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Article: Minimally Invasive Partial vs. Total Adrenalectomy for the Treatment of Unilateral Primary Aldosteronism: A Systematic Review and Meta-Analysis.

Flammia, Rocco Simone / Anceschi, Umberto / Tufano, Antonio / Bologna, Eugenio / Proietti, Flavia / Bove, Alfredo Maria / Misuraca, Leonardo / Mastroianni, Riccardo / Tirone, Giuseppe / Carrara, Alessandro / Luciani, Lorenzo / Cai, Tommaso / Leonardo, Costantino / Simone, Giuseppe

Journal of clinical medicine

2022 Volume 11, Issue 5

Abstract: Background: This systematic review and metanalysis was conducted to assess differences between perioperative and functional outcomes in patients undergoing minimally-invasive partial (mi-PA) and total adrenalectomy (mi-TA) for unilateral primary ... ...

Abstract	Background: This systematic review and metanalysis was conducted to assess differences between perioperative and functional outcomes in patients undergoing minimally-invasive partial (mi-PA) and total adrenalectomy (mi-TA) for unilateral primary aldosteronism (uPHA). Material and methods: Multiple scientific databases (PUBMED, Web of Science, and Cochrane Library) were searched up to November 2021 for surgical series comparing mi-PA vs. mi-TA for uPHA according to the PRISMA statement. Primary outcomes of interest were perioperative and functional outcomes. Results: Overall, a total of 802 patients from six eligible studies were identified, with mi-PA and mi-TA performed in 40.4% ( Conclusions: In a uPHA setting, mi-PA and mi-TA provide comparable perioperative and functional outcomes despite the use of mi-PA remains limited to patients with small adenoma size, or hereditary/bilateral disease. Due to limited use of standardized reporting criteria in most of current series, the quest for a superiority of mi-PA over mi-TA in the treatment of uPHA still remains open.
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11051263
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Teleurology in the Time of Covid-19 Pandemic

Luciani, Lorenzo Giuseppe / Mattevi, Daniele / Cai, Tommaso / Giusti, Guido / Proietti, Silvia / Malossini, Gianni

Urology

Here to Stay?

2020 Volume 140, Page(s) 4–6

Keywords	Urology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2020.04.004
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Teleurology in the Time of Covid-19 Pandemic: Here to Stay?

Luciani, Lorenzo Giuseppe / Mattevi, Daniele / Cai, Tommaso / Giusti, Guido / Proietti, Silvia / Malossini, Gianni

Urology

2020 Volume 140, Page(s) 4–6

Abstract: Objective: To assess the implementation and outcomes of telemedicine in a Department of Urology in Northern Italy during the outbreak of the Covid-19 pandemic.: Methods: All the outpatient clinical activities during the 4 weeks following the national ...

Abstract	Objective: To assess the implementation and outcomes of telemedicine in a Department of Urology in Northern Italy during the outbreak of the Covid-19 pandemic. Methods: All the outpatient clinical activities during the 4 weeks following the national lockdown (March 9-April 3, 2020) in the Department of Urology of the Trento Province, Italy, were reviewed and categorized. Expert staff members examined the electronic records, selecting whether the clinic appointments should be canceled or confirmed (via telephone consultation or face-to-face visit). The rate, indication, and modality of visits were investigated. Results: Overall, 415 of 928 (45%) scheduled patients canceled their clinic appointment themselves or were canceled by staff members without rescheduling. The remaining 523 (55%) cases were screened undergoing telephone consultation in 295 (56%) and face-to-face visit in 228 (44%). The rate of face-to-face visit decreased from 63% to 9% during week 1 and 4, respectively. Seventy-four percent of face-to-face visits regarded suspected recurrent or new onset malignancy or potentially dangerous clinical conditions (severe urinary symptoms or complicated urinary stones or infection). The median age of patients in the face-to-face and telephone groups was 59 (range 20-69) and 65 years old (range 37-88), respectively. Conclusion: A pandemic is a dynamic scenario, requiring reorganization and flexibility of the healthcare delivery. Forty-five percent visits were canceled without rescheduling. Although a minimum portion of face-to-face visit (<10% 1 month after the lockdown) was preserved mostly for suspected malignancy or potentially life-threatening conditions, telemedicine proved a pragmatic approach allowing efficient screening of cases and adequate protection for patients and clinicians.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Telemedicine/organization & administration ; Urology/organization & administration
Keywords	covid19
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2020.04.004
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Minimally Invasive Partial vs. Total Adrenalectomy for the Treatment of Unilateral Primary Aldosteronism

Rocco Simone Flammia / Umberto Anceschi / Antonio Tufano / Eugenio Bologna / Flavia Proietti / Alfredo Maria Bove / Leonardo Misuraca / Riccardo Mastroianni / Giuseppe Tirone / Alessandro Carrara / Lorenzo Luciani / Tommaso Cai / Costantino Leonardo / Giuseppe Simone

Journal of Clinical Medicine, Vol 11, Iss 1263, p

A Systematic Review and Meta-Analysis

2022 Volume 1263

Abstract	Background: This systematic review and metanalysis was conducted to assess differences between perioperative and functional outcomes in patients undergoing minimally-invasive partial (mi-PA) and total adrenalectomy (mi-TA) for unilateral primary aldosteronism (uPHA). Material and Methods: Multiple scientific databases (PUBMED, Web of Science, and Cochrane Library) were searched up to November 2021 for surgical series comparing mi-PA vs. mi-TA for uPHA according to the PRISMA statement. Primary outcomes of interest were perioperative and functional outcomes. Results: Overall, a total of 802 patients from six eligible studies were identified, with mi-PA and mi-TA performed in 40.4% ( n = 324) and 59.6% ( n = 478) of cases, respectively. No differences were recorded between the two groups according to number of transfusions, EBL and Clavien–Dindo complications ≥2. Similarly, no differences in clinical success, persistence of postoperative hypokalemia and improvement in HTN were reported between mi-PA and mi-TA. Conclusions: In a uPHA setting, mi-PA and mi-TA provide comparable perioperative and functional outcomes despite the use of mi-PA remains limited to patients with small adenoma size, or hereditary/bilateral disease. Due to limited use of standardized reporting criteria in most of current series, the quest for a superiority of mi-PA over mi-TA in the treatment of uPHA still remains open.
Keywords	unilateral primary aldosteronism ; Conn’s syndrome ; partial adrenalectomy ; total adrenalectomy ; PASO ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: External Validation of a Novel Comprehensive Trifecta System in Predicting Oncologic and Functional Outcomes of Partial Nephrectomy: Results of a Multicentric Series.

Anceschi, Umberto / Flammia, Rocco Simone / Mattevi, Daniele / Tufano, Antonio / Brassetti, Aldo / Ferriero, Maria Consiglia / Tuderti, Gabriele / Misuraca, Leonardo / Bove, Alfredo Maria / Mastroianni, Riccardo / Marsiliani, Davide / Puglisi, Marco / Cai, Tommaso / Leonardo, Costantino / Gallucci, Michele / Malossini, Gianni / Luciani, Lorenzo Giuseppe / Simone, Giuseppe

Journal of clinical medicine

2022 Volume 11, Issue 3

Abstract: Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset.: Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent ... ...

Abstract	Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset. Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent PN (n = 649). Trifecta was estimated for overall cohort and contributing centers. Overall survival (OS), cancer-specific survival (CSS) and end-stage renal disease (ESRD) probabilities were assessed by Kaplan-Meier. Cox regression was used to identify predictors of OS, CSS, ESRD. For all analyses, a Results: At a median follow-up of 22.7 months (IQR 12.5-76.5) overall trifecta was 76.7% [Centre A; (n = 230; 68.6%), B (n = 68; 77.3%), C (n = 200; 88.4%); Conclusions: On external validation, trifecta was an independent predictor of all PN endpoints, regardless of hilar control and ischemia duration.
Language	English
Publishing date	2022-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11030796
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Predictors of trainees' proficiency during the learning curve of robot-assisted radical prostatectomy at high- -volume institutions: results from a multicentric series.

Anceschi, Umberto / Morelli, Michele / Flammia, Rocco Simone / Brassetti, Aldo / Dell'Oglio, Paolo / Galfano, Antonio / Tappero, Stefano / Vecchio, Enrico / Martiriggiano, Marco / Luciani, Lorenzo Giuseppe / Sperduti, Isabella / Albisinni, Simone / Tuderti, Gabriele / Prata, Francesco / Ferriero, Maria Consiglia / Bove, Alfredo Maria / Mastroianni, Riccardo / Spadaro, Giuseppe / Russo, Andrea /

Mattevi, Daniele / Tufano, Antonio / Leonardo, Costantino / Lombardo, Riccardo / De Nunzio, Cosimo / Cai, Tommaso / Quackels, Thierry / Bocciardi, Aldo Massimo / Simone, Giuseppe

Central European journal of urology

2023 Volume 76, Issue 1, Page(s) 38–43

Abstract: Introduction: The aim of this series was to evaluate predictors of Proficiency score (PS) achievement on a multicentric series of robot-assisted radical prostatectomies (RARP) performed by trainee surgeons with two different surgical techniques at four ... ...

Abstract	Introduction: The aim of this series was to evaluate predictors of Proficiency score (PS) achievement on a multicentric series of robot-assisted radical prostatectomies (RARP) performed by trainee surgeons with two different surgical techniques at four tertiary-care centers. Material and methods: Four institutional datasets were merged and queried for RARPs performed by surgeons during their learning curve (LC) between 2010 and 2020 using two different approaches (Group A, Retzius-sparing RARP, n = 164; Group B, standard anterograde RARP, n = 79). Logistic regression analysis was performed to identify predictors of PS achievement for the overall trainee cohort. For all analyses, a two-sided p <0.05 was considered significant. Results: Group B showed significantly increased median operative time, positive surgical margins (PSM) status, increased number of nerve-sparing procedures, shorter LC time (each p <0.04). PS, continence status, potency, biochemical recurrence and 1-year trifecta rates were comparable between groups (each p >0.3). On multivariable analysis, time from LC starting ≥12 months (OR = 2.79; 95%IC [1.15-6.76]; p = 0.02) and a nerve-sparing intent (OR = 3.18; 95%IC [1.15-8.77]; p = 0.02) were independent predictors of PS score achievement (Table 3). Conclusions: Higher PS rates for RARP trainees may be expected after 12 months from LC beginning. Short-term training courses are unlikely to confer proper surgical training, while long-term structured training programs seem to be beneficial on perioperative outcomes.
Language	English
Publishing date	2023-03-03
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2672528-9
ISSN	2080-4873 ; 2080-4806
ISSN (online)	2080-4873
ISSN	2080-4806
DOI	10.5173/ceju.2023.260
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Article ; Online: External Validation of a Novel Comprehensive Trifecta System in Predicting Oncologic and Functional Outcomes of Partial Nephrectomy

Umberto Anceschi / Rocco Simone Flammia / Daniele Mattevi / Antonio Tufano / Aldo Brassetti / Maria Consiglia Ferriero / Gabriele Tuderti / Leonardo Misuraca / Alfredo Maria Bove / Riccardo Mastroianni / Davide Marsiliani / Marco Puglisi / Tommaso Cai / Costantino Leonardo / Michele Gallucci / Gianni Malossini / Lorenzo Giuseppe Luciani / Giuseppe Simone

Journal of Clinical Medicine, Vol 11, Iss 796, p

Results of a Multicentric Series

2022 Volume 796

Abstract: Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset. Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent PN (n = ...

Abstract	Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset. Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent PN (n = 649). Trifecta was estimated for overall cohort and contributing centers. Overall survival (OS), cancer-specific survival (CSS) and end-stage renal disease (ESRD) probabilities were assessed by Kaplan–Meier. Cox regression was used to identify predictors of OS, CSS, ESRD. For all analyses, a p < 0.05 was considered significant. Results: At a median follow-up of 22.7 months (IQR 12.5–76.5) overall trifecta was 76.7% [Centre A; (n = 230; 68.6%), B (n = 68; 77.3%), C (n = 200; 88.4%); p = 0.001). On Kaplan–Meier, patients achieving trifecta exhibited higher OS ( p = 0.024), higher CSS ( p = 0.015) and lower ESRD rates ( p = 0.024). On multivariable analysis, age (HR 1.04; 95% CI 1.01–1.08) and trifecta (HR 0.34; 95% CI 0.15–0.76) were independent predictors of OS while pT stage (HR 1.95; 95% CI 0.45–8.43) and trifecta (HR 0.33; 95% CI 0.16–0.67) were predictors of CSS (each p < 0.01). Preoperative CKD stage ≥ 3a (HR 13.1; 95% CI 4.07–42.6) and trifecta (HR 0.41; 95% CI 0.19–0.87) were independent predictors of ESRD (each p < 0.05). Conclusions: On external validation, trifecta was an independent predictor of all PN endpoints, regardless of hilar control and ischemia duration.
Keywords	partial nephrectomy ; trifecta ; survival ; end-stage renal disease (ESRD) ; ischemia ; Medicine ; R
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of predictors of early trifecta achievement after robot-assisted radical prostatectomy for trainers and expert surgeons: the learning curve never ends.

Minerva urology and nephrology

2022 Volume 74, Issue 2, Page(s) 133–136

MeSH term(s)	Humans ; Learning Curve ; Male ; Prostate/surgery ; Prostatectomy ; Robotics ; Surgeons
Language	English
Publishing date	2022-04-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.22.04805-4
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Article: Teleurology in the Time of Covid-19 Pandemic: Here to Stay?

Luciani, Lorenzo Giuseppe / Mattevi, Daniele / Cai, Tommaso / Giusti, Guido / Proietti, Silvia / Malossini, Gianni

Urology

Abstract: OBJECTIVE: To assess the implementation and outcomes of telemedicine in a Department of Urology in Northern Italy during the outbreak of the Covid-19 pandemic. METHODS: All the outpatient clinical activities during the 4 weeks following the national ... ...

Abstract	OBJECTIVE: To assess the implementation and outcomes of telemedicine in a Department of Urology in Northern Italy during the outbreak of the Covid-19 pandemic. METHODS: All the outpatient clinical activities during the 4 weeks following the national lockdown (March 9-April 3, 2020) in the Department of Urology of the Trento Province, Italy, were reviewed and categorized. Expert staff members examined the electronic records, selecting whether the clinic appointments should be canceled or confirmed (via telephone consultation or face-to-face visit). The rate, indication, and modality of visits were investigated. RESULTS: Overall, 415 of 928 (45%) scheduled patients canceled their clinic appointment themselves or were canceled by staff members without rescheduling. The remaining 523 (55%) cases were screened undergoing telephone consultation in 295 (56%) and face-to-face visit in 228 (44%). The rate of face-to-face visit decreased from 63% to 9% during week 1 and 4, respectively. Seventy-four percent of face-to-face visits regarded suspected recurrent or new onset malignancy or potentially dangerous clinical conditions (severe urinary symptoms or complicated urinary stones or infection). The median age of patients in the face-to-face and telephone groups was 59 (range 20-69) and 65 years old (range 37-88), respectively. CONCLUSION: A pandemic is a dynamic scenario, requiring reorganization and flexibility of the healthcare delivery. Forty-five percent visits were canceled without rescheduling. Although a minimum portion of face-to-face visit (<10% 1 month after the lockdown) was preserved mostly for suspected malignancy or potentially life-threatening conditions, telemedicine proved a pragmatic approach allowing efficient screening of cases and adequate protection for patients and clinicians.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46814
Database	COVID19

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Article ; Online: Visceral adiposity is associated with worse urinary and sexual function recovery after radical prostatectomy: Results from a longitudinal cohort study.

Cai, Tommaso / Cocci, Andrea / Di Maida, Fabrizio / Chiodini, Stefano / Ciarleglio, Francesco / Luciani, Lorenzo Giuseppe / Pedrotti, Giovanni / Palmieri, Alessandro / Malossini, Gianni / Rizzo, Michele / Liguori, Giovanni / Bjerklund Johansen, Truls E

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2021 Volume 93, Issue 3, Page(s) 285–290

Abstract: Objective: A prospective longitudinal cohort study on the impact of anthropometric measures on the sexual function and continence recovery in patients treated with laparoscopic radical prostatectomy (LRP) is presented.: Material and methods: ... ...

Abstract	Objective: A prospective longitudinal cohort study on the impact of anthropometric measures on the sexual function and continence recovery in patients treated with laparoscopic radical prostatectomy (LRP) is presented. Material and methods: Anthropometric measures, International Index of Erectile Function (IIEF-5) and International Prostatic Symptoms Score questionnaires, were collected before surgery and at the end of follow-up period. All patients were assigned into the following groups: A) non-obese; B) non-obese with central adiposity; C) obese without central adiposity; D) obese with central adiposity. Urinary and sexual functions were the outcome measures. Results: At the end of follow-up, in 29 patients with visceral adiposity (VA) the median IIEF-5 was 14 (IQR 7-18) while in 49 non-VA patients (62.8%) was 22 (IQR 17-24) (p < 0.001). Twenty-three patients (79.3%) with VA reported complete continence, while 6 (20.7%) used ≥ 2 pads per day. Forty-eight patients (97.9%) without VA reported complete continence. VA was confirmed as a strong independent predictor for worse continence (HR 3.67; 2.75-4.51 CI95% p = 0.003) and sexual function recovery (HR: 4.51; 3.09-5.63 CI95% p < 0.001). Conclusion: We truly believe obese with visceral adiposity patients with prostate cancer should receive detailed preoperative counseling before surgery, including higher risk of suboptimal functional outcomes.
MeSH term(s)	Adiposity ; Cohort Studies ; Erectile Dysfunction/epidemiology ; Erectile Dysfunction/etiology ; Humans ; Longitudinal Studies ; Male ; Prospective Studies ; Prostatectomy ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/surgery ; Recovery of Function
Language	English
Publishing date	2021-09-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2021.3.285
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