Article ; Online: Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans.
Free radical biology & medicine
2015 Volume 78, Page(s) 168–178
Abstract: Recent findings in diverse organisms strongly support a conserved role for mitochondrial electron transport chain dysfunction in longevity modulation, but the underlying mechanisms are not well understood. One way cells cope with mitochondrial ... ...
Abstract | Recent findings in diverse organisms strongly support a conserved role for mitochondrial electron transport chain dysfunction in longevity modulation, but the underlying mechanisms are not well understood. One way cells cope with mitochondrial dysfunction is through a retrograde transcriptional reprogramming response. In this review, we primarily focus on the work that has been performed in Caenorhabditis elegans to elucidate these mechanisms. We describe several transcription factors that participate in mitochondria-to-nucleus signaling and discuss how they mediate the relationship between mitochondrial dysfunction and life span. |
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MeSH term(s) | Animals ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Cell Nucleus/metabolism ; Longevity ; Mitochondria/metabolism ; Signal Transduction ; Transcription Factors/metabolism |
Chemical Substances | Caenorhabditis elegans Proteins ; Transcription Factors |
Language | English |
Publishing date | 2015-01 |
Publishing country | United States |
Document type | Journal Article ; Review |
ZDB-ID | 807032-5 |
ISSN | 1873-4596 ; 0891-5849 |
ISSN (online) | 1873-4596 |
ISSN | 0891-5849 |
DOI | 10.1016/j.freeradbiomed.2014.10.576 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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