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  1. Article ; Online: Sex matters in preclinical research.

    Justice, Monica J

    Disease models & mechanisms

    2024  Volume 17, Issue 3

    Abstract: International Women's Day 2024 has a theme of inclusion. As publishers of preclinical research, we aim to show how inclusion of females in research advances scientific rigor and improves treatment reliability. Sexual reproduction is key to all life ... ...

    Abstract International Women's Day 2024 has a theme of inclusion. As publishers of preclinical research, we aim to show how inclusion of females in research advances scientific rigor and improves treatment reliability. Sexual reproduction is key to all life across the plant and animal kingdoms. Biological sex takes many forms that are morphologically differentiated during development: stamens versus pistils in plants; color and plumage in birds; fallopian tubes versus vas deferens in mammals; and differences in size, for instance, males are smaller in the fruit fly Drosophila melanogaster. Physical differences may be obvious, but many traits may be more obscure, including hormonal, physiological and metabolic factors. These traits have a big influence on disease and responses to treatment. Thus, we call for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modeling research.
    MeSH term(s) Animals ; Male ; Humans ; Female ; Drosophila melanogaster ; Reproducibility of Results ; Drosophila ; Fallopian Tubes ; Phenotype ; Mammals ; Drosophila Proteins ; DEAD-box RNA Helicases
    Chemical Substances vas protein, Drosophila (EC 3.6.1.-) ; Drosophila Proteins ; DEAD-box RNA Helicases (EC 3.6.4.13)
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: From its roots come branches and growth for Disease Models & Mechanisms.

    Justice, Monica J

    Disease models & mechanisms

    2021  Volume 14, Issue 1

    MeSH term(s) Animals ; Cell Line ; Congresses as Topic ; Developmental Biology/organization & administration ; Developmental Biology/trends ; Disease Models, Animal ; Editorial Policies ; Humans ; Mice ; Publications ; Publishing ; Translational Research, Biomedical/methods
    Language English
    Publishing date 2021-01-24
    Publishing country England
    Document type Editorial
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.048915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: From its roots come branches and growth for Disease Models & Mechanisms

    Monica J. Justice

    Disease Models & Mechanisms, Vol 14, Iss

    2021  Volume 1

    Keywords Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: DMM Prize 2018 winner: Wenqing Zhou.

    Justice, Monica J

    Disease models & mechanisms

    2019  Volume 12, Issue 3

    Abstract: Disease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Prize 2018 is Wenqing Zhou, for her paper entitled 'Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish' ( ... ...

    Abstract Disease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Prize 2018 is Wenqing Zhou, for her paper entitled 'Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish' (Zhou et al., 2018a). The prize of $1000 is awarded to the first author of the paper that is judged by the journal's editors to be the most outstanding contribution to the journal that year. To be considered for the prize, the first author must be a student or a postdoc of no more than 5 years standing.
    MeSH term(s) Animals ; Awards and Prizes ; History, 20th Century ; History, 21st Century ; Periodicals as Topic ; Zebrafish/metabolism
    Language English
    Publishing date 2019-03-26
    Publishing country England
    Document type Biography ; Editorial ; Historical Article ; Portrait
    ISSN 1754-8411
    ISSN (online) 1754-8411
    DOI 10.1242/dmm.039586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Model systems inform rare disease diagnosis, therapeutic discovery and pre-clinical efficacy.

    Enikanolaiye, Adebola / Justice, Monica J

    Emerging topics in life sciences

    2021  Volume 3, Issue 1, Page(s) 1–10

    Abstract: Model systems have played a large role in understanding human diseases and are instrumental in taking basic research findings to the clinic; however, for rare diseases, model systems play an even larger role. Here, we outline how model organisms are ... ...

    Abstract Model systems have played a large role in understanding human diseases and are instrumental in taking basic research findings to the clinic; however, for rare diseases, model systems play an even larger role. Here, we outline how model organisms are crucial for confirming causal associations, understanding functional mechanisms and developing therapies for disease. As diseases that have been studied extensively through genetics and molecular biology, cystic fibrosis and Rett syndrome are portrayed as primary examples of how genetic diagnosis, model organism development and therapies have led to improved patient health. Considering which model to use, yeast, worms, flies, fish, mice or larger animals requires a careful evaluation of experimental genetic tools and gene pathway conservation. Recent advances in genome editing will aid in confirming diagnoses and developing model systems for rare disease. Genetic or chemical screening for disease suppression may reveal functional pathway members and provide candidate entry points for developing therapies. Model organisms may also be used in drug discovery and as preclinical models as a prelude to testing treatments in patient populations. Now, model organisms will increasingly be used as platforms for understanding variation in rare disease severity and onset, thereby informing therapeutic intervention.
    Language English
    Publishing date 2021-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20180057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Developmental disorders Journal Meeting: a collaboration between Development and Disease Models & Mechanisms.

    Hooper, Kirsty M / Justice, Monica J / Patton, E Elizabeth

    Disease models & mechanisms

    2021  Volume 14, Issue 9

    MeSH term(s) Child ; Developmental Disabilities ; Humans
    Language English
    Publishing date 2021-09-13
    Publishing country England
    Document type Editorial
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: DMM Prize 2018 winner

    Monica J. Justice

    Disease Models & Mechanisms, Vol 12, Iss

    Wenqing Zhou

    2019  Volume 3

    Abstract: Disease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Prize 2018 is Wenqing Zhou, for her paper entitled ‘Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish’ ( ... ...

    Abstract Disease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Prize 2018 is Wenqing Zhou, for her paper entitled ‘Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish’ (Zhou et al., 2018a). The prize of $1000 is awarded to the first author of the paper that is judged by the journal's editors to be the most outstanding contribution to the journal that year. To be considered for the prize, the first author must be a student or a postdoc of no more than 5 years standing.
    Keywords Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: CyTOF: An Emerging Technology for Single-Cell Proteomics in the Mouse.

    Tracey, Lauren J / An, Yeji / Justice, Monica J

    Current protocols

    2021  Volume 1, Issue 4, Page(s) e118

    Abstract: The ability to analyze the proteome of single cells is critical for the advancement of studies of steady-state and pathological processes. Mass cytometry, or CyTOF, combines principles of mass spectrometry and flow cytometry to enable single-cell ... ...

    Abstract The ability to analyze the proteome of single cells is critical for the advancement of studies of steady-state and pathological processes. Mass cytometry, or CyTOF, combines principles of mass spectrometry and flow cytometry to enable single-cell analysis of protein expression. CyTOF can simultaneously assess DNA content and proteins and has the capacity to measure 40 to 100 parameters in each cell. Applying this technology to tissues or cells on slides, termed imaging mass cytometry (IMC), allows for visualization of normal and diseased tissues in situ. The high-dimensional proteomic analysis that can be undertaken with CyTOF and IMC has the potential to enhance our understanding of complex and heterogeneous developmental and disease pathways. This article will describe the CyTOF experimental workflow, including reagent selection, sample preparation, and data analysis. CyTOF is compared to flow cytometry, focusing on the strengths and weaknesses of these powerful techniques. Importantly, we review key studies in mouse models of human disease that highlight the strength of CyTOF and IMC to drive discovery research and therapeutic advancement. © 2021 Wiley Periodicals LLC.
    MeSH term(s) Animals ; Flow Cytometry ; Image Cytometry ; Mice ; Proteomics ; Single-Cell Analysis ; Technology
    Language English
    Publishing date 2021-05-19
    Document type Journal Article ; Review
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: From gene to treatment: supporting rare disease translational research through model systems.

    Hmeljak, Julija / Justice, Monica J

    Disease models & mechanisms

    2019  Volume 12, Issue 2

    Abstract: Individual rare diseases may affect only a few people, making them difficult to recognize, diagnose or treat by studying humans alone. Instead, model organisms help to validate genetic associations, understand functional pathways and develop therapeutic ... ...

    Abstract Individual rare diseases may affect only a few people, making them difficult to recognize, diagnose or treat by studying humans alone. Instead, model organisms help to validate genetic associations, understand functional pathways and develop therapeutic interventions for rare diseases. In this Editorial, we point to the key parameters in face, construct, predictive and target validity for accurate disease modelling, with special emphasis on rare disease models. Raising the experimental standards for disease models will enhance successful clinical translation and benefit rare disease research.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Rare Diseases/genetics ; Rare Diseases/therapy ; Reproducibility of Results ; Translational Medical Research
    Language English
    Publishing date 2019-02-22
    Publishing country England
    Document type Editorial
    ISSN 1754-8411
    ISSN (online) 1754-8411
    DOI 10.1242/dmm.039271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14.

    Tracey, Lauren J / Justice, Monica J

    Trends in genetics : TIG

    2019  Volume 35, Issue 7, Page(s) 489–500

    Abstract: Despite advances in chemotherapies that improve cancer survival, most patients who relapse succumb to the disease due to the presence of cancer stem cells (CSCs), which are highly chemoresistant. The pluripotency factor PR domain 14 (PRDM14) has a key ... ...

    Abstract Despite advances in chemotherapies that improve cancer survival, most patients who relapse succumb to the disease due to the presence of cancer stem cells (CSCs), which are highly chemoresistant. The pluripotency factor PR domain 14 (PRDM14) has a key role in initiating many types of cancer. Normally, PRDM14 uses epigenetic mechanisms to establish and maintain the pluripotency of embryonic cells, and its role in cancer is similar. This important link between cancer and induced pluripotency is a key revelation for how CSCs may form: pluripotency genes, such as PRDM14, can expand stem-like cells as they promote ongoing DNA damage. PRDM14 and its protein-binding partners, the ETO/CBFA2T family, are ideal candidates for eliminating CSCs from relevant cancers, preventing relapse and improving long-term survival.
    MeSH term(s) DNA Damage ; DNA-Binding Proteins/physiology ; Epigenesis, Genetic ; Genomic Instability ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Pluripotent Stem Cells/pathology ; RNA-Binding Proteins/physiology ; Transcription Factors/physiology
    Chemical Substances DNA-Binding Proteins ; PRDM14 protein, human ; RNA-Binding Proteins ; Transcription Factors
    Language English
    Publishing date 2019-05-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2019.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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