LIVIVO - Search results -

Search results

Result 1 - 10 of total 148

Search options

Book ; Conference proceedings: From discovery to clinical practice

Conley, Barbara A.

NCI-EORTC present 2nd International Meeting on Cancer Diagnostic ; an interactive workshop focused on practical methods for bringing promising prognostic and predictive markers from the research laboratory to the bedside ; June 26 - 29, 2002, Grand Hyatt Hotel, Washington, DC, USA ; abstracts

(The international journal of biological markers ; 17, Suppl. 2)

2002

Institution	National Cancer Institute
Event/congress	International Meeting on Cancer Diagnostics (2, 2002, WashingtonDC)
Author's details	conference co-chairpersons Barbara A. Conley
Series title	The international journal of biological markers ; 17, Suppl. 2
Collection
Language	English
Size	S63 S. : graph. Darst.
Publisher	Wichtig
Publishing place	Milano
Publishing country	Italy
Document type	Book ; Conference proceedings
HBZ-ID	HT013431190
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 2491 -17,2,Suppl.-	not available for loan	Zeitschriften-Lesesaal

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Genomically guided cancer treatments: from "promising" to "clinically useful".

Conley, Barbara A

Journal of the National Cancer Institute

2015 Volume 107, Issue 7

MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Biomarkers, Tumor/genetics ; Decision Support Techniques ; Drugs, Investigational/pharmacology ; Genomics ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Precision Medicine/trends
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; Drugs, Investigational
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djv168
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.131: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multifaceted epigenetic regulation of porcine testicular aromatase.

Berger, Trish / Vanselow, Jens / Conley, Alan / Almand, Tana Jo / Nitta-Oda, Barbara S

Molecular and cellular endocrinology

2021 Volume 541, Page(s) 111526

Abstract: Testicular aromatase catalyzes the synthesis of estradiol, which contributes to regulation of porcine Sertoli cell proliferation and postpubertal maintenance of Sertoli cell numbers. Although aromatase enzymatic activity decreases with age and is ... ...

Abstract	Testicular aromatase catalyzes the synthesis of estradiol, which contributes to regulation of porcine Sertoli cell proliferation and postpubertal maintenance of Sertoli cell numbers. Although aromatase enzymatic activity decreases with age and is persistently reprogrammed by prepubertal treatment with the aromatase inhibitor letrozole, the molecular bases for regulation have not been identified. DNA methylation was examined as a potential regulatory mechanism using DNA from Leydig cells isolated from 16-, 40-, and 68-week-old boars and from 68- week-old littermates treated with the aromatase inhibitor, letrozole. Methylation levels of individual CpG dinucleotides located in the distal untranslated exon 1 of the relevant aromatase encoding gene, CYP19A3, were quite high in Leydig cell DNA, and increased further with maturity of boar (P < 0.05), while aromatase activity and transcript abundance decreased more than two-fold. However, reduced aromatase activity following letrozole treatment was not accompanied by altered DNA methylation. Testicular expression of miR378 was altered by prepubertal treatment with letrozole. The data provide evidence for two different epigenetic mechanisms that regulate aromatase expression and enzymatic activity in the boar testis.
MeSH term(s)	Animals ; Animals, Newborn ; Aromatase/genetics ; Aromatase/metabolism ; Aromatase Inhibitors/pharmacology ; Cells, Cultured ; Epigenesis, Genetic/drug effects ; Epigenesis, Genetic/physiology ; Gene Expression Regulation, Developmental/drug effects ; Gene Expression Regulation, Enzymologic/drug effects ; Letrozole/pharmacology ; Leydig Cells/drug effects ; Leydig Cells/metabolism ; Male ; Sertoli Cells/drug effects ; Sertoli Cells/metabolism ; Swine/genetics ; Swine/growth & development ; Testis/drug effects ; Testis/growth & development ; Testis/metabolism
Chemical Substances	Aromatase Inhibitors ; Letrozole (7LKK855W8I) ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2021-11-29
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2021.111526
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1127: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Exfoliation Syndrome and Exfoliation Glaucoma in the Navajo Nation.

Patil, Ayesha / Swiston, Cole / Wallace, Ryan T / Paulson, Chase / Conley, Matthew E / McCoy, Lori / Chaya, Craig / Wirostko, Barbara

Vision (Basel, Switzerland)

2022 Volume 6, Issue 4

Abstract: 1) Background: Exfoliation syndrome (XFS) is a common cause of secondary open angle glaucoma. In 1971, Faulkner et al. estimated the prevalence of XFS among 50 Navajo Nation residents as 38%. Given that XFS can cause irreversible blindness secondary to ... ...

Abstract	(1) Background: Exfoliation syndrome (XFS) is a common cause of secondary open angle glaucoma. In 1971, Faulkner et al. estimated the prevalence of XFS among 50 Navajo Nation residents as 38%. Given that XFS can cause irreversible blindness secondary to glaucoma (XFG), this study aims to identify the current prevalence of XFS among Navajo Nation residents within the Four Corners region of the U.S. (2) Methods: A retrospective chart review was conducted from 2016 to 2021 for patients aged 18 and older. All patients with XFS or XFG diagnosed by slit lamp exam were identified through chart review. (3) Results: Of the 1152 patient charts available for review, eight patients (11 eyes) were diagnosed with XFS with three patients (4 eyes) demonstrating concomitant XFG. Within this XFS population, 50% of the patients identified as male, with a mean age of 73 years. The overall prevalence of XFS was 0.7% and the overall prevalence of XFG was found to be 0.26%. The rate of XFG among patients with XFS was 37.5%. (4) Conclusion: Compared to Faulkner's study of Navajo Nation residents in 1971, our findings show a considerably lower prevalence of XFS at 0.7%. We present the largest study to date of XFS among this population.
Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Journal Article
ISSN	2411-5150
ISSN (online)	2411-5150
DOI	10.3390/vision6040061
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings.

Patil, Ayesha / Conley, Matthew / Paulson, Chase / Pompoco, Christian / Wallace, Ryan / Swiston, Cole / Ritch, Robert / Curtin, Karen / Wirostko, Barbara

Acta ophthalmologica

2022 Volume 101, Issue 5, Page(s) 478–484

Abstract: Several studies have suggested a possible relationship between exfoliation syndrome (XFS) and abdominal aortic aneurysm (AAA). A systematic literature review was undertaken to investigate this potential association. The systematic literature review was ... ...

Abstract	Several studies have suggested a possible relationship between exfoliation syndrome (XFS) and abdominal aortic aneurysm (AAA). A systematic literature review was undertaken to investigate this potential association. The systematic literature review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Clear definitions of XFS and AAA were used to identify eligible studies via an unrestricted search of the PubMed interface from 1979 to October 31st, 2021. After review, 876 citations were gathered and evaluated for inclusion, from which 22 articles were included. Of these 22, 16 were excluded because they did not assess the relationship between AAA and XFS or provide primary data. Ultimately, six studies were included in this literature review. Half of the studies explored AAA prevalence in a population with or without XFS, and the other half explored the opposite. Three studies supported XFS as a risk factor for the development of AAA, and the other three found this relationship to be inconclusive. This systematic review revealed inconsistent results regarding an association between AAA and XFS. A large database study including XFS and AAA patients would be useful in further determining if an association does in fact exist.
MeSH term(s)	Humans ; Exfoliation Syndrome/complications ; Exfoliation Syndrome/diagnosis ; Exfoliation Syndrome/epidemiology ; Risk Factors ; Aortic Aneurysm, Abdominal/complications ; Aortic Aneurysm, Abdominal/diagnosis ; Aortic Aneurysm, Abdominal/epidemiology ; Prevalence
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.15307
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul I Zs.90: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical Application of Liquid Biopsies.

Williams, P Mickey / Conley, Barbara A

JAMA oncology

2016 Volume 2, Issue 8, Page(s) 1003–1005

MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Clinical Decision-Making ; DNA, Neoplasm/analysis ; DNA, Neoplasm/blood ; High-Throughput Nucleotide Sequencing ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Mutation ; Polymerase Chain Reaction/methods ; Precision Medicine ; Proto-Oncogene Proteins p21(ras)/genetics ; Receptor, Epidermal Growth Factor/genetics ; Sequence Analysis, DNA
Chemical Substances	DNA, Neoplasm ; KRAS protein, human ; EGFR protein, human (EC 2.7.10.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2016-08-01
Publishing country	United States
Document type	Editorial
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2016.0240
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Oncology mental health providers' adaptation of an evidence-based intervention: A mixed-methods study.

Conley, Claire C / Ryba, Marlena M / Brothers, Brittany M / Lo, Stephen B / Andersen, Barbara L

Psycho-oncology

2024 Volume 33, Issue 1, Page(s) e6272

Abstract: Background: Adaptations are intentional modifications maximizing the fit of an evidence-based intervention (EBI) in new context. Little is known about EBI adaptation within psychosocial oncology. Guided by the Framework for Reporting Adaptations and ... ...

Abstract	Background: Adaptations are intentional modifications maximizing the fit of an evidence-based intervention (EBI) in new context. Little is known about EBI adaptation within psychosocial oncology. Guided by the Framework for Reporting Adaptations and Modifications-Enhanced (FRAME), this mixed-methods study describes oncology mental health providers' planned adaptations to a psychosocial oncology EBI and examines the relationship between planned adaptations and longitudinal EBI usage. Methods: Providers (N = 128) were social workers (47%) and psychologists (40%) practicing in community settings (44%) or academic medical centers (41%). They attended a 3-day training on a multicomponent psychosocial oncology EBI, the Biobehavioral Intervention (BBI). During training, providers prepared an "adaptation plan" describing necessary adaptations to BBI and rationales for change. Qualitative data from adaptation plans were analyzed using directed content analysis. Linear mixed models examined the relationship between adaptation characteristics (number, similarity to the manualized BBI) and EBI usage across 12 months post-training. Results: Three sets of qualitative themes reflecting FRAME elements emerged: (1) content modifications (e.g., shortening/condensing, selecting elements, adding/removing elements); (2) contextual changes (e.g., alternative group formats); and (3) reasons for adaptations (e.g., organization/setting, provider, and recipient factors). Neither number of adaptations nor adaptation similarity were associated with BBI usage across 12 months post-training. Conclusions: To our knowledge, this study is the first to characterize oncology mental health providers' planned adaptations to a psychosocial oncology EBI. Planned adaptations did not increase usage, but importantly they did not decrease usage. The adaptation process enabled providers to make thoughtful adaptation choices, with implementation successful irrespective of setting constraints.
MeSH term(s)	Humans ; Evidence-Based Medicine ; Mental Health ; Medical Oncology ; Social Workers
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.6272
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3550: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Wastewater treatment plants as a source of microplastics to an urban estuary: Removal efficiencies and loading per capita over one year.

Conley, Kenda / Clum, Allan / Deepe, Jestine / Lane, Haven / Beckingham, Barbara

Water research X

2019 Volume 3, Page(s) 100030

Abstract: Wastewater treatment plants serve to collect and treat wastes that are known to include microplastic (MP; synthetic polymer materials <5 mm in size) and other small anthropogenic litter as particles, fibers and microbeads. Here, we determined the ... ...

Abstract	Wastewater treatment plants serve to collect and treat wastes that are known to include microplastic (MP; synthetic polymer materials <5 mm in size) and other small anthropogenic litter as particles, fibers and microbeads. Here, we determined the microplastic loads and removal efficiencies of three wastewater treatment plants (WWTPs) with different treatment sizes, operations and service compositions discharging to Charleston Harbor, South Carolina, USA over the course of a year. Overall, we found that MP concentrations (counts per L) varied within a factor of 2.5 in influent and 4.8 in effluent at each WWTP, and that neither concentrations nor removal efficiencies demonstrated a seasonal trend. The largest wastewater treatment plant in the study, which also employed primary clarification, had the highest MP removal efficiency of 97.6 ± 1.2%. The other two smaller facilities had average removal efficiencies of 85.2 ± 6.0% and 85.5 ± 9.1%. We demonstrate through source modeling that microplastic fiber loads in influent were consistent with service area populations laundering textiles given previously published rates of microplastic generation in washing machines. Using measured WWTP flow rates and MP counts, we find a combined load of MPs leaving all three WWTPs with discharged effluent totaling 500-1000 million MPs per day. We estimate from this the emission of 0.34-0.68 g MP per capita per year in treated wastewater, which may only account for <0.1% of plastic debris input to this metropolitan area's surface waters on an annual mass basis when land-based (mis)managed plastic waste sources are also considered. However, the potential for sorption of chemicals present in wastewater to microplastics and their small size, which confers immediate bioaccessibility, may present unique toxicological risks for microplastics discharged from WWTPs.
Language	English
Publishing date	2019-04-10
Publishing country	England
Document type	Journal Article
ISSN	2589-9147
ISSN (online)	2589-9147
DOI	10.1016/j.wroa.2019.100030
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Molecular analysis for therapy choice: NCI MATCH.

Conley, Barbara A / Doroshow, James H

Seminars in oncology

2014 Volume 41, Issue 3, Page(s) 297–299

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/analysis ; Decision Making ; Humans ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Editorial
ZDB-ID	189220-4
ISSN	1532-8708 ; 0093-7754
ISSN (online)	1532-8708
ISSN	0093-7754
DOI	10.1053/j.seminoncol.2014.05.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1348: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Phase II Study of Osimertinib in Patients With Epidermal Growth Factor Receptor Mutations: Results From the NCI-MATCH ECOG-ACRIN (EAY131) Trial Subprotocol E.

JCO precision oncology

2024 Volume 8, Page(s) e2300454

Abstract: Purpose: The National Cancer Institute Molecular Analysis for Therapy Choice trial is a signal-finding genomically driven platform trial that assigns patients with any advanced refractory solid tumor, lymphoma, or myeloma to targeted therapies on the ... ...

Abstract	Purpose: The National Cancer Institute Molecular Analysis for Therapy Choice trial is a signal-finding genomically driven platform trial that assigns patients with any advanced refractory solid tumor, lymphoma, or myeloma to targeted therapies on the basis of next-generation sequencing results. Subprotocol E evaluated osimertinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in patients with Methods: Eligible patients had Results: A total of 19 patients were enrolled: 17 were evaluable for toxicity and 13 for efficacy. The median age of the 13 included in the efficacy analysis was 63 years, 62% had Eastern Cooperative Oncology Group performance status 1, and 31% received >three previous systemic therapies. The most common tumor type was brain cancers (54%). The ORR was 15.4% (n = 2 of 13; 90% CI, 2.8 to 41.0) and 6-month PFS was 16.7% (90% CI, 0 to 34.4). The two confirmed RECIST responses were observed in a patient with neuroendocrine carcinoma not otherwise specified ( Conclusion: In this pretreated cohort, osimertinib did not meet the prespecified end point threshold for efficacy, but responses were seen in a neuroendocrine carcinoma with an
MeSH term(s)	United States ; Humans ; Middle Aged ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; National Cancer Institute (U.S.) ; Antineoplastic Agents/adverse effects ; Protein Kinase Inhibitors/adverse effects ; Mutation ; Carcinoma, Neuroendocrine/drug therapy ; Acrylamides ; Aniline Compounds ; Indoles ; Pyrimidines
Chemical Substances	osimertinib (3C06JJ0Z2O) ; ErbB Receptors (EC 2.7.10.1) ; Antineoplastic Agents ; Protein Kinase Inhibitors ; Acrylamides ; Aniline Compounds ; Indoles ; Pyrimidines
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.23.00454
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED