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  1. Article ; Online: In Memoriam: Sidney Starkman.

    Carmichael, S Thomas / Saver, Jeffrey L

    Stroke

    2024  Volume 55, Issue 4, Page(s) 785–786

    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.124.046432
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    Zs.A 448: Show issues Location:
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  2. Article ; Online: A Funeral for a Neurologist.

    Carmichael, S Thomas

    JAMA neurology

    2022  Volume 80, Issue 1, Page(s) 9

    MeSH term(s) Humans ; Neurologists
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2022.3796
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  3. Article ; Online: The emergence of multiscale connectomics-based approaches in stroke recovery.

    Latifi, Shahrzad / Carmichael, S Thomas

    Trends in neurosciences

    2024  Volume 47, Issue 4, Page(s) 303–318

    Abstract: Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments in brain readout technologies and progress in ...

    Abstract Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments in brain readout technologies and progress in complex network modeling have revolutionized current understanding of the effects of stroke on brain networks at a macroscale, reorganization of smaller scale brain networks remains incompletely understood. In this review, we use a conceptual framework of graph theory to define brain networks from nano- to macroscales. Highlighting stroke-related brain connectivity studies at multiple scales, we argue that multiscale connectomics-based approaches may provide new routes to better evaluate brain structural and functional remapping after stroke and during recovery.
    MeSH term(s) Adult ; Humans ; Connectome ; Stroke ; Brain ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2024.01.003
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    Zs.A 1442: Show issues Location:
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  4. Article ; Online: Connecting the lines after a stroke.

    Carmichael, S Thomas

    eLife

    2022  Volume 11

    Abstract: In mice, stimulating cortical areas in the undamaged hemisphere of a brain affected by stroke impairs recovery. ...

    Abstract In mice, stimulating cortical areas in the undamaged hemisphere of a brain affected by stroke impairs recovery.
    MeSH term(s) Animals ; Brain ; Brain Mapping ; Humans ; Mice ; Neuronal Plasticity ; Recovery of Function ; Stroke ; Stroke Rehabilitation
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Editorial
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.81306
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  5. Book ; Online ; E-Book: Broken movement

    Krakauer, John W. / Carmichael, S. Thomas

    the neurobiology of motor recovery after stroke

    2017  

    Title variant Neurobiology of motor recovery after stroke
    Author's details John W. Krakauer and S. Thomas Carmichael
    Keywords Stroke Rehabilitation / methods ; Motor Activity / physiology ; Recovery of Function ; Psychomotor Performance ; Neurobiology
    Subject code 616.8/1
    Language English
    Size 1 Online-Ressource (xiv, 269 Seiten), Illustrationen
    Publisher The MIT Press
    Publishing place Cambridge, Massachusetts
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019715432
    ISBN 978-0-262-34396-1 ; 9780262037228 ; 9780262545839 ; 0-262-34396-7 ; 026203722X ; 0262545837
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia.

    Carmichael, S Thomas / Llorente, Irene L

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2022  Volume 20, Issue 1, Page(s) 39–47

    Abstract: White matter injury is a progressive vascular disease that leads to neurological deficits and vascular dementia. It comprises up to 30% of all diagnosed strokes, though up to ten times as many events go undiagnosed in early stages. There are several ... ...

    Abstract White matter injury is a progressive vascular disease that leads to neurological deficits and vascular dementia. It comprises up to 30% of all diagnosed strokes, though up to ten times as many events go undiagnosed in early stages. There are several pathologies that can lead to white matter injury. While some studies suggest that white matter injury starts as small infarcts in deep penetrating blood vessels in the brain, others point to the breakdown of endothelial function or the blood-brain barrier as the primary cause of the disease. Whether due to local endothelial or BBB dysfunction, or to local small infarcts (or a combination), white matter injury progresses, accumulates, and expands from preexisting lesions into adjacent white matter to produce motor and cognitive deficits that present as vascular dementia in the elderly. Vascular dementia is the second leading cause of dementia, and white matter injury-attributed vascular dementia represents 40% of all diagnosed dementias and aggravates Alzheimer's pathology. Despite the advances in the last 15 years, there are few animal models of progressive subcortical white matter injury or vascular dementia. This review will discuss recent progress in animal modeling of white matter injury and the emerging principles to enhance glial function as a means of promoting repair and recovery.
    MeSH term(s) Animals ; Dementia, Vascular/etiology ; Dementia, Vascular/pathology ; White Matter ; Brain/pathology ; Brain Injuries/pathology ; Ischemia/complications ; Ischemia/pathology ; Infarction/complications ; Infarction/pathology
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-022-01322-8
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    Zs.A 6156: Show issues Location:
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  7. Article ; Online: Quantitative Spatial Mapping of Axons Across Cortical Regions to Assess Axonal Sprouting After Stroke.

    Joy, Mary T / Bridges, Samuel P / Carmichael, S Thomas

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2616, Page(s) 171–180

    Abstract: Neurological disease such as a stroke causes death of brain tissue and loss of connectivity. Paradoxically, the stroke itself induces growth of new axonal collaterals, a phenomenon that is restrained in the normal adult brain. Enhancements in sprouting ... ...

    Abstract Neurological disease such as a stroke causes death of brain tissue and loss of connectivity. Paradoxically, the stroke itself induces growth of new axonal collaterals, a phenomenon that is restrained in the normal adult brain. Enhancements in sprouting of axons have been linked with enhancements in motor function. Here, we describe a method developed in-house using standard reagents to map and quantitatively assess differential sprouting responses in stroke and following treatment with candidate molecular or pharmacological targets. This method allows for measurements of axonal growth responses that act as structural correlates for neural repair processes in the brain that aid in stroke recovery.
    MeSH term(s) Humans ; Axons/physiology ; Stroke ; Neurogenesis ; Brain ; Recovery of Function/physiology ; Nerve Regeneration/physiology
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2926-0_13
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  8. Article ; Online: Learning and Stroke Recovery: Parallelism of Biological Substrates.

    Joy, Mary Teena / Carmichael, S Thomas

    Seminars in neurology

    2021  Volume 41, Issue 2, Page(s) 147–156

    Abstract: Stroke is a debilitating disease. Current effective therapies for stroke recovery are limited to neurorehabilitation. Most stroke recovery occurs in a limited and early time window. Many of the mechanisms of spontaneous recovery after stroke parallel ... ...

    Abstract Stroke is a debilitating disease. Current effective therapies for stroke recovery are limited to neurorehabilitation. Most stroke recovery occurs in a limited and early time window. Many of the mechanisms of spontaneous recovery after stroke parallel mechanisms of normal learning and memory. While various efforts are in place to identify potential drug targets, an emerging approach is to understand biological correlates between learning and stroke recovery. This review assesses parallels between biological changes at the molecular, structural, and functional levels during learning and recovery after stroke, with a focus on drug and cellular targets for therapeutics.
    MeSH term(s) Humans ; Learning ; Neuronal Plasticity ; Recovery of Function ; Stroke/drug therapy ; Stroke Rehabilitation
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0041-1725136
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    Zs.A 1737: Show issues Location:
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  9. Article ; Online: Subcortical White Matter Stroke in the Mouse: Inducing Injury and Tracking Cellular Proliferation.

    Marin, Miguel Alejandro / Gleichman, Amy J / Brumm, Andrew J / Carmichael, S Thomas

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2616, Page(s) 13–20

    Abstract: Here, we describe a method for inducing subcortical white matter stroke in mice, as well as tracking cellular proliferation through drinking water administration of EdU and ex vivo labeling. ...

    Abstract Here, we describe a method for inducing subcortical white matter stroke in mice, as well as tracking cellular proliferation through drinking water administration of EdU and ex vivo labeling.
    MeSH term(s) Mice ; Animals ; White Matter/pathology ; Stroke/pathology ; Cell Proliferation ; Hyperplasia/pathology
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2926-0_2
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  10. Article ; Online: A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences.

    Gleichman, Amy J / Kawaguchi, Riki / Sofroniew, Michael V / Carmichael, S Thomas

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7426

    Abstract: Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function. Genetically manipulating astrocytes is an essential tool in understanding and affecting their roles. Adeno-associated ... ...

    Abstract Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function. Genetically manipulating astrocytes is an essential tool in understanding and affecting their roles. Adeno-associated viruses (AAVs) enable rapid genetic manipulation; however, astrocyte specificity of AAVs can be limited, with high off-target expression in neurons and sparsely in endothelial cells. Here, we report the development of a cassette of four copies of six miRNA targeting sequences (4x6T) which triggers transgene degradation specifically in neurons and endothelial cells. In combination with the GfaABC1D promoter, 4x6T increases astrocytic specificity of Cre with a viral reporter from <50% to >99% in multiple serotypes in mice, and confers astrocyte specificity in multiple recombinases and reporters. We also present empty vectors to add 4x6T to other cargo, independently and in Cre/Dre-dependent forms. This toolbox of AAVs allows rapid manipulation of astrocytes throughout the CNS, is compatible with different AAV serotypes, and demonstrates the efficacy of using multiplexed miRNA targeting sequences to decrease expression in multiple off-target cell populations simultaneously.
    MeSH term(s) Mice ; Animals ; Astrocytes/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Serogroup ; Endothelial Cells ; Genetic Vectors/genetics ; Dependovirus/genetics ; Dependovirus/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42746-w
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