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  1. Article: Using Natural Language Processing and Machine Learning to Identify Opioids in Electronic Health Record Data.

    McDermott, Sean P / Wasan, Ajay D

    Journal of pain research

    2023  Volume 16, Page(s) 2133–2140

    Abstract: Purpose: This study evaluates the utility of machine learning (ML) and natural language processing (NLP) in the processing and initial analysis of data within the electronic health record (EHR). We present and evaluate a method to classify medication ... ...

    Abstract Purpose: This study evaluates the utility of machine learning (ML) and natural language processing (NLP) in the processing and initial analysis of data within the electronic health record (EHR). We present and evaluate a method to classify medication names as either opioids or non-opioids using ML and NLP.
    Patients and methods: A total of 4216 distinct medication entries were obtained from the EHR and were initially labeled by human reviewers as opioid or non-opioid medications. An approach incorporating bag-of-words NLP and supervised ML classification was implemented in MATLAB and used to automatically classify medications. The automated method was trained on 60% of the input data, evaluated on the remaining 40%, and compared to manual classification results.
    Results: A total of 3991 medication strings were classified as non-opioid medications (94.7%), and 225 were classified as opioid medications by the human reviewers (5.3%). The algorithm achieved a 99.6% accuracy, 97.8% sensitivity, 94.6% positive predictive value, F1 value of 0.96, and a receiver operating characteristic (ROC) curve with 0.998 area under the curve (AUC). A secondary analysis indicated that approximately 15-20 opioids (and 80-100 non-opioids) were needed to achieve accuracy, sensitivity, and AUC values of above 90-95%.
    Conclusion: The automated approach achieved excellent performance in classifying opioids or non-opioids, even with a practical number of human reviewed training examples. This will allow a significant reduction in manual chart review and improve data structuring for retrospective analyses in pain studies. The approach may also be adapted to further analysis and predictive analytics of EHR and other "big data" studies.
    Language English
    Publishing date 2023-06-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S389160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Solvent-Free Direct PEGylation of Collagen Fibers.

    Ward, Shawn P / Mcdermott, Sean T / Heichel, Danielle / Burke, Kelly A / Adamson, Douglas H

    ACS biomaterials science & engineering

    2022  Volume 8, Issue 12, Page(s) 5101–5109

    Abstract: The addition of poly(ethylene glycol) (PEG) to biomolecules and biomaterials is a well-established approach to modify their properties for therapeutic applications. For biomaterials, the approach is typically to blend or electrospray the synthetic ... ...

    Abstract The addition of poly(ethylene glycol) (PEG) to biomolecules and biomaterials is a well-established approach to modify their properties for therapeutic applications. For biomaterials, the approach is typically to blend or electrospray the synthetic polymer with the biomaterial. Effective surface modification approaches such as surface-initiated polymer brushes are challenging since the harsh solvents required for brush synthesis may destroy the biomaterial. Herein, we describe the PEGylation of collagen fibers by surface-initiated PEG brushes using a living anionic grafting-from mechanism. This brush synthesis is done in the absence of solvents to minimize the degradation of the native collagen structure. We quantify the effect the brush synthesis has on the native structure of the collagen fiber using differential scanning calorimetry (DSC) and find that even at long reaction times a significant fraction of the native structure remains. Dynamic mechanical analysis indicates the collagen undergoes only modest structural degradation, while adhesion studies find a significant improvement of antifouling properties. Further, our approach opens the way for further chemistry, as the growing polymer chain is a potassium alkoxy group that can be functionalized by termination or by subsequent reaction by a wide variety of molecules.
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c01071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults.

    Travers, John / Romero-Ortuno, Roman / Langan, John / MacNamara, Fergal / McCormack, Darren / McDermott, Christopher / McEntire, Jude / McKiernan, Joanne / Lacey, Seán / Doran, Peter / Power, Dermot / Cooney, Marie-Therese

    Age and ageing

    2023  Volume 52, Issue 2

    Abstract: ... confidence interval: 0.07-0.72; P = 0.011), adjusting for age, gender and site. Absolute risk reduction was 11.9% (CI ... 0.8%-22.9%). Number needed to treat was 8.4. Grip strength (P < 0.001) and bone mass (P = 0.040 ...

    Abstract Background: There is a need for effective primary care interventions that help older people combat frailty and build resilience.
    Objective: To study the effectiveness of an optimised exercise and dietary protein intervention.
    Design: Multicentre, randomised-controlled, parallel-arm trial.
    Setting: Six primary care practices, Ireland.
    Methods: Six general practitioners enrolled adults aged 65+ with Clinical Frailty Scale score ≤5 from December 2020 to May 2021. Participants were randomised to intervention or usual care with allocation concealed until enrolment. Intervention comprised a 3-month home-based exercise regime, emphasising strength, and dietary protein guidance (1.2 g/kg/day). Effectiveness was measured by comparing frailty levels, based on the SHARE-Frailty Instrument, on an intention-to-treat basis. Secondary outcomes included bone mass, muscle mass and biological age measured by bioelectrical impedance analysis. Ease of intervention and perceived health benefit were measured on Likert scales.
    Results: Of the 359 adults screened, 197 were eligible and 168 enrolled; 156 (92.9%) attended follow-up (mean age 77.1; 67.3% women; 79 intervention, 77 control). At baseline, 17.7% of intervention and 16.9% of control participants were frail by SHARE-FI. At follow-up, 6.3 and 18.2% were frail, respectively. The odds ratio of being frail between intervention and control groups post-intervention was 0.23 (95% confidence interval: 0.07-0.72; P = 0.011), adjusting for age, gender and site. Absolute risk reduction was 11.9% (CI: 0.8%-22.9%). Number needed to treat was 8.4. Grip strength (P < 0.001) and bone mass (P = 0.040) improved significantly. 66.2% found the intervention easy, 69.0% reported feeling better.
    Conclusion: A combination of exercises and dietary protein significantly reduced frailty and improved self-reported health.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Frailty/diagnosis ; Frailty/therapy ; Bone Density ; Emotions ; Exercise ; Primary Health Care
    Language English
    Publishing date 2023-02-26
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afad012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DNMT1-associated sensory neuropathy and cerebellar ataxia: A novel variant and review of genotype-phenotype correlation.

    Menon, Poornima Jayadev / Bogdanova-Mihaylova, Petya / McDermott, Garret / Crowley, Paul / Killeen, Ronan P / Alexander, Michael D / O'Dowd, Sean / Murphy, Sinéad M

    Journal of the peripheral nervous system : JPNS

    2023  Volume 28, Issue 3, Page(s) 508–512

    Abstract: ... pathogenic missense variant in DNMT1, c.1289G > A, p.Cys430Tyr. Cochlear implant was performed at 44 years ...

    Abstract Aim: Hereditary sensory neuropathy (HSN) 1E is a neurodegenerative disorder caused by pathogenic variants in DNA methyltransferase 1 (DNMT1). It is characterised by sensorineural deafness, sensory neuropathy and cognitive decline. Variants in DNMT1 are also associated with autosomal dominant cerebellar ataxia, deafness and narcolepsy.
    Methods: A 42-year-old man presented with imbalance, lancinating pain, numerous paucisymptomatic injuries, progressive deafness since his mid-20s, mild cognitive decline and apathy. Examination revealed abnormalities of eye movements, distal sensory loss to all modalities, areflexia without weakness and lower limb ataxia. MRI brain and FDG-PET scan demonstrated biparietal and cerebellar atrophy/hypometabolism. Whole exome sequencing detected a heterozygous likely pathogenic missense variant in DNMT1, c.1289G > A, p.Cys430Tyr. Cochlear implant was performed at 44 years for the bilateral high frequency sensorineural hearing loss with improvement in hearing and day-to-day function.
    Results and conclusion: We describe a novel variant in DNMT1 and confirm that an overlapping HSN1E-cerebellar phenotype can occur. Only one prior case of cochlear implant in HSN1E has been reported to date but this case adds to that literature, suggesting that cochlear implant can be successful in such patients. We further explore the clinical and radiological signature of the cognitive syndrome associated with this disorder.
    MeSH term(s) Humans ; Cerebellar Ataxia/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; Narcolepsy/complications ; Peripheral Nervous System Diseases/complications ; Neurodegenerative Diseases/complications ; Deafness/complications ; Deafness/genetics ; Genetic Association Studies ; Pedigree ; Mutation
    Chemical Substances DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37)
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns.12560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Effect of Specific Bioactive Collagen Peptides on Tendon Remodeling during 15 wk of Lower Body Resistance Training.

    Balshaw, Thomas G / Funnell, Mark P / McDermott, Emmet J / Maden-Wilkinson, Thomas M / Massey, Garry J / Abela, Sean / Quteishat, Btool / Edsey, Max / James, Lewis J / Folland, Jonathan P

    Medicine and science in sports and exercise

    2023  Volume 55, Issue 11, Page(s) 2083–2095

    Abstract: ... for any of the tendinous tissue adaptations to RT (ANOVA group-time, 0.365 ≤ P ≤ 0.877). There were within-group increases ... Young's modulus (CP, +17.8%; PLA, +20.6%) in both groups (paired t -tests (all), P ≤ 0.007). There were also ... in both groups (paired t -tests (all), P ≤ 0.006). Although no within-group changes in patellar tendon CSA (mean ...

    Abstract Purpose: Collagen peptide supplementation has been reported to enhance synthesis rates or growth in a range of musculoskeletal tissues and could enhance tendinous tissue adaptations to resistance training (RT). This double-blind placebo-controlled study aimed to determine if tendinous tissue adaptations, size (patellar tendon cross-sectional area (CSA) and vastus lateralis (VL) aponeurosis area), and mechanical properties (patellar tendon), after 15 wk of RT, could be augmented with collagen peptide (CP) versus placebo (PLA) supplementation.
    Methods: Young healthy recreationally active men were randomized to consume either 15 g of CP ( n = 19) or PLA ( n = 20) once every day during a standardized program of lower-body RT (3 times a week). Measurements pre- and post-RT included patellar tendon CSA and VL aponeurosis area (via magnetic resonance imaging), and patellar tendon mechanical properties during isometric knee extension ramp contractions.
    Results: No between-group differences were detected for any of the tendinous tissue adaptations to RT (ANOVA group-time, 0.365 ≤ P ≤ 0.877). There were within-group increases in VL aponeurosis area (CP, +10.0%; PLA, +9.4%), patellar tendon stiffness (CP, +17.3%; PLA, +20.9%) and Young's modulus (CP, +17.8%; PLA, +20.6%) in both groups (paired t -tests (all), P ≤ 0.007). There were also within-group decreases in patellar tendon elongation (CP, -10.8%; PLA, -9.6%) and strain (CP, -10.6%; PLA, -8.9%) in both groups (paired t -tests (all), P ≤ 0.006). Although no within-group changes in patellar tendon CSA (mean or regional) occurred for CP or PLA, a modest overall time effect ( n = 39) was observed for mean (+1.4%) and proximal region (+2.4%) patellar tendon CSA (ANOVA, 0.017 ≤ P ≤ 0.048).
    Conclusions: In conclusion, CP supplementation did not enhance RT-induced tendinous tissue remodeling (either size or mechanical properties) compared with PLA within a population of healthy young men.
    MeSH term(s) Male ; Humans ; Resistance Training/methods ; Tendons ; Patellar Ligament/diagnostic imaging ; Collagen ; Peptides ; Polyesters/pharmacology ; Muscle, Skeletal
    Chemical Substances Collagen (9007-34-5) ; Peptides ; Polyesters
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000003242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Surface-Initiated Passing-Through Polymerization on a Rubber Substrate: Supplying Monomer from Swollen Substrates

    McDermott, Sean T. / Ward, Shawn P. / Vy, Ngoc Chau H. / Wang, Zilu / Morales-Acosta, Mayra Daniela / Dobrynin, Andrey V. / Adamson, Douglas H.

    Macromolecules. 2022 Aug. 05, v. 55, no. 16

    2022  

    Abstract: Passing-through polymerization is a technique for growing surface-initiated polymer brushes where monomers are supplied to the growing chains by diffusing through the initiator-functionalized surface. This inverts the monomer concentration gradient ... ...

    Abstract Passing-through polymerization is a technique for growing surface-initiated polymer brushes where monomers are supplied to the growing chains by diffusing through the initiator-functionalized surface. This inverts the monomer concentration gradient relative to conventional grafting-from mechanisms, allowing for the synthesis of thicker and more densely packed brushes. Here we use a combination of coarse-grained computer simulations and experimental techniques to demonstrate how this approach can be implemented, with swellable network-like substrates supplying monomers to the functionalized surface as they diffuse out of the swollen network. Compared to grafting-from polymer brushes, this method shows a higher contact angle and a greater brush mass. Additionally, we observed that the passing-through approach could lead to strain-induced crystallization in the brush layer or wrinkling of the brush surface, which we used to estimate the brush thickness. The developed method opens a path for large-scale synthesis of the brush-modified elastic substrates.
    Keywords computers ; contact angle ; crystallization ; polymerization ; polymers ; rubber
    Language English
    Dates of publication 2022-0805
    Size p. 7265-7272.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1491942-4
    ISSN 1520-5835 ; 0024-9297
    ISSN (online) 1520-5835
    ISSN 0024-9297
    DOI 10.1021/acs.macromol.2c00685
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Effect of Aqueous Anions on Graphene Exfoliation.

    Ward, Shawn P / Abeykoon, Prabodha G / McDermott, Sean T / Adamson, Douglas H

    Langmuir : the ACS journal of surfaces and colloids

    2020  Volume 36, Issue 35, Page(s) 10421–10428

    Abstract: Ion partitioning behavior in electrolyte solutions plays an important role in drug delivery and therapeutics, protein folding, materials science, filtration, and energy applications such as supercapacitors. Here, we show that the segregation of ions in ... ...

    Abstract Ion partitioning behavior in electrolyte solutions plays an important role in drug delivery and therapeutics, protein folding, materials science, filtration, and energy applications such as supercapacitors. Here, we show that the segregation of ions in solutions also plays an important role in the exfoliation of natural flake graphite to pristine graphene. Polarizable anions such as iodide and acetate segregate to the interfacial region of the aqueous phase during solvent interfacial trapping exfoliation of graphene. Ordered water layers and accumulated charges near the graphene surface aid in separating graphene sheets from bulk graphite, and, more importantly, reduce the reversibility of the exfoliation event. The observed phenomenon results not only in the improved stability of graphene-stabilized emulsions but also in a low-cost and environmentally friendly way of enhancing the production of graphene.
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c01569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Abiotic redox reactions in hydrothermal mixing zones: Decreased energy availability for the subsurface biosphere.

    McDermott, Jill M / Sylva, Sean P / Ono, Shuhei / German, Christopher R / Seewald, Jeffrey S

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 34, Page(s) 20453–20461

    Abstract: Subseafloor mixing of high-temperature hot-spring fluids with cold seawater creates intermediate-temperature diffuse fluids that are replete with potential chemical energy. This energy can be harnessed by a chemosynthetic biosphere that permeates ... ...

    Abstract Subseafloor mixing of high-temperature hot-spring fluids with cold seawater creates intermediate-temperature diffuse fluids that are replete with potential chemical energy. This energy can be harnessed by a chemosynthetic biosphere that permeates hydrothermal regions on Earth. Shifts in the abundance of redox-reactive species in diffuse fluids are often interpreted to reflect the direct influence of subseafloor microbial activity on fluid geochemical budgets. Here, we examine hydrothermal fluids venting at 44 to 149 °C at the Piccard hydrothermal field that span the canonical 122 °C limit to life, and thus provide a rare opportunity to study the transition between habitable and uninhabitable environments. In contrast with previous studies, we show that hydrocarbons are contributed by biomass pyrolysis, while abiotic sulfate (SO
    MeSH term(s) Hot Temperature ; Hydrogen/chemistry ; Hydrothermal Vents/chemistry ; Hydrothermal Vents/microbiology ; Oxidation-Reduction ; Seawater/chemistry
    Chemical Substances Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2003108117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Characterization of seizure susceptibility in Pcdh19 mice.

    Rakotomamonjy, Jennifer / Sabetfakhri, Niki P / McDermott, Sean L / Guemez-Gamboa, Alicia

    Epilepsia

    2020  Volume 61, Issue 10, Page(s) 2313–2320

    Abstract: Objective: PCDH19-related epilepsy is characterized by a distinctive pattern of X-linked inheritance, where heterozygous females exhibit seizures and hemizygous males are asymptomatic. A cellular interference mechanism resulting from the presence of ... ...

    Abstract Objective: PCDH19-related epilepsy is characterized by a distinctive pattern of X-linked inheritance, where heterozygous females exhibit seizures and hemizygous males are asymptomatic. A cellular interference mechanism resulting from the presence of both wild-type and mutant PCDH19 neurons in heterozygous patients or mosaic carriers of PCDH19 variants has been hypothesized. We aim to investigate seizure susceptibility and progression in the Pchd19 mouse model.
    Methods: We assessed seizure susceptibility and progression in the Pcdh19 mouse model using three acute seizure induction paradigms. We first induced focal, clonic seizures using the 6-Hz psychomotor test. Mice were stimulated with increasing current intensities and graded according to a modified Racine scale. We next induced generalized seizures using flurothyl or pentylenetetrazol (PTZ), both γ-aminobutyric acid type A receptor function inhibitors, and recorded latencies to myoclonic and generalized tonic-clonic seizures.
    Results: Pcdh19 knockout and heterozygous females displayed increased seizure susceptibility across all current intensities in the 6-Hz psychomotor test, and increased severity overall. They also exhibited shorter latencies to generalized seizures following flurothyl, but not PTZ, seizure induction. Hemizygous males showed comparable seizure incidence and severity to their wild-type male littermates across all paradigms tested.
    Significance: The heightened susceptibility observed in Pcdh19 knockout females suggests additional mechanisms other than cellular interference are at play in PCDH19-related epilepsy. Further experiments are needed to understand the variability in seizure susceptibility so that this model can be best utilized toward development of future therapeutic strategies for PCDH19-related epilepsy.
    MeSH term(s) Animals ; Cadherins/deficiency ; Cadherins/genetics ; Electroencephalography/methods ; Female ; Genetic Predisposition to Disease/genetics ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Psychomotor Performance/physiology ; Seizures/genetics ; Seizures/metabolism ; Seizures/physiopathology
    Chemical Substances Cadherins ; Pcdh19 protein, mouse
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.16675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Designing a Low-Cost Thyroid Ultrasound Phantom for Medical Student Education.

    Schwartz, Cynthia M / Ivancic, Ryan J / McDermott, Sean M / Bahner, David P

    Ultrasound in medicine & biology

    2020  Volume 46, Issue 6, Page(s) 1545–1550

    Abstract: Using ultrasound for the diagnostic workup of thyroid lesions is a widely accepted technique. An inexpensive phantom model of thyroid lesions would be an invaluable tool for engaging medical students in learning the diagnostic algorithm for thyroid ... ...

    Abstract Using ultrasound for the diagnostic workup of thyroid lesions is a widely accepted technique. An inexpensive phantom model of thyroid lesions would be an invaluable tool for engaging medical students in learning the diagnostic algorithm for thyroid lesions and how to perform fine needle aspiration (FNA). The aim of this study was to devise an inexpensive and reproducible training phantom model for thyroid lesion detection, image interpretation and in vitro FNA using ultrasound guidance. A simple phantom model imitating benign cystic lesions, intermediately suspicious lesions and highly suspicious lesions was developed using a chicken breast, red seedless grapes, pimento olives and blackberries. The phantom was constructed for a total cost of $4.09 per unit and constructed in approximately 3 min. Nine models were constructed in total, demonstrating that the model design is replicable. This thyroid FNA phantom is an inexpensive, easy-to-produce model that allows medical students to practice measuring lesions and performing FNAs using ultrasonography. Future studies could be explored to assess this model's role in medical student education.
    MeSH term(s) Biopsy, Fine-Needle ; Education, Medical, Undergraduate/methods ; Humans ; Image-Guided Biopsy ; Phantoms, Imaging/economics ; Thyroid Diseases/diagnostic imaging ; Thyroid Gland/diagnostic imaging ; Ultrasonography/economics
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2020.01.033
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