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  1. Article ; Online: Hyperselective Tibial Neurotomy for Relieving Spasticity and Restoring Motor Functions.

    Bajaj, Jitin / Verma, Shashikant / Chaudhary, Vivek / Khandelwal, Namrata / Patidar, Jayant / Hedaoo, Ketan / Sinha, Mallika / Sharma, Mukesh / Kukrele, Rajeev / Bajaj, Diya / Yadav, Nishtha / Ratre, Shailendra / Parihar, Vijay S / Yadav, Prashant / Agarwal, Pawan / Swamy, M N / Yadav, Y R

    Neurology India

    2024  Volume 71, Issue 6, Page(s) 1142–1145

    MeSH term(s) Humans ; Muscle Spasticity/surgery ; Neurosurgical Procedures
    Language English
    Publishing date 2024-01-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.391363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Budd Chiari Syndrome with Portal Vein Thrombosis Managed Successfully with Direct Intrahepatic Portosystemic Shunt: A Case Report and Review of the Literature.

    Malakar, Sayan / Mathur, Akash / Agarwal, Ayushi / Mishra, Piyush / Shirol, Vivek V / Yadav, Rajanikant R / Ghoshal, Uday C

    Journal of clinical and experimental hepatology

    2023  Volume 13, Issue 5, Page(s) 917–920

    Abstract: Budd -Chiari syndrome (BCS) is a hepatic vascular disorder which affects hepatic veins or inferior vena cava. Portal vein thrombosis (PVT) occurs in around 15%-25% of patients with BCS. The presence of PVT in patients with BCS makes it more difficult to ... ...

    Abstract Budd -Chiari syndrome (BCS) is a hepatic vascular disorder which affects hepatic veins or inferior vena cava. Portal vein thrombosis (PVT) occurs in around 15%-25% of patients with BCS. The presence of PVT in patients with BCS makes it more difficult to intervene radiologically. We present a case of a BCS-related chronic liver disease that presented with a history of variceal upper gastrointestinal bleeding and worsening ascites. The patient had thrombosed hepatic veins (HV) and partial right portal vein thrombosis. He was started on anticoagulation, and treatment for portal hypertension was initiated. Given the inaccessibility of all the HVs for trans-jugular intrahepatic portosystemic shunts (TIPS), the patient underwent direct intrahepatic portosystemic shunts (DIPS). Next-generation sequencing identified the factor V Leiden mutation. Following DIPS, the patient's ascites disappeared, and liver function tests improved. On a nine-month follow-up, the patient was symptom-free with a patent DIPS. DIPS has been widely used in patients with BCS with thrombosed hepatic veins, but there are only a few case reports on the feasibility of DIPS in BCS patients with PVT. This is one of the very few case reports where a patient with BCS-PVT was successfully managed with DIPS.
    Language English
    Publishing date 2023-06-19
    Publishing country India
    Document type Case Reports
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2023.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recurrent Ischemic Strokes due to Chronic Otomastoiditis: A Rare Clinical Entity.

    Chauhan, Gaurav / Singh, Vivek / Phadke, R V / Yadav, Sapna

    Saudi journal of medicine & medical sciences

    2019  Volume 7, Issue 3, Page(s) 234–236

    Language English
    Publishing date 2019-08-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2734896-9
    ISSN 2321-4856 ; 1658-631X
    ISSN (online) 2321-4856
    ISSN 1658-631X
    DOI 10.4103/sjmms.sjmms_152_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of Novel Hematological Indices with Severity of Coronary Artery Disease using SYNTAX Score in Patients with Acute Coronary Syndrome.

    Mohanty, Vivek / Sharma, Shubham / Goswami, Sourabh / Kaushik, Atul / Choudhary, Rahul / Yadav, Dharamveer / Deora, Surender / Singh, Kuldeep

    Cardiovascular & hematological disorders drug targets

    2023  Volume 23, Issue 3, Page(s) 202–211

    Abstract: ... correlated with SYNTAX Score.: Results: All three indices: MHR (r=0.511; p <0.001), MLR (r=0.373; p <0.001 ... and NLR (r=0.292; p =0.001) showed significant correlation with SYNTAX Score. The MHR ROC was ...

    Abstract Introduction: Recent evidence suggests that systemic inflammation not only plays an important role in the pathogenesis of Acute Coronary Syndrome but also correlates with disease severity. Monocyte-to-high-density lipoprotein cholesterol ratio (MHR), Neutrophil-Lymphocyte Ratio (NLR), and Monocyte-Lymphocyte Ratio (MLR) are novel systemic inflammation markers used for predicting the burden of coronary artery disease (CAD) based on SYNTAX Score. This single-center, cross-sectional, observational study compared the association of these novel hematological indices with CAD severity using the SYNTAX Score in ACS patients and aimed to determine the best predictor of the severity of CAD.
    Methods: A total of 403 consecutive patients with ACS who underwent coronary angiography were enrolled. On the basis of the SYNTAX Score, patients were divided into three groups: Low: <22, Moderate 22 - 32 and High ≥ 32. MHR, MLR, and NLR were calculated and correlated with SYNTAX Score.
    Results: All three indices: MHR (r=0.511; p <0.001), MLR (r=0.373; p <0.001), and NLR (r=0.292; p =0.001) showed significant correlation with SYNTAX Score. The MHR ROC was significantly higher than that of MLR (difference between area: 0.158; 95% CI: 0.079-0.259) and NLR (difference between area: 0.279; 95% CI: 0.172-0.419) for the SYNTAX Score. Analysis showed a strong correlation between these indices with SYNTAX Score >22 compared to low scores <22 and that these also related to the LAD as an infarct artery. Multiple regression analysis showed that diabetes mellitus, eGFR, Infarct-related artery left anterior descending (IRALAD), MHR, MLR, and NLR were predictors of the severity of CAD in ACS patients based on SYNTAX Score.
    Conclusion: In ACS patients MHR, MLR, and NLR showed significant correlation with SYNTAX score >22 which may be indicative of severity of disease. MHR is a better predictor of the severity of CAD than MLR and NLR in ACS patients.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnosis ; Acute Coronary Syndrome/diagnosis ; Cross-Sectional Studies ; Inflammation ; Infarction ; Severity of Illness Index
    Language English
    Publishing date 2023-11-12
    Publishing country United Arab Emirates
    Document type Observational Study ; Journal Article
    ZDB-ID 2244164-5
    ISSN 2212-4063 ; 1871-529X
    ISSN (online) 2212-4063
    ISSN 1871-529X
    DOI 10.2174/011871529X269740231102045028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature.

    Almalouf, Catherina / Hakobyan, Narek / Yadav, Vivek / Gandhi, Anjula / Yadav, Ruchi

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38525

    Abstract: Cocaine is used as an illicit substance responsible for the most common cause of drug-related death. It is a stimulant that acts on the sympathetic nervous system and cardiovascular system leading to exaggerated, prolonged sympathetic activity due to the ...

    Abstract Cocaine is used as an illicit substance responsible for the most common cause of drug-related death. It is a stimulant that acts on the sympathetic nervous system and cardiovascular system leading to exaggerated, prolonged sympathetic activity due to the accumulation of neurotransmitters. Cardiovascular side effects of cocaine are coronary artery spasms, myocarditis, arrhythmias, and congestive heart failure. Takotsubo cardiomyopathy (TCM) is characterized by transient hypokinesis, akinesis, or dyskinesis of the left ventricle (LV) wall with or without apical involvement in the absence of obstructive coronary artery disease. Cocaine-induced TCM is an extremely rare condition emphasizing the need of its prompt diagnosis by the physicians. We present a case report of a 54-year-old male, brought to the emergency department (ED) after an out-of-hospital cardiac arrest (CA), found to have TCM in the setting of cocaine use. Clinicians need to understand the association between cocaine use and the development of TCM as cardiomyopathy of this type can result in complete remission after discontinuing the offending agent.
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Retrospective Observational Study of Complete Blood Count (CBC) Parameters and ICU Mortality of COVID-19 Disease in Delta Variant and Omicron Variant in a Community-Based Hospital in New York City.

    Yadav, Ruchi / Yadav, Vivek / Pokhriyal, Sindhu / Zahid, Umar / Gandhi, Anjula

    Cureus

    2023  Volume 15, Issue 2, Page(s) e34894

    Abstract: Background: Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is the official name of COVID-19, a respiratory infection that had the first case reported from the Hubei province of China on December 8, 2019. This virus is the main etiological ... ...

    Abstract Background: Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is the official name of COVID-19, a respiratory infection that had the first case reported from the Hubei province of China on December 8, 2019. This virus is the main etiological agent behind the most dreaded pandemic of pneumonia that has spread to the entire world in a brief period and continues to pose a threat. The first wave corresponded with the period from February 2020 to June 2020, the Delta variant occurred around the middle of June 2021 and the Omicron wave was reported from December 2021 to February 2022. Objective
    Methods: We conducted a retrospective observational study based on data from randomly selected hospitalized patients with COVID-19 in a community-based hospital in New York City during the Delta variant and the Omicron wave. A total of 211 patients COVID-19 positive from June to July 2021 (Delta variant) and 148 patients from December to February 2022 (Omicron wave) were included in the study. A comparison was done between the basic characteristics of patients with and without ICU admissions in both variants of COVID-19. We compared the relationship of different parameters of CBC (hemoglobin (Hgb), white blood count (WBC), lymphocytes, neutrophils, and platelets) on ICU admission and further analyzed any changes associated with ICU mortality. Logistic regression was performed to evaluate the relationship of different presenting CBCs on patients' disposition to ICU.  Result: A total of 211 patients (106 female) in the Delta wave (2021 variant) and 148 patients (80 female) in the Omicron wave (2022 variant) with an average ages of 60.9 ±18.10 (Delta variant) and 63.2 ± 19.10 (Omicron variant) were included in this study. There were 45 patients (21.3%) in the Delta wave and 42 patients (28.4%) in the Omicron wave were admitted to ICU. The average length of hospital stay was seven days in the Delta wave and nine days in the Omicron wave. No significant association was found between presenting cell count and ICU admission (p>0.05). Significant associations were found between different cell counts on admission and discharge and death in Delta waves except Hgb and platelets on admission. However, in the Omicron variant, a significant association was found only between WBC on admission and discharge, and Hgb and neutrophil on discharge with death in the univariate model.
    Conclusion:  Comparative study of different clinical parameters between the Delta and the Omicron variants of COVID-19 with the correlation of ICU stay and mortality can be used as a beneficial modality in assessing the outcome of the disease.
    Language English
    Publishing date 2023-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.34894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Character Association in Dolichos Bean [Lablab purpureus (L.) Sweet] in Agro-climatic Zone of North Bihar

    Pramila / Kumar, Udit / Tiwari, R.K. / Prasad, K. / Ghosh, S. / Sinha, B.M. / Yadav, L.M. / Patel, Vivek Kumar

    Legume research

    2023  Volume 46, Issue 3, Page(s) 301

    Document type Article
    ZDB-ID 407856-1
    ISSN 0250-5371
    Database Current Contents Nutrition, Environment, Agriculture

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  8. Article ; Online: Harnessing the potential of fatty Acid-Surfactant-Based micellar gel for enhanced topical delivery of Apremilast in psoriasis treatment.

    Sontakke, Arun / Dighe, Sayali / Sharma, Reena / Yadav, Vivek / Jain, Sanyog

    International journal of pharmaceutics

    2024  Volume 655, Page(s) 124026

    Abstract: Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier ...

    Abstract Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier system presents a novel option to increase the efficacy of the topical treatment of APR. The current investigation deals with the development of fatty acid-surfactant conjugate-based hybrid mixed micellar gel (HMMG) for the topical delivery of APR. The developed micelles exhibited an average size of 83.59 ± 4.46 nm, PDI of 0.239 ± 0.047, % entrapment efficiency of ∼ 94.78 ± 3.98 %, with % practical drug loading of ∼11.37 ± 3.14 %. TEM analysis revealed the spherical shape of micelles. The hybrid micelles were further loaded in a carbopol®934P gel base for ease of application. Ex vivo permeation study revealed enhanced permeation and ∼ 38-fold higher retention in deeper layers of skin from a hybrid micellar gel. In vivo, assessment demonstrated augmented efficacy of APR-HMMG as compared to 0.1 % betamethasone valerate. Also, APR-HMMG showed no sign of irritation, suggesting superior safety as a topical application. Thus, the proposed formulation strategy represents a viable avenue for enhancing the therapeutic efficacy of various anti-psoriatic moieties.
    MeSH term(s) Humans ; Micelles ; Fatty Acids ; Drug Carriers ; Surface-Active Agents ; Skin ; Gels ; Pulmonary Surfactants ; Psoriasis/drug therapy ; Particle Size ; Thalidomide/analogs & derivatives
    Chemical Substances Micelles ; Fatty Acids ; Drug Carriers ; Surface-Active Agents ; apremilast (UP7QBP99PN) ; Gels ; Pulmonary Surfactants ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2024-03-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.124026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders.

    Mohan, Aditi / Kumar, Ravi / Kumar, Vivek / Yadav, Mahendra

    Current cardiology reviews

    2023  Volume 19, Issue 4, Page(s) e090223213539

    Abstract: Cobalamin is an essential molecule for humans; it is exceptionally important for various body functions, including deoxyribonucleic acid synthesis and cellular energy production. Vegans are more vulnerable to vitamin B12 deficiency than natives with ... ...

    Abstract Cobalamin is an essential molecule for humans; it is exceptionally important for various body functions, including deoxyribonucleic acid synthesis and cellular energy production. Vegans are more vulnerable to vitamin B12 deficiency than natives with moderate consumption of animal dietary supplements or people with inadequate nutritional patterns. However, the long-term effects of sub-medical deficiency have not been thoroughly studied, but they may have a negative impact on the cardiovascular system, pregnancy outcomes, and vascular, renal, cognitive, bone, and eye health. Alongside the statin remedy, that is a powerful approach for CVD prevention. Another approach is related to the B nutrition substitution remedy with folic acid, and vitamins B6 and B12 are extensively practised nowadays. There is a tremendous interest in plasma homocysteine (tHcy) as a cardiovascular hazard factor. However, current research in the field of its prevention is more inclined toward confirming the benefit of tHcy-reducing remedy with vitamin B12. Thus, while folic acid fortification is primarily aimed at reducing neural-tube defects, it may also play a significant role in the primary prevention of CVD by lowering tHcy. Folate and B-vitamins play important roles in CVD prevention and nutrition policy implementation. Patients affected with Chronic Kidney Disease (CKD) or end-stage Stage Renal Disease (ESRD) experience a tremendous cardiovascular threat that may also further lead to death. As a result, routine monitoring of vitamin B12 levels is likely to be beneficial for the early detection and treatment of metabolic vitamin B12 deficiency, as well as the prevention of heart-related diseases.
    MeSH term(s) Humans ; Folic Acid/therapeutic use ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/complications ; Kidney Failure, Chronic ; Risk Factors ; Vitamins ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Kidney
    Chemical Substances Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204) ; Vitamins
    Language English
    Publishing date 2023-02-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/1573403X19666230209111854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Emerging role of miR-320a in lung cancer: a comprehensive review.

    Mohanta, Adrija / Kumar, Rajiv R / Singh, Rahul K / Mandal, Surojit / Yadav, Ritu / Khatkar, Rinku / Sharma, Uttam / Uttam, Vivek / Rana, Manjit K / Rana, Amrit Ps / Jain, Aklank

    Biomarkers in medicine

    2023  Volume 17, Issue 18, Page(s) 767–781

    Abstract: A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. ... ...

    Abstract A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. We found that miR-320a modulates levels of diverse cancer-associated molecules and signaling pathways, and is also involved in modulating the immune microenvironment of lung cancer during its pathogenesis. We also discuss how miR-320a encapsulated in exosomes inhibits invasive phenotypes of lung cancer. Therefore, based on the multimodal role of miR-320a in lung cancer development and progression, we believe that miR-320a may be utilized as a potential diagnostic/prognostic marker and therapeutic target for lung cancer patients.
    MeSH term(s) Humans ; Cell Line, Tumor ; Cell Proliferation/genetics ; Lung Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances MicroRNAs ; MIRN320A microRNA, human
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2023-0215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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