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  1. Article ; Online: Editorial: autoimmunity-the ever endless world.

    Toubi, Elias

    Immunologic research

    2019  Volume 66, Issue 6, Page(s) 633–636

    MeSH term(s) Autoimmune Diseases/immunology ; Autoimmunity/immunology ; Humans
    Language English
    Publishing date 2019-02-28
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-019-09071-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: IMAJ celebrates 20 years.

    Toubi, Elias

    The Israel Medical Association journal : IMAJ

    2019  Volume 21, Issue 3, Page(s) 143–146

    MeSH term(s) Anniversaries and Special Events ; History, 20th Century ; History, 21st Century ; Humans ; Israel ; Periodicals as Topic/history ; Societies, Medical/history
    Language English
    Publishing date 2019-03-21
    Publishing country Israel
    Document type Historical Article ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Conference proceedings: The 5th Israel-Italy Meeting: Advances in Rheumatology and Autoimmunity.

    Toubi, Elias

    The Israel Medical Association journal : IMAJ

    2017  Volume 19, Issue 7, Page(s) 401–402

    MeSH term(s) Autoimmunity ; Israel ; Italy ; Rheumatology
    Language English
    Publishing date 2017-07
    Publishing country Israel
    Document type Congresses ; Editorial
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The First Israel-Greece Meeting on Advances in Rheumatology and Autoimmunity.

    Toubi, Elias

    The Israel Medical Association journal : IMAJ

    2016  Volume 18, Issue 9, Page(s) 511–512

    Language English
    Publishing date 2016-09
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Conference proceedings: The Fourth Israel-Italy Meeting: Updates in Rheumatology and Autoimmunity.

    Toubi, Elias

    The Israel Medical Association journal : IMAJ

    2016  Volume 18, Issue 3-4, Page(s) 137–138

    MeSH term(s) Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Autoimmunity ; Humans ; Israel ; Italy ; Rheumatology/methods
    Language English
    Publishing date 2016-03
    Publishing country Israel
    Document type Congresses
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Predictive features associated with chronic spontaneous urticaria recurrence.

    Toubi, Elias / Vadasz, Zahava

    The Journal of dermatology

    2021  Volume 48, Issue 11, Page(s) 1786–1788

    Abstract: When chronic spontaneous urticaria (CSU) is resolved, patients are often apprehensive about the likelihood of recurrence, and want to know if we can predict this using clinical or laboratory markers. This question is crucial because CSU is frequently ... ...

    Abstract When chronic spontaneous urticaria (CSU) is resolved, patients are often apprehensive about the likelihood of recurrence, and want to know if we can predict this using clinical or laboratory markers. This question is crucial because CSU is frequently accompanied by a high incidence of stressful comorbidities, and the fear of experiencing this again can be devastating to the patient. This study was designed with the aim of focusing on the prevalence and characteristics of the recurrence of CSU. We used our CSU patient registry that includes data on 180 patients who are followed periodically. In 23 (13%) patients, CSU was resolved during the first year. In 47 (26%) patients, CSU lasted more than 5 years. The recurrence of CSU was recorded in 21% of our patients after having experienced a full remission anywhere between 1 to 10 years (mean ± 2.9 years). While investigating predictive clinical or laboratory markers, we noticed that bronchial asthma existed in 10/25 (40%) of patients in whom CSU recurred as compared with 45/180 (25%) in the general CSU population (p = 0.049). In addition, increased levels of total immunoglobulin (Ig)E were found in 10/25 (40%) of the recurrence group as compared with 34/150 (23%) of the general CSU group (p = 0.04). Anti-thyroid peroxidase antibodies were also found in 11/25 (44%) of the recurrence group as compared with 32/160 (20%) of the general group (p = 0.003). The prevalence of CSU recurrence after a full remission is significantly higher among patients with existing bronchial asthma, increased levels of total IgE, and autoimmunity. Further studies are required in order to substantiate this important issue.
    MeSH term(s) Autoimmunity ; Chronic Disease ; Chronic Urticaria ; Comorbidity ; Humans ; Urticaria/diagnosis ; Urticaria/epidemiology
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diagnostics and environmental factors.

    Toubi, Elias

    Immunologic research

    2015  Volume 61, Issue 1-2, Page(s) 104–106

    MeSH term(s) Autoimmune Diseases/diagnosis ; Autoimmune Diseases/etiology ; Autoimmunity ; Environment ; Humans
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-014-8611-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Emerging Role of IL-17 in the Immune-Pathogenesis of Chronic Spontaneous Urticaria.

    Toubi, Elias / Vadasz, Zahava

    ImmunoTargets and therapy

    2020  Volume 9, Page(s) 217–223

    Abstract: Chronic spontaneous urticaria (CSU) is considered to be an autoimmune disorder (type I and type II) in 50% of all cases. However, autoreactive T cells and their proximity with activated mast cells in the skin of CSU patients are believed to be the ... ...

    Abstract Chronic spontaneous urticaria (CSU) is considered to be an autoimmune disorder (type I and type II) in 50% of all cases. However, autoreactive T cells and their proximity with activated mast cells in the skin of CSU patients are believed to be the primary event in mast cell degranulation. The finding of anti-FcɛRIα on mast cells or IgE autoantibodies against thyroid antigens should be considered to be a consequence of the auto-reactive T cells' recognition of the above-mentioned antigens. Our recent finding of increased Th17 and IL-17 expression in both CD4+ T cells and mast cells in the skin of severe CSU patients is supportive for the major role that T cells perform in the pathogenesis of CSU. Supporting this are numerous previous reports in which increased serum IL-17 was found to be in association with CSU disease severity. The beneficial effect of anti-IL-17A (secukinumab) in CSU patients in whom high dose anti-histamines, recurrent course of steroids and omalizumab fail to achieve a reasonable response should be investigated as a new therapeutic strategy in future studies with a large cohort of patients.
    Language English
    Publishing date 2020-10-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 2253-1556
    ISSN 2253-1556
    DOI 10.2147/ITT.S266410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Highlights in Autoimmunity: 2020.

    Toubi, Elias / Vadasz, Zehava

    The Israel Medical Association journal : IMAJ

    2020  Volume 11, Issue 22, Page(s) 717–719

    Abstract: Background: Innate and adaptive immune response dysregulations are equally involved in the induction of autoimmunity. Toll-like receptors play a leading role in the activation of innate immune cells, thus priming auto-reactive T cells. Th17 cells and ... ...

    Abstract Background: Innate and adaptive immune response dysregulations are equally involved in the induction of autoimmunity. Toll-like receptors play a leading role in the activation of innate immune cells, thus priming auto-reactive T cells. Th17 cells and related cytokines are widely involved in many immune-mediated diseases such as rheumatoid arthritis. Thus, the recent introduction of anti-IL-17 therapies should be further evaluated. Janus kinase inhibitors and Fc receptor-targeting drugs are some of the new therapeutic strategies that are being implemented when old classical therapies lack sufficient beneficial outcomes.
    MeSH term(s) Adaptive Immunity/immunology ; Animals ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Autoimmune Diseases/physiopathology ; Autoimmunity/immunology ; Cytokines/immunology ; Humans ; Immunity, Innate/immunology ; Interleukin-17/immunology ; Janus Kinase Inhibitors/pharmacology ; Receptors, Fc/drug effects ; Receptors, Fc/immunology ; Toll-Like Receptors/immunology
    Chemical Substances Cytokines ; Interleukin-17 ; Janus Kinase Inhibitors ; Receptors, Fc ; Toll-Like Receptors
    Language English
    Publishing date 2020-11-29
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Anti-Hsp70 antibodies and Cogan's syndrome.

    Toubi, Elias

    The Israel Medical Association journal : IMAJ

    2014  Volume 16, Issue 5, Page(s) 311–312

    MeSH term(s) Autoantibodies/analysis ; Autoantibodies/blood ; Biomarkers/analysis ; Biomarkers/blood ; Cogan Syndrome/diagnosis ; Cogan Syndrome/immunology ; Cogan Syndrome/physiopathology ; HSP70 Heat-Shock Proteins/immunology ; Humans ; Immunologic Tests
    Chemical Substances Autoantibodies ; Biomarkers ; HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2014-05
    Publishing country Israel
    Document type Editorial
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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