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Article ; Online: A novel coumarin-fluorescein-based fluorescent probe for ultrafast and visual detection of H

Shen, Qian / Huang, Zhongxi / Zhang, Duoteng / Chen, Xingwei / Du, Fangning / Zhou, Zhiqiang / Fu, Chan / Li, Lin / Yang, Naidi / Yu, Changmin

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 306, Page(s) 123567

Abstract: Hydrogen sulfide ( ... ...

Abstract	Hydrogen sulfide (H
MeSH term(s)	Humans ; Animals ; Fluorescent Dyes ; Fluorescein ; HeLa Cells ; Zebrafish ; Parkinson Disease/diagnosis ; Hydrogen Sulfide ; Coumarins
Chemical Substances	Fluorescent Dyes ; Fluorescein (TPY09G7XIR) ; Hydrogen Sulfide (YY9FVM7NSN) ; Coumarins
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.123567
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.

Yang, Naidi / Shen, Han-Ming

International journal of biological sciences

2020 Volume 16, Issue 10, Page(s) 1724–1731

Abstract: Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome ( ... ...

Abstract	Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key element in viral infection is the process of viral entry into the host cells. In the last two decades, there is increasing understanding on the importance of the endocytic pathway and the autophagy process in viral entry and replication. As a result, the endocytic pathway including endosome and lysosome has become important targets for development of therapeutic strategies in combating diseases caused by CoVs. In this mini-review, we will focus on the importance of the endocytic pathway as well as the autophagy process in viral infection of several pathogenic CoVs inclusive of SARS-CoV, MERS-CoV and the new CoV named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and discuss the development of therapeutic agents by targeting these processes. Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19.
MeSH term(s)	Animals ; Autophagy ; Betacoronavirus/physiology ; Cell Line ; Coronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Endocytosis ; Humans ; Molecular Targeted Therapy ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS Virus ; Virus Internalization
Keywords	covid19
Language	English
Publishing date	2020-03-15
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.45498
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An interplay between BRD4 and G9a regulates skeletal myogenesis.

Yang, Naidi / Das, Dipanwita / Shankar, Shilpa Rani / Goy, Pierre-Alexis / Guccione, Ernesto / Taneja, Reshma

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 978931

Abstract: Histone acetylation and methylation are epigenetic modifications that are dynamically regulated by chromatin modifiers to precisely regulate gene expression. However, the interplay by which histone modifications are synchronized to coordinate cellular ... ...

Abstract	Histone acetylation and methylation are epigenetic modifications that are dynamically regulated by chromatin modifiers to precisely regulate gene expression. However, the interplay by which histone modifications are synchronized to coordinate cellular differentiation is not fully understood. In this study, we demonstrate a relationship between BRD4, a reader of acetylation marks, and G9a, a writer of methylation marks in the regulation of myogenic differentiation. Using loss- and gain-of-function studies, as well as a pharmacological inhibition of its activity, we examined the mechanism by which BRD4 regulates myogenesis. Transcriptomic analysis using RNA sequencing revealed that a number of myogenic differentiation genes are downregulated in
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.978931
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Paper-based microﬂuidics and tailored gold nanoparticles for visual colorimetric detection of multiplex allergens.

Yang, Yuxing / Zeng, Xiaofei / Fu, Chan / Tan, Lingxiao / Yang, Naidi / Liu, Yongxin / Shen, Qian / Wei, Jifu / Yu, Changmin / Lu, Chen

Analytica chimica acta

2023 Volume 1272, Page(s) 341497

Abstract: The highly efficient and accurate recognition of targeted allergens is an essential element in the diagnosis of allergic diseases and follow-up desensitization treatment in clinic. The current clinical methods widely used to detect sIgE are high cost, ... ...

Abstract	The highly efficient and accurate recognition of targeted allergens is an essential element in the diagnosis of allergic diseases and follow-up desensitization treatment in clinic. The current clinical methods widely used to detect sIgE are high cost, time-consuming procedures, and bulky equipment. Herein, a multiplex microfluidic paper-based device (multi-μPAD) was developed that combined with tailored gold nanoparticles for simultaneously visual, colorimetric detection of different allergens in serum. This device could be used as quantitative detection of sIgE with LOD as low as 0.246 KUA/L in colorimetric method. In vitro results also showed that this device possessed good repeatability, high accuracy and incredible stability in different pH (6.0-7.4) and temperature (24-37 °C), as well as long-term storage within 90-day. Finally, this method was successfully utilized for assessing clinical multi-sample screening in 35 allergic patients. After the addition of the samples from allergic patients, the agreement rate of clinical results with commercial enzyme-linked immunosorbent assay (ELISA) kit reached more than 97%, which further indicated that this device had the advantages of efficient, accurate and sensitive to screen various allergens in real clinical serum samples. Therefore, by simply altering antigens and antibodies, this device can also be used for high-throughput detection of other allergens, making it considerable potential for clinical diagnosis of allergic diseases.
MeSH term(s)	Humans ; Allergens/analysis ; Gold ; Colorimetry ; Microfluidics ; Metal Nanoparticles ; Immunoglobulin E
Chemical Substances	Allergens ; Gold (7440-57-5) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.341497
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An interplay between BRD4 and G9a regulates skeletal myogenesis

Naidi Yang / Dipanwita Das / Shilpa Rani Shankar / Pierre-Alexis Goy / Ernesto Guccione / Reshma Taneja

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract	Histone acetylation and methylation are epigenetic modifications that are dynamically regulated by chromatin modifiers to precisely regulate gene expression. However, the interplay by which histone modifications are synchronized to coordinate cellular differentiation is not fully understood. In this study, we demonstrate a relationship between BRD4, a reader of acetylation marks, and G9a, a writer of methylation marks in the regulation of myogenic differentiation. Using loss- and gain-of-function studies, as well as a pharmacological inhibition of its activity, we examined the mechanism by which BRD4 regulates myogenesis. Transcriptomic analysis using RNA sequencing revealed that a number of myogenic differentiation genes are downregulated in Brd4-depleted cells. Interestingly, some of these genes were upregulated upon G9a knockdown, indicating that BRD4 and G9a play opposing roles in the control of myogenic gene expression. Remarkably, the differentiation defect caused by Brd4 knockdown was rescued by inhibition of G9a methyltransferase activity. These findings demonstrate that the absence of BRD4 results in the upregulation of G9a activity and consequently impaired myogenic differentiation. Collectively, our study identifies an interdependence between BRD4 and G9a for the precise control of transcriptional outputs to regulate myogenesis.
Keywords	differentiation ; writer ; reader ; methylation ; acetylation ; muscle ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design and Synthesis of a Mitochondrial-Targeted JNK Inhibitor and Its Protective Effect on Parkinson's Disease Phenotypes.

Zhou, Zhiqiang / Zhang, Duoteng / Du, Fangning / An, Weizhen / Ge, Jingyan / Yu, Changmin / Yang, Naidi / Zhang, Chengwu / Lim, Kahleong / Li, Lin

Chembiochem : a European journal of chemical biology

2023 Volume 24, Issue 13, Page(s) e202200748

Abstract: C-Jun N-terminal kinase (JNK) is a key mediator involved in a variety of physiological processes. JNK activation is regulated in a complex manner by upstream kinases and phosphatases, and plays an important role in physiological processes such as the ... ...

Abstract	C-Jun N-terminal kinase (JNK) is a key mediator involved in a variety of physiological processes. JNK activation is regulated in a complex manner by upstream kinases and phosphatases, and plays an important role in physiological processes such as the immune response and neuronal function. Therefore, JNK has become a therapeutic target for neurodegenerative diseases, ankylosing spondylitis, psoriasis, arthritis and other diseases. Inhibition of JNK activation in mitochondria holds great potential for Parkinson's disease (PD) therapy. However, no specific mitochondrial-targeted JNK inhibitor has been reported. We have developed a mitochondrial-targeted JNK inhibitor, P2, by linking a mitochondrial-specific cell-penetrating peptide to SP600125 (SP), a commercialized specific inhibitor of JNK. We found that P2 specifically inhibited mitochondrial JNK phosphorylation instead of nuclear JNK signaling. Further studies showed that P2 effectively rescued PD phenotypes both in vitro and in vivo, thus indicating that it is a potential therapeutic for PD.
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Phosphorylation ; MAP Kinase Signaling System/physiology ; JNK Mitogen-Activated Protein Kinases/metabolism ; JNK Mitogen-Activated Protein Kinases/pharmacology ; Mitochondria/metabolism
Chemical Substances	JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2023-06-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202200748
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19

Yang, Naidi / Shen, Han-Ming

Int J Biol Sci

Abstract	Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key element in viral infection is the process of viral entry into the host cells. In the last two decades, there is increasing understanding on the importance of the endocytic pathway and the autophagy process in viral entry and replication. As a result, the endocytic pathway including endosome and lysosome has become important targets for development of therapeutic strategies in combating diseases caused by CoVs. In this mini-review, we will focus on the importance of the endocytic pathway as well as the autophagy process in viral infection of several pathogenic CoVs inclusive of SARS-CoV, MERS-CoV and the new CoV named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and discuss the development of therapeutic agents by targeting these processes. Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32226290
Database	COVID19

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Article ; Online: Surface engineering strategies of gold nanomaterials and their applications in biomedicine and detection.

Zhou, Bicong / Guo, Xiaolu / Yang, Naidi / Huang, Zhongxi / Huang, Lihua / Fang, Zhijie / Zhang, Chengwu / Li, Lin / Yu, Changmin

Journal of materials chemistry. B

2022 Volume 9, Issue 28, Page(s) 5583–5598

Abstract: Gold nanomaterials have potential applications in biosensors and biomedicine due to their controllable synthesis steps, high biocompatibility, low toxicity and easy surface modification. However, there are still various limitations including low water ... ...

Abstract	Gold nanomaterials have potential applications in biosensors and biomedicine due to their controllable synthesis steps, high biocompatibility, low toxicity and easy surface modification. However, there are still various limitations including low water solubility and stability, which greatly affect their applications. In addition, some synthetic methods are very complicated and costly. Therefore, huge efforts have been made to improve their properties. This review mainly introduces the strategies for surface modification of gold nanomaterials, such as amines, biological small molecules and organic small molecules as well as the biological applications of these functionalized AuNPs. We aim to provide effective ideas for better functionalization of gold nanomaterials in the future.
MeSH term(s)	Biomedical Research ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Surface Properties
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb00181g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson's Disease Models by Alleviating Oxidative Stress.

Wu, Yue / Zhao, Zhongting / Yang, Naidi / Xin, Chenqi / Li, Zheng / Xu, Jiajia / Ma, Bo / Lim, Kah-Leong / Li, Lin / Wu, Qiong / Yu, Changmin / Zhang, Chengwu

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 1

Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. ...

Abstract	Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. Increasing evidence suggests that oxidative stress is the key causative factor of PD. Due to their capacity to alleviate oxidative stress, antioxidants hold great potential for the treatment of PD. Vitamins are essential organic substances for maintaining the life of organisms. Vitamin deficiency is implicated in the pathogenesis of various diseases, such as PD. In the present study, we investigated whether administration of vitamin B12 (VB12) could ameliorate PD phenotypes in vitro and in vivo. Our results showed that VB12 significantly reduced the generation of reactive oxygen species (ROS) in the rotenone-induced SH-SY5Y cellular PD model. In a Parkin gene knockout
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12010153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson’s Disease Models by Alleviating Oxidative Stress

Wu, Yue / Zhao, Zhongting / Yang, Naidi / Xin, Chenqi / Li, Zheng / Xu, Jiajia / Ma, Bo / Lim, Kah-Leong / Li, Lin / Wu, Qiong / Yu, Changmin / Zhang, Chengwu

Antioxidants. 2023 Jan. 09, v. 12, no. 1

2023

Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. ...

Abstract	Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. Increasing evidence suggests that oxidative stress is the key causative factor of PD. Due to their capacity to alleviate oxidative stress, antioxidants hold great potential for the treatment of PD. Vitamins are essential organic substances for maintaining the life of organisms. Vitamin deficiency is implicated in the pathogenesis of various diseases, such as PD. In the present study, we investigated whether administration of vitamin B12 (VB12) could ameliorate PD phenotypes in vitro and in vivo. Our results showed that VB12 significantly reduced the generation of reactive oxygen species (ROS) in the rotenone-induced SH-SY5Y cellular PD model. In a Parkin gene knockout C. elegans PD model, VB12 mitigated motor dysfunction. Moreover, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse PD model, VB12 also displayed protective effects, including the rescue of mitochondrial function, dopaminergic neuron loss, and movement disorder. In summary, our results suggest that vitamin supplementation may be a novel method for the intervention of PD, which is safer and more feasible than chemical drug treatment.
Keywords	brain ; drug therapy ; etiology ; gene targeting ; mice ; mitochondria ; models ; neurodegenerative diseases ; neurons ; oxidative stress ; pathogenesis ; reactive oxygen species ; vitamin B12 ; vitamin deficiencies ; vitamin supplements
Language	English
Dates of publication	2023-0109
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12010153
Database	NAL-Catalogue (AGRICOLA)

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