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Article ; Online: Telemedicine as an instrument for cardiological consultation during the COVID-19 pandemic.

Roldán-Gómez, Francisco J / Jordán-Ríos, Antonio / Alvarez-Sangabriel, Amada / Guízar-Sánchez, Carlos / Pérez-de-Isla, Leopoldo / Lasses-Ojeda, Luis A / Domínguez-Rivera, David U / Correa-Carrera, Ramiro P / Cossío-Aranda, Jorge E

Archivos de cardiologia de Mexico

2020 Volume 90, Issue Supl, Page(s) 88–93

Abstract: Telemedicine is an underused instrument along our healthcare systems. It´s a technological tool that optimizes resources, save money, expands our capacities, decongests our traditional medical services and is an invaluable help for teaching and research. ...

Title translation	Telemedicina como instrumento de consulta cardiológica durante la pandemia COVID-19.
Abstract	Telemedicine is an underused instrument along our healthcare systems. It´s a technological tool that optimizes resources, save money, expands our capacities, decongests our traditional medical services and is an invaluable help for teaching and research. The COVID-19 pandemic is forcing us to expand its use and it gives us the opportunity to design an appropriate implementation.
MeSH term(s)	COVID-19 ; Cardiology/methods ; Cardiovascular Diseases/therapy ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Telemedicine/methods
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	Mexico
Document type	Journal Article
ISSN	1665-1731
ISSN (online)	1665-1731
DOI	10.24875/ACM.M20000065
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Article: Telemedicina como instrumento de consulta cardiológica durante la pandemia COVID-19./ Telemedicine as an instrument for cardiological consultation during the COVID-19 pandemic

Arch Cardiol Mex

Abstract	Telemedicine is an underused instrument along our healthcare systems. It´s a technological tool that optimizes resources, save money, expands our capacities, decongests our traditional medical services and is an invaluable help for teaching and research. The COVID-19 pandemic is forcing us to expand its use and it gives us the opportunity to design an appropriate implementation.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32523140
Database	COVID19

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Article: Telemedicina como instrumento de consulta cardiológica durante la pandemia COVID-19

Roldán-Gómez, Francisco J. / Jordán-Ríos, Antonio / Alvarez-Sangabriel, Amada / Guízar-Sánchez, Carlos / Pérez-de-Isla, Leopoldo / Lasses-Ojeda, Luis A. / Domínguez-Rivera, David U. / Correa-Carrera, Ramiro P. / Cossío-Aranda, Jorge E.

Arch Cardiol Mex

Abstract: Telemedicine is an underused instrument along our healthcare systems It´s a technological tool that optimizes resources, save money, expands our capacities, decongests our traditional medical services and is an invaluable help for teaching and research ... ...

Abstract	Telemedicine is an underused instrument along our healthcare systems It´s a technological tool that optimizes resources, save money, expands our capacities, decongests our traditional medical services and is an invaluable help for teaching and research The COVID-19 pandemic is forcing us to expand its use and it gives us the opportunity to design an appropriate implementation
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #603308
Database	COVID19

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Article: Inhibir la contractilidad sin provocar necrosis: ¿sería útil en miocardiopatía hipertrófica? Modelo experimental de administración intramiocárdica de toxina botulínica y de wortmanina.

Roldán-Gómez, Francisco Javier / Pavón-Martínez, Natalia / Gálvez-Pérez, Faustino / Vargas-Barrón, Jesús

Archivos de cardiologia de Mexico

2012 Volume 82, Issue 4, Page(s) 320–323

Abstract: The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and ... ...

Title translation	Inhibiting contractility without necrosis: would it be helpful for hypertrophic cardiomyopathy? Experimental model of intramyocardial botulinum toxin and wortmannin.
Abstract	The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.
MeSH term(s)	Androstadienes/administration & dosage ; Androstadienes/pharmacology ; Botulinum Toxins/administration & dosage ; Botulinum Toxins/pharmacology ; Cardiomyopathy, Hypertrophic/drug therapy ; Injections, Intralesional ; Models, Theoretical ; Myocardial Contraction/drug effects ; Necrosis/prevention & control
Chemical Substances	Androstadienes ; Botulinum Toxins (EC 3.4.24.69) ; wortmannin (XVA4O219QW)
Language	Spanish
Publishing date	2012-10
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	2047800-8
ISSN	1405-9940
ISSN	1405-9940
DOI	10.1016/j.acmx.2012.06.007
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Article: La extension de la calcificación aórtica evaluada mediante ecocardiografia asociada a trastornos de la conducción como predictors de marcapasos dedinitivos en el postoperatorio de cambio valvular aórtico.

Ávila-Vanzzini, Nydia / Romero-Aragonés, Cynthia / Verdejo-Paris, Juan / Meléndez-Ramírez, Gabriela / Arias-Godínez, José Antonio / Rodríguez-Chávez, Laura Leticia / Romero-Cárdenas, Ángel / Roldán-Gómez, Francisco Javier / Ruiz-Esparza, María Eugenia / Herrera-Bello, Héctor / Kuri-Alfaro, Jorge

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2015 Volume 66, Issue 6, Page(s) 520–526

Abstract: Introduction: Aortic valve replacement in patients with severe aortic stenosis may be complicated by complete atrioventricular block (CAVB), requiring a permanent pacemaker (PPM) implantation. Predicting this complication could help to plan the surgical. ...

Title translation	Aortic valve calcification evaluated by echocardiography associated with baseline conduction abnormalities as a predictor for pacemaker placement after aortic valve replacement.
Abstract	Introduction: Aortic valve replacement in patients with severe aortic stenosis may be complicated by complete atrioventricular block (CAVB), requiring a permanent pacemaker (PPM) implantation. Predicting this complication could help to plan the surgical. Objective: Determine whether electrocardiography and echocardiography are useful methods for predicting the need for PPM. Material and methods: A retrospective, observational and transversal study was performed. An echocardiography based semi-quantitative classification was implemented to graduate the extent of calcification of the aortic valve. Results: We included 95 patients; 10 of them required PPM implantation (10.52%). In the pre-surgical basal electrocardiogram we observed that 90% of patients that required PPM had conduction abnormalities as opposed to only 24.7% in the other group, p = 0.001. A 1st and 2nd degree AV block (AVB 1 and 2) was identified in 8 patients that subsequently needed PPM (80%) vs. 5 patients (5.9%), in the group that did not required it, p = 0.001.OR 41.7, IC 95% 6.5-68. We found a grade 3 calcification extent in 80% of patients who required PPM implant compared with only 17.6% of patients in the other group, p = 0.04, OR 4.8, IC 95% 0.76-29. The AVB 1 and 2 were the single predictor in multivariate analysis but the calcification 3 + AVB 1 and 2, increased sensibility. Concluison: In patients with aortic stenosis in whom aortic valve replacement was performed, identifying AVB 1 and 2 on the basal electrocardiogram is a useful tool in order to identify requirement of PPM. The grade 3 of calcification extent increased the sensibility of this prediction.
MeSH term(s)	Adult ; Aged ; Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Atrioventricular Block/etiology ; Atrioventricular Block/therapy ; Calcinosis/diagnosis ; Calcinosis/surgery ; Cardiac Pacing, Artificial/methods ; Cross-Sectional Studies ; Echocardiography/methods ; Electrocardiography/methods ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/methods ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Pacemaker, Artificial ; Retrospective Studies
Language	Spanish
Publishing date	2015-03-04
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
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Article: High Molecular Weight ACTH-Precursor Presence in a Metastatic Pancreatic Neuroendocrine Tumor Causing Severe Ectopic Cushing's Syndrome: A Case Report.

Mehta, Roopa / Lam-Chung, César Ernesto / Hinojosa-Amaya, José Miguel / Roldán-Sarmiento, Paola / Guillen-Placencia, Maria Fernanda / Villanueva-Rodriguez, Gerladine / Juarez-Leon, Oscar Alfredo / Leon-Domínguez, Jefsi / Grajales-Gómez, Mariana / Ventura-Gallegos, Jose Luis / León-Suárez, Andrés / Gómez-Pérez, Francisco J / Cuevas-Ramos, Daniel

Frontiers in endocrinology

2020 Volume 11, Page(s) 557

Abstract: Ectopic ACTH-secretion causing Cushing's syndrome is unusual and its diagnosis is frequently challenging. The presence of high-molecular-weight precursors throughout pro-opiomelanocortin (POMC) translation by these tumors is often not reported. We ... ...

Abstract	Ectopic ACTH-secretion causing Cushing's syndrome is unusual and its diagnosis is frequently challenging. The presence of high-molecular-weight precursors throughout pro-opiomelanocortin (POMC) translation by these tumors is often not reported. We present the case of a 49-year-old woman with a 3-month history of proximal muscular weakness, skin pigmentation, and weight loss. Upon initial evaluation, she had a full moon face, hirsutism, and a buffalo hump. Laboratory workup showed hyperglycemia, hypokalemia and metabolic alkalosis. ACTH, plasma cortisol, and urinary free cortisol levels were quite elevated. Serum cortisol levels were not suppressed on dexamethasone suppression testing. An octreo-SPECT scan showed enhanced nucleotide uptake in the liver and pancreas. Transendoscopic ultrasound-guided biopsy confirmed the diagnosis of a pancreatic ACTH-secreting neuroendocrine tumor (NET). Surgical excision of both pancreatic and liver lesions was carried out. Western blot analysis of the tumor and metastases revealed the presence of a high-molecular-weight precursor possibly POMC (at 30 kDa) but not ACTH (normally 4.5 kDa). ACTH-precursor secretion is more frequent in ectopic ACTH-secreting tumors compared with other causes of Cushing's syndrome. Hence, the measurement of such ACTH precursors warrants further evaluation, especially in the context of ACTH-dependent hypercortisolism.
MeSH term(s)	ACTH Syndrome, Ectopic/blood ; ACTH Syndrome, Ectopic/etiology ; ACTH Syndrome, Ectopic/pathology ; Adrenocorticotropic Hormone/blood ; Female ; Humans ; Middle Aged ; Neuroendocrine Tumors/blood ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/pathology ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/secondary
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2020-08-13
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2020.00557
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Article ; Online: 3D Printing of Diffuse Low-Grade Gliomas Involving Eloquent Cortical Areas and Subcortical Functional Pathways: Technical Note.

Gomez-Feria, Jose / Narros, Jose Luis / Ciriza, Gorka Gómez / Roldan-Lora, Florinda / Schrader, Ignacio Martin / Martin-Rodríguez, Juan Francisco / Mir, Pablo

World neurosurgery

2021 Volume 147, Page(s) 164–171.e4

Abstract: Background: Surgical resection of diffuse low-grade gliomas (DLGGs) involving cortical eloquent areas and subcortical functional pathways represents a challenge in neurosurgery. Patient-specific, 3-dimensional (3D)-printed models of head and brain ... ...

Abstract	Background: Surgical resection of diffuse low-grade gliomas (DLGGs) involving cortical eloquent areas and subcortical functional pathways represents a challenge in neurosurgery. Patient-specific, 3-dimensional (3D)-printed models of head and brain structures have emerged in recent years as an educational and clinical tool for patients, doctors, and surgical residents. Methods: Using multimodal high-definition magnetic resonance imaging data, which incorporates information from specific task-based functional neuroimaging and diffusion tensor imaging tractography and rapid prototyping technologies with specialized software and "in-house" 3D printing, we were able to generate 3D-printed head models that were used for preoperative patient education and consultation, surgical planning, and resident training in 2 complicated DLGG surgeries. Results: This 3D-printed model is rapid prototyped and shows a means to model individualized, diffuse, low-level glioma in 3D space with respect to cortical eloquent areas and subcortical pathways. Survey results from 8 surgeons with different levels of expertise strongly support the use of this model for surgical planning, intraoperative surgical guidance, doctor-patient communication, and surgical training (>95% acceptance). Conclusions: Spatial proximity of DLGG to cortical eloquent areas and subcortical tracts can be readily assessed in patient-specific 3D printed models with high fidelity. 3D-printed multimodal models could be helpful in preoperative patient consultation, surgical planning, and resident training.
MeSH term(s)	Adult ; Astrocytoma/diagnostic imaging ; Astrocytoma/pathology ; Astrocytoma/surgery ; Brain Mapping ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Broca Area/diagnostic imaging ; Diffusion Tensor Imaging ; Female ; Functional Neuroimaging ; Glioma/diagnostic imaging ; Glioma/pathology ; Glioma/surgery ; Humans ; Intraoperative Period ; Magnetic Resonance Imaging ; Male ; Models, Anatomic ; Neoplasm Grading ; Neural Pathways/diagnostic imaging ; Neurosurgical Procedures/education ; Neurosurgical Procedures/methods ; Patient Education as Topic ; Patient-Specific Modeling ; Printing, Three-Dimensional ; Pyramidal Tracts/diagnostic imaging ; Wakefulness ; Wernicke Area/diagnostic imaging ; Young Adult
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.12.082
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Article ; Online: Diabetes, Active Disease, and Afternoon Serum Cortisol Levels Predict Cushing's Disease Mortality: A Cohort Study.

Roldán-Sarmiento, Paola / Lam-Chung, César Ernesto / Hinojosa-Amaya, José Miguel / Morales-García, Mariana / Guillén-Placencia, María Fernanda / Pérez-Flores, Greta E / León-Suárez, Andrés / León-Domínguez, Jefsi / Balbuena-Álvarez, Salvador / Nava de la Vega, Alfredo / Pérez-Guzmán, Citlalli Mireya / Gómez-Sámano, Miguel Ángel / Enríquez-Estrada, Víctor / Gómez-Pérez, Francisco J / Cuevas-Ramos, Daniel

The Journal of clinical endocrinology and metabolism

2020 Volume 106, Issue 1, Page(s) e103–e111

Abstract: Context: Cushing's disease (CD) is a life-threating disease, with increased mortality in comparison with the general population.: Objective: This study aimed to evaluate standardized mortality ratios (SMRs) in CD patients. We also analyzed ... ...

Abstract	Context: Cushing's disease (CD) is a life-threating disease, with increased mortality in comparison with the general population. Objective: This study aimed to evaluate standardized mortality ratios (SMRs) in CD patients. We also analyzed independent risk factors related to increased mortality. Design: We conducted a longitudinal cohort study in a 3rd level specialty center, from 1979 to 2018, in patients with CD. Results: From 1375 cases with a pathology diagnosis of pituitary adenoma, 191 cases had the confirmed diagnosis of CD (14%). A total of 172 patients completed follow-up, with a mean age at diagnosis of 33 ± 11 years, female predominance (n = 154, 89.5%), majority of them with microadenoma (n = 136, 79%), and a median follow-up of 7.5 years (2.4-15). Eighteen patients (10.5%) died, 8 of them (44%) were with active CD, 8 (44%) were under remission, and 2 (11%) were under disease control. Estimated all-cause SMR = 3.1, 95% confidence interval (CI) 1.9-4.8, P < 0.001. Cardiovascular disease was the main cause of death (SMR = 4.2, 1.5-9.3, P = 0.01). Multivariate Cox regression models adjusted for potential cofounders showed that diabetes (HR = 5.2, IC 95% 1.8-15.4, P = 0.002), high cortisol levels after 1600 hours at diagnosis (3.4, 2.3-7.0, P = 0.02), and active CD (7.5, 3.8-17.3, P = 0.003) significantly increased the risk of mortality. Conclusions: Main cause of CD mortality was cardiovascular disease. Main risk factors for mortality were uncontrolled diabetes, persistently high cortisol levels after 1600 hours at diagnosis, and active disease at last follow-up.
MeSH term(s)	Adenoma/blood ; Adenoma/complications ; Adenoma/diagnosis ; Adenoma/mortality ; Adult ; Circadian Rhythm ; Cohort Studies ; Disease Progression ; Female ; Follow-Up Studies ; History, 20th Century ; History, 21st Century ; Humans ; Hydrocortisone/blood ; Longitudinal Studies ; Male ; Mexico/epidemiology ; Middle Aged ; Mortality ; Pituitary ACTH Hypersecretion/blood ; Pituitary ACTH Hypersecretion/diagnosis ; Pituitary ACTH Hypersecretion/etiology ; Pituitary ACTH Hypersecretion/mortality ; Pituitary Neoplasms/blood ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/mortality ; Prognosis ; Young Adult
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgaa774
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Article ; Online: Seed Morphology in Key Spanish Grapevine Cultivars

Emilio Cervantes / José Javier Martín-Gómez / Francisco Emmanuel Espinosa-Roldán / Gregorio Muñoz-Organero / Ángel Tocino / Félix Cabello-Sáenz de Santamaría

Agronomy, Vol 11, Iss 734, p

2021 Volume 734

Abstract: ... shared by the two figures, the seed and the model ( J index). The comparison of seed images ...

Abstract	Ampelography, the botanical discipline dedicated to the identification and classification of grapevine cultivars, was grounded on the description of morphological characters and more recently is based on the application of DNA polymorphisms. New methods of image analysis may help to optimize morphological approaches in ampelography. The objective of this study was the classification of representative cultivars of Vitis vinifera conserved in the Spanish collection of IMIDRA according to seed shape. Thirty eight cultivars representing the diversity of this collection were analyzed. A consensus seed silhouette was defined for each cultivar representing the geometric figure that better adjusted to their seed shape. All the cultivars tested were classified in ten morphological groups, each corresponding to a new model. The models are geometric figures defined by equations and similarity to each model is evaluated by quantification of percent of the area shared by the two figures, the seed and the model ( J index). The comparison of seed images with geometric models is a rapid and convenient method to classify cultivars. A large proportion of the collection may be classified according to the new models described and the method permits to find new models according to seed shape in other cultivars.
Keywords	ampelography ; geometry ; grapevine ; morphology ; peduncle ; shape ; Agriculture ; S
Subject code	580
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance.

Rivera-Izquierdo, Mario / Láinez-Ramos-Bossini, Antonio Jesús / Rivera-Izquierdo, Carlos / López-Gómez, Jairo / Fernández-Martínez, Nicolás Francisco / Redruello-Guerrero, Pablo / Martín-delosReyes, Luis Miguel / Martínez-Ruiz, Virginia / Moreno-Roldán, Elena / Jiménez-Mejías, Eladio

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 1

Abstract: Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward ... ...

Abstract	Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain.
Language	English
Publishing date	2021-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10010089
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