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  1. Book: AMPK

    Neumann, Dietbert / Viollet, Benoit

    methods and protocols

    (Methods in molecular biology ; 1732 ; Springer protocols)

    2018  

    Author's details edited by Dietbert Neumann, Benoit Viollet
    Series title Methods in molecular biology ; 1732
    Springer protocols
    Collection
    Keywords bacterial expression ; baculoviral ; upstream kinase ; protein crystallisation ; pharmacological activators
    Subject code 570
    Language English
    Size 520 Seiten, Illustrationen, 25.4 cm x 17.8 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019605521
    ISBN 978-1-4939-7597-6 ; 1-4939-7597-8 ; 9781493975983 ; 1493975986
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1732- verfügbar in Königswinter Königswinter

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  2. Book ; Online: Metformin: Beyond Diabetes

    Bost, Frederic / Rena, Graham / Viollet, Benoit

    2020  

    Keywords Medicine ; Endocrinology ; metformin ; cancer ; diabetes ; neurodegenerative disease ; mitochondria ; gut microbiota ; PCOS (polycystic ovarian syndrome)
    Size 1 electronic resource (134 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230344
    ISBN 9782889634071 ; 2889634078
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: AMP-Activated Protein Kinase Signalling

    Viollet, Benoit / Neumann, Dietbert

    2019  

    Abstract: Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in ... ...

    Abstract Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included
    Keywords Science (General) ; Biology (General)
    Size 1 electronic resource (452 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020102470
    ISBN 9783038976622 ; 3038976628
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: AMP-activated protein kinase

    Cordero, Mario D. / Viollet, Benoit

    (Experentia Supplementum ; 107)

    2016  

    Author's details Mario D. Cordero, Benoit Viollet, editors
    Series title Experentia Supplementum ; 107
    Experientia
    Collection Experientia
    Language English
    Size X, 523 Seiten, Illustrationen
    Publisher Springer
    Publishing place Basel
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019184728
    ISBN 978-3-319-43587-9 ; 9783319435893 ; 3-319-43587-6 ; 3319435892
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 195 -Suppl.107- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Metformin: update on mechanisms of action and repurposing potential.

    Foretz, Marc / Guigas, Bruno / Viollet, Benoit

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 8, Page(s) 460–476

    Abstract: Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients. Surprisingly, the mechanisms underlying its therapeutic action are complex and are still not fully ... ...

    Abstract Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients. Surprisingly, the mechanisms underlying its therapeutic action are complex and are still not fully understood. Early evidence highlighted the liver as the major organ involved in the effect of metformin on reducing blood levels of glucose. However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal tract, the gut microbial communities and the tissue-resident immune cells. At the molecular level, it seems that the mechanisms of action vary depending on the dose of metformin used and duration of treatment. Initial studies have shown that metformin targets hepatic mitochondria; however, the identification of a novel target at low concentrations of metformin at the lysosome surface might reveal a new mechanism of action. Based on the efficacy and safety records in T2DM, attention has been given to the repurposing of metformin as part of adjunct therapy for the treatment of cancer, age-related diseases, inflammatory diseases and COVID-19. In this Review, we highlight the latest advances in our understanding of the mechanisms of action of metformin and discuss potential emerging novel therapeutic uses.
    MeSH term(s) Humans ; Metformin/therapeutic use ; Metformin/pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; COVID-19 ; Glucose
    Chemical Substances Metformin (9100L32L2N) ; Hypoglycemic Agents ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00833-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 93: Show issues

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  6. Book ; Online: The Energy Sensor AMPK

    Viollet, Benoit

    Adaptations to Exercise, Nutritional and Hormonal Signals

    2019  

    Abstract: To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed in essentially ... ...

    Abstract To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed in essentially all eukaryotic cells as heterotrimeric complexes containing catalytic $\alpha$ subunits and regulatory $\beta$ and $\gamma$ subunits. When cellular energy status has been compromised, AMPK is activated by increases in AMP:ATP or ADP:ATP ratios and acts to restore energy homeostasis by stimulating energy production via catabolic pathways while decreasing non-essential energy-consuming pathways. Although the primary function of AMPK is to regulate energy homeostasis at a cell-autonomous level, in multicellular organisms, the AMPK system has evolved to interact with hormones to regulate energy intake and expenditure at the whole body level. Thus, AMPK functions as a signaling hub, coordinating anabolic and catabolic pathways to balance nutrient supply with energy demand at both the cellular and whole-body levels. AMPK is activated by various metabolic stresses such as ischemia or hypoxia or glucose deprivation and has both acute and long-term effects on metabolic pathways and key cellular functions. In addition, AMPK appears to be a major sensor of energy demand in exercising muscle and acts both as a multitask gatekeeper and an energy regulator in skeletal muscle. Acute activation of AMPK has been shown to promote glucose transport and fatty acid oxidation while suppressing glycogen synthase activity and protein synthesis. Chronic activation of AMPK induces a shift in muscle fiber type composition, reduces markers of muscle degeneration and enhances muscle oxidative capacity potentially by stimulating mitochondrial biogenesis. Furthermore, recent evidence demonstrates that AMPK may not only regulate metabolism during exercise but also in the recovery phase. AMPK acts as a molecular transducer between exercise and insulin signaling and is necessary for the ability of prior contraction/exercise to increase muscle insulin sensitivity. Based on these observations, drugs that activate AMPK might be expected to be useful in the treatment of metabolic disorders and insulin resistance in various conditions.
    Keywords Quantitative Biology - Tissues and Organs
    Subject code 571
    Publishing date 2019-11-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation.

    Audet-Walsh, Étienne / Vernier, Mathieu / Viollet, Benoit

    Frontiers in cell and developmental biology

    2021  Volume 8, Page(s) 641552

    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.641552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: AMP-Activated Protein Kinase Signalling.

    Neumann, Dietbert / Viollet, Benoit

    International journal of molecular sciences

    2019  Volume 20, Issue 3

    Abstract: AMP-activated protein kinase (AMPK) regulates energy homeostasis in eukaryotic cells and organisms [ ... ]. ...

    Abstract AMP-activated protein kinase (AMPK) regulates energy homeostasis in eukaryotic cells and organisms [...].
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Animals ; Energy Metabolism/physiology ; Homeostasis/physiology ; Humans ; Signal Transduction/physiology
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2019-02-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20030766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial

    Étienne Audet-Walsh / Mathieu Vernier / Benoit Viollet

    Frontiers in Cell and Developmental Biology, Vol

    AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation

    2021  Volume 8

    Keywords AMPK ; mTOR ; metformin ; cell metabolism ; nucleus ; transcriptional regulation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Editorial: Metformin: Beyond Diabetes.

    Bost, Frédéric / Rena, Graham / Viollet, Benoit

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 851

    Language English
    Publishing date 2019-12-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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