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Article ; Online: Venetoclax-rituximab is active in patients with BTKi-exposed CLL, but durable treatment-free remissions are uncommon.

Lew, Thomas E / Bennett, Rory / Lin, Victor S / Whitechurch, Ashley / Handunnetti, Sasanka M / Marlton, Paula / Shen, Yandong / Mulligan, Stephen P / Casan, Joshua / Blombery, Piers / Tam, Constantine S / Roberts, Andrew W / Seymour, John F / Thompson, Philip A / Anderson, Mary A

Blood advances

2024 Volume 8, Issue 6, Page(s) 1439–1443

MeSH term(s)	Humans ; Rituximab/therapeutic use ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Neoplasm Recurrence, Local ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Sulfonamides
Chemical Substances	Rituximab (4F4X42SYQ6) ; venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023011327
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Article ; Online: Time to switch from CLSI to EUCAST? A Southeast Asian perspective.

Cusack, T P / Ashley, E A / Ling, C L / Roberts, T / Turner, P / Wangrangsimakul, T / Dance, D A B

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2019 Volume 25, Issue 7, Page(s) 782–785

MeSH term(s)	Anti-Infective Agents/pharmacology ; Global Health ; Humans ; Microbial Sensitivity Tests/methods ; Microbial Sensitivity Tests/standards
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2019-03-25
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2019.03.016
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Impact of CLSI and EUCAST breakpoint discrepancies on reporting of antimicrobial susceptibility and AMR surveillance.

Cusack, T P / Ashley, E A / Ling, C L / Rattanavong, S / Roberts, T / Turner, P / Wangrangsimakul, T / Dance, D A B

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2019 Volume 25, Issue 7, Page(s) 910–911

MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Humans ; Klebsiella pneumoniae/drug effects ; Microbial Sensitivity Tests/methods ; Pseudomonas aeruginosa/drug effects
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-03-23
Publishing country	England
Document type	Comparative Study ; Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2019.03.007
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers.

Ayton, Scott / Janelidze, Shorena / Kalinowski, Pawel / Palmqvist, Sebastian / Belaidi, Abdel Ali / Stomrud, Erik / Roberts, Anne / Roberts, Blaine / Hansson, Oskar / Bush, Ashley Ian

Journal of neurology, neurosurgery, and psychiatry

2022 Volume 94, Issue 3, Page(s) 211–219

Abstract: ... complicated by previously reported associations with neuroinflammation, apolipoprotein E and AD proteinopathy ... proteins increased with clinical diagnosis, not pathology. CSF ferritin was positively associated with p ... tau181, which was mediated by apolipoprotein E. An optimised threshold of ferritin predicted cognitive ...

Abstract	Background: A putative role for iron in driving Alzheimer's disease (AD) progression is complicated by previously reported associations with neuroinflammation, apolipoprotein E and AD proteinopathy. To establish how iron interacts with clinicopathological features of AD and at what disease stage iron influences cognitive outcomes, we investigated the association of cerebrospinal fluid (CSF) biomarkers of iron (ferritin), inflammation (acute phase response proteins) and apolipoproteins with pathological biomarkers (CSF Aβ Methods: Ferritin, acute phase response proteins (n=9) and apolipoproteins (n=6) were measured in CSF samples from BioFINDER (n=1239; 4 years cognitive follow-up) participants stratified by cognitive status (cognitively unimpaired, mild cognitive impairment, AD) and for the presence of amyloid and tangle pathology using CSF Aβ Results: In both cohorts, ferritin and apoE were elevated in A-T+ and A+T+ subjects (16%-40%), but not clinical diagnosis. Other apolipoproteins and acute phase response proteins increased with clinical diagnosis, not pathology. CSF ferritin was positively associated with p-tau181, which was mediated by apolipoprotein E. An optimised threshold of ferritin predicted cognitive deterioration in mild cognitive impairment subjects in the BioFINDER cohort, especially those people classified as A-T- and A+T-. Conclusions: CSF markers of iron and neuroinflammation have distinct associations with disease stages, while iron may be more intimately associated with apolipoprotein E and tau pathology.
MeSH term(s)	Humans ; Alzheimer Disease/cerebrospinal fluid ; Ferritins/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid ; Neuroinflammatory Diseases ; Acute-Phase Reaction ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/diagnosis ; Apolipoproteins E/genetics ; Iron ; Inflammation ; Amyloid beta-Peptides/cerebrospinal fluid ; Peptide Fragments/cerebrospinal fluid ; Disease Progression
Chemical Substances	Ferritins (9007-73-2) ; tau Proteins ; Biomarkers ; Apolipoproteins E ; Iron (E1UOL152H7) ; Amyloid beta-Peptides ; Peptide Fragments
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2022-330052
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Article ; Online: Positron emission tomography and magnetic resonance imaging of the brain in experimental human malaria, a prospective cohort study.

Woodford, John / Gillman, Ashley / Jenvey, Peter / Roberts, Jennie / Woolley, Stephen / Barber, Bridget E / Fernandez, Melissa / Rose, Stephen / Thomas, Paul / Anstey, Nicholas M / McCarthy, James S

Scientific reports

2022 Volume 12, Issue 1, Page(s) 5696

Abstract: ... IBSM) infection, and compared results to individuals with P. vivax infection, in whom coma is rare ... a median 9 days following inoculation (n = 4 P. falciparum, n = 3 P. vivax). Participants with P ... to the relatively stable uptake in participants with P. vivax infection (wCV: 3.5%). No consistent imaging changes ...

Abstract	Cerebral malaria is the most serious manifestation of severe falciparum malaria. Sequestration of infected red blood cells and microvascular dysfunction are key contributing processes. Whether these processes occur in early stage disease prior to clinical manifestations is unknown. To help localize and understand these processes during the early stages of infection, we performed 18-F fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in volunteers with Plasmodium falciparum induced blood stage malaria (IBSM) infection, and compared results to individuals with P. vivax infection, in whom coma is rare. Seven healthy, malaria-naïve participants underwent imaging at baseline, and at early symptom onset a median 9 days following inoculation (n = 4 P. falciparum, n = 3 P. vivax). Participants with P. falciparum infection demonstrated marked lability in radiotracer uptake across all regions of the brain, exceeding expected normal variation (within subject coefficient of variation (wCV): 14.4%) compared to the relatively stable uptake in participants with P. vivax infection (wCV: 3.5%). No consistent imaging changes suggestive of microvascular dysfunction were observed in either group. Neuroimaging in early IBSM studies is safe and technically feasible, with preliminary results suggesting that differences in brain tropism between P. falciparum and P. vivax may occur very early in infection.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Humans ; Magnetic Resonance Imaging ; Malaria, Cerebral/diagnostic imaging ; Malaria, Falciparum/diagnostic imaging ; Malaria, Falciparum/pathology ; Malaria, Vivax/pathology ; Plasmodium falciparum ; Plasmodium vivax ; Positron-Emission Tomography ; Prospective Studies
Language	English
Publishing date	2022-04-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-09748-y
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Article ; Online: Identifying Suicide Risk in Adolescents and Young Adults With Type 1 Diabetes: Are Depression Screeners Sufficient?

Moss, Ashley C / Roberts, Alissa J / Yi-Frazier, Joyce P / Read, Kendra L / Taplin, Craig E / Weaver, Kathryn W / Pihoker, Catherine / Hirsch, Irl B / Malik, Faisal S

Diabetes care

2022 Volume 45, Issue 5, Page(s) 1288–1291

Abstract: Objective: Examine the utility of suicide-risk items embedded within depression screeners for identifying the presence of suicide risk in adolescents and young adults (AYA) with type 1 diabetes.: Research design and methods: Sensitivity, specificity, ...

Abstract	Objective: Examine the utility of suicide-risk items embedded within depression screeners for identifying the presence of suicide risk in adolescents and young adults (AYA) with type 1 diabetes. Research design and methods: Sensitivity, specificity, and predictive value of self-report of suicide risk on the Patient Health Questionniaire-9 (PHQ-9) were compared with the pediatric psychologist-administered Columbia-Suicide Severity Rating Scale (C-SSRS) as the reference standard for AYA with type 1 diabetes seen in a multidisciplinary AYA Diabetes Program clinic. Results: Of 133 participants, 9.8% and 11.3% reported suicide risk on the PHQ-9 and C-SSRS, respectively. Sensitivity of the PHQ-9 risk item was 53.3% (95% CI 27.4%-77.7%), specificity was 95.7% (95% CI 89.9%-98.4%), positive predictive value was 61.5% (95% CI 32.3%-84.9%), and negative predictive value was 94.2% (95% CI 87.9-97.4%). Conclusions: Depression screeners appear to under-identify AYA with type 1 diabetes who may otherwise be at risk for suicide.
MeSH term(s)	Adolescent ; Child ; Depression/diagnosis ; Diabetes Mellitus, Type 1/complications ; Disease Susceptibility ; Humans ; Predictive Value of Tests ; Suicide ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc21-1553
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article ; Online: Correction: Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.

Alandijany, Thamir / Roberts, Ashley P E / Conn, Kristen L / Loney, Colin / McFarlane, Steven / Orr, Anne / Boutell, Chris

PLoS pathogens

2018 Volume 14, Issue 2, Page(s) e1006927

Abstract: This corrects the article DOI: 10.1371/journal.ppat.1006769.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.ppat.1006769.].
Language	English
Publishing date	2018-02-22
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1006927
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Article ; Online: Can biodiversity of preexisting and created salt marshes match across scales? An assessment from microbes to predators

Friedrich W. Keppeler / James R. Junker / Margaret J. Shaw / Scott B. Alford / Annette S. Engel / Linda M. Hooper‐Bùi / Olaf P. Jensen / Katelyn Lamb / Paola C. López‐Duarte / Charles W. Martin / Ashley M. McDonald / Jill A. Olin / Audrey T. Paterson / Michael J. Polito / Nancy N. Rabalais / Brian J. Roberts / Ryann E. Rossi / Erick M. Swenson

Ecosphere, Vol 14, Iss 3, Pp n/a-n/a (2023)

2023

Abstract: ... marshes. Richness decomposition varied greatly among assemblages and marshes (e.g., soil microbes showed ...

Abstract	Abstract Coastal wetlands are rapidly disappearing worldwide due to a variety of processes, including climate change and flood control. The rate of loss in the Mississippi River Delta is among the highest in the world and billions of dollars have been allocated to build and restore coastal wetlands. A key question guiding assessment is whether created coastal salt marshes have similar biodiversity to preexisting, reference marshes. However, the numerous biodiversity metrics used to make these determinations are typically scale dependent and often conflicting. Here, we applied ecological theory to compare the diversity of different assemblages (surface and below‐surface soil microbes, plants, macroinfauna, spiders, and on‐marsh and off‐marsh nekton) between two created marshes (4–6 years old) and four reference marshes. We also quantified the scale‐dependent effects of species abundance distribution, aggregation, and density on richness differences and explored differences in species composition. Total, between‐sample, and within‐sample diversity (γ, β, and α, respectively) were not consistently lower at created marshes. Richness decomposition varied greatly among assemblages and marshes (e.g., soil microbes showed high equitability and α diversity, but plant diversity was restricted to a few dominant species with high aggregation). However, species abundance distribution, aggregation, and density patterns were not directly associated with differences between created and reference marshes. One exception was considerably lower density for macroinfauna at one of the created marshes, which was drier because of being at a higher elevation and having coarser substrate compared with the other marshes. The community compositions of created marshes were more dissimilar than reference marshes for microbe and macroinfauna assemblages. However, differences were small, particularly for microbes. Together, our results suggest generally similar taxonomic diversity and composition between created and reference marshes. This ...
Keywords	diversity ; estuary ; restoration ; salt marshes ; spatial scale ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study.

Woodford, John / Gillman, Ashley / Jenvey, Peter / Roberts, Jennie / Woolley, Stephen / Barber, Bridget E / Fernandez, Melissa / Rose, Stephen / Thomas, Paul / Anstey, Nicholas M / McCarthy, James S

PLoS medicine

2021 Volume 18, Issue 5, Page(s) e1003567

Abstract: ... little is known about the behavior of P. vivax outside of the circulating compartment. This may be due ... To identify organ-specific changes during the early stages of P. vivax infection, we performed 18-F ... to onset of clinical illness in P. vivax experimentally induced blood-stage malaria (IBSM) and compared ...

Abstract	Background: Plasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium falciparum, which is known to undergo microvascular tissue sequestration, little is known about the behavior of P. vivax outside of the circulating compartment. This may be due in part to difficulties in studying parasite location and activity in life. Methods and findings: To identify organ-specific changes during the early stages of P. vivax infection, we performed 18-F fluorodeoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) at baseline and just prior to onset of clinical illness in P. vivax experimentally induced blood-stage malaria (IBSM) and compared findings to P. falciparum IBSM. Seven healthy, malaria-naive participants were enrolled from 3 IBSM trials: NCT02867059, ACTRN12616000174482, and ACTRN12619001085167. Imaging took place between 2016 and 2019 at the Herston Imaging Research Facility, Australia. Postinoculation imaging was performed after a median of 9 days in both species (n = 3 P. vivax; n = 4 P. falciparum). All participants were aged between 19 and 23 years, and 6/7 were male. Splenic volume (P. vivax: +28.8% [confidence interval (CI) +10.3% to +57.3%], P. falciparum: +22.9 [CI -15.3% to +61.1%]) and radiotracer uptake (P. vivax: +15.5% [CI -0.7% to +31.7%], P. falciparum: +5.5% [CI +1.4% to +9.6%]) increased following infection with each species, but more so in P. vivax infection (volume: p = 0.72, radiotracer uptake: p = 0.036). There was no change in FDG uptake in the bone marrow (P. vivax: +4.6% [CI -15.9% to +25.0%], P. falciparum: +3.2% [CI -3.2% to +9.6%]) or liver (P. vivax: +6.2% [CI -8.7% to +21.1%], P. falciparum: -1.4% [CI -4.6% to +1.8%]) following infection with either species. In participants with P. vivax, hemoglobin, hematocrit, and platelet count decreased from baseline at the time of postinoculation imaging. Decrements in hemoglobin and hematocrit were significantly greater in participants with P. vivax infection compared to P. falciparum. The main limitations of this study are the small sample size and the inability of this tracer to differentiate between host and parasite metabolic activity. Conclusions: PET/MRI indicated greater splenic tropism and metabolic activity in early P. vivax infection compared to P. falciparum, supporting the hypothesis of splenic accumulation of P. vivax very early in infection. The absence of uptake in the bone marrow and liver suggests that, at least in early infection, these tissues do not harbor a large parasite biomass or do not provoke a prominent metabolic response. PET/MRI is a safe and noninvasive method to evaluate infection-associated organ changes in morphology and glucose metabolism.
MeSH term(s)	Bone Marrow/metabolism ; Bone Marrow/parasitology ; Bone Marrow/pathology ; Female ; Glucose/metabolism ; Humans ; Liver/metabolism ; Liver/parasitology ; Liver/pathology ; Magnetic Resonance Imaging ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/pathology ; Malaria, Falciparum/physiopathology ; Malaria, Vivax/parasitology ; Malaria, Vivax/pathology ; Malaria, Vivax/physiopathology ; Male ; Plasmodium falciparum ; Plasmodium vivax ; Positron-Emission Tomography ; Prospective Studies ; Queensland ; Spine/metabolism ; Spine/parasitology ; Spine/pathology ; Spleen/metabolism ; Spleen/parasitology ; Spleen/pathology ; Young Adult
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185925-5
ISSN	1549-1676 ; 1549-1277
ISSN (online)	1549-1676
ISSN	1549-1277
DOI	10.1371/journal.pmed.1003567
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Article ; Online: Correction

Thamir Alandijany / Ashley P E Roberts / Kristen L Conn / Colin Loney / Steven McFarlane / Anne Orr / Chris Boutell

PLoS Pathogens, Vol 14, Iss 2, p e

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.

2018 Volume 1006927

Abstract: This corrects the article DOI:10.1371/journal.ppat.1006769.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.ppat.1006769.].
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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