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  1. Article ; Online: Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?

    Mohamed, Mahmoud M A / El-Shimy, Ismail Amr / Hadi, Muhammad Abdul

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 311

    MeSH term(s) COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Hospitalization ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Proteinase Inhibitory Proteins, Secretory/therapeutic use ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/virology ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Proteinase Inhibitory Proteins, Secretory
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03023-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS-CoV-2 in the respiratory tract.

    El-Shimy, Ismail A / Mohamed, Mahmoud M A / Hasan, Syed Shahzad / Hadi, Muhammad A

    Pharmacology research & perspectives

    2020  Volume 9, Issue 1, Page(s) e00698

    Abstract: As the death toll of Coronavirus disease 19 (COVID-19) continues to rise worldwide, it is imperative to explore novel molecular mechanisms for targeting SARS-CoV-2. Rather than looking for drugs that directly interact with key viral proteins inhibiting ... ...

    Abstract As the death toll of Coronavirus disease 19 (COVID-19) continues to rise worldwide, it is imperative to explore novel molecular mechanisms for targeting SARS-CoV-2. Rather than looking for drugs that directly interact with key viral proteins inhibiting its replication, an alternative and possibly add-on approach is to dismantle the host cell machinery that enables the virus to infect the host cell and spread from one cell to another. Excellent examples of such machinery are host cell proteases whose role in viral pathogenesis has been demonstrated in numerous coronaviruses. In this review, we propose two therapeutic modalities to tackle SARS-CoV-2 infections; the first is to transcriptionally modulate the expression of cellular proteases and their endogenous inhibitors and the second is to directly inhibit their enzymatic activity. We present a nonexhaustive collection of clinically investigated drugs that act by one of these mechanisms and thus represent promising candidates for preclinical in vitro testing and hopefully clinical testing in COVID-19 patients.
    MeSH term(s) COVID-19/enzymology ; Humans ; Molecular Targeted Therapy/methods ; Peptide Hydrolases/metabolism ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; Respiratory System/drug effects ; Respiratory System/virology ; SARS-CoV-2/growth & development ; COVID-19 Drug Treatment
    Chemical Substances Protease Inhibitors ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2020-12-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?

    Mohamed, Mahmoud M A / El-Shimy, Ismail Amr / Hadi, Muhammad Abdul

    Crit Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #574525
    Database COVID19

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  4. Article ; Online: Neutrophil Elastase Inhibitors

    Mohamed, Mahmoud M. A. / El-Shimy, Ismail Amr / Hadi, Muhammad Abdul

    Critical Care

    A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?

    2020  Volume 24, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041406-7
    ISSN 1364-8535
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03023-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Neutrophil Elastase Inhibitors

    Mahmoud M. A. Mohamed / Ismail Amr El-Shimy / Muhammad Abdul Hadi

    Critical Care, Vol 24, Iss 1, Pp 1-

    A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?

    2020  Volume 2

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Estimating nursing requirements using bed occupancy levels.

    Ismail, Abdul Qader / Gandhi, Anjum / El-Shimy, Nagui

    Nursing children and young people

    2011  Volume 23, Issue 4, Page(s) 13

    MeSH term(s) Bed Occupancy ; Management Audit ; Nursing Staff, Hospital/supply & distribution ; Societies, Nursing ; United Kingdom
    Language English
    Publishing date 2011-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2603456-6
    ISSN 2046-2336
    ISSN 2046-2336
    DOI 10.7748/ncyp2011.05.23.4.13.p5170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online ; Thesis: Dissecting the effect of EGF starvation on the signaling and transcriptomic landscapes of the mouse intestinal epithelium

    Hassanin, Ismail El-Shimy [Verfasser] / Blüthgen, Nils [Gutachter] / Morkel, Markus [Gutachter] / Brummer, Tilman [Gutachter]

    2023  

    Author's details Ismail El-Shimy Hassanin ; Gutachter: Nils Blüthgen, Markus Morkel, Tilman Brummer
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Intractable neonatal jaundice due to hereditary spherocytosis and Gilbert's syndrome.

    Ismail, Abdul Qader Tahir / Gandhi, Anjum / El-Shimy, Nagui

    BMJ case reports

    2011  Volume 2011

    Abstract: In this article the authors present a case of pathological neonatal jaundice resistant to phototherapy in a baby with a family history of Gilbert's syndrome and hereditary spherocytosis. Her presentation was ultimately explained with a diagnosis of both ... ...

    Abstract In this article the authors present a case of pathological neonatal jaundice resistant to phototherapy in a baby with a family history of Gilbert's syndrome and hereditary spherocytosis. Her presentation was ultimately explained with a diagnosis of both conditions, and required treatment with phenobarbitone. The authors discuss the mechanism by which Gilbert's syndrome results in hyperbilirubinaemia and its similarities with Crigler-Najjar syndrome. The presentation of hereditary spherocystosis in the neonatal period is also explored, as is the mechanism of exaggerated hyperbilirubinaemia when the two conditions co-exist.
    MeSH term(s) Diagnosis, Differential ; Female ; GABA Modulators/therapeutic use ; Gilbert Disease/complications ; Gilbert Disease/diagnosis ; Humans ; Infant, Newborn ; Jaundice, Neonatal/diagnosis ; Jaundice, Neonatal/drug therapy ; Jaundice, Neonatal/etiology ; Phenobarbital/therapeutic use ; Spherocytosis, Hereditary/complications ; Spherocytosis, Hereditary/diagnosis
    Chemical Substances GABA Modulators ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2011-07-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.05.2011.4293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Minocycline attenuates Aβ oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aβ fibrils phagocytosis.

    El-Shimy, Ismail Amr / Heikal, Ola Ahmed / Hamdi, Nabila

    Neuroscience letters

    2015  Volume 609, Page(s) 36–41

    Abstract: Microglia, the brain innate immune cells, are activated in response to amyloid beta (Aβ) resulting in neuroinflammation in AD brains. Recently, two phenotypes have been described for microglia: the pro-inflammatory classical and the anti-inflammatory ... ...

    Abstract Microglia, the brain innate immune cells, are activated in response to amyloid beta (Aβ) resulting in neuroinflammation in AD brains. Recently, two phenotypes have been described for microglia: the pro-inflammatory classical and the anti-inflammatory alternative. Changes in microglia phenotype that control their phagocytic function are yet to be determined. The highly neurotoxic Aβ oligomers (oAβ) formed at an early disease stage induce pro-inflammatory microglia activation releasing neurotoxic mediators and contributing to neurodegeneration. A novel strategy for AD treatment is to attenuate microglia-induced inflammation while maintaining efficient Aβ clearance. Minocycline effectively crosses the blood-brain barrier and has widely reported neuroprotective effects. Yet, its exact mechanism of neuroprotection and its effects on microglia are still unknown. The aim of this study is to investigate the effect of minocycline on the phagocytic uptake of fAβ by primary microglia in relation to their activation state in an inflammatory milieu generated by oAβ or LPS. The study shows that minocycline is able to attenuate oAβ-induced neuroinflammatory response of microglia by inhibiting their pro-inflammatory phenotype activation. In addition, a significant enhancement of fAβ phagocytosis by minocycline- treated microglia is reported for the first time, providing novel insight into its neuroprotective role in AD.
    MeSH term(s) Amyloid/metabolism ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/pharmacology ; Animals ; Brain/cytology ; Brain/metabolism ; Cells, Cultured ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Minocycline/pharmacology ; Neuroprotective Agents/pharmacology ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Phagocytosis
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Lipopolysaccharides ; Neuroprotective Agents ; Peptide Fragments ; amyloid beta-protein (1-42) ; Minocycline (FYY3R43WGO)
    Language English
    Publishing date 2015-11-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2015.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1166: Show issues Location:
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  10. Article ; Online: Strangulated diaphragmatic hernia presenting at 7 weeks of life as intractable shock.

    Ismail, Abdul Qader Tahir / Alake, Oluwaseyi / El-Shimy, Nagui

    BMJ case reports

    2013  Volume 2013

    Abstract: A 7-week-old infant presented to hospital pale and floppy, with 5 s capillary refill time. Blood gas showed severe acidosis (pH 6.86, partial pressure of carbondioxide 10.55 kPa, base excess 21.1). Hypotension persisted despite several fluid boluses so ... ...

    Abstract A 7-week-old infant presented to hospital pale and floppy, with 5 s capillary refill time. Blood gas showed severe acidosis (pH 6.86, partial pressure of carbondioxide 10.55 kPa, base excess 21.1). Hypotension persisted despite several fluid boluses so she was intubated and started on inotropic support. A chest X-ray revealed a congenital diaphragmatic hernia (CDH). Despite steroids and blood transfusions she remained unstable, and could not be resuscitated following cardiac arrest. Postmortem revealed 39 cm of herniated, necrotic colon. 5-25% of CDH presents after the neonatal period, and while not associated with pulmonary hypoplasia is primarily still a diaphragmatic defect. In late presenting cases, herniation occurs shortly prior to developing symptoms; therefore, an antenatal ultrasound (US) cannot pick it up. If we could diagnose the isolated diaphragmatic defect antenatally, this would allow elective postnatal surgical closure. This is not feasible currently; however, with the advent of antenatal three-dimensional US scans it may be possible in the future.
    MeSH term(s) Fatal Outcome ; Female ; Hernia, Diaphragmatic/complications ; Hernia, Diaphragmatic/diagnostic imaging ; Hernias, Diaphragmatic, Congenital ; Humans ; Infant ; Radiography, Thoracic ; Shock/etiology
    Language English
    Publishing date 2013-10-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-200788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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