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Article ; Online: Implications of DNA damage repair alterations for the management of prostate cancer.

Lozano, Rebeca / Olmos, David / Castro, Elena

2022 Volume 32, Issue 3, Page(s) 302–310

Abstract: Purpose of review: In this review, we summarize the prevalence of alterations in DNA damage repair (DDR) genes in prostate cancer, their clinical significance, the therapeutic strategies developed to take advantage of the impaired tumour ability to ... ...

Abstract	Purpose of review: In this review, we summarize the prevalence of alterations in DNA damage repair (DDR) genes in prostate cancer, their clinical significance, the therapeutic strategies developed to take advantage of the impaired tumour ability to repair DNA and the diagnostic approaches available to identify patients likely to benefit from DDR-targeting agents. Recent findings: DDR alterations are more frequent in metastatic than in localized prostate cancer and some of them associate with aggressive disease whereas the significance of others remain unclear. The most appropriate management approach for DDR-defective prostate cancer patients is unknown. Clinical trials have demonstrated the efficacy of different poly-ADP ribose polymerase inhibitors (PARPi) to treat metastatic castration-resistant prostate cancer patients with BRCA1/2 alterations, although there may be other DDR alterations that sensitize patients to these drugs. Multiple strategies to target DDR defects are being investigated, including PARPi in combination, platinum-based chemotherapy and immunotherapy, both in earlier and late disease stages. Optimization of molecular testing is paramount for the implementation of precision oncology in prostate cancer. Summary: Certain DDR defects present in prostate cancer have prognostic and therapeutic implications whereas the significance of other DDR alterations is yet to be elucidated.
MeSH term(s)	DNA Damage ; DNA Repair ; Humans ; Male ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Precision Medicine ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/MOU.0000000000000983
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Article ; Online: Urban dynamics through the lens of human mobility.

Xu, Yanyan / Olmos, Luis E / Mateo, David / Hernando, Alberto / Yang, Xiaokang / González, Marta C

Nature computational science

2023 Volume 3, Issue 7, Page(s) 611–620

Abstract: The urban spatial structure represents the distribution of public and private spaces in cities and how people move within them. Although it usually evolves slowly, it can change quickly during large-scale emergency events, as well as due to urban renewal ...

Abstract	The urban spatial structure represents the distribution of public and private spaces in cities and how people move within them. Although it usually evolves slowly, it can change quickly during large-scale emergency events, as well as due to urban renewal in rapidly developing countries. Here we present an approach to delineate such urban dynamics in quasi-real time through a human mobility metric, the mobility centrality index ΔKS. As a case study, we tracked the urban dynamics of eleven Spanish cities during the COVID-19 pandemic. The results revealed that their structures became more monocentric during the lockdown in the first wave, but kept their regular spatial structures during the second wave. To provide a more comprehensive understanding of mobility from home, we also introduce a dimensionless metric, KS
MeSH term(s)	Humans ; Pandemics ; Cities/epidemiology ; COVID-19/epidemiology ; Travel
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ISSN	2662-8457
ISSN (online)	2662-8457
DOI	10.1038/s43588-023-00484-5
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Article ; Online: Optimizing the precision of laser speckle contrast imaging.

González Olmos, Alberto / Zilpelwar, Sharvari / Sunil, Smrithi / Boas, David A / Postnov, Dmitry D

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17970

Abstract: Laser speckle contrast imaging (LSCI) is a rapidly developing technology broadly applied for the full-field characterization of tissue perfusion. Over the recent years, significant advancements have been made in interpreting LSCI measurements and ... ...

Abstract	Laser speckle contrast imaging (LSCI) is a rapidly developing technology broadly applied for the full-field characterization of tissue perfusion. Over the recent years, significant advancements have been made in interpreting LSCI measurements and improving the technique's accuracy. On the other hand, the method's precision has yet to be studied in detail, despite being as important as accuracy for many biomedical applications. Here we combine simulation, theory and animal experiments to systematically evaluate and re-analyze the role of key factors defining LSCI precision-speckle-to-pixel size ratio, polarisation, exposure time and camera-related noise. We show that contrary to the established assumptions, smaller speckle size and shorter exposure time can improve the precision, while the camera choice is less critical and does not affect the signal-to-noise ratio significantly.
MeSH term(s)	Animals ; Laser Speckle Contrast Imaging ; Computer Simulation ; Upper Extremity ; Laser-Doppler Flowmetry/methods ; Regional Blood Flow
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45303-z
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Article ; Online: Reduced default mode network effective connectivity in healthy aging is modulated by years of education.

Stöffel, Tibor / Vaqué-Alcázar, Lídia / Bartrés-Faz, David / Peró-Cebollero, Maribel / Cañete-Massé, Cristina / Guàrdia-Olmos, Joan

NeuroImage

2024 Volume 288, Page(s) 120532

Abstract: Aging is a major risk factor for neurodegenerative diseases like dementia and Alzheimer's disease. Even in non-pathological aging, decline in cognitive functioning is observed in the majority of the elderly population, necessitating the importance of ... ...

Abstract	Aging is a major risk factor for neurodegenerative diseases like dementia and Alzheimer's disease. Even in non-pathological aging, decline in cognitive functioning is observed in the majority of the elderly population, necessitating the importance of studying the processes involved in healthy aging in order to identify brain biomarkers that promote the conservation of functioning. The default mode network (DMN) has been of special interest to aging research due to its vulnerability to atrophy and functional decline over the course of aging. Prior work has focused almost exclusively on functional (i.e. undirected) connectivity, yet converging findings are scarce. Therefore, we set out to use spectral dynamic causal modeling to investigate changes in the effective (i.e. directed) connectivity within the DMN and to discover changes in information flow in a sample of cognitively normal adults spanning from 48 to 89 years (n = 63). Age was associated to reduced verbal memory performance. Modeling of effective connectivity revealed a pattern of age-related downregulation of posterior DMN regions driven by inhibitory connections from the hippocampus and middle temporal gyrus. Additionally, there was an observed decline in the hippocampus' susceptibility to network inputs with age, effectively disconnecting itself from other regions. The estimated effective connectivity parameters were robust and able to predict the age in out of sample estimates in a leave-one-out cross-validation. Attained education moderated the effects of aging, largely reversing the observed pattern of inhibitory connectivity. Thus, medial prefrontal cortex, hippocampus and posterior DMN regions formed an excitatory cycle of extrinsic connections related to the interaction of age and education. This suggests a compensatory role of years of education in effective connectivity, stressing a possible target for interventions. Our findings suggest a connection to the concept of cognitive reserve, which attributes a protective effect of educational level on cognitive decline in aging (Stern, 2009).
MeSH term(s)	Adult ; Humans ; Aged ; Healthy Aging ; Default Mode Network ; Magnetic Resonance Imaging ; Aging/physiology ; Brain/pathology ; Educational Status
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2024.120532
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Prosocial behaviour axioms and values: Influence of gender and volunteering.

Olmos-Gómez, María Del Carmen / Ruiz-Garzón, Francisca / Azancot-Chocron, David / López-Cordero, Rafael

Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS

2023 Volume 36, Issue 1, Page(s) 16

Abstract: To promote prosocial behaviour, in the present study, we observed the human values that may predict it within the realms of the transcendental views of life, society's shared culture and the world of personal and interpersonal affections. To do this, we ... ...

Abstract	To promote prosocial behaviour, in the present study, we observed the human values that may predict it within the realms of the transcendental views of life, society's shared culture and the world of personal and interpersonal affections. To do this, we started with two hypotheses: (1) prosocial behaviour differs according to gender and participation in volunteering; and (2) the variables of transcendental values, cultural development, affective development, gender and participation in volunteering predict prosocial behaviour.To do so, we conducted a quantitative study based on the cross-sectional, social analytical-empirical research method. We used a validated instrument with a large sample of 1,712 individuals living in the multicultural context of the Spanish city of Melilla, located in North Africa and one of only two land borders between Europe and Morocco. Values that could promote prosocial behaviour were grouped into four dimensions to locate relevant factors that helped identify which values are linked to specific actions, both formal and informal, through an inferential analysis focusing on regression and multivariate analysis of variance.Our findings highlighted the linkage of the transcendent dimension of the individual in relation to his or her level of prosocial behaviour and the role of women as socialising agents.
Language	English
Publishing date	2023-07-10
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2038349-6
ISSN	1678-7153 ; 0102-7972
ISSN (online)	1678-7153
ISSN	0102-7972
DOI	10.1186/s41155-023-00258-y
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Article: Medical representations in Mexican muralism. Medical-historical analysis of the murals at La Raza National Medical Center General Hospital.

Vargas-Olmos, Rebeca / Rodríguez-Pérez, Martha E

Gaceta medica de Mexico

2023 Volume 159, Issue 5, Page(s) 398–404

Abstract: ... to participate were Diego Rivera and David Alfaro Siqueiros, who, with their work, bore testimony to the advent ...

Title translation	Representaciones médicas en el muralismo mexicano. Análisis histórico-médico de los murales del Hospital General en el Centro Médico Nacional La Raza.
Abstract	Background: In 1944, the call for the construction of "La Raza" Hospital in Mexico City was launched. The project included the proposal to create two murals, and the artists who were invited to participate were Diego Rivera and David Alfaro Siqueiros, who, with their work, bore testimony to the advent of modern medicine and the construction of the social security model in force in Mexico. Objective: To determine how mural art is historically linked to medicine in Mexico and how they complement each other, considering two works carried out at the same time and in the same hospital. Material and methods: Analysis of the historical context and iconographic and iconological analysis of "La Raza" Hospital murals. Results: It was possible to clarify the relationship of the artists with medicine and the role murals play within the modern vision of medicine. Conclusions: Mural art is intertwined with medicine because it bears witness to the advent of the construction of the social security model currently in force in Mexico, since hospitals became social achievements of the State and were to be known as symbols of welfare and modernity in Mexico.
MeSH term(s)	Hospitals, General ; Medicine ; Mexico ; Art
Language	English
Publishing date	2023-12-14
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M23000821
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Article ; Online: Vapochromic behaviour of a gold(I)-lead(II) complex as a VOC sensor.

Moreno, Sonia / Royo, David / El-Hachimi, Abdel G / Rodríguez-Castillo, María / Monge, Miguel / Olmos, M Elena / López-de-Luzuriaga, José M

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 46, Page(s) 17119–17131

Abstract: The reaction among [ ... ...

Abstract	The reaction among [Au
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt02000b
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Article ; Online: Comments on "Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5-year follow-up results from the STAMPEDE randomised trial (NCT00268476)".

Cattrini, Carlo / Messina, Carlo / Mennitto, Alessia / Di Maio, Massimo / Gennari, Alessandra / Olmos, David

International journal of cancer

2022 Volume 151, Issue 12, Page(s) 2291–2292

MeSH term(s)	Humans ; Male ; Abiraterone Acetate/therapeutic use ; Prednisolone/therapeutic use ; Follow-Up Studies ; Androgen Antagonists/therapeutic use ; Hormones ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prednisone/therapeutic use ; Treatment Outcome
Chemical Substances	Abiraterone Acetate (EM5OCB9YJ6) ; Prednisolone (9PHQ9Y1OLM) ; Androgen Antagonists ; Hormones ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2022-09-05
Publishing country	United States
Document type	Randomized Controlled Trial ; Letter ; Comment
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34246
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Terpyridine isomerism as a tool for tuning red-to-NIR emissive properties in heteronuclear gold(I)-thallium(I) complexes.

Royo, David / Moreno, Sonia / Rodríguez-Castillo, María / Monge, Miguel / Olmos, M Elena / Zubkov, Fedor I / Pronina, Anastasia A / Mahmoudi, Ghodrat / López-de-Luzuriaga, José M

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 10, Page(s) 4652–4661

Abstract: The polymeric linear chain [AuTl( ... ...

Abstract	The polymeric linear chain [AuTl(C
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt04161a
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Article ; Online: Improving Photostability of Photosystem I-Based Nanodevice by Plasmonic Interactions with Planar Silver Nanostructures.

Szalkowski, Marcin / Kowalska, Dorota / Olmos, Julian David Janna / Kargul, Joanna / Maćkowski, Sebastian

International journal of molecular sciences

2022 Volume 23, Issue 6

Abstract: One of the crucial challenges for science is the development of alternative pollution-free and renewable energy sources. One of the most promising inexhaustible sources of energy is solar energy, and in this field, solar fuel cells employing naturally ... ...

Abstract	One of the crucial challenges for science is the development of alternative pollution-free and renewable energy sources. One of the most promising inexhaustible sources of energy is solar energy, and in this field, solar fuel cells employing naturally evolved solar energy converting biocomplexes-photosynthetic reaction centers, such as photosystem I-are of growing interest due to their highly efficient photo-powered operation, resulting in the production of chemical potential, enabling synthesis of simple fuels. However, application of the biomolecules in such a context is strongly limited by the progressing photobleaching thereof during illumination. In the current work, we investigated the excitation wavelength dependence of the photosystem I photodamage dynamics. Moreover, we aimed to correlate the PSI-LHCI photostability dependence on the excitation wavelength with significant (ca. 50-fold) plasmonic enhancement of fluorescence due to the utilization of planar metallic nanostructure as a substrate. Finally, we present a rational approach for the significant improvement in the photostability of PSI in anoxic conditions. We find that photobleaching rates for 5 min long blue excitation are reduced from nearly 100% to 20% and 70% for substrates of bare glass and plasmonically active substrate, respectively. Our results pave promising ways for optimization of the biomimetic solar fuel cells due to synergy of the plasmon-induced absorption enhancement together with improved photostability of the molecular machinery of the solar-to-fuel conversion.
MeSH term(s)	Nanostructures/chemistry ; Photosystem I Protein Complex/metabolism ; Silver/chemistry ; Solar Energy ; Sunlight
Chemical Substances	Photosystem I Protein Complex ; Silver (3M4G523W1G)
Language	English
Publishing date	2022-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23062976
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