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  1. Article ; Online: Pancreato-hepatobiliary endoscopy: Cholangioscopy.

    Tsuyuguchi, Toshio

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2021  Volume 34 Suppl 2, Page(s) 107–110

    MeSH term(s) Biliary Tract Surgical Procedures ; Endoscopy ; Endoscopy, Digestive System ; Gallbladder ; Humans ; Laparoscopy
    Language English
    Publishing date 2021-09-29
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14138
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  2. Article: [Diagnosis and treatment of benign biliary stricture except for PSC and IgG4 related-disease].

    Tsuyuguchi, Toshio

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2020  Volume 117, Issue 8, Page(s) 657–666

    MeSH term(s) Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/therapy ; Cholestasis ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/therapy ; Diagnosis, Differential ; Humans ; Immunoglobulin G
    Chemical Substances Immunoglobulin G
    Language Japanese
    Publishing date 2020-08-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.117.657
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  3. Article: Natural history of asymptomatic gallbladder stones in clinic without beds: A long-term prognosis over 10 years.

    Sakai, Yuji / Tsuyuguchi, Toshio / Ohyama, Hiroshi / Kumagai, Junichiro / Kaiho, Takashi / Ohtsuka, Masayuki / Kato, Naoya / Sakai, Tadao

    World journal of clinical cases

    2023  Volume 12, Issue 1, Page(s) 42–50

    Abstract: Background: Several studies have explored the long-term prognosis of patients with asymptomatic gallbladder stones. These reports were primarily conducted in facilities equipped with beds for addressing symptomatic cases.: Aim: To report the long- ... ...

    Abstract Background: Several studies have explored the long-term prognosis of patients with asymptomatic gallbladder stones. These reports were primarily conducted in facilities equipped with beds for addressing symptomatic cases.
    Aim: To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed facilities.
    Methods: We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October 2022. When symptoms developed, patients were transferred to hospitals where appropriate treatment was possible. We investigated the asymptomatic and survival periods during the follow-up.
    Results: Among the 237 patients, 214 (90.3%) remained asymptomatic, with a mean asymptomatic period of 3898.9279 ± 46.871 d (50-4111 d, 10.7 years on average). Biliary complications developed in 23 patients (9.7%), with a mean survival period of 4010.0285 ± 31.2788 d (53-4112 d, 10.9 years on average). No patient died of biliary complications.
    Conclusion: The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was favorable. When the condition became symptomatic, the patients were transferred to hospitals with beds that could address it; thus, no deaths related to biliary complications were reported. This finding suggests that follow-up care in clinics without beds is possible.
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v12.i1.42
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  4. Article ; Online: Ursodeoxycholic acid is associated with improved long-term outcome in patients with primary sclerosing cholangitis.

    Arizumi, Toshihiko / Tazuma, Susumu / Isayama, Hiroyuki / Nakazawa, Takahiro / Tsuyuguchi, Toshio / Takikawa, Hajime / Tanaka, Atsushi

    Journal of gastroenterology

    2022  Volume 57, Issue 11, Page(s) 902–912

    Abstract: Background: It remains unclear whether ursodeoxycholic acid (UDCA) treatment improves long-term outcomes in patients with primary sclerosing cholangitis (PSC). In this study, we investigated whether UDCA treatment is associated with improved liver ... ...

    Abstract Background: It remains unclear whether ursodeoxycholic acid (UDCA) treatment improves long-term outcomes in patients with primary sclerosing cholangitis (PSC). In this study, we investigated whether UDCA treatment is associated with improved liver transplantation (LT)-free survival in a cohort of Japanese patients with PSC.Journal instruction requires a city and country for affiliations; however, these are missing in affiliation [6]. Please verify if the provided city and country are correct and amend if necessary.'Tokyo, Japan' is correct.
    Methods: We used retrospective data from the Japanese PSC registry that included 435 patients with PSC. In this study, we enrolled patients with a complete dataset at diagnosis, along with the diagnosis year, treatment protocol, follow-up period, and outcome data. The association between UDCA treatment and all-cause death or LT was analyzed using Cox regression and inverse probability of UDCA treatment weighting (IPTW)-adjusted Cox regression models adjusted for covariates.
    Results: Among 435 patients with PSC, 110 were excluded due to insufficient or missing data, and the remaining 325 patients (male, 187 (58%); mean age at diagnosis, 45.8 years) were enrolled. The mean follow-up period was 5.1 years, and 57 deaths and 24 LTs occurred during observation. UDCA was administered to 278 patients (86%). The Cox regression model demonstrated that UDCA treatment was associated with an improvement in LT-free survival [adjusted hazard ratio (aHR) 0.47, 95% confidence interval (CI) 0.28-0.78, p = 0.003]. In addition, the IPTW-adjusted model indicated a significant association between UDCA and LT-free survival (aHR 0.43, 95% CI 0.25-0.75, p = 0.020). Sensitivity analysis excluding patients treated with bezafibrate indicated a similarly significant association between UDCA treatment and LT-free survival.
    Conclusion: In this Japanese PSC cohort, UDCA treatment was significantly associated with improved LT-free survival.
    MeSH term(s) Humans ; Male ; Middle Aged ; Ursodeoxycholic Acid/therapeutic use ; Cholagogues and Choleretics/therapeutic use ; Cholangitis, Sclerosing/drug therapy ; Cholangitis, Sclerosing/diagnosis ; Bezafibrate/therapeutic use ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Cholagogues and Choleretics ; Bezafibrate (Y9449Q51XH)
    Language English
    Publishing date 2022-09-06
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-022-01914-3
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  5. Article ; Online: Endoscopic recovery of multiple migrated plastic stents during EUS-guided transmural drainage of pancreatic fluid collections.

    Nishikawa, Takao / Okabe, Shinichiro / Tsuyuguchi, Toshio / Kiyono, Soichiro / Saito, Shuichi

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2017  Volume 2, Issue 3, Page(s) 46–47

    Language English
    Publishing date 2017-01-06
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2016.12.012
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  6. Article ; Online: Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct.

    Sakai, Yuji / Ohtsuka, Masayuki / Sugiyama, Harutoshi / Mikata, Rintaro / Yasui, Shin / Ohno, Izumi / Iino, Yotaro / Kato, Jun / Tsuyuguchi, Toshio / Kato, Naoya

    World journal of gastroenterology

    2021  Volume 27, Issue 15, Page(s) 1569–1577

    Abstract: Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low ... ...

    Abstract Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these features, intraductal papillary neoplasm of the bile duct (IPNB), as precancerous lesion of biliary carcinoma. IPNB is currently classified into type 1 that is similar to IPMN, and type 2 that is not similar to IPMN. Many of IPNB spreads superficially, and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression. Prognosis of IPNB is said to be better than normal bile duct cancer.
    MeSH term(s) Bile Duct Neoplasms/diagnostic imaging ; Bile Duct Neoplasms/surgery ; Bile Ducts, Extrahepatic ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/diagnostic imaging ; Cholangiocarcinoma/therapy ; Humans ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/therapy
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i15.1569
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  7. Article ; Online: Endoscopic recovery of multiple migrated plastic stents during EUS-guided transmural drainage of pancreatic fluid collections.

    Nishikawa, Takao / Okabe, Shinichiro / Tsuyuguchi, Toshio / Kiyono, Soichiro / Saito, Shuichi

    Gastrointestinal endoscopy

    2017  Volume 85, Issue 4, Page(s) 860–861

    MeSH term(s) Adult ; Device Removal/methods ; Drainage ; Endoscopy, Digestive System/methods ; Endosonography ; Humans ; Male ; Pancreatic Cyst/surgery ; Prosthesis Failure/adverse effects ; Stents/adverse effects
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2017.02.011
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    Zs.B 283: Show issues Location:
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  8. Article ; Online: Evidence-based clinical practice guidelines for cholelithiasis 2021.

    Fujita, Naotaka / Yasuda, Ichiro / Endo, Itaru / Isayama, Hiroyuki / Iwashita, Takuji / Ueki, Toshiharu / Uemura, Kenichiro / Umezawa, Akiko / Katanuma, Akio / Katayose, Yu / Suzuki, Yutaka / Shoda, Junichi / Tsuyuguchi, Toshio / Wakai, Toshifumi / Inui, Kazuo / Unno, Michiaki / Takeyama, Yoshifumi / Itoi, Takao / Koike, Kazuhiko /
    Mochida, Satoshi

    Journal of gastroenterology

    2023  Volume 58, Issue 9, Page(s) 801–833

    Abstract: The Japanese Society of Gastroenterology first published evidence-based clinical practice guidelines for cholelithiasis in 2010, followed by a revision in 2016. Currently, the revised third edition was published to reflect recent evidence on the ... ...

    Abstract The Japanese Society of Gastroenterology first published evidence-based clinical practice guidelines for cholelithiasis in 2010, followed by a revision in 2016. Currently, the revised third edition was published to reflect recent evidence on the diagnosis, treatment, and prognosis of cholelithiasis conforming to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Following this revision, the present English version of the guidelines was updated and published herein. The clinical questions (CQ) in the previous version were reviewed and rearranged into three newly divided categories: background questions (BQ) dealing with basic background knowledge, CQ, and future research questions (FRQ), which refer to issues that require further accumulation of evidence. Finally, 52 questions (29 BQs, 19 CQs, and 4 FRQs) were adopted to cover the epidemiology, pathogenesis, diagnosis, treatment, complications, and prognosis. Based on a literature search using MEDLINE, Cochrane Library, and Igaku Chuo Zasshi databases for the period between 1983 and August 2019, along with a manual search of new information reported over the past 5 years, the level of evidence was evaluated for each CQ. The strengths of recommendations were determined using the Delphi method by the committee members considering the body of evidence, including benefits and harms, patient preference, and cost-benefit balance. A comprehensive flowchart was prepared for the diagnosis and treatment of gallbladder stones, common bile duct stones, and intrahepatic stones, respectively. The current revised guidelines are expected to be of great assistance to gastroenterologists and general physicians in making decisions on contemporary clinical management for cholelithiasis patients.
    MeSH term(s) Humans ; Evidence-Based Practice ; Gallstones ; Gastrointestinal Tract ; Sphincterotomy, Endoscopic ; Practice Guidelines as Topic
    Language English
    Publishing date 2023-07-15
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-02014-6
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  9. Article ; Online: Long-term effects of endoscopic papillary large balloon dilation in patients with challenging bile duct calculi: A retrospective observational study.

    Kamezaki, Hidehiro / Iwanaga, Terunao / Maeda, Takahiro / Senoo, Jun-Ichi / Sakamoto, Dai / Yasui, Shin / Sugiyama, Harutoshi / Tsuyuguchi, Toshio / Kato, Naoya

    Medicine

    2021  Volume 100, Issue 36, Page(s) e27227

    Abstract: Abstract: Endoscopic papillary large balloon dilation (EPLBD) can be used to treat challenging common bile duct stones. No previous studies have reported intractable cases treated either by EPLBD or mechanical lithotripter use. We aimed to evaluate and ... ...

    Abstract Abstract: Endoscopic papillary large balloon dilation (EPLBD) can be used to treat challenging common bile duct stones. No previous studies have reported intractable cases treated either by EPLBD or mechanical lithotripter use. We aimed to evaluate and compare the long-term effects of EPLBD with mechanical lithotripter use.This retrospective cohort study reviewed data from 153 patients admitted to the Eastern Chiba Medical Center from April 2014 to March 2020, presenting with common bile duct calculi that could not be removed using a basket or balloon catheter. Patients were divided into groups depending on whether the treatment was performed using a mechanical lithotripter or EPLBD. The primary outcome was the recurrence rate of common bile duct calculi, and the secondary outcome was the rate of postoperative adverse events. The Wilcoxon test was used to compare the 2 groups. Statistical significance was set at P < .05.The median age of patients included in the lithotripter and EPLBD groups were 73 years and 83 years, respectively (P = .006), while the sex ratio (male:female) in the groups was 18:13 and 55:67, respectively. The EPLBD group showed a statistically larger median bile duct diameter (13 mm [range: 8-24 mm] vs 11 mm [range: 5-16 mm]; P < .001), larger maximal calculus diameter (median, 13.5 mm [range: 8-25 mm] vs 11 mm [range: 7-16 mm]; P < .001), and shorter median cumulative treatment time after reaching the duodenal papilla (35.5 minutes [range: 10-176 minutes] vs 47 minutes [range: 22-321 minutes]; P = .026) in comparison to the lithotripter group. There was no significant difference in the rate of adverse events between the EPLBD and the mechanical lithotripter groups. The recurrence rate was significantly lower (P = .014) in the EPLBD group.EPLBD increases therapeutic efficacy and reduces treatment duration for patients in whom calculus removal is difficult, without increasing the frequency of adverse events. No serious adverse events were observed. Additionally, EPLBD appears to reduce the risk of long-term recurrence. Future studies are needed to evaluate long-term outcomes in younger patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cholangiopancreatography, Endoscopic Retrograde ; Dilatation ; Disease-Free Survival ; Female ; Gallstones/mortality ; Gallstones/surgery ; Humans ; Japan ; Male ; Middle Aged ; Postoperative Complications ; Retrospective Studies
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000027227
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  10. Article: [PTCS/POCS].

    Tsuyuguchi, Toshio / Sugiyama, Harutoshi / Sakai, Yuji / Yokosuka, Osamu

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 3, Page(s) 520–523

    MeSH term(s) Biliary Tract Neoplasms/diagnostic imaging ; Cholangiography/adverse effects ; Drainage ; Hemorrhage/etiology ; Humans
    Language Japanese
    Publishing date 2015-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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