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Article ; Online: Conventional Rotary Technique and Piezosurgical Technique in the Removal of Impacted Mandibular Third Molar: A Comparative Study.

Hamza, Shameem P / Aslam, Sachin / Roshni, A / Cherian, Mathew Pynummoottil / Soman, Sooraj / Akhila, K

The journal of contemporary dental practice

2023 Volume 24, Issue 2, Page(s) 97–102

Abstract: Aim: To compare the operating time, postoperative pain, edema, trismus, and patient acceptance following surgical removal of impacted third molar using piezosurgery and conventional rotary technique.: Materials and methods: About 42 patients with ... ...

Abstract	Aim: To compare the operating time, postoperative pain, edema, trismus, and patient acceptance following surgical removal of impacted third molar using piezosurgery and conventional rotary technique. Materials and methods: About 42 patients with impacted mesioangular mandibular third molars were included in this study. Subjects are divided into two groups: group I (treated with conventional rotary technique) and group II (treated with piezosurgery). Duration of surgery, pain, trismus, and swelling were assessed. The patients were evaluated on the 1st, 3rd, and 7th postoperative days. Results: Postoperative pain, trismus, and edema were reduced with piezosurgery compared with conventional technique. Even though the duration of time was longer with piezosurgery, patient comfort was found to be better. Conclusion: Piezosurgery is a meticulous and innovative ultrasonic technique with selective bone cutting and better postoperative outcomes. However, it is expensive, and the operating time is prolonged. Clinical significance: Piezosurgery is an alternative in the surgical removal of third molars as it ensures precise and selective cutting, with no injury to the surrounding soft tissues. Postoperative outcome and patient acceptance are improved with piezosurgery.
MeSH term(s)	Humans ; Molar, Third/surgery ; Trismus/etiology ; Tooth Extraction/methods ; Pain, Postoperative/prevention & control ; Tooth, Impacted/surgery ; Edema/etiology
Language	English
Publishing date	2023-02-01
Publishing country	India
Document type	Journal Article
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3469
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Article ; Online: Dosimetric comparison of 3DCRT and IMRT in radical chemoradiotherapy of squamous cell carcinoma esophagus.

Krishnapriya, P / Sivanandan, C D / Roshni, S / Sarin, B / Geethi, M H / Jagathnath Krishna, K M

Journal of cancer research and therapeutics

2023 Volume 19, Issue 7, Page(s) 1844–1851

Abstract: Background: Radical chemoradiation is the standard of treatment for locally advanced squamous cell carcinoma of esophagus and for patients with operable disease, but who are medically unfit or unwilling for surgery. As the esophagus is a central organ, ... ...

Abstract	Background: Radical chemoradiation is the standard of treatment for locally advanced squamous cell carcinoma of esophagus and for patients with operable disease, but who are medically unfit or unwilling for surgery. As the esophagus is a central organ, the planning target volume (PTV) is central, lies close to the spinal cord and heart, and is surrounded by the lung, which is a radiosensitive organ. Irradiation of these critical structures is reduced by the use of three-dimensional conformal radiation therapy (3DCRT). Intensity-modulated radiation therapy (IMRT) has the potential to improve the uniformity of dose distribution to the tumor and reduce the dose received by surrounding normal tissues. Aim and objectives: 1. To compare the dose distribution, conformity, and homogeneity indices in radical radiotherapy of squamous cell carcinoma of esophagus using 3DCRT and IMRT techniques 2. To compare the doses received by critical structures such as heart, lung, spinal cord, and liver. Materials and methods: All cases of squamous cell carcinoma esophagus treated with radical chemoradiation to a dose of 50 Gy in 25 fractions using 3DCRT technique from January 2018 to July 2019 were included. IMRT plans were generated for these cases.The parameters that represent dose distribution to the target volume and the dose received by the organs at risk were obtained from the dose-volume histogram. The difference in the mean values of the parameters between the two techniques was calculated. The statistical significance of the difference was determined using Student's t-test and Wilcoxon signed-rank test. Results: The volume of PTV receiving 105% and 107% of prescribed dose was significantly lower with IMRT (3.540% and 0.008%, respectively) compared to 3DCRT (7.654% and 0.623%). The homogeneity index was better with IMRT (0.088 vs. 0.107) than 3DCRT. Conformity index was found to be better with IMRT (1.149 vs. 1.573). Mean heart dose (18.216 vs. 24.591 Gy) and the volume of heart receiving 30 Gy were reduced with IMRT. The volume of lung receiving 20 Gy and the volume receiving 5 Gy were not significantly different between 3DCRT and IMRT. Maximum dose to spinal cord was similar with 3DCRT and IMRT. Conclusions: IMRT avoids areas of excessive irradiation within the PTV. IMRT improves dose conformity to the target volume and homogeneity of dose distribution within the PTV. The cardiac dose is significantly reduced with IMRT. The mean lung dose remains similar to 3DCRT. There is no significant increase in the volume of lung receiving low-dose radiation with IMRT.
MeSH term(s)	Humans ; Radiotherapy, Intensity-Modulated ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Chemoradiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Esophageal Neoplasms
Language	English
Publishing date	2023-04-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_1664_21
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Article: Reproductive ecology of an invasive cichlid fish oreochromis mossambicus

Roshni, K. / Renjithkumar, C.R.

Indian journal of ecology. 2020 Dec., v. 47, no. 4

2020

Abstract: ... sex ratio was 1:1.40 (X²=17.83, p< 0.05), which significantly deviated from theoretical 1:1 distribution ...

Abstract	Reproductive ecology of an invasive cichlid, Oreochromis mossambicus was studied using 654 specimens collected from Vembanad Lake, Kerala state. Females were predominant in the catches and the overall sex ratio was 1:1.40 (X²=17.83, p< 0.05), which significantly deviated from theoretical 1:1 distribution with 41.74% males and 58.26% females. Males and females in reproductive activity occurred throughout the year, the peak spawning period occurring between May to August and November to December. The length at which 50% (L) of the fish were mature was 154.88 mm TL for males and 141.72 mm TL for females. The absolute fecundity ofO. mossambicus varied from 644-2210 eggs/fish with an average of 1469 and the relative fecundity ranged from10.12-19.23 eggs/g with an average of 15.54. Continuous spawning pattern, extreme parental care, fast sexual maturation, comparatively small eggs, predominance of females and tolerance to a wide range of environmental conditions promote the high recruitment of this invasive species in the lake and the adjoining rivers.
Keywords	Oreochromis mossambicus ; ecology ; fecundity ; fish ; invasive species ; lakes ; sex ratio ; sexual maturity ; India
Language	English
Dates of publication	2020-12
Size	p. 1180-1184.
Publishing place	Indian Ecological Society
Document type	Article
ZDB-ID	193796-0
ISSN	0304-5250
ISSN	0304-5250
Database	NAL-Catalogue (AGRICOLA)

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Article: Insight into sea water intrusion due to pumping: a case study of Ernakulam coast, India

Pramada, S. K. / Minnu, K. P. / Roshni, Thendiyath

ISH journal of hydraulic engineering. 2021 Oct. 02, v. 27, no. 4

2021

Abstract: Extensive groundwater extraction and rise in sea level in coastal aquifers leads to saline water intrusion and contamination of groundwater. It requires practical measures to protect the available resources from pollution, saltwater intrusion, and other ... ...

Abstract	Extensive groundwater extraction and rise in sea level in coastal aquifers leads to saline water intrusion and contamination of groundwater. It requires practical measures to protect the available resources from pollution, saltwater intrusion, and other contaminants. This study analyses the Ernakulam coast of Kerala State, India, which is repeatedly reported for saline intrusion into the wells of this coastal aquifer. The optimal pumpages to arrest the deterioration of the aquifer has been derived using a linked simulation-optimization approach and response matrix approach. Simulation model was developed using SEAWAT. The results showed an increasing trend of rapid movement of interface in the Chellanam area in Ernakulam coast. Using optimization techniques, optimum rates for the wells were found out. The SEAWAT simulation model ensemble with optimization model permits the determination of optimum pumping from Ernakulam coastal aquifer, which is a viable management option.
Keywords	aquifers ; case studies ; coasts ; groundwater contamination ; groundwater extraction ; saltwater intrusion ; sea level ; simulation models ; India
Language	English
Dates of publication	2021-1002
Size	p. 442-451.
Publishing place	Taylor & Francis
Document type	Article
ISSN	2164-3040
DOI	10.1080/09715010.2018.1553642
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Article ; Online: β-Ni(OH)2 supported over g-C3N4

C.P. Roshni / K. Jithesh / M. Manuraj / K. Govind Raj / R.B. Rakhi

Results in Chemistry, Vol 4, Iss , Pp 100498- (2022)

A novel catalyst for para-nitrophenol reduction and supercapacitor electrode

2022

Abstract: β-Ni(OH)2 supported over g-C3N4 was synthesized by two simple approaches. Its catalytic activity in reducing hazardous para-nitrophenol (PNP) to the industrially important para-aminophenol (PAP) was studied in detail. The applicability of this material ... ...

Abstract	β-Ni(OH)2 supported over g-C3N4 was synthesized by two simple approaches. Its catalytic activity in reducing hazardous para-nitrophenol (PNP) to the industrially important para-aminophenol (PAP) was studied in detail. The applicability of this material as a supercapacitor electrode was also studied. The material shows 100% conversion efficiency with a rate constant of 65.4410 × 10−3 s−1. The catalytic efficiency and the supercapacitor electrode behaviour of the material can be explained based on the structure of β-Ni(OH)2 nanoparticle and the synergy between β-Ni(OH)2 and g-C3N4.
Keywords	Carbon nitride ; Catalytic reduction ; Nickel hydroxide ; Para-nitrophenol ; Supercapacitor ; Chemistry ; QD1-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and electrophysiological correlates of hopelessness in the context of suicide risk

Ballard, Elizabeth D / Nischal, Roshni P / Burton, Courtney R / Greenstein, Deanna K / Anderson, Grace E / Waldman, Laura R / Zarate, Carlos A / Gilbert, Jessica R

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2024 Volume 80, Page(s) 38–45

Abstract: Hopelessness is a key risk factor for suicide. This analysis explored whether hopelessness indicates a recent suicide crisis state and is linked with magnetoencephalography (MEG) oscillatory power and effective connectivity differences. Change in ... ...

Abstract	Hopelessness is a key risk factor for suicide. This analysis explored whether hopelessness indicates a recent suicide crisis state and is linked with magnetoencephalography (MEG) oscillatory power and effective connectivity differences. Change in hopelessness ratings and effective connectivity post-ketamine were also evaluated in a subsample of high-risk individuals to evaluate correlates of dynamic changes over time. Participants (66F;44 M;1 transgender) included individuals with suicide crisis in the last two weeks (High Risk (HR), n = 14), those with past suicide attempt but no recent suicide ideation (SI) (Low Risk (LR), n = 37), clinical controls (CC, n = 33), and healthy volunteers at minimal risk (MinR, n = 27). MEG oscillatory power and clinical hopelessness ratings (via the Beck Hopelessness Scale (BHS)) were evaluated across groups. Dynamic casual modeling (DCM) evaluated connectivity within and between the anterior insula (AI) and anterior cingulate cortex (ACC). A subsample of HR individuals who received ketamine (n = 10) were evaluated at Day 1 post-infusion. The HR group reported the highest levels of hopelessness, even when adjusting for SI. MEG results linked hopelessness with reduced activity across frequency bands in salience network regions, with no group or group-by-interaction effects. Using DCM, the HR group had reduced intrinsic drive from granular Layer IV stellate cells to superficial pyramidal cells in the ACC and AI. In the pilot HR study, reduced hopelessness was linked with increased drive for this same connection post-ketamine. Hopelessness is a possible proxy for suicide risk. Electrophysiological targets for hopelessness include widespread reductions in salience network activity, particularly in the ACC and AI.
MeSH term(s)	Humans ; Ketamine/pharmacology ; Suicide, Attempted ; Suicidal Ideation ; Affect ; Risk Factors
Chemical Substances	Ketamine (690G0D6V8H)
Language	English
Publishing date	2024-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2023.12.002
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Article ; Online: Exploring the Effect of Trataka (A Yogic Cleansing Technique) and Cold Eye Pack on Eye Strain During COVID-19 Pandemic: A Randomized Three-Arm Trial.

Saoji, Apar Avinash / Swathi, P S / Bhat, Raghavendra / Bansal, Bhavit / Mohanty, Sriloy / Raj Lakshmi, R K Roshni

Journal of integrative and complementary medicine

2023 Volume 30, Issue 4, Page(s) 345–351

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Asthenopia/therapy ; COVID-19 ; Meditation ; Pandemics ; Syndrome ; Yoga
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ISSN	2768-3613
ISSN (online)	2768-3613
DOI	10.1089/jicm.2023.0175
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Article ; Online: Current Perspective of COVID-19 on Neurology: A Mechanistic Insight.

Kumar, Rajesh / Harilal, Seetha / M, Sabitha / Pappachan, Leena K / P R, Roshni / Mathew, Bijo

Combinatorial chemistry & high throughput screening

2021 Volume 25, Issue 5, Page(s) 763–767

Abstract: SARS-CoV-2, the novel coronavirus and the causative organism of the Covid-19 pandemic wreaked havoc worldwide producing asymptomatic to symptomatic cases leading to significant morbidity and mortality even after infection. Most of the countries reported ... ...

Abstract	SARS-CoV-2, the novel coronavirus and the causative organism of the Covid-19 pandemic wreaked havoc worldwide producing asymptomatic to symptomatic cases leading to significant morbidity and mortality even after infection. Most of the countries reported a mortality rate of 2-3 % majorly due to cardiorespiratory failures. Recent studies highlighted the neurological involvement playing a key role in cardiorespiratory failures and other symptoms such as headache, anosmia, and ageusia observed in Covid-19 patients. Studies suggest SARS-CoV-2 entry via Olfactory Epithelium (OE), and the expression of type 2 transmembrane serine protease (TMPRSS2) in addition to Angiotensin-Converting Enzyme 2 (ACE2) can facilitate SARS-CoV-2 neurotropism. The virus can either travel via peripheral blood vessel causing endothelial dysfunction, triggering coagulation cascade and multiple organ dysfunction or reach the systemic circulation and take a different route to the Blood-Brain Barrier (BBB), disrupting the BBB causing neuroinflammation or neuronal excitotoxicity resulting in the development of encephalitis, encephalopathy, seizures, and strokes. SARS-CoV-2 invasion on the brain stem is believed to be responsible for the cardiorespiratory failures observed in Covid-19 patients. Apart from viral invasion via hematogenous route, SARS-CoV-2 neural invasion via PNS nerve terminal, results in viral replication and retrograde transportation to soma leading to invasion of the CNS including the brain producing neurological manifestations of the disease either in the initial stages or during the course of the disease and even for a long period post-infection in many cases. The ACE2 receptors are expressed in the brain and glial cells and SARS-CoV-2 acts via neuronal as well as nonneuronal pathways. But the exact cell types involved and how they can trigger inflammatory pathways need further in-depth study for the development of targeted therapy.
MeSH term(s)	COVID-19 ; Humans ; Neurology ; Pandemics ; SARS-CoV-2 ; Stroke
Language	English
Publishing date	2021-08-06
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/1386207324666210805121828
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Article ; Online: Advanced virtual mentoring of dentists in oral cancer screening and tobacco cessation - An interventional study.

Nethan, Suzanne T / John, Amrita / Ravi, Priyanka / Dhanasekaran, Kavitha / Babu, Roshni / Hariprasad, Roopa

Indian journal of dental research : official publication of Indian Society for Dental Research

2022 Volume 33, Issue 3, Page(s) 241–246

Abstract: Context: Oral cancer is the third common cancer in India. Its mortality can be reduced through early detection and tobacco cessation ideally by dentists owing to their forte of work.: Aim: This study was conducted to discuss effectiveness of an ... ...

Abstract	Context: Oral cancer is the third common cancer in India. Its mortality can be reduced through early detection and tobacco cessation ideally by dentists owing to their forte of work. Aim: This study was conducted to discuss effectiveness of an advanced tele-mentoring programme in oral cancer screening and tobacco cessation for dentists across India. Settings and design: Online, interventional study. Methods and material: The 14-week long training programme with 52 participants/spokes from across India had weekly hour-long online sessions comprising of an expert-led didactic and case discussions by spokes. Online evaluation (pre- and post-training, post-session), weekly and post-one-year feedback were conducted. Successful spokes attended a hands-on workshop subsequently. Statistical analysis used: One and independent sample t-tests determined the significance of the evaluation scores of the participants. Findings on attitudes and practice-related questions are presented as simple percentages. Results: A notable increase in the overall and per-session mean knowledge score, and confidence in oral cancer screening was observed. Many participants started these services at their clinics, thereby reducing further referrals, and were also motivated to spread community awareness about the same. Conclusion: This tele-mentoring programme, based on the novel Extension for Community Healthcare Outcomes model, is the first oral cancer screening training programme for dentists. This model-comprising of expert didacts, case discussions, and significant spoke-expert interaction-is a promising best-practices tool for reducing the disparity in knowledge and skills regarding oral cancer prevention among dentists across different locations. This would enable these most appropriate healthcare providers to contribute toward the overall goal of oral cancer prevention.
MeSH term(s)	Humans ; Tobacco Use Cessation/methods ; Mentoring ; Dentists ; Counseling/education ; Counseling/methods ; Early Detection of Cancer ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/prevention & control ; Attitude of Health Personnel ; Surveys and Questionnaires ; Practice Patterns, Dentists'
Language	English
Publishing date	2022-12-02
Publishing country	India
Document type	Journal Article
ZDB-ID	1354886-4
ISSN	1998-3603 ; 0970-9290
ISSN (online)	1998-3603
ISSN	0970-9290
DOI	10.4103/ijdr.ijdr_8_21
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Article ; Online: Association of pro-fibrinolytic receptor AnnexinA2 with tissue plasminogen activator/Inhibitor-1 in pre-eclampsia.

Ruikar, Komal / Khode, Vitthal / Shetty, Shilpa S / Sarathkumar, E / Patil, Prakash / Patil, Satish / Bargale, Anil / Sadashiv, Roshni / Shetty, Praveenkumar

African health sciences

2023 Volume 23, Issue 1, Page(s) 309–319

Abstract: ... to control group (p<0.005). AnxA2 expression showed positive correlation with tPA (r=+0.895, p=0.002) and negative ... correlation with PAI-1(r=-0.905, p=0.020) in control group whereas in the PE group AnxA2 expression was ... negatively correlated with tPA ((r=-0.801, p=0.016) and PAI-1 (R=-0.831, P=0.010).: Conclusion: Decreased ...

Abstract	Background: The clinical manifestations of pre-eclampsia are related to placental anti-angiogenic factor alteration. These variations are mainly due to the alteration of plasminolytic components. The study aims to compare the expression of plasminolytic components in the placenta of women with and without pre-eclampsia. Material and methods: The study included pregnant women with pre-eclampsia as PE group (n = 30) and without pre-eclampsia as a control group (n = 30). Placental bed biopsy tissues were collected. AnxA2, tPA, PAI-1 expression in the placental villous tissue was quantitatively evaluated using immunohistochemistry, western blot, and real time-PCR analysis. Results: The results of the study showed a significant decrease in the expression of ANXA2 and increased expression of tPA and PAI-1 in PE group compared to control group (p<0.005). AnxA2 expression showed positive correlation with tPA (r=+0.895, p=0.002) and negative correlation with PAI-1(r=-0.905, p=0.020) in control group whereas in the PE group AnxA2 expression was negatively correlated with tPA ((r=-0.801, p=0.016) and PAI-1 (R=-0.831, P=0.010). Conclusion: Decreased AnxA2 with increased expression of PAI-1 and tPA may be responsible for the altered fibrinolytic activity and play a significant role in pre-eclampsia pathogenesis.
MeSH term(s)	Female ; Humans ; Pregnancy ; Fibrinolysis ; Placenta ; Plasminogen Activator Inhibitor 1/metabolism ; Pre-Eclampsia/metabolism ; Tissue Plasminogen Activator/metabolism ; Annexin A2/metabolism
Chemical Substances	Plasminogen Activator Inhibitor 1 ; Tissue Plasminogen Activator (EC 3.4.21.68) ; SERPINE1 protein, human ; PLAT protein, human (EC 3.4.21.68) ; ANXA2 protein, human ; Annexin A2
Language	English
Publishing date	2023-07-11
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v23i1.33
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