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  1. Article: The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges.

    Hamel, Mouna / Rolain, Jean-Marc / Baron, Sophie Alexandra

    Microorganisms

    2021  Volume 9, Issue 2

    Abstract: Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance ( ...

    Abstract Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (
    Language English
    Publishing date 2021-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9020442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Rapid Identification of

    Robinne, Simon / Saad, Jamal / Morsli, Madjid / Hamidou, Zelika Harouna / Tazerart, Fatah / Drancourt, Michel / Baron, Sophie Alexandra

    Frontiers in microbiology

    2022  Volume 13, Page(s) 753969

    Abstract: Mycobacteria that form ... ...

    Abstract Mycobacteria that form the
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.753969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: In Vitro Screening of a 1280 FDA-Approved Drugs Library against Multidrug-Resistant and Extensively Drug-Resistant Bacteria.

    Peyclit, Lucie / Baron, Sophie Alexandra / Hadjadj, Linda / Rolain, Jean-Marc

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: Alternative strategies against multidrug-resistant (MDR) bacterial infections are suggested to clinicians, such as drug repurposing, which uses rapidly available and marketed drugs. We gathered a collection of MDR bacteria from our hospital and performed ...

    Abstract Alternative strategies against multidrug-resistant (MDR) bacterial infections are suggested to clinicians, such as drug repurposing, which uses rapidly available and marketed drugs. We gathered a collection of MDR bacteria from our hospital and performed a phenotypic high-throughput screening with a 1280 FDA-approved drug library. We used two Gram positive (Enterococcus faecium P5014 and Staphylococcus aureus P1943) and six Gram negative (Acinetobacter baumannii P1887, Klebsiella pneumoniae P9495, Pseudomonas aeruginosa P6540, Burkholderia multivorans P6539, Pandoraea nosoerga P8103, and Escherichia coli DSM105182 as the reference and control strain). The selected MDR strain panel carried resistance genes or displayed phenotypic resistance to last-line therapies such as carbapenems, vancomycin, or colistin. A total of 107 compounds from nine therapeutic classes inhibited >90% of the growth of the selected Gram negative and Gram positive bacteria at a drug concentration set at 10 µmol/L, and 7.5% were anticancer drugs. The common hit was the antiseptic chlorhexidine. The activity of niclosamide, carmofur, and auranofin was found against the selected methicillin-resistant S. aureus. Zidovudine was effective against colistin-resistant E. coli and carbapenem-resistant K. pneumoniae. Trifluridine, an antiviral, was effective against E. faecium. Deferoxamine mesylate inhibited the growth of XDR P. nosoerga. Drug repurposing by an in vitro screening of a drug library is a promising approach to identify effective drugs for specific bacteria.
    Language English
    Publishing date 2022-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11030291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The History of Colistin Resistance Mechanisms in Bacteria

    Mouna Hamel / Jean-Marc Rolain / Sophie Alexandra Baron

    Microorganisms, Vol 9, Iss 2, p

    Progress and Challenges

    2021  Volume 442

    Abstract: Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance ( mcr ) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial ...

    Abstract Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance ( mcr ) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial strains whose mechanism remains unknown and whose exploitation requires complementary technologies. In this review, through the history of colistin, we underline the methods used over the last decades, both old and recent, to facilitate the discovery of the main colistin resistance mechanisms and how new technological approaches may help to improve the rapid and efficient exploration of new target genes. To accomplish this, a systematic search was carried out via PubMed and Google Scholar on published data concerning polymyxin resistance from 1950 to 2020 using terms most related to colistin. This review first explores the history of the discovery of the mechanisms of action and resistance to colistin, based on the technologies deployed. Then we focus on the most advanced technologies used, such as MALDI-TOF-MS, high throughput sequencing or the genetic toolbox. Finally, we outline promising new approaches, such as omics tools and CRISPR-Cas9, as well as the challenges they face. Much has been achieved since the discovery of polymyxins, through several innovative technologies. Nevertheless, colistin resistance mechanisms remains very complex.
    Keywords polymyxins ; colistin history ; mechanisms of action and resistance ; technological approaches ; innovative technologies ; Biology (General) ; QH301-705.5
    Subject code 900
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: The Antibacterial Effect of Platelets on

    Ezzeroug Ezzraimi, Amina / Hannachi, Nadji / Mariotti, Antoine / Rolland, Clara / Levasseur, Anthony / Baron, Sophie Alexandra / Rolain, Jean-Marc / Camoin-Jau, Laurence

    Biomedicines

    2022  Volume 10, Issue 7

    Abstract: Platelets play an important role in defense against pathogens; however, the interaction ... ...

    Abstract Platelets play an important role in defense against pathogens; however, the interaction between
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10071533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of glyphosate in the emergence of antimicrobial resistance in bacteria?

    Raoult, Didier / Hadjadj, Linda / Baron, Sophie Alexandra / Rolain, Jean-Marc

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue 7, Page(s) 1655–1657

    Abstract: There is a discrepancy between antibiotic use in medicine and agriculture in the intertropical zone and frequency of antibiotic resistance in clinical bacteria in these countries. We provide evidence that glyphosate (a herbicide but also an antibiotic ... ...

    Abstract There is a discrepancy between antibiotic use in medicine and agriculture in the intertropical zone and frequency of antibiotic resistance in clinical bacteria in these countries. We provide evidence that glyphosate (a herbicide but also an antibiotic drug) could be a possible driver of antibiotic resistance in countries where this herbicide is widely used because of modification of the microbial environment. Emergence of resistance in bacteria and fungi is correlated with glyphosate use in the world over the last 40 years.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; Drug Resistance, Bacterial ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Glyphosate
    Chemical Substances Anti-Bacterial Agents ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Corrigendum to "Acquisition of multidrug-resistant bacteria and colistin resistance genes in French medical students on internships abroad" [Travel Med Infect Dis. 39 (2021 Jan-Feb) 101940].

    Dao, Thi Loi / Hoang, Van Thuan / Magmoun, Amal / Ly, Tran Duc Anh / Baron, Sophie Alexandra / Hadjadj, Linda / Canard, Naomie / Drali, Tassadit / Gouriet, Frédérique / Raoult, Didier / Parola, Philippe / Marty, Pierre / Rolain, Jean-Marc / Gautret, Philippe

    Travel medicine and infectious disease

    2023  Volume 54, Page(s) 102610

    Language English
    Publishing date 2023-08-08
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  8. Article ; Online: fosM

    Khabthani, Sami / Hamel, Mouna / Baron, Sophie Alexandra / Diene, Seydina M / Rolain, Jean-Marc / Merhej, Vicky

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 2

    Abstract: Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a ... ...

    Abstract Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; Drug Resistance, Bacterial/genetics ; Fosfomycin/pharmacology ; Humans ; Microbial Sensitivity Tests ; Microbiota
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01712-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  9. Article: The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges

    Hamel, Mouna / Rolain, Jean-Marc / Baron, Sophie Alexandra

    Microorganisms. 2021 Feb. 20, v. 9, no. 2

    2021  

    Abstract: Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (mcr) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial ... ...

    Abstract Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (mcr) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial strains whose mechanism remains unknown and whose exploitation requires complementary technologies. In this review, through the history of colistin, we underline the methods used over the last decades, both old and recent, to facilitate the discovery of the main colistin resistance mechanisms and how new technological approaches may help to improve the rapid and efficient exploration of new target genes. To accomplish this, a systematic search was carried out via PubMed and Google Scholar on published data concerning polymyxin resistance from 1950 to 2020 using terms most related to colistin. This review first explores the history of the discovery of the mechanisms of action and resistance to colistin, based on the technologies deployed. Then we focus on the most advanced technologies used, such as MALDI-TOF-MS, high throughput sequencing or the genetic toolbox. Finally, we outline promising new approaches, such as omics tools and CRISPR-Cas9, as well as the challenges they face. Much has been achieved since the discovery of polymyxins, through several innovative technologies. Nevertheless, colistin resistance mechanisms remains very complex.
    Keywords CRISPR-Cas systems ; colistin
    Language English
    Dates of publication 2021-0220
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9020442
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The risk of pig and chicken farming for carriage and transmission of

    Sudatip, Duangdao / Mostacci, Nadezda / Tiengrim, Surapee / Thamlikitkul, Visanu / Chasiri, Kittipong / Kritiyakan, Anamika / Phanprasit, Wantanee / Thinphovong, Chuanphot / Abdallah, Rim / Baron, Sophie Alexandra / Rolain, Jean-Marc / Morand, Serge / Oppliger, Anne / Hilty, Markus

    Microbial genomics

    2023  Volume 9, Issue 3

    Abstract: South-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin- ... ...

    Abstract South-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin-resistant
    MeSH term(s) Animals ; Humans ; Escherichia coli/genetics ; Colistin/pharmacology ; Chickens ; Escherichia coli Proteins/genetics ; Thailand/epidemiology ; beta-Lactamases/genetics ; Farms
    Chemical Substances Colistin (Z67X93HJG1) ; Escherichia coli Proteins ; beta-Lactamases (EC 3.5.2.6) ; MCR-1 protein, E coli
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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