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Article ; Online: Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China.

Zhou, Wenqian / Guo, Jinping / Li, Yujie / Ma, Xiaoya / Yang, Shuangyu / Wei, Jie / Zhang, Huan / Zhang, Shanshan / Jin, Tianbo

Functional & integrative genomics

2023 Volume 23, Issue 2, Page(s) 85

Abstract: ... among different populations. However, there is little pharmacogenomic information about the Chinese Hui population ... Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical ... foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment ...

Abstract	Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among different populations. However, there is little pharmacogenomic information about the Chinese Hui population. Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment of diseases. This study genotyped 53 VIP variants of 26 genes in 200 independent Hui individuals based on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB). Remarkable differences in the genotype and allele frequencies between the Hui and 26 other populations from the 1000 Genomes Project were assessed using the χ
MeSH term(s)	Humans ; Pharmacogenetics ; Cytochrome P-450 CYP2D6/genetics ; Cyclooxygenase 2/genetics ; Ethnicity/genetics ; Polymorphism, Single Nucleotide ; Genotype ; China ; Arylamine N-Acetyltransferase/genetics
Chemical Substances	Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; NAT2 protein, human (EC 2.3.1.5) ; Arylamine N-Acetyltransferase (EC 2.3.1.5)
Language	English
Publishing date	2023-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01021-3
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Article ; Online: Comparative analysis of the clinical features of nonvalvular atrial fibrillation among Tibetan, Han, and Hui patients in Qinghai Province, China.

Cao, Jiandong / Ma, Xiaofeng / Deng, Yong / Wang, Hong / Zhang, Shengqi / Zhao, Longxiang / Cao, Feifei

Heart & lung : the journal of critical care

2024 Volume 66, Page(s) 9–15

Abstract: ... to compares cardiac features in AF among Tibetan, Han, and Hui patients to develop tailored prevention and ... This study included a total of 3445 Tibetan, Han, and Hui patients diagnosed with nonvalvular ... between Tibetan, Han, and Hui patients (P < 0.05). Tibetan, Han, and Hui patients also differed ...

Abstract	Background: Global nonvalvular AF rises, impacting health severely. In Qinghai, China's diverse setting, studying AF among varied ethnic groups is crucial OBJECTIVES: The purpose of this study was to compares cardiac features in AF among Tibetan, Han, and Hui patients to develop tailored prevention and treatment strategies for this region, the goal was to enhance the understanding of AF and provide an empirical basis for developing prevention and treatment strategies specific to this region METHODS: This study included a total of 3445 Tibetan, Han, and Hui patients diagnosed with nonvalvular atrial fibrillation and treated at the Qinghai Cardiovascular and Cerebrovascular Specialist Hospital, China, between January 2019 and January 2021. We analyzed the differences in cardiac structure, comorbidities, and other influencing factors among the different ethnic groups RESULTS: We found significant differences in gender, age, smoking history, lone atrial fibrillation, left heart failure, dilated cardiomyopathy, and diabetes between Tibetan, Han, and Hui patients (P < 0.05). Tibetan, Han, and Hui patients also differed with regard to left ventricular end-diastolic volume, left ventricular ejection fraction, fractional shortening, NT-proBNP, glycated hemoglobin, red blood cell distribution width, platelet count, platelet hematocrit, platelet distribution width, homocysteine (Hcy), C-reactive protein, and superoxide dismutase (SOD) (P < 0.05) CONCLUSION: Our study revealed variations in comorbidities, cardiac structure, and blood indexes among Tibetan, Han, and Hui AF patients, highlighting distinct patterns in complications and biomarker levels across ethnic groups.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2024.03.001
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Article: Quality of Life and Glucose Regulation in Pediatric Patients with Type 1 Diabetes: A Study in the Ningxia Hui Autonomous Region.

Bai, Hua / He, Na / Zhang, Yan / Ahmad, Aqsa / Yang, Xing-Xing / Ma, Yan / Liang, Li-Jun

Diabetes, metabolic syndrome and obesity : targets and therapy

2024 Volume 17, Page(s) 1267–1278

Abstract: ... in the Ningxia Hui autonomous region.: Methods: The study involved children with T1DM admitted ...

Abstract	Objective: In this study, we aimed to evaluate the current status of the quality of life (QOL) of pediatric patients and plasma glucose concentration regulation in children with type 1 diabetes (T1DM) in the Ningxia Hui autonomous region. Methods: The study involved children with T1DM admitted to the General Hospital of Ningxia Medical University between October 2011 and October 2021. The children and their parents completed general information and quality of life (QOL) questionnaires. The regulation of plasma glucose concentration was assessed based on HbA1c levels, and plasma glucose and QOL-influencing components were investigated. Results: Among the 136 pediatric patients diagnosed with T1DM, the mean glycated hemoglobin (HbA1c) level was recorded at 8.7% (7.2%, 10.5%). A breakdown of the patient cohort revealed that 44 patients (32.4%) demonstrated good regulation of plasma glucose, 33 patients (24.3%) exhibited acceptable glycemic control, and 59 patients (43.3%) displayed poor regulation of plasma glucose. The control of plasma glucose in pediatric patients diagnosed with T1DM was affected by the duration of the disease, the patient's age, the frequency of daily plasma glucose measurements, the use of CGM, diabetic ketoacidosis (DKA), and the education level of the mother. The control of plasma glucose, dietary management, DKA, the ability to learn, and health education are interfering factors of quality of life in children diagnosed with T1DM. Effective control of plasma glucose may ensure the QOL in children with T1DM, and DKA was the risk factor for QOL. Conclusion: In Ningxia, the regulation of plasma glucose in pediatric and adolescent patients with T1DM remains suboptimal, leading to poor QOL. There is a pressing need to enhance glucose regulation and QOL through comprehensive strategies, which include reinforced dietary management, rigorous monitoring of plasma glucose levels, and heightened health education levels.
Language	English
Publishing date	2024-03-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S446387
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Article: [Summary of Hui prescriptions for treating cough].

Zhang, Wen-jin / Liu, Yue / Zhang, Xin-hui

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2015 Volume 40, Issue 4, Page(s) 753–757

Abstract: ... therapy has been screened out from Hui medicine through collecting the ancient and modern literature ... summarizing the common drugs of Hui medicine for asthma are Pinellia, almond, white sugar, walnut. According ... to the commonly used drugs, the pathogeny and treatment principle about Hui medicine for asthma is preliminarily ...

Abstract	In this study, by using the method of literature research, 35 prescriptions related to asthma therapy has been screened out from Hui medicine through collecting the ancient and modern literature. A comparison of fragrant medicine between the name in Arab and Chinese herbal medicine is done. The countif function in Microsoft Excel 2007 is used to get the prescriptions of the drug on the frequency statistics, summarizing the common drugs of Hui medicine for asthma are Pinellia, almond, white sugar, walnut. According to the commonly used drugs, the pathogeny and treatment principle about Hui medicine for asthma is preliminarily inferred combining literature research and the related Hui medical theory. In this study, those prescriptions have been classified into 21 cases which are effective and can be used in medical therapy according to the relevant literatures with the development of the Hui people in their long process of formation of the unique diet culture, 14 useful and convenient Halal diet therapies are made up according to the indications, therapies, party name and composition. Halal diet and "medicine and food" herbs are preliminarily analyzed and summarized, which can be convenient for the people to reduce pains through the diet and improve health awareness.
MeSH term(s)	Asthma/drug therapy ; Asthma/ethnology ; China ; Cough/drug therapy ; Cough/ethnology ; Diet/ethnology ; Drug Prescriptions ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2015-02
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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Article: [Summary of Hui prescriptions for treating cough].

Zhang, Wen-Jin / Xue, Ting / Fu, Xue-Yan / Zhang, Xin-Hui

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2015 Volume 40, Issue 1, Page(s) 154–159

Abstract: By using the method of philology, 65 Hui prescriptions for treating cough were been collected ... of drugs in the prescriptions and summarize eight common Hui medicine for treating cough, namely sugar, honey, almond ... philological studies and theories of Hui medicines, pathology and therapy of Hui medicines for treating cough ...

Abstract	By using the method of philology, 65 Hui prescriptions for treating cough were been collected to compare Arabic and Chinese names of pennisetum, anemarrhenae, honey, pease, white mustard, perilla and towel gourd stem. The Countif function in Microsoft Excel 2007 was used to count frequency of drugs in the prescriptions and summarize eight common Hui medicine for treating cough, namely sugar, honey, almond, fritillaria, liquorice, orange peel, white mulberry root-bark and lily. According to the commonly used drugs, philological studies and theories of Hui medicines, pathology and therapy of Hui medicines for treating cough were preliminarily inferred. In this study, 35 practical prescriptions and 30 simple and convenient Halal dietary prescriptions were summarized from collected prescriptions according to relevant literatures. On the basis of the long-lasting unique dietary therapy culture developed for Hui people, the simple and practical dietary prescriptions were defined according indications, therapy, prescription name and composition, and eight types of drug-admixed foods were summarized to relieve pains and improve health awareness and quality of life. Meanwhile, this study could also enrich and perfect the prescriptions, provide new ideas for improving health of patients, and lay a certain realistic foundation for further study of Hui medicines.
MeSH term(s)	China/ethnology ; Cough/drug therapy ; Cough/ethnology ; Drug Prescriptions ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Humans ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2015-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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Article ; Online: Population data and phylogenetic analysis of 37 Y-STR loci in the Hui population from Yunnan Province, Southwest China.

Zhang, Xiufeng / Li, Kunya / Duan, Yifan

Annals of human biology

2023 Volume 50, Issue 1, Page(s) 196–199

Abstract: ... characteristics of Chinese Hui residing in Yunnan province, Southwest China, remain unclear.: Aim: To provide ... genetic data for 37 Y-STRs in the Chinese Hui population of Yunnan province, as well as to investigate ... population genetic relationships between the Chinese Hui and another 26 populations from China and neighbouring ...

Abstract	Background: Previous studies of the genetic polymorphism of the Y-chromosomal short tandem repeat (Y-STR) of Huis were focussed on the northwest of China. However, the population genetic characteristics of Chinese Hui residing in Yunnan province, Southwest China, remain unclear. Aim: To provide genetic data for 37 Y-STRs in the Chinese Hui population of Yunnan province, as well as to investigate population genetic relationships between the Chinese Hui and another 26 populations from China and neighbouring countries. Subjects and methods: In total, 326 unrelated healthy male individuals were genotyped using the Goldeneye Results: A total of 279 haplotypes were detected, out of which 244 were unique. The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.9989 and 0.8611, respectively. The gene diversity (GD) ranged from 0.0544 (DYS645) to 0.9656 (DYS385). Conclusions: The population comparison indicated that Muslim populations (Hui, Salar and Uighur) showed significantly more genetic affinity than other populations. Our results could be applied in forensic practice and population genetic studies.
MeSH term(s)	Humans ; Male ; Phylogeny ; China ; Ethnicity/genetics ; Chromosomes, Human, Y/genetics ; Genetics, Population ; Microsatellite Repeats/genetics ; Haplotypes
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.1080/03014460.2023.2188258
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Article ; Online: Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China

Zhou, Wenqian / Guo, Jinping / Li, Yujie / Ma, Xiaoya / Yang, Shuangyu / Wei, Jie / Zhang, Huan / Zhang, Shanshan / Jin, Tianbo

Funct Integr Genomics. 2023 June, v. 23, no. 2 p.85-85

2023

Abstract	Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among different populations. However, there is little pharmacogenomic information about the Chinese Hui population. Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment of diseases. This study genotyped 53 VIP variants of 26 genes in 200 independent Hui individuals based on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB). Remarkable differences in the genotype and allele frequencies between the Hui and 26 other populations from the 1000 Genomes Project were assessed using the χ² test. The genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in PTGS2 (rs20417), NAT2 (rs1801280), NAT2 (rs1208), ACE (rs4291), and CYP2D6 (rs1065852) were considerably different in the Hui population compared with those in the other 26 populations. Besides, using the PharmGKB database, we identified several VIP variants that may alter the drug metabolism of ibuprofen, rofecoxib (PTGS2), captopril (ACE), citalopram, and escitalopram (CYP2D6). We also discovered other variants associated with adverse reactions to cisplatin and cyclophosphamide (NAT2). Our study indicated that the loci of PTGS2 (rs20417), NAT2 (rs1801280 and rs1208), ACE (rs4291), and CYP2D6 (rs1065852) in the Hui population were obviously different from those in the other 26 populations, which provides reliable information for predicting drug efficacy. Besides, it supplements the pharmacogenomic knowledge of the Hui population and lays the foundation for the individualized treatment for the Hui population.
Keywords	alleles ; cisplatin ; cyclophosphamide ; databases ; genotype ; ibuprofen ; pharmacogenomics ; pharmacokinetics ; China
Language	English
Dates of publication	2023-06
Size	p. 85.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01021-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The effect and pharmacology of Yizhi Sheng Hui decoction on Alzheimer's disease.

Li, Qiubing / Hou, Yi / Zhao, Baosheng / Li, Yingfan / Zhang, Xinyu / Mei, Rong / Wang, Shuo / Wang, Peng / Liu, Ying

Annals of palliative medicine

2021 Volume 10, Issue 5, Page(s) 5244–5251

Abstract: ... after treatment with the traditional Chinese medicine compound, Yizhi Sheng Hui (YZSH) decoction. This study ...

Abstract	Background: Alzheimer's disease (AD) has gradually increased as society has aged and is now a serious social problem. In the clinical treatment of AD, patients show improvement in cognitive function after treatment with the traditional Chinese medicine compound, Yizhi Sheng Hui (YZSH) decoction. This study systematically investigates the effect and pharmacology of the YZSH decoction on AD. Methods: In this study, 24 SAMP8 AD model mice were randomly divided into three groups: an untreated control group, a group treated with the YZSH decoction, and a positive control group treated with donepezil hydrochloride. Eight SAMR1 mice were placed in the normal control group. A Morris water maze test and a step-down test were conducted at 8 and 13 weeks after continuous intragastric administration of the two drugs. After 13 weeks of administration, the hippocampal expression of Aβ1-42 and tau protein were measured. Results: There was no change in the latent period duration and the number of platform crossings in each group after 8 weeks of administration, but after 13 weeks of administration, the latent period of the treatment group and the positive control group were significantly shorter than the untreated control group. Initially, the SAMP8 mice showed a lower spatial exploration ability than the SAMR1 mice. However, after 13 weeks of administration, the treatment group and the control group exhibited a better exploration ability. Compared with the SAMR1 mice, the on-stage evasion time and step-down errors significantly increased in the untreated group. Compared with the untreated group, mice in the treatment group and the positive control group showed a shorter latent period after 8 weeks of administration, and the on-stage evasion time for both groups was significantly reduced after 13 weeks of administration. The treatment group showed fewer instances of electric shock. Hippocampal expression of Aβ1-42 was high in the untreated group, was much lower in the positive control group, and no Aβ1-42 expression was observed in the treatment group. Conclusions: The YZSH decoction improved the learning and memory of mice with AD, related to the inhibition of Aβ1-42 expression.
MeSH term(s)	Aged ; Alzheimer Disease/drug therapy ; Animals ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Learning ; Memory ; Mice
Chemical Substances	Drugs, Chinese Herbal ; yi-zhi (1QBV21VOZI)
Language	English
Publishing date	2021-05-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-20-1629
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Article ; Online: Analysis of Function Role and Long Noncoding RNA Expression in Chronic Heart Failure Rats Treated with Hui Yang Jiu Ji Decoction.

Zhang, Huan / Zhang, Li / Yin, Kejing / Zhang, Miao / Hao, Yanjiao / Zhou, Hongwei / Ren, Huifeng

Journal of healthcare engineering

2023 Volume 2023, Page(s) 7438567

Abstract: Hui Yang Jiu Ji (HYJJ) decoction has been applied as a prescription of traditional Chinese medicine ...

Abstract	Hui Yang Jiu Ji (HYJJ) decoction has been applied as a prescription of traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, its comprehensive molecular mechanism remains unclear now. Our study aimed to explore the possible function and lncRNA-miRNA regulation networks of HYJJ on CHF induced by doxorubicin (DOX) in rats. Our study showed that HYJJ could recover cardiac function and alleviate myocardial injury of DOX-induced CHF. Besides, HYJJ had an effect on restraining myocardial apoptosis in CHF rats. Moreover, RNA-sequencing and bioinformatics analysis indicated that among a total of 548 significantly up- and down-regulated differentially expressed (DE) long noncoding RNA (lncRNA), 511 up- and down-regulated DE miRNAs were identified. Cushing's syndrome and Adrenergic signaling in cardiomyocytes were common pathways between DE-lncRNAs-enriched pathways and DE-miRNAs-enriched pathways. Finally, we observed a new pathway-MSTRG.598.1/Lilrb2 pathway with the HYJJ treatment; however, it needs further studies. In conclusion, this study provided evidence that HYJJ may be a suitable medicine for treating CHF. Moreover, several pivotal miRNAs may serve important roles in these processes by regulating some key miRNAs or pathways in CHF.
MeSH term(s)	Animals ; Rats ; Doxorubicin ; Heart Failure/drug therapy ; Heart Failure/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocardium/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Doxorubicin (80168379AG) ; MicroRNAs ; RNA, Long Noncoding ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2023/7438567
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Article ; Online: Optimization of the N footprint model and analysis of nitrogen pollution in irrigation areas: A case study of Ningxia Hui Autonomous Region, China.

Zhang, Tianpeng / Lei, Qiuliang / Liang, Xia / Lindsey, Stuart / Luo, Jiafa / Pei, Wei / Du, Xinzhong / Wu, Shuxia / An, Miaoying / Qiu, Weiwen / Liu, Hongbin

Journal of environmental management

2023 Volume 340, Page(s) 118002

Abstract: ... in Ningxia Hui Autonomous Region (Ningxia), China, the study assessed the contribution of water diversion to N ...

Abstract	Water diverted from rivers for irrigation areas often contains large amounts of nitrogen (N), which is frequently overlooked and its role in contributing to N pollution is unknown. To investigate the influence of water diversion on N in different systems within irrigation areas, we developed and optimized the N footprint model, taking into account the N carried by irrigation water diversion and drainage in irrigated areas. This optimized model can serve as a reference for evaluating N pollution in other irrigated areas. By analyzing 29 years (1991-2019) of statistical data from a diverted irrigation area in Ningxia Hui Autonomous Region (Ningxia), China, the study assessed the contribution of water diversion to N in agriculture, animal husbandry, and human domestic activities. The results demonstrated that water diversion and drainage accounted for 10.3% and 13.8% in whole system, of the total N input and output in Ningxia, highlighting the potential N pollution risks associated with these activities. Additionally, the use of fertilizers in the plant subsystem, feed in the animal subsystem, and sanitary sewage in the human subsystem represented the main sources of N pollution in each subsystem. On a temporal scale, the study found that N loss increased year by year before reaching a stable level, indicating that N loss had reached its peak in Ningxia. The correlation analysis suggested that rainfall could regulate N input and output in irrigated areas by showing a negative correlation with water diversion, agricultural water consumption, and N from irrigated areas. Moreover, the study revealed that the amount of N brought by water diverted from rivers for irrigation should be taken into account when calculating the amount of fertilizer N required in the irrigation area.
MeSH term(s)	Humans ; Animals ; Nitrogen/analysis ; Agricultural Irrigation/methods ; Environmental Pollution/analysis ; Agriculture/methods ; Water/analysis ; China ; Fertilizers/analysis
Chemical Substances	Nitrogen (N762921K75) ; Water (059QF0KO0R) ; Fertilizers
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.118002
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