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  1. Article ; Online: Brain Leukocytes as the Potential Therapeutic Target for Post-COVID-19 Brain Fog.

    Kazama, Itsuro

    Neurochemical research

    2023  Volume 48, Issue 8, Page(s) 2345–2349

    Abstract: After recovering from the acute phase of coronavirus disease 2019 (COVID-19), many patients struggle with additional symptoms of long COVID during the chronic phase. Among them, the neuropsychiatric manifestations characterized by a short-term memory ... ...

    Abstract After recovering from the acute phase of coronavirus disease 2019 (COVID-19), many patients struggle with additional symptoms of long COVID during the chronic phase. Among them, the neuropsychiatric manifestations characterized by a short-term memory loss and inability to concentrate are called "brain fog". Recent studies have revealed the involvement of "chronic neuro-inflammation" in the pathogenesis of brain fog following COVID-19 infection. In the COVID-related brain fog, similarly to neurodegenerative disorders caused by neuro-inflammation, brain leukocytes, such as microglia and lymphocytes, are hyperactivated, suggesting the overexpression of delayed rectifier K
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Leukocytes ; Inflammation ; Anti-Bacterial Agents ; Brain
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Letter
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-023-03912-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease.

    Kazama, Itsuro

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2022  Volume 71, Issue 10-11, Page(s) 1123–1126

    Abstract: Patients with chronic kidney disease (CKD) are at higher risk for severe coronavirus disease 2019 (COVID-19). Such patients are more likely to develop "COVID-19-induced acute kidney injury (AKI)", which exacerbates the pre-existing CKD and increases the ... ...

    Abstract Patients with chronic kidney disease (CKD) are at higher risk for severe coronavirus disease 2019 (COVID-19). Such patients are more likely to develop "COVID-19-induced acute kidney injury (AKI)", which exacerbates the pre-existing CKD and increases the mortality rate of the patients. COVID-19-induced AKI is pathologically characterized by acute tubular necrosis and the interstitial infiltration of proinflammatory leukocytes. In our rat model with advanced CKD, immunohistochemistry for angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) demonstrated their strong expression in the cytoplasm of damaged proximal tubular cells and the infiltrating leukocytes within the cortical interstitium, which overlapped with the lesions of COVID-19-induced AKI. Since ACE2 and TMPRSS2 are enzymes that facilitate the viral entry into the cells and trigger the onset of cytokine storm, the renal distribution of these proteins in advanced CKD was thought to be responsible for the development of COVID-19-induced AKI. Concerning such mechanisms, the pharmacological blockade of ACE2 or the use of soluble forms of the ACE2 protein may halt the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells. This would protect against the COVID-19-induced exacerbation of pre-existing CKD by preventing the development of AKI.
    MeSH term(s) Rats ; Animals ; Angiotensin-Converting Enzyme 2 ; COVID-19/complications ; SARS-CoV-2 ; Renal Insufficiency, Chronic/prevention & control ; Acute Kidney Injury/etiology ; Acute Kidney Injury/prevention & control
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-07-24
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-022-01619-6
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    Zs.A 675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Targeting colonic BK channels: A novel therapeutic strategy against hyperkalemia in chronic kidney disease.

    Kazama, Itsuro / Shoji, Michiko

    Nefrologia

    2023  

    Language English
    Publishing date 2023-05-11
    Publishing country Spain
    Document type Letter
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High-magnesium exposure to bullfrog heart causes ST segment elevation.

    Kazama, Itsuro

    The Journal of veterinary medical science

    2021  Volume 83, Issue 4, Page(s) 675–679

    Abstract: Hypermagnesemia occurs in elderly people or patients with renal insufficiency after excessive ingestion of magnesium-containing laxatives. In addition to typical electrocardiogram (ECG) findings caused by conduction defects, changes in the ST segments ... ...

    Abstract Hypermagnesemia occurs in elderly people or patients with renal insufficiency after excessive ingestion of magnesium-containing laxatives. In addition to typical electrocardiogram (ECG) findings caused by conduction defects, changes in the ST segments and T waves are also observed in patients with severe hypermagnesemia. This suggested the involvement of similar pathophysiology to acute myocardial infarction, as we previously demonstrated using burn-induced subepicardial injury model in frog hearts. In the present study, by exposing the bullfrog heart to high-magnesium solution, we reproduced prominent ST segment changes in ECG as actually observed in patients with severe hypermagnesemia. In addition to the great increase in the T waves, the ECG showed a marked elevation of the ST segments and the cardiac action potential demonstrated a marked shift of the resting membrane potential to the depolarized side. High-magnesium exposure did not affect the abundance of Na
    MeSH term(s) Animals ; Arrhythmias, Cardiac/veterinary ; Electrocardiography ; Heart ; Magnesium ; Rana catesbeiana
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2021-02-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.20-0720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 579: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article: Potential prophylactic efficacy of mast cell stabilizers against COVID-19 vaccine-induced anaphylaxis.

    Kazama, Itsuro

    Clinical and molecular allergy : CMA

    2021  Volume 19, Issue 1, Page(s) 25

    Abstract: To fight against coronavirus disease 2019 (COVID-19), the vaccination is currently the most effective approach. However, in addition to common systemic side effects, the vaccines can cause serious allergic reactions or anaphylaxis. In anaphylaxis, the ... ...

    Abstract To fight against coronavirus disease 2019 (COVID-19), the vaccination is currently the most effective approach. However, in addition to common systemic side effects, the vaccines can cause serious allergic reactions or anaphylaxis. In anaphylaxis, the exposure to the allergen causes a sudden release of chemical mediators from mast cells, for which adrenaline is the drug of first choice. In our previous basic studies, in addition to adrenaline, anti-allergic drugs (olopatadine, loratadine, tranilast and ketotifen), antibiotics (clarithromycin), corticosteroids (hydrocortisone and dexamethasone) and certain food constituents (caffeine and catechin) inhibited the process of exocytosis and showed their effectiveness as highly potent mast cell stabilizers. In these studies, since mast cells were pre-incubated with these drugs or the food constituents before exocytosis was induced, the findings strongly indicated their prophylactic efficacy in stabilizing mast cells. Considering such pharmacological properties of these commonly prescribed medications or the food constituents, their prophylactic use may potentially be beneficial in preventing anaphylaxis caused by COVID-19 vaccination.
    Language English
    Publishing date 2021-12-13
    Publishing country England
    Document type Letter
    ISSN 1476-7961
    ISSN 1476-7961
    DOI 10.1186/s12948-021-00162-9
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  6. Article ; Online: Targeting lymphocyte Kv1.3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy?

    Kazama, Itsuro

    Drug discoveries & therapeutics

    2020  Volume 14, Issue 3, Page(s) 143–144

    Abstract: In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier ... ...

    Abstract In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier K
    MeSH term(s) Azithromycin/administration & dosage ; Betacoronavirus ; COVID-19 ; Chloroquine/administration & dosage ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Drug Delivery Systems/methods ; Drug Delivery Systems/trends ; Humans ; Kv1.3 Potassium Channel/antagonists & inhibitors ; Kv1.3 Potassium Channel/metabolism ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; Severity of Illness Index
    Chemical Substances Cytokines ; Kv1.3 Potassium Channel ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-7831
    ISSN (online) 1881-784X
    ISSN 1881-7831
    DOI 10.5582/ddt.2020.03046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Stabilizing mast cells by commonly used drugs: a novel therapeutic target to relieve post-COVID syndrome?

    Kazama, Itsuro

    Drug discoveries & therapeutics

    2020  Volume 14, Issue 5, Page(s) 259–261

    Abstract: Regardless of the severity of coronavirus disease 2019 (COVID-19), a high proportion of patients struggle with persistent respiratory or systemic symptoms after recovery. This is called "postCOVID syndrome", for which pulmonary fibrosis is one of the ... ...

    Abstract Regardless of the severity of coronavirus disease 2019 (COVID-19), a high proportion of patients struggle with persistent respiratory or systemic symptoms after recovery. This is called "postCOVID syndrome", for which pulmonary fibrosis is one of the pathogenesis. Besides T-lymphocytes and macrophages, mast cells also contribute to the development of cytokine storm and thus stimulate the activity of fibroblasts. Additionally, by the exocytotic release of fibroblast-activating factors, mast cells directly facilitate the progression of pulmonary fibrosis. In our previous basic studies, anti-allergic drugs (olopatadine, ketotifen), antibiotics (clarithromycin) and corticosteroids (hydrocortisone, dexamethasone) inhibited the process of exocytosis and showed their potency as highly effective mast cell stabilizers. Given such pharmacological properties of these commonly used drugs, they may be useful in the treatment of post-COVID-19 pulmonary fibrosis and in relieving the symptoms of post-COVID syndrome.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Animals ; Anti-Allergic Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Betacoronavirus/pathogenicity ; COVID-19 ; Cell Degranulation/drug effects ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Mast Cells/drug effects ; Mast Cells/immunology ; Mast Cells/virology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/immunology ; Pulmonary Fibrosis/virology ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones ; Anti-Allergic Agents ; Anti-Bacterial Agents
    Keywords covid19
    Language English
    Publishing date 2020-10-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-7831
    ISSN (online) 1881-784X
    ISSN 1881-7831
    DOI 10.5582/ddt.2020.03095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sodium bicarbonate and salbutamol facilitate recovery from hyperkalemia-induced electrocardiogram abnormalities in bullfrog hearts.

    Azuma, Saya / Kuwana, Ryo / Narisawa, Ken / Kazama, Itsuro

    The Journal of veterinary medical science

    2023  Volume 85, Issue 10, Page(s) 1063–1067

    Abstract: Hyperkalemia is a common electrolyte abnormality frequently complicated with chronic kidney disease. By injecting potassium chloride (KCl) solutions intravenously into bullfrogs, we reproduced typical electrocardiogram (ECG) abnormalities of hyperkalemia ...

    Abstract Hyperkalemia is a common electrolyte abnormality frequently complicated with chronic kidney disease. By injecting potassium chloride (KCl) solutions intravenously into bullfrogs, we reproduced typical electrocardiogram (ECG) abnormalities of hyperkalemia in the frog hearts, such as the peaked T waves and the widening of QRS complexes. Simultaneous recordings of cardiac action potentials showed morphological changes that synchronized with those of ECG. After 100 mM KCl injection, the widened QRS complexes continued for a while and gradually restored to their baseline widths. However, pre-treatment with sodium bicarbonate or salbutamol, which directly or indirectly stimulates Na
    MeSH term(s) Animals ; Hyperkalemia/chemically induced ; Hyperkalemia/drug therapy ; Hyperkalemia/veterinary ; Sodium Bicarbonate/therapeutic use ; Rana catesbeiana ; Albuterol/therapeutic use ; Potassium ; Potassium Chloride ; Electrocardiography/veterinary
    Chemical Substances Sodium Bicarbonate (8MDF5V39QO) ; Albuterol (QF8SVZ843E) ; Potassium (RWP5GA015D) ; Potassium Chloride (660YQ98I10)
    Language English
    Publishing date 2023-08-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.23-0292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 579: Show issues Location:
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  9. Article: Targeting lymphocyte Kv1.3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy?

    Kazama, Itsuro

    Drug Discov Ther

    Abstract: In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier K+-channels (Kv1.3) in leukocytes is responsible for the ... ...

    Abstract In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier K+-channels (Kv1.3) in leukocytes is responsible for the overactivation of cellular immunity and the subsequent cytokine storm. In our previous basic studies, drugs including chloroquine and azithromycin strongly suppressed the channel activity and pro-inflammatory cytokine production from lymphocytes. These findings suggest a novel pharmacological mechanism by which chloroquine, with or without azithromycin, is effective for severe cases of COVID-19, in which the overactivation of cellular immunity and the subsequent cytokine storm are responsible for the pathogenesis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612733
    Database COVID19

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  10. Article: Stabilizing mast cells by commonly used drugs: a novel therapeutic target to relieve post-COVID syndrome?

    Kazama, Itsuro

    Drug Discov Ther

    Abstract: Regardless of the severity of coronavirus disease 2019 (COVID-19), a high proportion of patients struggle with persistent respiratory or systemic symptoms after recovery. This is called "postCOVID syndrome", for which pulmonary fibrosis is one of the ... ...

    Abstract Regardless of the severity of coronavirus disease 2019 (COVID-19), a high proportion of patients struggle with persistent respiratory or systemic symptoms after recovery. This is called "postCOVID syndrome", for which pulmonary fibrosis is one of the pathogenesis. Besides T-lymphocytes and macrophages, mast cells also contribute to the development of cytokine storm and thus stimulate the activity of fibroblasts. Additionally, by the exocytotic release of fibroblast-activating factors, mast cells directly facilitate the progression of pulmonary fibrosis. In our previous basic studies, anti-allergic drugs (olopatadine, ketotifen), antibiotics (clarithromycin) and corticosteroids (hydrocortisone, dexamethasone) inhibited the process of exocytosis and showed their potency as highly effective mast cell stabilizers. Given such pharmacological properties of these commonly used drugs, they may be useful in the treatment of post-COVID-19 pulmonary fibrosis and in relieving the symptoms of post-COVID syndrome.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #895584
    Database COVID19

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