to set up an additional orthogonal binding motif (Zn(Por)-N(spacer)), three structurally different, still dynamic, four-component A(n)B(m)C(l)D(k) assemblies were cleanly formed, as indicated by UV/Vis and NMR titrations as well as by DOSY investigations. The structures were identified as a bridged monotweezer A(2)BC(2)D, a doubly bridged double tweezer A(4)B(2)C(4)D(2), and a triply bridged double tweezer A(4)B(2)C(4)D(3), the latter resembling a porphyrin stack. Notably, the same structures were equally formed directly from a mixture of the constituents A, B, C, and D put together in any sequence if the correct stoichiometry was applied.
    MeSH term(s) Piperazines/chemical synthesis ; Porphyrins/chemical synthesis ; Porphyrins/chemistry ; Pyridines/chemical synthesis
    Chemical Substances Piperazines ; Porphyrins ; Pyridines ; triethylenediamine (X8M57R0JS5)
    Language English
    Publishing date 2006-10-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.200600463
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  2. Book ; Online ; E-Book: Microbial control of vector-borne diseases

    Tyagi, B. K. / Dhanasekaran, Dharumadurai

    2018  

    Author's details edited by Brij Kishore Tyagi, Dharumadurai Dhanasekaran
    Keywords Insect Vectors ; Insect Control ; Communicable Disease Control ; Environmental Microbiology
    Language English
    Size 1 Online-Ressource (xv, 463 Seiten)
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019767972
    ISBN 978-1-351-67788-2 ; 9781138055810 ; 1-351-67788-8 ; 1138055816
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Development, Characterization, and Antibacterial Analysis of the Selenium-Doped Bio-Glass-Collagen-Gelatin Composite Scaffold for Guided Bone Regeneration.

    Reddy, Sushma B / Arumugam, Parkavi / Kishore, Obuli G / K, Saranya

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48838

    Abstract: Background Guided bone regeneration (GBR) is an often-used technique to aid the successful placement of dental implants in sites with deficient bone. The search for the ideal GBR membrane with bioactive components improving the regenerative outcomes is ... ...

    Abstract Background Guided bone regeneration (GBR) is an often-used technique to aid the successful placement of dental implants in sites with deficient bone. The search for the ideal GBR membrane with bioactive components improving the regenerative outcomes is still on. In this study, a novel composite GBR membrane was developed using selenium-doped bio-glass, collagen, and gelatin. It was further characterized for surface, chemical, biocompatibility, and antibacterial properties. Methodology Selenium-doped bio-glass was prepared using the sol-gel method. The membrane was fabricated using an equal ratio of collagen and gelatin mixed with 1% selenium-doped bio-glass. The solution was poured to obtain a thin layer of the material which was lyophilized to obtain the final GBR membrane. The membrane was analyzed with scanning electron microscopy, energy dispersive X-ray (EDX) analysis, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), zebrafish cytotoxicity test, and antibacterial assay. Results The membrane revealed good surface roughness with lamellar and fibrillar arrangement with a minute granular surface ideal for cell attachment and proliferation. The EDX analysis revealed the presence of carbon, oxygen, and nitrogen as predominant components with trace amounts of calcium, phosphorus, silica, and selenium. Fourier transform infrared spectroscopy analysis also proved the presence of collagen, gelatin, and bio-glass. The membrane revealed excellent biocompatibility with zebrafish growth at a normal rate with 90% viability maintained at 48, 72, and 96 hours and 95% viability at 120 hours. It also exhibited excellent antibacterial activity against
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48838
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  4. Article ; Online: The Inflation Reduction Act: How Will Medicare Negotiating Drug Prices Impact Patients with Heart Disease?

    Johnson, Micah / Kishore, Sanjay / Nayak, Rahul K / Dusetzina, Stacie B

    Current cardiology reports

    2023  Volume 25, Issue 6, Page(s) 577–581

    Abstract: Purpose of review: Cardiovascular medications improve health and prevent early death. However, high drug prices reduce the use of these medications and strain the health system. The Inflation Reduction Act (IRA) of 2022 allows Medicare to negotiate drug ...

    Abstract Purpose of review: Cardiovascular medications improve health and prevent early death. However, high drug prices reduce the use of these medications and strain the health system. The Inflation Reduction Act (IRA) of 2022 allows Medicare to negotiate drug prices with manufacturers and reduces out-of-pocket drug costs for Medicare beneficiaries. This article explores the potential impact that the IRA will have on the treatment of cardiovascular disease.
    Recent findings: Cardiovascular disease medications are likely to be selected for price negotiations under the IRA, leading to savings for patients and for Medicare. Recent work suggests that the IRA's reforms to the Medicare Part D drug benefit will meaningfully reduce out-of-pocket costs for important cardiovascular medications. The IRA is expected to impact cardiovascular disease treatments via price negotiations and through the broader access to medications afforded by improvements to Part D coverage design.
    MeSH term(s) Aged ; Humans ; United States ; Negotiating ; Cardiovascular Diseases ; Medicare Part D ; Heart Diseases ; Drug Costs
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-023-01878-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5524: Show issues Location:
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  5. Book ; Conference proceedings: Vector-borne diseases

    Tyagi, B. K.

    epidemiology and control ; [proceedings book ... 8th International Symposium of Vectors & Vector Borne Diseases ... 13 - 15 October 2006]

    2008  

    Title variant Vector borne diseases
    Event/congress International Symposium of Vectors & Vector Borne Diseases (8, 2006, Madurai)
    Author's details ed. B. K. Tyagi
    Language English
    Size XXIV, 298 S. : Ill., graph. Darst.
    Publisher Centre for Research in Medical Entomology
    Publishing place Madurai
    Publishing country India
    Document type Book ; Conference proceedings
    HBZ-ID HT015740757
    ISBN 978-81-7233-541-0 ; 81-7233-541-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 183 order for loan Magazin

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  6. Article ; Online: Hyperacute Central Retinal Artery Occlusion With Normal Fundus: A Diagnostic and Therapeutic Challenge.

    Hansen, Allison B / Kishore, Kamal / Klein, Kelly L

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  

    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001893
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    Zs.A 1670: Show issues Location:
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  7. Book: Changing faunal ecology in the Thar Desert

    Tyagi, B. K.

    2005  

    Author's details ed.: B. K. Tyagi
    Language English
    Size Getr. Zählung : Ill., graph. Darst., Kt.
    Publisher Scientific Publ
    Publishing place Jodhpur
    Publishing country India
    Document type Book
    HBZ-ID HT014729195
    ISBN 81-7233-402-8 ; 978-81-7233-402-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    068/1627 available for loan (reading room) Freihandmagazin (U1)

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  8. Article ; Online: Finite element analysis of an intact lumbar spine model: Effects of loading under different coordinate systems.

    Pradeep, Kishore / Pal, Bidyut

    Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

    2023  Volume 237, Issue 7, Page(s) 815–828

    Abstract: Finite element (FE) analysis has been used in studying the biomechanics of the lumbar spine. While some FE studies used a follower load technique that intended to replace the compressing effect of local muscle force, other studies considered satisfying ... ...

    Abstract Finite element (FE) analysis has been used in studying the biomechanics of the lumbar spine. While some FE studies used a follower load technique that intended to replace the compressing effect of local muscle force, other studies considered satisfying the relationship between the human body's posture and the centre of gravity (CG) for investigating spine biomechanics. However, the above studies did not reveal the importance of a coordinate system that gratifies the posture-CG relation and follower load techniques. The present FE study compares the variation in ranges of motion (ROM) and stress-strain distributions due to the application of loading via different coordinate systems, follower (FCS) and global (GCS). A subject-specific computed tomography scan-based intact spine (L1-L5) FE model was developed and simulated for physiological movements. The FE results indicated a minimum deviation in ROM of 2.7° for the L1-L5 full model at all physiological activities between the defined coordinate systems. The observed variation for the L3-L4 functional spinal unit was between 4.7° and 19°. The von Mises strain in the vertebrae was between 0.0007 and 0.003 for the FCS case. In contrast, the peak von Mises strain for the GCS case was above the compressive yield strain limit of cancellous bone by 38.5%. The GCS model transferred the load unsymmetrically, whereas the distribution was symmetrical for the FCS case, without any potential risk of bone failure. These observations clearly indicate that the selection of the appropriate loading coordinate system is as crucial as the magnitude of loading.
    MeSH term(s) Humans ; Finite Element Analysis ; Weight-Bearing/physiology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/physiology ; Movement ; Posture/physiology ; Biomechanical Phenomena ; Range of Motion, Articular/physiology ; Spinal Fusion/methods
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065942-0
    ISSN 2041-3033 ; 0046-2039 ; 0954-4119
    ISSN (online) 2041-3033
    ISSN 0046-2039 ; 0954-4119
    DOI 10.1177/09544119231177346
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2652: Show issues Location:
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  9. Article ; Online: Effects of open and minimally invasive Transforaminal Lumbar Interbody Fusion (TLIF) surgical techniques on mechanical behaviour of fused L3-L4 FSU: A comparative finite element study.

    Pradeep, Kishore / Pal, Bidyut

    Medical engineering & physics

    2023  Volume 123, Page(s) 104084

    Abstract: For predicting the biomechanical effects of the fusion procedure, finite element (FE) analysis is widely used as a preclinical tool. Although several FE studies examined the efficacies of various fusion surgical techniques, comparative studies on Open ... ...

    Abstract For predicting the biomechanical effects of the fusion procedure, finite element (FE) analysis is widely used as a preclinical tool. Although several FE studies examined the efficacies of various fusion surgical techniques, comparative studies on Open and minimally invasive (MIS) transforaminal lumbar interbody fusion (TLIF) procedures incorporating a follower coordinate system have not been investigated yet. The current FE study evaluates the ranges of motion (ROM) and load distributions of Open-TLIF and MIS-TLIF implanted models, under physiological loading such as compression, flexion, extension and lateral bending. The most noteworthy finding from the investigation is that both the fusion procedures significantly reduced the ROMs of the implanted segment (L3-L4) and full model (L1-L5) by at least 89 % and 44 %, respectively, compared to the intact model. For all loading situations, over 95 % of the implanted models' cancellous bone volume was subjected to von Mises strains ranging from 0.0003 to 0.005. The maximum von Mises strain was observed to be localized on a small amount of cancellous bone volume (<5 %). The likelihood of adjacent segment degeneration is higher in the case of MIS-TLIF due to the higher stress (22-53 MPa) and strain (0.018-0.087) noticed on the upper facet of the L3 vertebra.
    MeSH term(s) Biomechanical Phenomena ; Finite Element Analysis ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/physiology ; Minimally Invasive Surgical Procedures ; Range of Motion, Articular/physiology ; Spinal Fusion/methods
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2023.104084
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    Zs.B 2231: Show issues Location:
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  10. Article ; Online: Biomechanical and clinical studies on lumbar spine fusion surgery: a review.

    Pradeep, Kishore / Pal, Bidyut

    Medical & biological engineering & computing

    2023  Volume 61, Issue 3, Page(s) 617–634

    Abstract: Low back pain is associated with degenerative disc diseases of the spine. Surgical treatment includes fusion and non-fusion types. The gold standard is fusion surgery, wherein the affected vertebral segment is fused. The common complication of fusion ... ...

    Abstract Low back pain is associated with degenerative disc diseases of the spine. Surgical treatment includes fusion and non-fusion types. The gold standard is fusion surgery, wherein the affected vertebral segment is fused. The common complication of fusion surgery is adjacent segment degeneration (ASD). The ASD often leads to revision surgery, calling for a further fusion of adjacent segments. The existing designs of nonfusion type implants are associated with clinical problems such as subsidence, difficulty in implantation, and the requirement of revision surgeries. Various surgical approaches have been adopted by the surgeons to insert the spinal implants into the affected segment. Over the years, extensive biomechanical investigations have been reported on various surgical approaches and prostheses to predict the outcomes of lumbar spine implantations. Computer models have been proven to be very effective in identifying the best prosthesis and surgical procedure. The objective of the study was to review the literature on biomechanical studies for the treatment of lumbar spinal degenerative diseases. A critical review of the clinical and biomechanical studies on fusion spine surgeries was undertaken. The important modeling parameters, challenges, and limitations of the current studies were identified, showing the future research directions.
    MeSH term(s) Humans ; Intervertebral Disc Degeneration/surgery ; Low Back Pain/surgery ; Lumbar Vertebrae/surgery ; Neurosurgical Procedures ; Spinal Fusion/methods ; Artificial Limbs/adverse effects ; Biomechanical Phenomena
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-022-02750-6
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