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  1. Article ; Online: Olefin skeletal rearrangement enabling access to multiarylated

    Cui, Chen-Chang / Lin, Feng / Wang, Lu-Yao / Liu, Yin-Ping / Tu, Shu-Jiang / Tu, Man-Su / Hao, Wen-Juan / Jiang, Bo

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 11, Page(s) 1492–1495

    Abstract: A base-promoted olefin skeletal rearrangement strategy ... ...

    Abstract A base-promoted olefin skeletal rearrangement strategy from
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05977d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: 不同年龄段过敏性紫癜性肾炎患儿接受霉酚酸酯或环磷酰胺治疗的疗效差异分析.

    DU, Pei-Wei / Wen, Yu-Bing / Chen, Chao-Ying / Tu, Juan / Li, Hua-Rong

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2023  Volume 25, Issue 11, Page(s) 1113–1117

    Abstract: Objectives: To investigate the difference in the therapeutic effect of mycophenolate mofetil (MMF) or cyclophosphamide (CTX) in children with Henoch-Schönlein purpura nephritis (HSPN) of different age groups.: Methods: A retrospective analysis was ... ...

    Title translation Therapeutic effect of mycophenolate mofetil or cyclophosphamide in children with Henoch-Schönlein purpura nephritis of different age groups.
    Abstract Objectives: To investigate the difference in the therapeutic effect of mycophenolate mofetil (MMF) or cyclophosphamide (CTX) in children with Henoch-Schönlein purpura nephritis (HSPN) of different age groups.
    Methods: A retrospective analysis was conducted on the clinical data of 135 children with HSPN who were treated with MMF or CTX in the Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics, from October 2018 to October 2020. According to the immunosuppressant used, they were divided into two groups: MMF group and CTX group, and according to the age, each group was further divided into two subgroups: ≤12 years and >12 years, producing four groups, i.e, the ≤12 years MMF subgroup (
    Results: There was no significant difference in the complete response rate between the MMF group and the CTX group after 3, 6, and 12 months of treatment (
    Conclusions: The efficacy and adverse reactions of MMF are not associated with age, but the efficacy of CTX is affected by age, with a higher incidence rate of adverse reactions. CTX should be selected with caution for children with HSPN aged >12 years.
    MeSH term(s) Child ; Humans ; Mycophenolic Acid/adverse effects ; IgA Vasculitis/drug therapy ; Retrospective Studies ; Cyclophosphamide/adverse effects ; Immunosuppressive Agents/adverse effects ; Vasculitis/chemically induced ; Vasculitis/complications ; Vasculitis/drug therapy ; Nephritis/etiology ; Nephritis/complications
    Chemical Substances Mycophenolic Acid (HU9DX48N0T) ; Cyclophosphamide (8N3DW7272P) ; Immunosuppressive Agents
    Language Chinese
    Publishing date 2023-11-21
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1008-8830
    ISSN 1008-8830
    DOI 10.7499/j.issn.1008-8830.2306085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In situ fabrication of covalent organic frameworks on solid-phase microextraction probes coupled with electrospray ionization mass spectrometry for enrichment and determination of androgens in biosamples.

    Li, Heming / Tu, Yuxin / Xie, Wen / Shi, Xinye / Zhang, Qiuting / Lin, Juan / Zhong, Yanhui / Lin, Zian / Cai, Zongwei

    Mikrochimica acta

    2024  Volume 191, Issue 5, Page(s) 276

    Abstract: Solid-phase microextraction (SPME) coupled with electrospray ionization mass spectrometry (ESI-MS) was developed for rapid and sensitive determination of endogenous androgens. The SPME probe is coated with covalent organic frameworks (COFs) synthesized ... ...

    Abstract Solid-phase microextraction (SPME) coupled with electrospray ionization mass spectrometry (ESI-MS) was developed for rapid and sensitive determination of endogenous androgens. The SPME probe is coated with covalent organic frameworks (COFs) synthesized by reacting 1,3,5-tri(4-aminophenyl)benzene (TPB) with 2,5-dioctyloxybenzaldehyde (C8PDA). This COFs-SPME probe offers several advantages, including enhanced extraction efficiency and stability. The analytical method exhibited wide linearity (0.1-100.0 µg L
    MeSH term(s) Solid Phase Microextraction/methods ; Spectrometry, Mass, Electrospray Ionization/methods ; Humans ; Androgens/blood ; Androgens/analysis ; Androgens/chemistry ; Limit of Detection ; Female ; Metal-Organic Frameworks/chemistry ; Reproducibility of Results
    Chemical Substances Androgens ; Metal-Organic Frameworks
    Language English
    Publishing date 2024-04-22
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-024-06355-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
    Z 8.1: Show issues

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  4. Article ; Online: Lewis Acid-Catalyzed Remote Site-Selective Ring Deconstruction of Cyclobuteno[

    Li, Meng-Fan / Chen, Ling-Qi / Wang, Jia-Yin / Tu, Man-Su / Hao, Wen-Juan / Jiang, Bo

    The Journal of organic chemistry

    2023  Volume 88, Issue 6, Page(s) 3615–3625

    Abstract: A catalytic site-selective ring deconstruction of cyclobuteno[ ...

    Abstract A catalytic site-selective ring deconstruction of cyclobuteno[
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c02804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Identification of a novel astrovirus from intestinal tissue of a donkey foal with severe diarrhea in China.

    Tian, Feng-Juan / Li, Jing / Tu, Qi-Hang / Xu, Shan / Liu, Wen-Li / Li, Yang / Bai, Yu / Yu, Jie / Liu, Wen-Hua / Xiao, Yue-Qiang / Ren, Hui-Ying / Tong, Yi-Gang

    Zoological research

    2023  Volume 44, Issue 5, Page(s) 932–935

    MeSH term(s) Horses ; Animals ; Equidae ; Diarrhea/veterinary ; Intestines ; China
    Language English
    Publishing date 2023-09-09
    Publishing country China
    Document type Letter
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2022.523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Compound heterozygous p.L483P and p.S310G mutations in GBA1 cause type 1 adult Gaucher disease: A case report.

    Wen, Xiao-Ling / Wang, Yao-Zi / Zhang, Xia-Lin / Tu, Jia-Qiang / Zhang, Zhi-Juan / Liu, Xia-Xia / Lu, Hai-Yan / Hao, Guo-Ping / Wang, Xiao-Huan / Yang, Lin-Hua / Zhang, Rui-Juan

    World journal of clinical cases

    2023  Volume 10, Issue 36, Page(s) 13426–13434

    Abstract: Background: Gaucher disease (GD) is caused by a : Case summary: Here, we report a rare adult-onset type 1 GD in a 46-year-old female patient with clinical manifestations of giant spleen, thrombocytopenia, and bone pain, diagnosed by enzymatic and ... ...

    Abstract Background: Gaucher disease (GD) is caused by a
    Case summary: Here, we report a rare adult-onset type 1 GD in a 46-year-old female patient with clinical manifestations of giant spleen, thrombocytopenia, and bone pain, diagnosed by enzymatic and genetic testing. Enzymology and whole exome sequencing revealed heterozygous missense mutations in exon 10 c.1448T>C (p.L483P) and exon 7 c.928A>G (p.S310G) of
    Conclusion: The p.L483P/p.S310G novel compound heterozygous mutation underlies type 1 GD and likely affects GCase protein function. This is the first description of p.S310G being associated with mild type 1 GD in the context of a coinherited p.L483P mutation.
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i36.13426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cell-free DNA methylation profiles enable early detection of colorectal and gastric cancer.

    Lei, Xiaotian / Zhou, Dongxun / Wen, Ying / Sha, Weihong / Ma, Juan / Tu, Xixiang / Zhai, Kewei / Li, Caixia / Wang, Hong / Tao, Jinsheng / Chen, Zhiwei / Ruan, Weimei / Fan, Jian-Bing / Wang, Bin / Cui, Chunhui

    American journal of cancer research

    2024  Volume 14, Issue 2, Page(s) 744–761

    Abstract: Colorectal cancer (CRC) and gastric cancer (GC) rank the top five common and lethal cancers worldwide. Early detection can significantly reduce the mortality of CRC and GC. However, current clinical screening methods including invasive endoscopic ... ...

    Abstract Colorectal cancer (CRC) and gastric cancer (GC) rank the top five common and lethal cancers worldwide. Early detection can significantly reduce the mortality of CRC and GC. However, current clinical screening methods including invasive endoscopic techniques and noninvasive fecal occult blood test screening tests/fecal immunochemical test have shown low sensitivity or unsatisfactory patient's compliance. Aberrant DNA methylation occurs frequently in tumorigenesis and cell-free DNA (cfDNA) methylation has shown the potential in multi-cancer detection. Herein, we aimed to explore the value of cfDNA methylation in the gastrointestinal cancer detection and develop a noninvasive method for CRC and GC detection. We applied targeted methylation sequencing on a total of 407 plasma samples from patients diagnosed with CRC, GC, and noncancerous gastrointestinal benign diseases (Non-Ca). By analyzing the methylation profiles of 34 CRC, 62 GC and 107 Non-Ca plasma samples in the training set (n=203), we identified 40,110 gastrointestinal cancer-specific markers and 63 tissue of origin (TOO) prediction markers. A new integrated model composed of gastrointestinal cancer detection and TOO prediction for three types of classification of CRC, GC and Non-Ca patients was further developed through logistic regression algorithm and validated in an independent validation set (n=103). The model achieved overall sensitivities of 83% and 81.3% at specificities of 81.5% and 80% for identifying gastrointestinal cancers in the test set and validation set, respectively. The detection sensitivities for GC and CRC were respectively 81.4% and 83.3% in the cohort of the test and validation sets. Among these true positive cancer samples, further TOO prediction showed accuracies of 95.8% and 95.8% for GC patients and accuracies of 86.7% and 93.3% for CRC patients, in test set and validation set, respectively. Collectively, we have identified novel cfDNA methylation biomarkers for CRC and GC detection and shown the promising potential of cfDNA as a noninvasive gastrointestinal cancer detection tool.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  8. Article ; Online: Gold self-relay catalysis enabling annulative oxygenation of propargylic alcohols with O-nucleophiles.

    Hao, Meng-Ying / Zhang, Yin / Lin, Na / Fu, Rong / Ji, Xiao-Shuang / Jiang, Bo / Tu, Shu-Jiang / Hao, Wen-Juan

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 27, Page(s) 4032–4035

    Abstract: A new gold(I) self-relay catalysis reaction enabling the annulative oxygenation of propargylic alcohols with various O-nucleophiles, such as carboxylic acids, alcohols and TBHP, is reported, producing a series of functionalized benzofurans in moderate to ...

    Abstract A new gold(I) self-relay catalysis reaction enabling the annulative oxygenation of propargylic alcohols with various O-nucleophiles, such as carboxylic acids, alcohols and TBHP, is reported, producing a series of functionalized benzofurans in moderate to good yields under mild conditions. This protocol benefits from the π- and σ-Lewis acid capability of gold complexes, demonstrating high molecular convergence, broad substrate flexibility, high functional group compatibility and mild conditions.
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc00089c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Azofuran activation for annulative rearrangement enabled by gold(I)/Brønsted acid relay catalysis.

    Rao, Qian / Zhang, Yin / Liu, Yin-Ping / Jiang, Bo / Wang, Xiang / Tu, Shu-Jiang / Hao, Wen-Juan

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 38, Page(s) 5725–5728

    Abstract: A novel gold(I)/Brønsted acid relay catalysis enabling azofuran activation to induce annulative rearrangement from 3-yne-1,2-diols and aryldiazonium tetrafluoroborates is reported, producing a series of furan-2-yl-substituted pyrrol-2-ones bearing a ... ...

    Abstract A novel gold(I)/Brønsted acid relay catalysis enabling azofuran activation to induce annulative rearrangement from 3-yne-1,2-diols and aryldiazonium tetrafluoroborates is reported, producing a series of furan-2-yl-substituted pyrrol-2-ones bearing a quaternary carbon center with good yields. Exchanging aryldiazonium tetrafluoroborate for azofuran led to skeletally identical but substituent-diverse furan-2-yl-containing pyrrol-2-ones with good yields, supporting the key azofuran activation and annulative rearrangement by gold/Brønsted acid relay catalysis.
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc00531c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of a novel astrovirus from intestinal tissue of a donkey foal with severe diarrhea in China

    Feng-Juan Tian / Jing Li / Qi-Hang Tu / Shan Xu / Wen-Li Liu / Yang Li / Yu Bai / Jie Yu / Wen-Hua Liu / Yue-Qiang Xiao / Hui-Ying Ren / Yi-Gang Tong

    Zoological Research, Vol 44, Iss 5, Pp 932-

    2023  Volume 935

    Keywords Zoology ; QL1-991
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Science Press, PR China
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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