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  1. Article ; Online: A novel neuroimmune modulation system for the treatment of rheumatoid arthritis.

    Bonaz, Bruno

    Bioelectronic medicine

    2024  Volume 10, Issue 1, Page(s) 9

    Abstract: The vagus nerve has an anti-inflammatory effect through the inflammatory reflex, which inhibits the release of proinflammatory cytokines by macrophages. Recent pilot clinical trials, using implantable bioelectronic devices, have demonstrated the efficacy ...

    Abstract The vagus nerve has an anti-inflammatory effect through the inflammatory reflex, which inhibits the release of proinflammatory cytokines by macrophages. Recent pilot clinical trials, using implantable bioelectronic devices, have demonstrated the efficacy of vagus nerve stimulation in adult patients with rheumatoid arthritis and inflammatory bowel diseases as an alternative to drugs, which are not devoid of side effects and are costly. In this issue of Bioelectronic Medicine, Peterson et al. report the safety of novel implantable neuroimmune modulation device for treating rheumatoid arthritis (The RESET RA study), which I will discuss in this commentary.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-024-00142-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis.

    Bonaz, Bruno

    Inflammopharmacology

    2024  Volume 32, Issue 2, Page(s) 1005–1015

    Abstract: The gut and the brain communicate bidirectionally through the autonomic nervous system. The vagus nerve is a key component of this gut-brain axis, and has numerous properties such as anti-inflammatory, antinociceptive, anti-depressive effects. A ... ...

    Abstract The gut and the brain communicate bidirectionally through the autonomic nervous system. The vagus nerve is a key component of this gut-brain axis, and has numerous properties such as anti-inflammatory, antinociceptive, anti-depressive effects. A perturbation of this gut-brain communication is involved in the pathogeny of functional digestive disorders, such as irritable bowel syndrome, and inflammatory bowel diseases. Stress plays a role in the pathogeny of these diseases, which are biopsychosocial models. There are presently unmet needs of pharmacological treatments of these chronic debilitating diseases. Treatments are not devoid of side effects, cost-effective, do not cure the diseases, can lose effects over time, thus explaining the poor satisfaction of patients, their lack of compliance, and their interest for non-drug therapies. The gut-brain axis can be targeted for therapeutic purposes in irritable bowel syndrome and inflammatory bowel disease through non-drug therapies, such as hypnosis and vagus nerve stimulation, opening up possibilities for responding to patient expectations.
    MeSH term(s) Humans ; Irritable Bowel Syndrome/drug therapy ; Vagus Nerve Stimulation ; Inflammatory Bowel Diseases/drug therapy ; Brain ; Hypnosis
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-024-01446-7
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    Zs.A 3274: Show issues Location:
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  3. Article ; Online: Dysregulation of hypothalamic-vagal neurocircuits by perinatal high fat diet.

    Bonaz, Bruno

    The Journal of physiology

    2023  Volume 601, Issue 14, Page(s) 2757–2758

    MeSH term(s) Pregnancy ; Female ; Humans ; Diet, High-Fat/adverse effects ; Vagus Nerve/physiology ; Hypothalamus
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284986
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  4. Article ; Online: Non-invasive vagus nerve stimulation: the future of inflammatory bowel disease treatment?

    Bonaz, Bruno

    Bioelectronic medicine

    2023  Volume 9, Issue 1, Page(s) 26

    Abstract: The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated the efficacy of vagus nerve stimulation (VNS) in adult patients with ... ...

    Abstract The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated the efficacy of vagus nerve stimulation (VNS) in adult patients with inflammatory bowel diseases (IBD) as an alternative to drug treatments. However, the use of non-invasive VNS should be of interest in adults with IBD and even more in pediatric IBD. In this issue of Bioelectronic Medicine, Sahn et al. report that non-invasive transcutaneous auricular VNS attenuated signs and symptoms in a pediatric cohort with mild to moderate IBD thus opening new therapeutic avenues in the management of pediatric but also adult IBD patients.
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Letter
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-023-00129-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anti-inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction.

    Bonaz, Bruno

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2022  Volume 34, Issue 10, Page(s) e14456

    Abstract: The vagus nerve (VN), the longest nerve of the organism innervating the gastrointestinal tract, is a mixed nerve with anti-inflammatory properties through its afferents, activating the hypothalamic-pituitary adrenal axis, and its efferents through the ... ...

    Abstract The vagus nerve (VN), the longest nerve of the organism innervating the gastrointestinal tract, is a mixed nerve with anti-inflammatory properties through its afferents, activating the hypothalamic-pituitary adrenal axis, and its efferents through the cholinergic anti-inflammatory pathway inhibiting the release of pro-inflammatory cytokines (e.g., TNFα) by splenic and gut macrophages. In addition, the VN is also able to modulate the permeability of the intestinal barrier although the VN does not innervate directly the intestinal epithelium. Targeting the VN through VN stimulation (VNS) has been developed in experimental model of intestinal inflammation and in inflammatory bowel disease (IBD) and might be of interest to decrease intestinal permeability in gastrointestinal disorders with intestinal barrier defect such as IBD, irritable bowel syndrome (IBS), and celiac disease. In this issue of neurogastroenterology and motility, Mogilevski et al. report that a brief non-invasive transcutaneous auricular VNS in healthy volunteers consistently reduces the permeability of the small intestine induced by intravenous administration of the stress peptide corticotropin releasing hormone, known to increase intestinal permeability and to inhibit the VN. In this review, we outline the mechanistic underpinning the effect of stress, of the VN and VNS on intestinal permeability. In particular, the VN can act on intestinal permeability through enteric nerves, and/or cells such as enteric glial cells. We also review the existing evidence of the effects VNS on intestinal permeability in models such as burn intestinal injury and traumatic brain injury, which pave the way for future clinical trials in IBD, IBS, and celiac disease.
    MeSH term(s) Burns ; Celiac Disease ; Corticotropin-Releasing Hormone/metabolism ; Cytokines/metabolism ; Humans ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/therapy ; Irritable Bowel Syndrome/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Vagus Nerve/physiology ; Vagus Nerve Stimulation
    Chemical Substances Cytokines ; Tumor Necrosis Factor-alpha ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.14456
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2979: Show issues Location:
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  6. Article ; Online: Targeting the Vagus Nerve to Treat Inflammatory Bowel Disease?

    Bonaz, Bruno / Sinniger, Valérie

    Journal of Crohn's & colitis

    2023  Volume 17, Issue 12, Page(s) 1893–1894

    MeSH term(s) Humans ; Crohn Disease ; Vagus Nerve Stimulation ; Prospective Studies ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; Vagus Nerve/immunology
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjad149
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    Zs.A 6634: Show issues Location:
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  7. Article ; Online: Parameters matter: modulating cytokines using nerve stimulation.

    Bonaz, Bruno

    Bioelectronic medicine

    2020  Volume 6, Page(s) 12

    Abstract: The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients with rheumatoid arthritis and inflammatory ... ...

    Abstract The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients with rheumatoid arthritis and inflammatory bowel disease have demonstrated the efficacy of targeting neural circuits as an efficient alternative to drug treatments. However, the optimal vagus nerve stimulation parameters to achieve efficacious symptomatic relief for inflammation are still unknown. In this issue of Bioelectronic Medicine, Tsaava et al. tested whether altering these electrical stimulation parameters would change circulating cytokine levels in healthy mice. They found that specific combinations of parameters produced significant increases in serum TNF while other parameters selectively lowered serum TNF levels, as compared to sham stimulated mice. These results have considerable implications for determining the optimal stimulation parameters to better treat common conditions and diseases that involve immune regulation.
    Language English
    Publishing date 2020-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-020-00049-1
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  8. Article ; Online: The vagus nerve and the sympathetic nervous system act in concert to modulate immunity.

    Bonaz, Bruno

    Brain, behavior, and immunity

    2019  Volume 84, Page(s) 6–7

    MeSH term(s) Lymph Nodes ; Neuroimmunomodulation ; Spleen ; Sympathetic Nervous System ; Vagus Nerve
    Language English
    Publishing date 2019-11-27
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2019.11.018
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    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  9. Article ; Online: Is-there a place for vagus nerve stimulation in inflammatory bowel diseases?

    Bonaz, Bruno

    Bioelectronic medicine

    2018  Volume 4, Page(s) 4

    Abstract: The vagus nerve (VN), the longest nerve of the organism that innervates the gastrointestinal tract, is a mixed nerve composed of 80% of afferent and 20% of efferent fibers. The VN has anti-inflammatory properties, in particular an anti-TNFα effect ... ...

    Abstract The vagus nerve (VN), the longest nerve of the organism that innervates the gastrointestinal tract, is a mixed nerve composed of 80% of afferent and 20% of efferent fibers. The VN has anti-inflammatory properties, in particular an anti-TNFα effect through the cholinergic anti-inflammatory pathway. The VN is a key component of the autonomic nervous system, i.e. the parasympathetic nervous system. An imbalance of the autonomic nervous system, as represented by a low vagal tone, is described in many diseases and has a pro-inflammatory role. Inflammatory bowel diseases (IBD) are chronic disorders of the gastro-intestinal tract where TNFα is a key cytokine. VN stimulation (VNS), classically used for the treatment of drug resistant epilepsy and depression, would be of interest in the treatment of IBD. We have recently reported in a 6 month follow-up pilot study that VNS improves active Crohn's disease. Preliminary data of another pilot study confirm this interest. Similarly, VNS has recently been reported to improve rheumatoid arthritis, another TNFα mediated disease. Bioelectronic Medicine, as represented by VNS, opens new therapeutic avenues in the treatment of such chronic inflammatory disorders. In the present manuscript, we will focus on the interest of VNS in IBD.
    Language English
    Publishing date 2018-04-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-018-0004-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Autonomic Dysfunction: A Predictive Factor of Risk to Develop Rheumatoid Arthritis?

    Bonaz, Bruno

    EBioMedicine

    2016  Volume 6, Page(s) 20–21

    MeSH term(s) Arthritis, Rheumatoid ; Autonomic Nervous System Diseases ; Humans ; Risk
    Language English
    Publishing date 2016-03-04
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2016.03.005
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    Zs.A 7090: Show issues Location:
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