LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 20

Search options

  1. Article ; Online: Targeting Th17 cells in HIV-1 remission/cure interventions.

    Fert, Augustine / Raymond Marchand, Laurence / Wiche Salinas, Tomas Raul / Ancuta, Petronela

    Trends in immunology

    2022  Volume 43, Issue 7, Page(s) 580–594

    Abstract: Since the discovery of HIV-1, progress has been made in deciphering the viral replication cycle and mechanisms of host-pathogen interactions that has facilitated the implementation of effective antiretroviral therapies (ARTs). Major barriers to HIV-1 ... ...

    Abstract Since the discovery of HIV-1, progress has been made in deciphering the viral replication cycle and mechanisms of host-pathogen interactions that has facilitated the implementation of effective antiretroviral therapies (ARTs). Major barriers to HIV-1 remission/cure include the persistence of viral reservoirs (VRs) in long-lived CD4
    MeSH term(s) CD4-Positive T-Lymphocytes ; HIV Infections ; HIV-1 ; Humans ; Th17 Cells ; Virus Latency
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Targeting the interleukin-17 pathway to prevent acute respiratory distress syndrome associated with SARS-CoV-2 infection.

    Wiche Salinas, Tomas Raul / Zheng, Boyang / Routy, Jean-Pierre / Ancuta, Petronela

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 8, Page(s) 797–799

    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13875
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4957: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Alterations in Th17 Cells and Non-Classical Monocytes as a Signature of Subclinical Coronary Artery Atherosclerosis during ART-Treated HIV-1 Infection.

    Wiche Salinas, Tomas Raul / Zhang, Yuwei / Gosselin, Annie / Rosario, Natalia Fonseca / El-Far, Mohamed / Filali-Mouhim, Ali / Routy, Jean-Pierre / Chartrand-Lefebvre, Carl / Landay, Alan L / Durand, Madeleine / Tremblay, Cécile L / Ancuta, Petronela

    Cells

    2024  Volume 13, Issue 2

    Abstract: Cardiovascular disease (CVD) remains an important comorbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed in the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Score ( ... ...

    Abstract Cardiovascular disease (CVD) remains an important comorbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed in the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Score (FRS) > 5%) revealed a 2-3-fold increase in non-calcified coronary artery atherosclerosis (CAA) plaque burden, measured by computed tomography angiography scan (CTAScan) as the total (TPV) and low attenuated plaque volume (LAPV), in ART-treated PLWH (HIV+) versus uninfected controls (HIV-). In an effort to identify novel correlates of subclinical CAA, markers of intestinal damage (sCD14, LBP, FABP2); cell trafficking/inflammation (CCL20, CX3CL1, MIF, CCL25); subsets of Th17-polarized and regulatory (Tregs) CD4
    MeSH term(s) Humans ; Adult ; HIV-1 ; Monocytes ; Cohort Studies ; Lipopolysaccharide Receptors ; Th17 Cells ; Canada ; Coronary Artery Disease/complications ; HIV Infections/complications ; HIV Infections/drug therapy ; Cardiovascular Diseases ; Atherosclerosis
    Chemical Substances Lipopolysaccharide Receptors
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: A Blood Immunological Signature of Subclinical Coronary Artery Atherosclerosis in People Living with HIV-1 Receiving Antiretroviral Therapy.

    Wiche Salinas, Tomas Raul / Zhang, Yuwei / Gosselin, Annie / Do Rosario, Natalia Fonseca / El-Far, Mohamed / Filali-Mouhim, Ali / Routy, Jean-Pierre / Chartrand-Lefebvre, Carl / Landay, Alan L / Durand, Madeleine / Tremblay, Cécile L / Ancuta, Petronela

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cardiovascular disease (CVD) remains an important co-morbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed on the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Score ( ...

    Abstract Cardiovascular disease (CVD) remains an important co-morbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed on the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Score (FRS) >5%), revealed a 2-3-fold increase in non-calcified coronary artery atherosclerosis (CAA) plaque burden, measured by Computed tomography angiography scan (CTAScan) as total (TPV) and low attenuated plaque volume (LAPV) in ART-treated PLWH (HIV+)
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.15.571922
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Targeting the interleukin-17 pathway to prevent acute respiratory distress syndrome associated with SARS-CoV-2 infection

    Wiche Salinas, Tomas Raul / Zheng, Boyang / Routy, Jean-Pierre / Ancuta, Petronela

    Respirology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #618370
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4

    Chatterjee, Debashree / Zhang, Yuwei / Ngassaki-Yoka, Christ-Dominique / Dutilleul, Antoine / Khalfi, Soumia / Hernalsteens, Olivier / Wiche Salinas, Tomas Raul / Dias, Jonathan / Chen, Huicheng / Smail, Yasmine / Goulet, Jean-Philippe / Bell, Brendan / Routy, Jean-Pierre / Van Lint, Carine / Ancuta, Petronela

    Cell reports

    2023  Volume 42, Issue 6, Page(s) 112634

    Abstract: The aryl hydrocarbon receptor (AhR) regulates Th17-polarized ... ...

    Abstract The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4
    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/metabolism ; HIV-1/physiology ; Receptors, Aryl Hydrocarbon/genetics ; Th17 Cells ; Virus Replication
    Chemical Substances Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112634
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Targeting the interleukin‐17 pathway to prevent acute respiratory distress syndrome associated with SARS‐CoV ‐2 infection

    Wiche Salinas, Tomas Raul / Zheng, Boyang / Routy, Jean‐Pierre / Ancuta, Petronela

    Respirology

    2020  Volume 25, Issue 8, Page(s) 797–799

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13875
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4957: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Lymph-Node-Based CD3

    Samer, Sadia / Chowdhury, Ankita / Wiche Salinas, Tomas Raul / Estrada, Perla M Del Rio / Reuter, Morgan / Tharp, Gregory / Bosinger, Steven / Cervasi, Barbara / Auger, James / Gill, Kiran / Ablanedo-Terrazas, Yuria / Reyes-Teran, Gustavo / Estes, Jacob D / Betts, Michael R / Silvestri, Guido / Paiardini, Mirko

    Journal of virology

    2023  Volume 97, Issue 6, Page(s) e0176022

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Animals ; Humans ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/immunology ; HIV Infections/virology ; Lymph Nodes/cytology ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/genetics ; T Follicular Helper Cells/immunology ; T Follicular Helper Cells/virology ; B-Lymphocytes/immunology ; B-Lymphocytes/virology ; CD40 Ligand/genetics ; Gene Expression/immunology ; DNA, Viral/metabolism ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Lymphoid Tissue/virology
    Chemical Substances CD40 Ligand (147205-72-9) ; DNA, Viral
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01760-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth.

    Wiche Salinas, Tomas Raul / Zhang, Yuwei / Sarnello, Daniele / Zhyvoloup, Alexander / Marchand, Laurence Raymond / Fert, Augustine / Planas, Delphine / Lodha, Manivel / Chatterjee, Debashree / Karwacz, Katarzyna / Oxenford, Sally / Routy, Jean-Pierre / Irlbeck, David / Amrine-Madsen, Heather / Ancuta, Petronela / Fassati, Ariberto

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 118, Issue 48

    Abstract: ... Among ... ...

    Abstract Among CD4
    MeSH term(s) Adult ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cytokines/metabolism ; Female ; Gene Expression/genetics ; Gene Expression Regulation, Viral/genetics ; HIV Infections/immunology ; HIV-1/genetics ; HIV-1/growth & development ; Humans ; Lymphocyte Activation ; Male ; Middle Aged ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Primary Cell Culture ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/metabolism ; Th17 Cells/physiology ; Transcription Factors/metabolism ; Viremia/immunology ; Viremia/virology ; Virus Replication/physiology
    Chemical Substances Cytokines ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; RORC protein, human ; Transcription Factors
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2105927118
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ART.

    Dufour, Caroline / Ruiz, Maria Julia / Pagliuzza, Amélie / Richard, Corentin / Shahid, Aniqa / Fromentin, Rémi / Ponte, Rosalie / Cattin, Amélie / Wiche Salinas, Tomas Raul / Salahuddin, Syim / Sandstrom, Teslin / Schinkel, Stephanie Burke / Costiniuk, Cecilia T / Jenabian, Mohammad-Ali / Ancuta, Petronela / Routy, Jean-Pierre / Cohen, Éric A / Brumme, Zabrina L / Power, Christopher /
    Angel, Jonathan B / Chomont, Nicolas

    Cell reports

    2023  Volume 42, Issue 9, Page(s) 113053

    Abstract: HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of different anatomical compartments to the viral reservoir in humans remains unknown. We performed an extensive characterization of HIV reservoirs in two men who ... ...

    Abstract HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of different anatomical compartments to the viral reservoir in humans remains unknown. We performed an extensive characterization of HIV reservoirs in two men who donated their bodies to HIV cure research and who had been on suppressive ART for years. HIV DNA is detected in all tissues, with large variations across anatomical compartments and between participants. Intact HIV genomes represent 2% and 25% of all proviruses in the two participants and are mainly detected in secondary lymphoid organs, with the spleen and mediastinal lymph nodes harboring intact viral genomes in both individuals. Multiple copies of identical HIV genomes are found in all tissues, indicating that clonal expansions are common in anatomical sites. The majority (>85%) of these expanded clones are shared across multiple tissues. These findings suggest that infected cells expand, migrate, and possibly circulate between anatomical sites.
    MeSH term(s) Male ; Humans ; Anti-Retroviral Agents/therapeutic use ; HIV Infections ; Proviruses/genetics ; Clone Cells ; Lymph Nodes ; CD4-Positive T-Lymphocytes ; Viral Load/genetics
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top