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Article ; Online: Effects of inhaled corticosteroids (ICS) on lung microbiota and local immune response in long-term treatment of chronic obstructive pulmonary disease (COPD): utility of titration and therapeutic index.

Toraldo, Domenico Maurizio / Rizzo, Emanuele / Conte, Luana

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 395, Issue 7, Page(s) 849–858

Abstract: Administration of inhaled corticosteroids (ICS) is one of the most controversial issues in the treatment of stable chronic obstructive pulmonary disease (COPD). Associations between these drugs and increased incidence of severe pneumonia and other ... ...

Abstract	Administration of inhaled corticosteroids (ICS) is one of the most controversial issues in the treatment of stable chronic obstructive pulmonary disease (COPD). Associations between these drugs and increased incidence of severe pneumonia and other respiratory infections have already been reported in literature, as well as effects on the immune system and on the lung microbiota. ICS vary in their pharmacodynamic and pharmacokinetic properties, despite being widely considered therapeutically similar. The use of ICS requires, therefore, a deep knowledge of their pharmacokinetics and pharmacodynamics to obtain the maximum benefit and the least side effects. Defining new phenotypes-endotypes of COPD may lead to novel pharmacological and therapeutic scenarios while define the correct indications for prescription of ICS. Titration is certainly an important means by which these objectives can be achieved.
MeSH term(s)	Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; Humans ; Immunity ; Lung ; Microbiota ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Therapeutic Index
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2022-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-022-02237-z
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Article ; Online: Targeting the gut-lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection.

Conte, Luana / Toraldo, Domenico Maurizio

Therapeutic advances in respiratory disease

2020 Volume 14, Page(s) 1753466620937170

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the microbial patterns through the use of probiotics and dietary fibers consumption may contribute to reduce inflammation and strengthen the immune system response in COVID-19 infection.
MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diet therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Diet ; Dietary Fiber/administration & dosage ; Gastrointestinal Microbiome ; Humans ; Immune System/virology ; Inflammation/pathology ; Inflammation/virology ; Lung/virology ; Pandemics ; Pneumonia, Viral/diet therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Probiotics/administration & dosage ; SARS-CoV-2
Chemical Substances	Dietary Fiber
Keywords	covid19
Language	English
Publishing date	2020-06-29
Publishing country	England
Document type	Letter
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/1753466620937170
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Article ; Online: Targeting the gut–lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection

Luana Conte / Domenico Maurizio Toraldo

Therapeutic Advances in Respiratory Disease, Vol

2020 Volume 14

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the microbial patterns through the use of probiotics and dietary fibers consumption may contribute to reduce inflammation and strengthen the immune system response in COVID-19 infection. The reviews of this paper are available via the supplemental material section.
Keywords	Diseases of the respiratory system ; RC705-779 ; covid19
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Statistical analysis and generative Artificial Intelligence (AI) for assessing pain experience, pain-induced disability, and quality of life in Parkinson's disease patients.

Conte, Luana / Lupo, Roberto / Lezzi, Pierluigi / Pedone, Alessio / Rubbi, Ivan / Lezzi, Alessia / Vitale, Elsa / Fasano, Antonio / De Nunzio, Giorgio

Brain research bulletin

2024 Volume 208, Page(s) 110893

Abstract: The Parkinson's Disease (PD) is a chronic neurodegenerative condition characterized by motor symptoms such as tremors, rigidity, and bradykinesia, which can significantly impact various aspects of daily life. Among these aspects, pain is a prominent ... ...

Abstract	The Parkinson's Disease (PD) is a chronic neurodegenerative condition characterized by motor symptoms such as tremors, rigidity, and bradykinesia, which can significantly impact various aspects of daily life. Among these aspects, pain is a prominent element. Despite the widespread use of therapies aimed at improving symptoms and quality of life, effective pain management is essential to enhance the quality of life of individuals affected by this disease. However, a detailed understanding of the factors associated with pain in PD is still evolving. In this study, we examined the disability caused by pain and the pain experienced by PD patients using two validated questionnaires, namely the Parkinson's Disease Questionnaire (PDQ) and the King's Parkinson's Disease Pain Questionnaire (KPPQ). Customized questions were also included to further explore the pain experience and management strategies adopted by PD patients. Through statistical analysis, we explored the relationships between questionnaire scores, socio-demographic data, and other relevant variables. Additionally, generative Artificial Intelligence (AI) was employed to gain a deeper understanding of patient responses. The results indicate the extent and impact of pain in PD and provide valuable insights for more targeted and personalized management. This study lays the foundation for future research and the development of interventions aimed at improving the quality of life for individuals affected by this condition.
MeSH term(s)	Humans ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; Quality of Life ; Artificial Intelligence ; Pain/diagnosis ; Pain/etiology ; Pain Management
Language	English
Publishing date	2024-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2024.110893
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Article ; Online: Work-family conflict in a cohort of Italian nurses. An observational, multicenter, cross-sectional study.

Carvello, Maicol / Lupo, Roberto / Cicognani, Corin / Conte, Luana / Artioli, Giovanna / Vitale, Elsa / Rubbi, Ivan

Acta bio-medica : Atenei Parmensis

2023 Volume 94, Issue 4, Page(s) e2023206

Abstract: Background and aim of the work: Work-family and family-work conflict can be defined as the degree to which participation in one role, in this case as a worker, interferes with the ability to cope with the responsibilities of another role, namely that of ...

Abstract	Background and aim of the work: Work-family and family-work conflict can be defined as the degree to which participation in one role, in this case as a worker, interferes with the ability to cope with the responsibilities of another role, namely that of a member of a household. The aim of the study is to investigate the presence of indicators of work- family and/or family-work conflict in a cohort of Italian nurses and possible correlations with social and work variables. Research design and methods: An observational, quantitative, multicenter survey was conducted for the study through the computerized administration of a validated questionnaire (Work-Family and Family-Work Conflict, CLF), with the implementation of sociographic variables. The cooperation of 15 Orders of Nursing Professions throughout the country was sought for sample collection. Data collection was bimonthly. Results: Among the participating nurses, there is a statistically significant predominance of conflict in the family-work direction. In particular, the phenomenon seems to be related to age and the presence of children and/or elderly at home to care for. Some work variables seem to positively affect the prevention of potential work-life conflict, such as rostering and work articulation. Conclusions: These findings place emphasis on the need for healthcare organizations to address the work-family balance of their employees.
MeSH term(s)	Child ; Humans ; Aged ; Family Conflict ; Conflict, Psychological ; Cross-Sectional Studies ; Surveys and Questionnaires ; Italy ; Nurses
Language	English
Publishing date	2023-08-03
Publishing country	Italy
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v94i4.14719
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Article ; Online: Which socio-demographic characteristics impact on the fatigue conditions in nurses: an Italian investigatory study.

Vitale, Elsa / Lupo, Roberto / Lezzi, Alessia / Artioli, Giovanna / Zacchino, Simone / Valenzano, Laura / Conte, Luana

Acta bio-medica : Atenei Parmensis

2023 Volume 94, Issue 3, Page(s) e2023175

Abstract: Background and aim: Fatigue describes a wholeness feeling of tiredness or lack of energy. To assess which sampling nurses relating characteristics could influence the fatigue condition among nurses.: Methods: From May 2020 to September 2021 a cross ... ...

Abstract	Background and aim: Fatigue describes a wholeness feeling of tiredness or lack of energy. To assess which sampling nurses relating characteristics could influence the fatigue condition among nurses. Methods: From May 2020 to September 2021 a cross sectional, multicenter study was conducted among Italian nursing professional orders. An on-line ad hoc questionnaire was spread including sampling characteristics both on socio-demographic and nursing-relating work characteristics. Results: Significant associations were reported between item no.1 and gender (p<0.001) and BMI conditions (p=0.013), as most of the female participants (47%) affirmed to often feel themselves tired when they wake up, despite most of participants were at normal weight (32%). Item no.2 was significantly associated with gender (p=0.009), job role (p=0.039) and shift (p=0.030), as most of females never (31%) or often (31%) were not concentrated in their working tasks and, most of them were registered nurses (never: 41% and often: 35%), despite they were employed also during the night shift (never: 28%; often: 22%). Most of females (p=<0.001) were never slow in their reactions (42%), and they were young nurses (p=0.023). 44% of females declared to make an effort to express clearly themselves (p=0.031). Females reported significant high frequencies (p=0.016) in constant excitant substance assumption, such as caffeine (30%) and high significant percentage of females (p=0.047; 41%) reported the need to sleep during the day. Conclusions: The fatigue will have a strong impact on the quality of life of nursing professionals, compromising their functional abilities, social relationships and their work and family roles.
MeSH term(s)	Humans ; Female ; Work Schedule Tolerance ; Cross-Sectional Studies ; Quality of Life ; Fatigue/epidemiology ; Caffeine ; Surveys and Questionnaires ; Nurses
Chemical Substances	Caffeine (3G6A5W338E)
Language	English
Publishing date	2023-06-14
Publishing country	Italy
Document type	Multicenter Study ; Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v94i3.14563
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Article: Influence of the Lung Microbiota Dysbiosis in Chronic Obstructive Pulmonary Disease Exacerbations: The Controversial Use of Corticosteroid and Antibiotic Treatments and the Role of Eosinophils as a Disease Marker.

Toraldo, Domenico Maurizio / Conte, Luana

Journal of clinical medicine research

2019 Volume 11, Issue 10, Page(s) 667–675

Abstract: Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease associated with loss of lung function, poorer quality of life, co-morbidities, significant mortality, and higher health care costs. Frequent acute exacerbations of COPD are ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease associated with loss of lung function, poorer quality of life, co-morbidities, significant mortality, and higher health care costs. Frequent acute exacerbations of COPD are sudden worsening of symptoms, the nature of which is associated with bacterial or viral infections. However, one-third of exacerbations remain of undetermined origin. Although it is largely discussed and controversial, current guidelines recommend treatment of exacerbations with bronchodilators, antibiotics, and systemic corticosteroids; this is despite being associated with limited benefits in term of reducing mortality, side effects and without paying attention to the heterogeneity of these exacerbations. Increasing evidence suggests that the lung microbiota plays an important role in COPD and numerous studies have reported differences in the microbiota between healthy and disease states, as well as between exacerbations and stable COPD, leading to the hypothesis that frequent acute exacerbation is more likely to experience significant changes in lung microbiota composition. These findings will need further examination to explain the causes of lung dysbiosis, namely microbial composition, the host response, including the recruitment of eosinophils, lifestyle, diet, cigarette smoking and the use of antibiotics and corticosteroids. It is now important to assess: 1) Whether alterations in the lung microbiota contribute to disease pathogenesis, especially in exacerbations of unknown origin; 2) The role of eosinophils; and 3) Whether the microbiota of the lung can be manipulated therapeutically to improve COPD exacerbation event and disease progression. In summary, we hypothesize that the alterations of the lung microbiota may explain the undetermined origins of exacerbations and that there is an urgent need to facilitate the design of intervention studies that aim at conserving the lung microbial flora.
Language	English
Publishing date	2019-10-04
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr3875
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Article ; Online: Correction to: Gambling and internet addiction: a pilot study among a population of italian healthcare workers.

Lupo, Roberto / Vitale, Elsa / Carriero, Maria Chiara / Calabrò, Antonino / Imperiale, Chiara / Ercolani, Maurizio / Filippini, Aurelio / Santoro, Pietro / Carvello, Maicol / Rizzo, Emanuele / Artioli, Giovanna / Conte, Luana

Journal of gambling studies

2024

Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2016895-0
ISSN	1573-3602 ; 1050-5350
ISSN (online)	1573-3602
ISSN	1050-5350
DOI	10.1007/s10899-024-10289-4
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Article: Targeting the gut-lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection

Conte, Luana / Toraldo, Domenico Maurizio

Ther Adv Respir Dis

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the microbial patterns through the use of probiotics and dietary fibers consumption may contribute to reduce inflammation and strengthen the immune system response in COVID-19 infection. The reviews of this paper are available via the supplemental material section.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #618981
Database	COVID19

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Article ; Online: Targeting the gut–lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection

Conte, Luana / Toraldo, Domenico Maurizio

Therapeutic Advances in Respiratory Disease

2020 Volume 14, Page(s) 175346662093717

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the microbial patterns through the use of probiotics and dietary fibers consumption may contribute to reduce inflammation and strengthen the immune system response in COVID-19 infection. The reviews of this paper are available via the supplemental material section.
Keywords	Pharmacology (medical) ; Pulmonary and Respiratory Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/1753466620937170
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