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Article ; Online: Iron overload disorders: Growth and gonadal dysfunction in childhood and adolescence.

Tenuta, Marta / Cangiano, Biagio / Rastrelli, Giulia / Carlomagno, Francesco / Sciarra, Francesca / Sansone, Andrea / Isidori, Andrea M / Gianfrilli, Daniele / Krausz, Csilla

Pediatric blood & cancer

2024 , Page(s) e30995

Abstract: Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body, resulting in organ damage. Endocrine complications are particularly common, especially when the condition manifests in childhood or adolescence, when HC can ... ...

Abstract	Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body, resulting in organ damage. Endocrine complications are particularly common, especially when the condition manifests in childhood or adolescence, when HC can adversely affect linear growth or pubertal development, with significant repercussions on quality of life even into adulthood. Therefore, a timely and accurate diagnosis of these disorders is mandatory, but sometimes complex for hematologists without endocrinological support. This is a narrative review focused on puberty and growth disorders during infancy and adolescence aiming to offer guidance for diagnosis, treatment, and proper follow-up. Additionally, it aims to highlight gaps in the existing literature and emphasizes the importance of collaboration among specialists, which is essential in the era of precision medicine.
Language	English
Publishing date	2024-04-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30995
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Zs.A 1131: Show issues

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Article ; Online: Nutritional and metabolic aspects related to vulvodynia: What do we really know?

Mocini, Edoardo / Donini, Lorenzo Maria / Isidori, Andrea M / Minnetti, Marianna

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 117, Page(s) 112232

Abstract: Objectives: Vulvodynia is an emerging health problem, still insufficiently studied, that causes a significant reduction in quality of life in many women and individuals assigned female sex at birth. Little is known about the effects of diet and ... ...

Abstract	Objectives: Vulvodynia is an emerging health problem, still insufficiently studied, that causes a significant reduction in quality of life in many women and individuals assigned female sex at birth. Little is known about the effects of diet and metabolic disorders on this condition. The objective of this study was to review currently available evidence on the diet and the nutritional and metabolic status of patients affected by vulvodynia. Methods: Published articles were systematically searched in the PubMed, Scopus, and Web of Science databases. Results: The few available studies that reported data on patients' body mass index (BMI) described a BMI within the normal range in most patients affected by vulvodynia, showing no difference or a slightly lower BMI with respect to control individuals. Data on the relationship between metabolic diseases and vulvodynia are lacking. Regarding nutrition, the few available data do not support the prescription of a low-oxalate diet in women with vulvodynia. To date, studies on other dietary behaviors are also lacking. Conclusions: This review emphasizes-for the first time, to our knowledge-the lack of data and the importance of conducting prospective studies investigating the nutritional and metabolic aspects related to the onset, maintenance, and therapy of vulvodynia.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Vulvodynia/therapy ; Prospective Studies ; Quality of Life ; Diet ; Research Design
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112232
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Zs.A 2290: Show issues

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Article ; Online: COVID-19 pandemic and adrenals: deep insights and implications in patients with glucocorticoid disorders.

Cozzolino, Alessia / Hasenmajer, Valeria / Newell-Price, John / Isidori, Andrea M

Endocrine

2023 Volume 82, Issue 1, Page(s) 1–14

Abstract: Purpose: Coronavirus disease-19 (COVID-19) has spread throughout the world. It was initially defined as a potentially severe syndrome affecting the respiratory tract, but it has since been shown to be a systemic disease with relevant extrapulmonary ... ...

Abstract	Purpose: Coronavirus disease-19 (COVID-19) has spread throughout the world. It was initially defined as a potentially severe syndrome affecting the respiratory tract, but it has since been shown to be a systemic disease with relevant extrapulmonary manifestations that increase mortality. The endocrine system has been found to be vulnerable to COVID-19 infection. The current review aims to evaluate the available data on the impact of COVID-19 infection and treatment, as well as COVID-19 vaccines, on adrenal gland function, particularly in patients with GC disorders. Methods: A thorough search of published peer-reviewed studies in PubMed was performed using proper keywords. Results: Adrenal viral tropism and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the adrenal glands have been demonstrated, and adrenal insufficiency (AI) is a rare, but potentially severe complication in COVID-19 disease, whose recognition can be difficult if only for the empirical treatments administered in the early stages. Glucocorticoid (GC) treatment have had a pivotal role in preventing clinical deterioration in patients with COVID-19, but long-term GC use may increase COVID-19-related mortality and the development of iatrogenic AI. Patients with GC disorders, especially AI and Cushing's syndrome, have been identified as being at high risk of COVID-19 infection and complications. Published evidence suggests that AI patient awareness and proper education may help adjust GC replacement therapy appropriately when necessary, thereby reducing COVID-19 severity. The COVID-19 pandemic has had an impact on AI management, particularly in terms of adherence to patients' care plans and self-perceived challenges. On the other hand, published evidence suggests that the clinical course of COVID-19 may be affected by the severity of hypercortisolism in patients with CS. Therefore, to ameliorate the risk profile in these patients, cortisol levels should be adequately controlled, along with careful monitoring of metabolic and cardiovascular comorbidities. To date, the COVID-19 vaccine remains the only available tool to face SARS-CoV-2, and it should not be treated differently in patients with AI and CS. Conclusion: SARS-CoV-2 infection has been linked to adrenal damage and AI is a rare complication in COVID-19 disease, requiring prompt recognition. Educational efforts and patient awareness may reduce COVID-19 severity in patients with AI. Control of cortisol levels and monitoring of complications may improve the clinical course of COVID-19 in patients with CS.
MeSH term(s)	Humans ; Glucocorticoids/adverse effects ; COVID-19/complications ; Hydrocortisone/therapeutic use ; COVID-19 Vaccines ; Pandemics ; SARS-CoV-2 ; Adrenal Insufficiency/epidemiology ; Adrenal Insufficiency/etiology ; Cushing Syndrome/drug therapy ; Adrenal Glands ; Disease Progression
Chemical Substances	Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ) ; COVID-19 Vaccines
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03411-w
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Zs.A 3884: Show issues

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Article ; Online: Testosterone therapy and cardiovascular diseases.

Cittadini, Antonio / Isidori, Andrea M / Salzano, Andrea

Cardiovascular research

2021 Volume 118, Issue 9, Page(s) 2039–2057

Abstract: Since it was first synthesized in 1935, testosterone (T) has been viewed as the mythical Fountain of Youth, promising rejuvenation, restoring sexual appetites, growing stronger muscles, and quicker thinking. T is endowed with direct effects on myocardial ...

Abstract	Since it was first synthesized in 1935, testosterone (T) has been viewed as the mythical Fountain of Youth, promising rejuvenation, restoring sexual appetites, growing stronger muscles, and quicker thinking. T is endowed with direct effects on myocardial and vascular structure and function, as well as on risk factors for cardiovascular (CV) disease. Indeed, low serum T levels are a risk factor for diabetes, metabolic syndrome, inflammation, and dyslipidaemia. Moreover, many studies have shown that T deficiency per se is an independent risk factor of CV and all-cause mortality. On this background and due to direct-to-patient marketing by drug companies, we have witnessed to the widespread use of T replacement therapy without clear indications particularly in late-life onset hypogonadism. The current review will dwell upon current evidence and controversies surrounding the role of T in the pathophysiology of CV diseases, the link between circulating T levels and CV risk, and the use of replacing T as a possible adjuvant treatment in specific CV disorders. Specifically, recent findings suggest that heart failure and type 2 diabetes mellitus represent two potential targets of T therapy once that a state of hypogonadism is diagnosed. However, only if ongoing studies solve the CV safety issue the T orchid may eventually 'bloom'.
MeSH term(s)	Adolescent ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Hormone Replacement Therapy/adverse effects ; Humans ; Hypogonadism/chemically induced ; Hypogonadism/diagnosis ; Hypogonadism/drug therapy ; Testosterone/adverse effects
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvab241
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Zs.A 565: Show issues

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Article ; Online: Imaging andrology of the future: Where functional imaging embraces the clinic.

Isidori, Andrea M / Dogra, Vikram S / Sidhu, Paul S

Andrology

2021 Volume 9, Issue 5, Page(s) 1287–1289

MeSH term(s)	Andrology/trends ; Genital Diseases, Male/diagnostic imaging ; Humans ; Male ; Radiology/trends
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Editorial
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13054
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Zs.A 6983: Show issues

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Article: Cell Shortening and Calcium Homeostasis Analysis in Adult Cardiomyocytes via a New Software Tool.

Fassina, Lorenzo / Assenza, Maria Rita / Miragoli, Michele / Isidori, Andrea M / Naro, Fabio / Barbagallo, Federica

Biomedicines

2022 Volume 10, Issue 3

Abstract: Intracellular calcium ( ... ...

Abstract	Intracellular calcium (Ca
Language	English
Publishing date	2022-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10030640
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Article ; Online: Correction: Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study.

Puliani, Giulia / Sbardella, Emilia / Cozzolino, Alessia / Sada, Valentina / Tozzi, Rossella / Andreoli, Chiara / Fiorelli, Marco / Di Biasi, Claudio / Corallino, Diletta / Balla, Andrea / Paganini, Alessandro M / Venneri, Mary Anna / Lenzi, Andrea / Lubrano, Carla / Isidori, Andrea M

International journal of obesity (2005)

2023 Volume 47, Issue 10, Page(s) 1027

Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Published Erratum
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-023-01363-9
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Zs.A 1325: Show issues

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Article ; Online: Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous analysis of androgens, estrogens, glucocorticoids and progestagens in human serum.

Iannone, Michele / Dima, Anna Pia / Sciarra, Francesca / Botrè, Francesco / Isidori, Andrea M

Biomedical chromatography : BMC

2022 Volume 36, Issue 5, Page(s) e5344

Abstract: We present a liquid chromatography tandem mass spectrometry method for the simultaneous analysis of 16 endogenous steroids (androgens, estrogens, glucocorticoids and progestogens) in human serum. Samples (250 μl of matrix) were extracted with t- ... ...

Abstract	We present a liquid chromatography tandem mass spectrometry method for the simultaneous analysis of 16 endogenous steroids (androgens, estrogens, glucocorticoids and progestogens) in human serum. Samples (250 μl of matrix) were extracted with t-butylmethyl ether prior to LC-MS/MS analysis. The chromatographic separation was achieved on a reversed-phase column using a methanol-water gradient. The HPLC was coupled to a triple quadrupole mass spectrometer equipped with an electrospray ionization source with acquisition in multiple reaction monitoring mode. The method was validated using surrogate matrices and human serum samples. The specificity of the method was confirmed for all of the considered steroids; linearity was also assessed (R
MeSH term(s)	Androgens ; Chromatography, High Pressure Liquid ; Chromatography, Liquid/methods ; Estrogens ; Glucocorticoids ; Humans ; Progestins ; Reproducibility of Results ; Steroids ; Tandem Mass Spectrometry/methods
Chemical Substances	Androgens ; Estrogens ; Glucocorticoids ; Progestins ; Steroids
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5344
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Zs.A 2166: Show issues

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Article ; Online: Testosterone replacement therapy: For whom, when and how?

Tsametis, Christos P / Isidori, Andrea M

Metabolism: clinical and experimental

2018 Volume 86, Page(s) 69–78

Abstract: The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in ...

Abstract	The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in older men is highly debated. The aim of this narrative review is to summarize the steps necessary to formulate a proper diagnosis and to guide toward an individualized treatment. While universally recognized the need to treat the young adults with known causes of pituitary or testicular failure, there are controversies on the cost-benefit of treating testosterone deficiency in older men. Discrepancies among the several available guidelines do not help to clarify the scenario, however, the recent larger clinical trials have shed some light on the fact that testosterone treatment carries some benefit, that is not free from risks. We provide an updated review of the diagnostic hallmarks, the several treatment modalities, with their advantages and disadvantages, and how to individualize and monitor treatment in order to maximize the benefits and minimize the risks. The treatment of male hypogonadism can no longer be downgraded and must become part of the cultural baggage of the endocrinologist.
MeSH term(s)	Age Factors ; Diagnostic Techniques, Endocrine ; Drug Administration Schedule ; Early Diagnosis ; Hormone Replacement Therapy/methods ; Humans ; Hypogonadism/diagnosis ; Hypogonadism/drug therapy ; Hypogonadism/epidemiology ; Male ; Patient Selection ; Testosterone/deficiency ; Testosterone/therapeutic use ; Time Factors ; Time-to-Treatment
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2018-03-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80230-x
ISSN	1532-8600 ; 0026-0495
ISSN (online)	1532-8600
ISSN	0026-0495
DOI	10.1016/j.metabol.2018.03.007
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Article ; Online: Priming metabolism with the type 5 phosphodiesterase: the role of cGMP-hydrolyzing enzymes.

Campolo, Federica / Pofi, Riccardo / Venneri, Mary Anna / Isidori, Andrea M

Current opinion in pharmacology

2021 Volume 60, Page(s) 298–305

Abstract: The cyclic guanosine monophosphate (cGMP) signaling system is one of the most prominent regulators of many physiopathological processes in humans and rodents. It has been strongly established as an accomplished cellular signal involved in the regulation ... ...

Abstract	The cyclic guanosine monophosphate (cGMP) signaling system is one of the most prominent regulators of many physiopathological processes in humans and rodents. It has been strongly established as an accomplished cellular signal involved in the regulation of energy homeostasis and cell metabolism, and pharmacological enhancement of cGMP has shown beneficial effects in metabolic disorders models. cGMP intracellular levels are finely regulated by phosphodiesterases (PDEs). The main enzyme responsible for the degradation of cGMP is PDE5. Preclinical and clinical studies have shown that PDE5 inhibitors (PDE5i) have beneficial effects on improving insulin resistance and glucose metabolism representing a promising therapeutic strategy for the treatment of metabolic disorders. This review aims to describe the molecular basis underlying the use of PDE5i to prompt cell metabolism and summarize current clinical trials assessing the effects of PDE5i on glucose metabolism.
MeSH term(s)	Cyclic GMP ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Humans ; Signal Transduction
Chemical Substances	Cyclic Nucleotide Phosphodiesterases, Type 5 (EC 3.1.4.35) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2021.08.007
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