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  1. Article ; Online: Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model.

    Op 't Veld, Roel C / Joosten, Lieke / Laverman, Peter / Bronkhorst, Ewald M / Jansen, John A / Walboomers, X Frank / Wagener, Frank A D T G

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed by reversing the ...

    Abstract Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed by reversing the gelation and washing it away with a cold irrigation solution. The impact on wound healing of the regular application and removal of PIC dressings is compared to a single application of PIC and the clinically used Tegaderm™ in murine splinted full-thickness wounds for up to 14 days. SPECT/CT analysis of
    MeSH term(s) Humans ; Mice ; Animals ; Hydrogels ; Wound Healing ; Bandages ; Polyvinyl Alcohol ; Povidone
    Chemical Substances Hydrogels ; Polyvinyl Alcohol (9002-89-5) ; Povidone (FZ989GH94E)
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel Synthetic Polymer-Based 3D Contraction Assay: A Versatile Preclinical Research Platform for Fibrosis.

    Kumari, Jyoti / Wagener, Frank A D T G / Kouwer, Paul H J

    ACS applied materials & interfaces

    2022  Volume 14, Issue 17, Page(s) 19212–19225

    Abstract: The driving factors causing fibrosis and scar formation include fibroblast differentiation into myofibroblasts and hampered myofibroblast apoptosis, which ultimately results in collagen accumulation and tissue contraction. Currently, only very few drugs ... ...

    Abstract The driving factors causing fibrosis and scar formation include fibroblast differentiation into myofibroblasts and hampered myofibroblast apoptosis, which ultimately results in collagen accumulation and tissue contraction. Currently, only very few drugs are available for fibrosis treatment, and there is an urgent demand for new pharmaceutical products. High-throughput
    MeSH term(s) Actins/metabolism ; Cell Differentiation ; Cells, Cultured ; Collagen/metabolism ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Hydrogels/metabolism ; Hydrogels/pharmacology ; Myofibroblasts ; Oligopeptides/pharmacology
    Chemical Substances Actins ; Hydrogels ; Oligopeptides ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c02549
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  3. Article ; Online: Antifibrotic properties of hyaluronic acid crosslinked polyisocyanide hydrogels.

    Kumari, Jyoti / Hammink, Roel / Baaij, Jochem / Wagener, Frank A D T G / Kouwer, Paul H J

    Biomaterials advances

    2023  Volume 156, Page(s) 213705

    Abstract: Fibrosis is characterized by the formation of fibrous connective tissue in response to primary injury. As a result, an affected organ may lose part of its functionality due to chronic, organ-specific tissue damage. Since fibrosis is a leading cause of ... ...

    Abstract Fibrosis is characterized by the formation of fibrous connective tissue in response to primary injury. As a result, an affected organ may lose part of its functionality due to chronic, organ-specific tissue damage. Since fibrosis is a leading cause of death worldwide, targeting fibrotic diseases with antifibrotic hydrogels can be a lifesaving therapeutic strategy. This study developed a novel hybrid antifibrotic hydrogel by combining the synthetic polyisocyanide (PIC) with hyaluronic acid (HA). Gels of PIC are highly tailorable, thermosensitive, and strongly biomimetic in architecture and mechanical properties, whereas HA is known to promote non-fibrotic fetal wound healing and inhibits inflammatory signaling. The developed HA-PIC hybrids were biocompatible with physical properties comparable to those of the PIC gels. The antifibrotic nature of the gels was assessed by 3D cultures of human foreskin fibroblasts in the presence (or absence as control) of TGFβ1 that promotes differentiation into myofibroblasts, a critical step in fibrosis. Proliferation and macroscopic contraction assays and studies on the formation of stress fibers and characteristic fibrosis markers all indicate a strong antifibrotic nature of HA-PIC hydrogel. We showed that these effects originate from both the lightly crosslinked architecture and the presence of HA itself. The hybrid displaying both these effects shows the strongest antifibrotic nature and is a promising candidate for use as in vivo treatment for skin fibrosis.
    MeSH term(s) Humans ; Hydrogels/pharmacology ; Hyaluronic Acid/pharmacology ; Fibroblasts ; Myofibroblasts ; Fibrosis
    Chemical Substances Hydrogels ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213705
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  4. Article ; Online: Conductive Polyisocyanide Hydrogels Inhibit Fibrosis and Promote Myogenesis.

    Kumari, Jyoti / Paul, Odile / Verdellen, Lisa / Berking, Bela / Chen, Wen / Gerrits, Lotte / Postma, Jelle / Wagener, Frank A D T G / Kouwer, Paul H J

    ACS applied bio materials

    2024  

    Abstract: Reliable in vitro models closely resembling native tissue are urgently needed for disease modeling and drug screening applications. Recently, conductive biomaterials have received increasing attention in the development of in vitro models as they permit ... ...

    Abstract Reliable in vitro models closely resembling native tissue are urgently needed for disease modeling and drug screening applications. Recently, conductive biomaterials have received increasing attention in the development of in vitro models as they permit exogenous electrical signals to guide cells toward a desired cellular response. Interestingly, they have demonstrated that they promote cellular proliferation and adhesion even without external electrical stimulation. This paper describes the development of a conductive, fully synthetic hydrogel based on hybrids of the peptide-modified polyisocyanide (PIC-RGD) and the relatively conductive poly(aniline-
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.4c00210
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  5. Article ; Online: Protective mechanisms harnessing against injurious heme and preventing kidney damage in STEC-HUS: toward new therapies?

    Wagener, Frank A D T G / van de Kar, Nicole C A J / van den Heuvel, Lambert P

    Kidney international

    2022  Volume 101, Issue 6, Page(s) 1107–1109

    Abstract: Hemolytic uremic syndrome can be initiated by Escherichia coli infections (Shiga-toxin-producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome). When hemoglobin and heme released from ruptured erythrocytes interact with the kidney cells, ... ...

    Abstract Hemolytic uremic syndrome can be initiated by Escherichia coli infections (Shiga-toxin-producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome). When hemoglobin and heme released from ruptured erythrocytes interact with the kidney cells, this can result in platelet activation, vascular inflammation and occlusion, and kidney injury. Pirschel et al. now report that in the absence of protective mechanisms against free hemoglobin and heme, heme-induced kidney injury can be exacerbated. Therapeutic strategies should therefore also target heme-mediated deleterious effects in (severely ill) patients with Shiga-toxin-producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome.
    MeSH term(s) Escherichia coli Infections/complications ; Escherichia coli Infections/drug therapy ; Heme/therapeutic use ; Hemolytic-Uremic Syndrome/therapy ; Humans ; Kidney ; Shiga Toxin/therapeutic use ; Shiga-Toxigenic Escherichia coli
    Chemical Substances Heme (42VZT0U6YR) ; Shiga Toxin (75757-64-1)
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.02.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Disruption of the

    Raterman, Sophie T / Von Den Hoff, Johannes W / Dijkstra, Sietske / De Vriend, Cheyenne / Te Morsche, Tim / Broekman, Sanne / Zethof, Jan / De Vrieze, Erik / Wagener, Frank A D T G / Metz, Juriaan R

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1143844

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1143844
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  7. Article: Corrigendum: Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors.

    Raterman, S T / Metz, J R / Wagener, Frank A D T G / Von den Hoff, Johannes W

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 650948

    Abstract: This corrects the article DOI: 10.3389/fcell.2020.600926.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2020.600926.].
    Language English
    Publishing date 2021-06-24
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.650948
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  8. Article ; Online: Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing.

    Wang, Zhihao / Knight, Rob / Stephens, Phil / Ongkosuwito, E M / Wagener, Frank A D T G / Von den Hoff, Johannes W

    Stem cell research & therapy

    2023  Volume 14, Issue 1, Page(s) 203

    Abstract: Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneration during ... ...

    Abstract Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneration during wound repair. This may hamper maxillofacial growth and speech development. To promote the regeneration of injured orofacial soft tissue and attenuate scarring and fibrosis, intraoral and extraoral stem cells have been studied for their properties of facilitating maintenance and repair processes. In addition, the administration of stem cell-derived extracellular vesicles (EVs) may prevent fibrosis and promote the regeneration of orofacial soft tissues. Applying stem cells and EVs to treat orofacial defects forms a challenging but promising strategy to optimize treatment. This review provides an overview of the putative pitfalls, promises and the future of stem cells and EV therapy, focused on orofacial soft tissue regeneration.
    MeSH term(s) Humans ; Cicatrix ; Quality of Life ; Stem Cells ; Extracellular Vesicles ; Fibrosis
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03423-3
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  9. Article ; Online: Revolutionizing non-conventional wound healing using honey by simultaneously targeting multiple molecular mechanisms.

    Pleeging, Carlos C F / Wagener, Frank A D T G / de Rooster, Hilde / Cremers, Niels A J

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

    2022  Volume 62, Page(s) 100834

    Abstract: Hospital-acquired infections and treatment-related wound complications constitute a tremendous burden for the health care system, particularly given the serious increase in multidrug resistant pathogens. Imagine that a large part of nosocomial infections ...

    Abstract Hospital-acquired infections and treatment-related wound complications constitute a tremendous burden for the health care system, particularly given the serious increase in multidrug resistant pathogens. Imagine that a large part of nosocomial infections can be prevented using a simple treatment. In this respect, honey is used mainly in topical cutaneous wound care because of its potent broad-spectrum antibacterial and wound healing activities. However, therapeutic use outside this scope has been limited. The current review provides an in-depth view of studies using honey outside the conventional wound care indications. Non-conventional routes of honey application include subcutaneous, intra-socket, abdominal, and oral administration in novel indications, such as post colon surgery, mucositis, and tooth extraction. Honey consistently demonstrates beneficial therapeutic activities in these novel applications, orchestrating antimicrobial and prophylactic activity, reducing inflammation and wound dehiscence, and inducing healing, epithelialization, and analgesic activity. Several molecular mechanisms are responsible for these beneficial clinical effects of honey during the course of wound healing. Pro-inflammatory effects of honey, such as induction of iNOS, IL-1β, and COX-2, are mediated by TLR4 signaling. In contrast, honey's anti-inflammatory actions and flavonoids induce anti-inflammatory and antioxidant pathways by inducing NRF2 target genes, including HO-1 and PRDX1. The molecular and biochemical pathways activated by honey during the different phases of wound healing are also discussed in more detail in this review. Variation between different honey origins exists, and therefore standardized medical-grade honey may offer an optimized and safe treatment. Honey is a valuable alternative to conventional antimicrobial and anti-inflammatory therapies that can strongly reduce nosocomial infections.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Cross Infection/drug therapy ; Honey ; Humans ; Wound Healing
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Anti-Inflammatory Agents
    Language English
    Publishing date 2022-04-05
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 1474513-6
    ISSN 1532-2084 ; 1368-7646
    ISSN (online) 1532-2084
    ISSN 1368-7646
    DOI 10.1016/j.drup.2022.100834
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5099: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: An Improved Understanding of the Pathophysiology of Pelvic Organ Prolapse: A 3D In Vitro Model under Static and Mechanical Loading Conditions.

    van Velthoven, Melissa J J / Gudde, Aksel N / van der Kruit, Marit / van Loon, Malou P C / Rasing, Lissy / Wagener, Frank A D T G / Roovers, Jan-Paul / Guler, Zeliha / Kouwer, Paul H J

    Advanced healthcare materials

    2024  Volume 13, Issue 8, Page(s) e2302905

    Abstract: The suboptimal outcomes of pelvic organ prolapse (POP) surgery illustrate the demand for improved therapies. However, their development is hampered by the limited knowledge on the cellular pathophysiology of POP. Current investigations, that are limited ... ...

    Abstract The suboptimal outcomes of pelvic organ prolapse (POP) surgery illustrate the demand for improved therapies. However, their development is hampered by the limited knowledge on the cellular pathophysiology of POP. Current investigations, that are limited to tissues and 2D in vitro models, provide highly inconclusive results on how the extracellular matrix (ECM) metabolism and fibroblasts are affected in POP. This study uses a physiologically relevant 3D in vitro model to investigate the cellular pathophysiology of POP by determining the differences between POP and non-POP fibroblasts on ECM metabolism, proliferation, and fibroblast-to-myofibroblast (FMT) transition. This model, based on the synthetic and biomimetic polyisocyanide hydrogel, enables the incorporation of mechanical loading, which simulates the forces exerted on the pelvic floor. Under static conditions, 3D cultured POP fibroblasts are less proliferative, undergo FMT, and exhibit lower collagen and elastin contents compared to non-POP fibroblasts. However, under mechanical loading, the differences between POP and non-POP fibroblasts are less pronounced. This study contributes to the development of more comprehensive models that can accurately mimic the POP pathophysiology, which will aid in an enhanced understanding and may contribute to improved therapies in the future.
    MeSH term(s) Humans ; Collagen/metabolism ; Extracellular Matrix/metabolism ; Pelvic Organ Prolapse/metabolism ; Pelvic Organ Prolapse/surgery ; Fibroblasts/metabolism ; Cells, Cultured
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2024-01-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202302905
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    Zs.A 6966: Show issues Location:
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