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Article: Coconut (

Erukainure, Ochuko L / Chukwuma, Chika I

2024 Volume 13, Issue 5

Abstract: The present study investigated the effect of coconut water on glucose uptake and utilization, and metabolic activities linked to hyperglycemia in isolated rat psoas muscles. Coconut water was subjected to in vitro antioxidant and antidiabetic assays, ... ...

Abstract	The present study investigated the effect of coconut water on glucose uptake and utilization, and metabolic activities linked to hyperglycemia in isolated rat psoas muscles. Coconut water was subjected to in vitro antioxidant and antidiabetic assays, which cover 2,2'-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferric reducing antioxidant power (FRAP), and inhibition of α-glucosidase and α-amylase activities. Psoas muscles were isolated from male Sprague Dawley rats and incubated with coconut water in the presence of glucose. Control consisted of muscles incubated with glucose only, while normal control consisted of muscles not incubated in coconut water and/or glucose. The standard antidiabetic drug was metformin. Incubation with coconut water led to a significant increase in muscle glucose uptake, with concomitant exacerbation of glutathione level, and SOD and catalase activities, while suppressing malondialdehyde level, and ATPase and E-NTDase activities. Coconut water showed significant scavenging activity against DPPH, and significantly inhibited α-glucosidase and α-amylase activities. LC-MS analysis of coconut water revealed the presence of ellagic acid, butin, quercetin, protocatechuic acid, baicalin, and silibinin. Molecular docking analysis revealed potent molecular interactions between the LC-MS-identified compounds, and AKT-2 serine and PI-3 kinase. These results indicate the potential of coconut water to enhance glucose uptake, while concomitantly improving antioxidative and purinergic activities. They also indicate the potential of coconut water to suppress postprandial hyperglycemia. These activities may be attributed to the synergistic effects of the LC-MS-identified compounds.
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13050665
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Article ; Online: Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients.

Gumenku, Lemohang / Sekhoacha, Mamello / Abrahams, Beynon / Mashele, Samson / Shoko, Aubrey / Erukainure, Ochuko L

Current issues in molecular biology

2024 Volume 46, Issue 3, Page(s) 2263–2277

Abstract: Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a ... ...

Abstract	Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes. Escalating chemotherapy resistance in prostate cancer patients has prompted increased research into its underlying mechanisms. The heterogeneous nature of transcriptomic organization among men makes the pursuit of universal biomarkers and one-size-fits-all treatments impractical. This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC transporters and LncRNA-mediated therapeutic resistance (WP3672), while CYP1B1 was linked to ovarian steroidogenesis, tryptophan metabolism, steroid hormone biosynthesis, benzo(a)pyrene metabolism, the sulindac metabolic pathway, and the estrogen receptor pathway, which are associated with drug resistance. Both ABCB1 and CYP1B1 correlated with microRNAs in cancer and the Nuclear Receptors Meta-Pathway. STRING analysis predicted protein-protein interactions of ABCB1 and CYP1B1 with Glutathione S-transferase Pi, Catechol O-methyltransferase, UDP-glucuronosyltransferase 1-6, Leucine-rich Transmembrane and O-methyltransferase (LRTOMT), and Epoxide hydrolase 1, with scores of 0.973, 0.971, 0.966, 0.966, and 0.966, respectively. Furthermore, molecular docking analysis of the chemotherapy drug, docetaxel, with CYP1B1 and ABCB1 revealed robust molecular interactions, with binding energies of -20.37 and -15.25 Kcal/mol, respectively. These findings underscore the susceptibility of cancer patients to drug resistance due to increased ABCB1 and CYP1B1 expression in tumor samples from patients in the poor-responders category that affects associated molecular pathways. The potent molecular interactions of ABCB1 and CYP1B1 with docetaxel further emphasize the potential basis for chemotherapy resistance.
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb46030145
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Article ; Online: Vernonia amygdalina stimulates muscle glucose uptake and modulates redox activities and functional chemistry in oxidative hepatic injury.

Erukainure, Ochuko L / Islam, Md Shahidul

Journal of food biochemistry

2021 Volume 46, Issue 3, Page(s) e13794

Abstract: The ethyl acetate, ethanol, and aqueous extracts sequentially obtained from the leaves of Vernonia amygdalina were investigated for their antidiabetic and antioxidant protective effect in oxidative hepatic injury. The extracts showed significant (p < .05) ...

Abstract	The ethyl acetate, ethanol, and aqueous extracts sequentially obtained from the leaves of Vernonia amygdalina were investigated for their antidiabetic and antioxidant protective effect in oxidative hepatic injury. The extracts showed significant (p < .05) free radical scavenging and reducing power activities. They significantly (p < .05) elevated reduced glutathione level, superoxide dismutase, and catalase activities, with concomitant depletion of malondialdehyde level. The ethanol and aqueous extracts caused a removal of oxidative-included chemical functional group at 1,500-1,200 (amide II)/cm region, with the inclusion of a functional group at 3,000-2,800 (carboxylic acid)/cm region. The extracts significantly (p < .05) inhibited the activities of α-glucosidase and α-amylase and stimulated glucose uptake in rat muscles. Gas chromatography-mass spectrometric (GC-MS) analysis revealed phytol as the predominant compound, with ethanol having the highest concentration. Based on the IC
MeSH term(s)	Animals ; Antioxidants/chemistry ; Diabetes Mellitus, Type 2/metabolism ; Ethanol ; Glucose/metabolism ; Hypoglycemic Agents/chemistry ; Liver ; Muscles/chemistry ; Oxidation-Reduction ; Oxidative Stress ; Plant Extracts/chemistry ; Rats ; Vernonia/chemistry
Chemical Substances	Antioxidants ; Hypoglycemic Agents ; Plant Extracts ; Ethanol (3K9958V90M) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13794
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Article: Lippia javanica (Burm. F.) Herbal Tea: Modulation of Hepatoprotective Effects in Chang Liver Cells via Mitigation of Redox Imbalance and Modulation of Perturbed Metabolic Activities.

Salau, Veronica F / Erukainure, Ochuko L / Olofinsan, Kolawole A / Schoeman, Recardia L S / Matsabisa, Motlalepula G

Frontiers in pharmacology

2023 Volume 14, Page(s) 1221769

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1221769
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Article ; Online: Evaluation of the antidiabetic, antiobesity and antioxidant potential of Anthophycus longifolius ((Turner) Kützing)

S'thandiwe N. Magwaza / Ochuko L. Erukainure / Kolawole Olofinsan / Balaji Meriga / Md. Shahidul Islam

Scientific African, Vol 23, Iss , Pp e02051- (2024)

2024

Abstract: Obesity is a major public health problem that is associated with many metabolic disorders including diabetes, hypertension, and cardiovascular diseases. Anthophycus longifolius is a brown seaweed that have been shown to possess antioxidant, antibacterial ...

Abstract	Obesity is a major public health problem that is associated with many metabolic disorders including diabetes, hypertension, and cardiovascular diseases. Anthophycus longifolius is a brown seaweed that have been shown to possess antioxidant, antibacterial and anti-inflammatory activities. The present study investigated the anti-diabetic, anti-obesity and oxidative stress ameliorating properties of cold water (CW) and ethanolic (EtOH) extracts of A. longifolius using in vitro and ex vivo experimental models. The extracts significantly inhibited the activities of carbohydrate and lipid digestive enzymes α - glucosidase (IC50 = CW: 176.9±2.1 µg/ml; EtOH: 179.8±1.9 µg/ml); α-amylase (IC50 = CW: 86.1±1.7 µg/ml; EtOH: 77.8±1.9 µg/ml); and pancreatic lipase (IC50 = CW: 184.3±1.7 µg/ml; EtOH: 534.1±2.3 µg/ml), and stimulated adipose glucose uptake (CW: 10- 50.5 mg/g adipose tissue; EtOH: 9 - 79 mg/g adipose tissue). Incubation of adipose tissues with FeSO4 significantly depleted reduced glutathione (GSH) level, super oxide dismutase (SOD) and catalase activities, while concomitantly elevated malondialdehyde (MDA) level. These changes were significantly reversed following the treatment of A. longifolius extracts. Liquid chromatography-mass spectrometry (LC-MS) analysis of the extracts revealed the presence of rhodomycinone, salsolinol, 5-hydroxyconiferyl alcohol, 2-caffeoylisocitrate and demethylalangiside in the cold water extract, while petromyzonol 24-sulfate, atractyloside, abyssinone VI and podecdysone B in the ethanolic extract. Molecular docking analysis revealed potent interactions of the phytochemicals with GLUT4 and leptin. These results indicate the possible antidiabetic, antiobesity and oxidative stress ameliorating potentials of A. longifolius extracts at in vitro and ex vivo experimental models. The identified compounds may be responsible for the observed biological activities.
Keywords	Amylase ; Diabetes ; Glucosidase ; Obesity ; Oxidative stress ; Pancreatic lipase ; Science ; Q
Subject code	500
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hibiscus sabdariffa L. polyphenolic-rich extract promotes muscle glucose uptake and inhibits intestinal glucose absorption with concomitant amelioration of Fe

Mohamed, Almahi I / Salau, Veronica F / Erukainure, Ochuko L / Islam, Md Shahidul

Journal of food biochemistry

2022 , Page(s) e14399

Abstract: In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa and its protective function against ... ...

Abstract	In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa and its protective function against Fe
Language	English
Publishing date	2022-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14399
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Article: Vernonia amygdalina stimulates muscle glucose uptake and modulates redox activities and functional chemistry in oxidative hepatic injury

Erukainure, Ochuko L. / Islam, Md. Shahidul

Journal of food biochemistry. 2022 Mar., v. 46, no. 3

2022

Abstract	The ethyl acetate, ethanol, and aqueous extracts sequentially obtained from the leaves of Vernonia amygdalina were investigated for their antidiabetic and antioxidant protective effect in oxidative hepatic injury. The extracts showed significant (p < .05) free radical scavenging and reducing power activities. They significantly (p < .05) elevated reduced glutathione level, superoxide dismutase, and catalase activities, with concomitant depletion of malondialdehyde level. The ethanol and aqueous extracts caused a removal of oxidative‐included chemical functional group at 1,500–1,200 (amide II)/cm region, with the inclusion of a functional group at 3,000–2,800 (carboxylic acid)/cm region. The extracts significantly (p < .05) inhibited the activities of α‐glucosidase and α‐amylase and stimulated glucose uptake in rat muscles. Gas chromatography‐mass spectrometric (GC‐MS) analysis revealed phytol as the predominant compound, with ethanol having the highest concentration. Based on the IC₅₀ values, the ethanol extract exhibited the best activities, followed by the ethyl acetate extract, while the aqueous extract was the least. These results suggest the antioxidative and antidiabetic properties of V. amygdalina as evident by their modulation of antioxidant biomarkers and oxidative‐induced chemistry changes and stimulate muscle glucose uptake. PRACTICAL APPLICATIONS: Vernonia amygdalina (bitter leaf) is amongst the common leafy vegetables in West Africa reported for its various medicinal and nutritional properties. It is utilized as a food ingredient as well as supplement for the treatment and management of type 2 diabetes. The ability of its extracts to stimulate glucose uptake and protect against diabetic‐induced changes in the chemical functional groups of the liver gives more credence to its reported antidiabetic properties. Being a common leafy vegetable, V. amygdalina can be a cheap source of nutraceutical for the treatment and management of type 2 diabetes and its complications.
Keywords	Vernonia amygdalina ; alpha-amylase ; antioxidant biomarkers ; carboxylic acids ; catalase ; dietary supplements ; ethanol ; ethyl acetate ; food composition ; free radicals ; glucose ; glutathione ; leaves ; liver ; malondialdehyde ; muscles ; noninsulin-dependent diabetes mellitus ; protective effect ; rats ; superoxide dismutase ; Western Africa
Language	English
Dates of publication	2022-03
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13794
Database	NAL-Catalogue (AGRICOLA)

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Article: Cannabis sativa

Erukainure, Ochuko L / Oyenihi, Omolola R / Amaku, James F / Chukwuma, Chika I / Nde, Adeline Lum / Salau, Veronica F / Matsabisa, Motlalepula G

Heliyon

2023 Volume 9, Issue 5, Page(s) e16156

Abstract: The present study investigated the ability ... ...

Abstract	The present study investigated the ability of
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16156
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Article: Phytochemical Properties of

Ncume, Paul V / Salau, Veronica F / Mtshali, Sibahle / Olofinsan, Kolawole A / Erukainure, Ochuko L / Matsabisa, Motlalepula G

Plants (Basel, Switzerland)

2023 Volume 12, Issue 16

Abstract: Oxidative stress plays a vital role in the pathogenesis and progression of various liver diseases. Traditional medicinal herbs have been used worldwide for the treatment of chronic liver diseases due to their high phytochemical constituents. The present ... ...

Abstract	Oxidative stress plays a vital role in the pathogenesis and progression of various liver diseases. Traditional medicinal herbs have been used worldwide for the treatment of chronic liver diseases due to their high phytochemical constituents. The present study investigated the phytochemical properties of
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12162915
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Article ; Online: Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats.

Salau, Veronica F / Erukainure, Ochuko L / Ijomone, Omamuyovwi M / Islam, Md Shahidul

The Journal of pharmacy and pharmacology

2022 Volume 74, Issue 7, Page(s) 973–984

Abstract: Objectives: The antidiabetic potential of caffeic acid in fructose/streptozotocin-induced type 2 diabetic rats was examined in this study.: Methods: Male Sprague-Dawley rats were supplied with 10% fructose solution for 14 days followed by an ... ...

Abstract	Objectives: The antidiabetic potential of caffeic acid in fructose/streptozotocin-induced type 2 diabetic rats was examined in this study. Methods: Male Sprague-Dawley rats were supplied with 10% fructose solution for 14 days followed by an intraperitoneal injection of 40 mg/kg bw streptozotocin to induce type 2 diabetes (T2D). Rats were treated with both low (150 mg/kg bw) and high (300 mg/kg bw) doses of caffeic acid for 5 weeks, while the positive control group was treated with metformin (200 mg/kg bw). Key findings: Treatment with caffeic acid significantly decreased blood glucose levels and elevated serum insulin levels while improving glucose tolerance, pancreatic β-cell function and morphology. It also led to a significant reduction of serum cholesterol, triglyceride, LDL-cholesterol, ALT, AST, creatinine, urea and uric acid levels, while increasing HDL cholesterol levels. Caffeic acid significantly (P < 0.05) elevated hepatic glycogen level, serum and pancreatic glutathione level, superoxide dismutase and catalase activities with a concomitant decrease in malondialdehyde level, α-amylase, lipase, adenosine triphosphatase (ATPase), ectonucleoside triphosphate diphosphohydrolase (ENTPDase), 5'-nucleotidase (5'-NTD) and acetylcholinesterase activities. Conclusion: The results suggest caffeic acid as a potent natural product with therapeutic effects against T2D. Further molecular and clinical studies are, however, required to ascertain these findings.
MeSH term(s)	Acetylcholinesterase ; Animals ; Blood Glucose ; Caffeic Acids/pharmacology ; Cholesterol ; Cholinergic Agents ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/drug therapy ; Dyslipidemias/chemically induced ; Dyslipidemias/drug therapy ; Fructose/adverse effects ; Homeostasis ; Hypoglycemic Agents/therapeutic use ; Male ; Oxidative Stress ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Streptozocin/pharmacology
Chemical Substances	Blood Glucose ; Caffeic Acids ; Cholinergic Agents ; Hypoglycemic Agents ; Plant Extracts ; Fructose (30237-26-4) ; Streptozocin (5W494URQ81) ; Cholesterol (97C5T2UQ7J) ; Acetylcholinesterase (EC 3.1.1.7) ; caffeic acid (U2S3A33KVM)
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgac021
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