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  1. Article: Correction: Stoll et al. Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients.

    Stoll, Matthew L / DeQuattro, Kimberly / Li, Zhixiu / Sawhney, Henna / Weiss, Pamela F / Nigrovic, Peter A / Wright, Tracey B / Schikler, Kenneth / Edelheit, Barbara / Morrow, Casey D / Reveille, John D / Brown, Matthew A / Gensler, Lianne S

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 8

    Abstract: The authors wish to make the following correction to this paper [ ... ]. ...

    Abstract The authors wish to make the following correction to this paper [...].
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9081158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients.

    Stoll, Matthew L / DeQuattro, Kimberly / Li, Zhixiu / Sawhney, Henna / Weiss, Pamela F / Nigrovic, Peter A / Wright, Tracey B / Schikler, Kenneth / Edelheit, Barbara / Morrow, Casey D / Reveille, John D / Brown, Matthew A / Gensler, Lianne S

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 4

    Abstract: Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities. We analyzed the impact of HLA-B27 on the microbiota ... ...

    Abstract Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities. We analyzed the impact of HLA-B27 on the microbiota of children at risk for SpA and compared the microbiota of HLA-B27+ pediatric offspring of ankylosing spondylitis (AS) patients with that of HLA-B27+ children with SpA. Human DNA was obtained from the offspring for determination of HLA-B27 status and polygenic risk score (PRS). Fecal specimens were collected from both groups for sequencing of the V4 region of the 16S ribosomal RNA gene. Among the offspring of AS patients, there was slight clustering by HLA-B27 status. After adjusting for multiple comparisons, five operational taxonomic units (OTUs) representing three unique taxa distinguished the HLA-B27+ from negative children:
    Language English
    Publishing date 2022-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9040569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Computational prediction of protein hot spot residues.

    Morrow, John Kenneth / Zhang, Shuxing

    Current pharmaceutical design

    2012  Volume 18, Issue 9, Page(s) 1255–1265

    Abstract: Most biological processes involve multiple proteins interacting with each other. It has been recently discovered that certain residues in these protein-protein interactions, which are called hot spots, contribute more significantly to binding affinity ... ...

    Abstract Most biological processes involve multiple proteins interacting with each other. It has been recently discovered that certain residues in these protein-protein interactions, which are called hot spots, contribute more significantly to binding affinity than others. Hot spot residues have unique and diverse energetic properties that make them challenging yet important targets in the modulation of protein-protein complexes. Design of therapeutic agents that interact with hot spot residues has proven to be a valid methodology in disrupting unwanted protein-protein interactions. Using biological methods to determine which residues are hot spots can be costly and time consuming. Recent advances in computational approaches to predict hot spots have incorporated a myriad of features, and have shown increasing predictive successes. Here we review the state of knowledge around protein-protein interactions, hot spots, and give an overview of multiple in silico prediction techniques of hot spot residues.
    MeSH term(s) Computational Biology/methods ; Computer-Aided Design ; Drug Design ; Drug Discovery/methods ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Protein Interaction Mapping/methods ; Proteins/chemistry ; Proteins/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2012-02-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161212799436412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Dental laboratory procedures / 2

    Morrow, Robert M. / Rudd, Kenneth D. / Rhoads, John E.

    1986  

    Author's details Robert M. Morrow ; Kenneth D. Rudd ; John E. Rhoads
    Collection Dental laboratory procedures
    Language English
    Size XV, 489, 17 S. : zahlr. Ill.
    Edition 2. ed.
    Publisher Mosby
    Publishing place St. Louis u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003591759
    ISBN 0-8016-4141-1 ; 978-0-8016-4141-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5603 -2- order for loan Magazin

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  5. Book: Dental laboratory procedures / 1

    Morrow, Robert M. / Rudd, Kenneth D. / Rhoads, John E.

    1986  

    Author's details Robert M. Morrow ; Kenneth D. Rudd ; John E. Rhoads
    Collection Dental laboratory procedures
    Language English
    Size XIV, 565, 17 S. : zahlr. Ill.
    Edition 2. ed.
    Publisher Mosby
    Publishing place St. Louis u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003591745
    ISBN 0-8016-3519-5 ; 978-0-8016-3519-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5603 -1- order for loan Magazin

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  6. Book: Dental laboratory procedures / 3

    Morrow, Robert M. / Rudd, Kenneth D. / Rhoads, John E.

    1986  

    Author's details Robert M. Morrow ; Kenneth D. Rudd ; John E. Rhoads
    Collection Dental laboratory procedures
    Language English
    Size XIV, 685, 17 S. : zahlr. Ill.
    Edition 2. ed.
    Publisher Mosby
    Publishing place St. Louis u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003591773
    ISBN 0-8016-4206-X ; 978-0-8016-4206-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5603 -3- order for loan Magazin

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  7. Article: Calibration lamp design, characterization, and implementation for the Michelson Interferometer for Global High-Resolution Thermospheric Imaging instrument on the Ionospheric Connection satellite.

    Marr, Kenneth D / Morrow, William H / Brown, Charles M / Englert, Christoph R / Harlander, John M / Cerrato, Angel / Lamport, Kelvin / Harris, Stewart E

    Optical engineering (Redondo Beach, Calif.)

    2019  Volume 58, Issue 5

    Abstract: We describe the design and ground-based performance of the two-color calibration lamp for the Michelson Interferometer for Global High-Resolution Thermospheric Imaging (MIGHTI) instrument on the NASA Ionospheric Connection (ICON) satellite. The ... ...

    Abstract We describe the design and ground-based performance of the two-color calibration lamp for the Michelson Interferometer for Global High-Resolution Thermospheric Imaging (MIGHTI) instrument on the NASA Ionospheric Connection (ICON) satellite. The calibration lamp assembly contains radio frequency excited krypton and neon lamps, which generate emission lines at 557 and 630 nm, respectively, and which are used to monitor thermal drifts in the two MIGHTI Doppler asymmetric spatial heterodyne interferometers. The lamps are coupled to two mixed optical fiber bundles that deliver the calibration signals to the two MIGHTI optical units. The assembly starts reliably, consumes <8 W, and has passed environmental testing for the ICON satellite. The total mass of the lamp assembly is 1.8 kg. Special features of the assembly and its implementation are described along with results of life tests.
    Language English
    Publishing date 2019-05-31
    Publishing country United States
    Document type Journal Article
    ISSN 0091-3286
    ISSN 0091-3286
    DOI 10.1117/1.oe.58.5.054104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy.

    Sykes, Robert A / Neves, Karla B / Alves-Lopes, Rhéure / Caputo, Ilaria / Fallon, Kirsty / Jamieson, Nigel B / Kamdar, Anna / Legrini, Assya / Leslie, Holly / McIntosh, Alasdair / McConnachie, Alex / Morrow, Andrew / McFarlane, Richard W / Mangion, Kenneth / McAbney, John / Montezano, Augusto C / Touyz, Rhian M / Wood, Colin / Berry, Colin

    European heart journal. Cardiovascular pharmacotherapy

    2023  Volume 9, Issue 4, Page(s) 371–386

    Abstract: Background: In post-coronavirus disease-19 (post-COVID-19) conditions (long COVID), systemic vascular dysfunction is implicated, but the mechanisms are uncertain, and the treatment is imprecise.: Methods and results: Patients convalescing after ... ...

    Abstract Background: In post-coronavirus disease-19 (post-COVID-19) conditions (long COVID), systemic vascular dysfunction is implicated, but the mechanisms are uncertain, and the treatment is imprecise.
    Methods and results: Patients convalescing after hospitalization for COVID-19 and risk factor matched controls underwent multisystem phenotyping using blood biomarkers, cardiorenal and pulmonary imaging, and gluteal subcutaneous biopsy (NCT04403607). Small resistance arteries were isolated and examined using wire myography, histopathology, immunohistochemistry, and spatial transcriptomics. Endothelium-independent (sodium nitroprusside) and -dependent (acetylcholine) vasorelaxation and vasoconstriction to the thromboxane A2 receptor agonist, U46619, and endothelin-1 (ET-1) in the presence or absence of a RhoA/Rho-kinase inhibitor (fasudil), were investigated. Thirty-seven patients, including 27 (mean age 57 years, 48% women, 41% cardiovascular disease) 3 months post-COVID-19 and 10 controls (mean age 57 years, 20% women, 30% cardiovascular disease), were included. Compared with control responses, U46619-induced constriction was increased (P = 0.002) and endothelium-independent vasorelaxation was reduced in arteries from COVID-19 patients (P < 0.001). This difference was abolished by fasudil. Histopathology revealed greater collagen abundance in COVID-19 arteries {Masson's trichrome (MT) 69.7% [95% confidence interval (CI): 67.8-71.7]; picrosirius red 68.6% [95% CI: 64.4-72.8]} vs. controls [MT 64.9% (95% CI: 59.4-70.3) (P = 0.028); picrosirius red 60.1% (95% CI: 55.4-64.8), (P = 0.029)]. Greater phosphorylated myosin light chain antibody-positive staining in vascular smooth muscle cells was observed in COVID-19 arteries (40.1%; 95% CI: 30.9-49.3) vs. controls (10.0%; 95% CI: 4.4-15.6) (P < 0.001). In proof-of-concept studies, gene pathways associated with extracellular matrix alteration, proteoglycan synthesis, and viral mRNA replication appeared to be upregulated.
    Conclusion: Patients with post-COVID-19 conditions have enhanced vascular fibrosis and myosin light change phosphorylation. Rho-kinase activation represents a novel therapeutic target for clinical trials.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; rho-Associated Kinases/metabolism ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Post-Acute COVID-19 Syndrome ; COVID-19
    Chemical Substances C.I. direct red 80 (1294D5G72N) ; rho-Associated Kinases (EC 2.7.11.1) ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (76898-47-0) ; fasudil (Q0CH43PGXS)
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvad025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Skp2: a dream target in the coming age of cancer therapy.

    Chan, Chia-Hsin / Morrow, John Kenneth / Zhang, Shuxing / Lin, Hui-Kuan

    Cell cycle (Georgetown, Tex.)

    2014  Volume 13, Issue 5, Page(s) 679–680

    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Drug Discovery ; Humans ; Neoplasms/enzymology ; Neoplastic Stem Cells/drug effects ; S-Phase Kinase-Associated Proteins/antagonists & inhibitors ; Ubiquitin-Protein Ligases/antagonists & inhibitors
    Chemical Substances Antineoplastic Agents ; S-Phase Kinase-Associated Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2014-01-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.27853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Targeting ubiquitination for cancer therapies.

    Morrow, John Kenneth / Lin, Hui-Kuan / Sun, Shao-Cong / Zhang, Shuxing

    Future medicinal chemistry

    2015  Volume 7, Issue 17, Page(s) 2333–2350

    Abstract: Ubiquitination, the structured degradation and turnover of cellular proteins, is regulated by the ubiquitin-proteasome system (UPS). Most proteins that are critical for cellular regulations and functions are targets of the process. Ubiquitination is ... ...

    Abstract Ubiquitination, the structured degradation and turnover of cellular proteins, is regulated by the ubiquitin-proteasome system (UPS). Most proteins that are critical for cellular regulations and functions are targets of the process. Ubiquitination is comprised of a sequence of three enzymatic steps, and aberrations in the pathway can lead to tumor development and progression as observed in many cancer types. Recent evidence indicates that targeting the UPS is effective for certain cancer treatment, but many more potential targets might have been previously overlooked. In this review, we will discuss the current state of small molecules that target various elements of ubiquitination. Special attention will be given to novel inhibitors of E3 ubiquitin ligases, especially those in the SCF family.
    MeSH term(s) Carrier Proteins/antagonists & inhibitors ; Carrier Proteins/metabolism ; Humans ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Proteasome Inhibitors/chemistry ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/therapeutic use ; Protein Interaction Domains and Motifs/drug effects ; Ubiquitin-Protein Ligases/antagonists & inhibitors ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Ubiquitins/metabolism
    Chemical Substances Carrier Proteins ; Immunosuppressive Agents ; Proteasome Inhibitors ; Ubiquitins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2015-12-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc.15.148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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