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  1. Article ; Online: Investigation of IL6 expression in patients with colorectal adenocarcinoma

    Jósa, Valéria / Féderer, Krisztina / Zrubka, Zsombor / Reiniger, Lilla / Baranyai, Zsolt

    Orvosi hetilap

    2021  Volume 162, Issue 37, Page(s) 1502–1507

    Title translation Az interleukin-6-expresszió vizsgálata colorectalis adenocarcinomában szenvedő betegeken
    MeSH term(s) Adenocarcinoma/genetics ; Colorectal Neoplasms/genetics ; Humans ; Interleukin-6
    Chemical Substances Interleukin-6
    Language Hungarian
    Publishing date 2021-09-12
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2021.32206
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  2. Article ; Online: Gyermekkori agydaganatok: diagnózis és terápia – komprehenzív genomikai profilozás.

    Brückner, Edit / Bedics, Gábor / Reiniger, Lilla / Rajnai, Hajnalka / Jakab, Zsuzsanna / Bödör, Csaba / Scheich, Bálint / Garami, Miklós

    Magyar onkologia

    2023  Volume 67, Issue 4, Page(s) 315–320

    Abstract: With the advancement of molecular oncology, numerous new opportunities are available for the effective and efficient treatment of patients diagnosed with childhood brain tumors. This includes gene panel analysis aiding personalized treatment used in ... ...

    Title translation Childhood brain tumors: diagnosis and therapy - comprehensive genomic profiling.
    Abstract With the advancement of molecular oncology, numerous new opportunities are available for the effective and efficient treatment of patients diagnosed with childhood brain tumors. This includes gene panel analysis aiding personalized treatment used in clinical trials, and the application of targeted therapy independent of tissue type (tumor agnostic therapy). Most personalized therapies inhibit certain kinases. In our review, we present the modern pathological diagnosis of childhood brain tumors, as well as the complex intracellular regulation of signal transduction pathways important from the point of view of clinical practice, and we describe their further targets defined on the basis of pharmacological characteristics of the pathway, based on international and our own results. Despite common mutations affecting kinases, personalized therapy is not available in many types of tumors. Through the example of childhood brain tumors, we demonstrate the expected future therapeutic significance of tyrosine kinases.
    MeSH term(s) Humans ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Signal Transduction/genetics ; Protein-Tyrosine Kinases/genetics ; Biomarkers, Tumor/genetics ; Genomics/methods ; Molecular Targeted Therapy
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Biomarkers, Tumor
    Language Hungarian
    Publishing date 2023-10-30
    Publishing country Hungary
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 414033-3
    ISSN 2060-0399 ; 0025-0244
    ISSN (online) 2060-0399
    ISSN 0025-0244
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  3. Article ; Online: Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas.

    Bedics, Gábor / Szőke, Péter / Bátai, Bence / Nagy, Tibor / Papp, Gergő / Kránitz, Noémi / Rajnai, Hajnalka / Reiniger, Lilla / Bödör, Csaba / Scheich, Bálint

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18436

    Abstract: Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently harboring mutations in the TERT gene promoter (pTERT) and utilizing the subsequent telomerase overexpression for telomere length maintenance. However, some rare cases ... ...

    Abstract Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently harboring mutations in the TERT gene promoter (pTERT) and utilizing the subsequent telomerase overexpression for telomere length maintenance. However, some rare cases show loss of ATRX and use alternative mechanisms of telomere lengthening. In this study, we performed the first complex genomic analysis specifically concentrating on the latter subgroup. Comprehensive genomic profiling of 12 ATRX-deficient and 13 ATRX-intact IDH-wildtype adult high-grade gliomas revealed that ATRX and pTERT mutations are mutually exclusive. DNMT3A alterations were confined to ATRX-deficient, while PTEN mutations to ATRX-intact cases. RAS-MAPK pathway alterations, including NF1 mutations, were more characteristic in the ATRX-deficient group. Variants of genes related to homologous recombination repair showed different patterns of affected genes. Two ATRX-deficient tumors with high tumor mutational burden and mismatch repair deficiency were found. One of these contained a novel fusion involving the NTRK2 and LRRFIP2 genes, while the other showed loss of MSH2 and MSH6 without genetic alterations in the encoding genes suggesting an epigenetic background. Genetic characteristics of ATRX-deficient IDH-wildtype adult high-grade gliomas suggest that these tumors are particularly intriguing targets of potential future therapeutic interventions including immunotherapies combined with MAPK pathway inhibition and DNA repair inhibitors.
    MeSH term(s) Adult ; Humans ; Glioma/genetics ; Glioma/pathology ; Brain Neoplasms/pathology ; Glioblastoma/pathology ; Telomere Homeostasis ; Mutation ; Genomics ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; X-linked Nuclear Protein/genetics
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41) ; ATRX protein, human (EC 3.6.4.12) ; X-linked Nuclear Protein (EC 3.6.4.12)
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45786-w
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  4. Article ; Online: Novel actionable ROS1::GIT2 fusion in non-Langerhans cell histiocytosis with central nervous system involvement.

    Bedics, Gábor / Csóka, Monika / Reiniger, Lilla / Varga, Edit / Liptai, Zoltán / Papp, Gergő / Bekő, Anna / Cervi, Catherine / Bödör, Csaba / Scheich, Bálint

    Acta neuropathologica

    2022  Volume 145, Issue 1, Page(s) 153–156

    MeSH term(s) Humans ; Protein-Tyrosine Kinases ; Proto-Oncogene Proteins ; Histiocytosis ; Central Nervous System ; GTPase-Activating Proteins
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins ; ROS1 protein, human (EC 2.7.10.1) ; GIT2 protein, human ; GTPase-Activating Proteins
    Language English
    Publishing date 2022-11-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-022-02520-6
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  5. Article ; Online: Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas

    Gábor Bedics / Péter Szőke / Bence Bátai / Tibor Nagy / Gergő Papp / Noémi Kránitz / Hajnalka Rajnai / Lilla Reiniger / Csaba Bödör / Bálint Scheich

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently harboring mutations in the TERT gene promoter (pTERT) and utilizing the subsequent telomerase overexpression for telomere length maintenance. However, some rare ... ...

    Abstract Abstract Glioblastomas are the most common IDH-wildtype adult high-grade gliomas, frequently harboring mutations in the TERT gene promoter (pTERT) and utilizing the subsequent telomerase overexpression for telomere length maintenance. However, some rare cases show loss of ATRX and use alternative mechanisms of telomere lengthening. In this study, we performed the first complex genomic analysis specifically concentrating on the latter subgroup. Comprehensive genomic profiling of 12 ATRX-deficient and 13 ATRX-intact IDH-wildtype adult high-grade gliomas revealed that ATRX and pTERT mutations are mutually exclusive. DNMT3A alterations were confined to ATRX-deficient, while PTEN mutations to ATRX-intact cases. RAS–MAPK pathway alterations, including NF1 mutations, were more characteristic in the ATRX-deficient group. Variants of genes related to homologous recombination repair showed different patterns of affected genes. Two ATRX-deficient tumors with high tumor mutational burden and mismatch repair deficiency were found. One of these contained a novel fusion involving the NTRK2 and LRRFIP2 genes, while the other showed loss of MSH2 and MSH6 without genetic alterations in the encoding genes suggesting an epigenetic background. Genetic characteristics of ATRX-deficient IDH-wildtype adult high-grade gliomas suggest that these tumors are particularly intriguing targets of potential future therapeutic interventions including immunotherapies combined with MAPK pathway inhibition and DNA repair inhibitors.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: PD-1 and PD-L1 expression in rare lung tumors.

    Gyulai, Marton / Megyesfalvi, Zsolt / Reiniger, Lilla / Harko, Tunde / Ferencz, Bence / Karsko, Luca / Agocs, Laszlo / Fillinger, Janos / Dome, Balazs / Szallasi, Zoltan / Moldvay, Judit

    Pathology oncology research : POR

    2023  Volume 29, Page(s) 1611164

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Retrospective Studies ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor ; Lung Neoplasms/pathology ; Lung/pathology ; Biomarkers, Tumor/metabolism
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Biomarkers, Tumor
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.3389/pore.2023.1611164
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    Zs.A 4936: Show issues Location:
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  7. Article ; Online: Távoli áttétet adó nem kissejtes tüdõdaganatban szenvedõ betegek immunellenõrzõpont-gátló terápiás lehetõségei.

    Téglási, Vanda / Moldvay, Judit / Szállási, Zoltán / Reiniger, Lilla

    Magyar onkologia

    2019  Volume 63, Issue 3, Page(s) 233–238

    Abstract: Survival of patients with lung cancer is unfavorable. Distant metastasis is detected in more than half of the patients at diagnosis. In advanced stages, platinum-based chemotherapy has been the main therapeutic approach for a long time, however, in 2004 ... ...

    Title translation Possibilities of immune checkpoint inhibitor therapy for patients with metastatic non-small cell lung cancer.
    Abstract Survival of patients with lung cancer is unfavorable. Distant metastasis is detected in more than half of the patients at diagnosis. In advanced stages, platinum-based chemotherapy has been the main therapeutic approach for a long time, however, in 2004 targeted therapies emerged. Recently, PDL1/ PD-1 inhibitors have been introduced in the treatment of metastatic lung cancers, for which the therapeutic criteria are increasingly outlined. Based on international and Hungarian data, it is likely that determination of PD-L1 expression in the primary tumor samples may be sufficient for the establishment of therapeutic indication, if PD-L1 expression of tumor cells remains the sole criterion. However, if the combined positive score, which takes into account PD-L1 expression of both tumor and immune cells, will be introduced as a therapeutic criterion, testing of all the actual tumor samples may be required to initiate treatment, as conventional oncotherapies may affect the PD-L1 expression of immune cells.
    MeSH term(s) B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/immunology ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/metabolism
    Chemical Substances B7-H1 Antigen ; CD274 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language Hungarian
    Publishing date 2019-07-26
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 414033-3
    ISSN 2060-0399 ; 0025-0244
    ISSN (online) 2060-0399
    ISSN 0025-0244
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  8. Article ; Online: Catalog of genetic progression of human cancers: non-Hodgkin lymphoma.

    Bödör, Csaba / Reiniger, Lilla

    Cancer metastasis reviews

    2016  Volume 35, Issue 1, Page(s) 109–127

    Abstract: The recent application of next-generation sequencing technologies lead to significant improvements in our understanding of genetic underpinnings of non-Hodgkin lymphomas with identification of an unexpectedly high number of novel mutation targets across ... ...

    Abstract The recent application of next-generation sequencing technologies lead to significant improvements in our understanding of genetic underpinnings of non-Hodgkin lymphomas with identification of an unexpectedly high number of novel mutation targets across the different B-cell lymphoma entities. These recently discovered molecular lesions are expected to have a major impact on development of novel biomarkers and targeted therapies as well as patient stratification based on the underlying genetic profile. This review will cover the major discoveries in B-cell lymphomas using next-generation sequencing technologies over the last few years, highlighting alterations associated with relapse and progression of these diseases.
    MeSH term(s) Carcinogenesis/genetics ; Disease Progression ; Evolution, Molecular ; High-Throughput Nucleotide Sequencing ; Humans ; Lymphoma, Non-Hodgkin/classification ; Lymphoma, Non-Hodgkin/genetics ; Lymphoma, Non-Hodgkin/pathology ; Mutation ; Neoplasm Proteins/genetics
    Chemical Substances Neoplasm Proteins
    Language English
    Publishing date 2016-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-016-9608-2
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    Zs.A 1812: Show issues Location:
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  9. Article ; Online: Differentially Expressed miRNAs Influence Metabolic Processes in Pituitary Oncocytoma.

    Krokker, Lilla / Nyírő, Gábor / Reiniger, Lilla / Darvasi, Ottó / Szücs, Nikolette / Czirják, Sándor / Tóth, Miklós / Igaz, Péter / Patócs, Attila / Butz, Henriett

    Neurochemical research

    2019  Volume 44, Issue 10, Page(s) 2360–2371

    Abstract: Spindle cell oncocytomas (SCO) of the pituitary are rare tumors accounting for 0.1-0.4% of all sellar tumors. Due to their rarity, little information is available regarding their pathogenesis. Our aim was to investigate miRNA expression profile of ... ...

    Abstract Spindle cell oncocytomas (SCO) of the pituitary are rare tumors accounting for 0.1-0.4% of all sellar tumors. Due to their rarity, little information is available regarding their pathogenesis. Our aim was to investigate miRNA expression profile of pituitary oncocytomas. Total RNA was extracted from 9 formalin-fixed paraffin embedded pituitary samples (4 primary, 3 recurrent oncocytomas and 2 normal tissues). Next-generation sequencing was performed for miRNA profiling. Transcriptome data of additional 6 samples' were obtained from NBCI GEO database for gene expression reanalysis and tissue-specific target prediction. Bioinformatical analysis, in vitro miRNA mimics transfection, luciferase reporter system and AlamarBlue assay were applied to characterize miRNA's function. 54 differentially expressed miRNAs and 485 genes in pituitary SCO vs. normal tissue and 8 miRNAs in recurrent vs. primary SCO were determined. Global miRNA downregulation and decreased level of DROSHA were detected in SCO samples vs. normal tissue. Transcriptome analysis revealed cell cycle alterations while miRNAs influenced mainly metabolic processes (tricarboxylic acid cycle-TCA, carbohydrate, lipid metabolism). Through miRNA-target interaction network the overexpressed Aconitase 2 potentially targeted by two downregulated miRNAs (miR-744-5p, miR-127-3p) was revealed. ACO2 and miR-744-5p interaction was validated by luciferase assay. MiR-127-3p and miR-744-5p significantly decreased cell proliferation in vitro. Our study firstly reported miRNA profile of pituitary oncocytoma. Our results suggest that tumor suppressor miRNAs may have an essential role in the pathogenesis of pituitary oncocytoma. Earlier reports showed downregulated TCA cycle in SCO which is extended by our results adding the role of miR-744-5p targeting ACO2.
    MeSH term(s) Adenoma, Oxyphilic/genetics ; Adenoma, Oxyphilic/metabolism ; Adult ; Biomarkers, Tumor/genetics ; Cell Proliferation/genetics ; Down-Regulation ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/metabolism ; Transcriptome/genetics
    Chemical Substances Biomarkers, Tumor ; MicroRNAs
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-019-02789-2
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    Zs.A 1368: Show issues Location:
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  10. Article: Case of the month 1-2019: CNS high-grade neuroepithelial tumor with

    Haberler, Christine / Reiniger, Lilla / Rajnai, Hajnalka / Kalev, Ognian / Gelpi, Ellen / Tamesberger, Melanie / Pietsch, Torsten

    Clinical neuropathology

    2018  Volume 38, Issue 1, Page(s) 4–7

    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Child, Preschool ; Humans ; Male ; Neoplasms, Neuroepithelial/genetics ; Neoplasms, Neuroepithelial/pathology ; Proto-Oncogene Proteins/genetics ; Repressor Proteins/genetics
    Chemical Substances BCOR protein, human ; Proto-Oncogene Proteins ; Repressor Proteins
    Language English
    Publishing date 2018-12-06
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 603167-5
    ISSN 0722-5091
    ISSN 0722-5091
    DOI 10.5414/NP301162
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