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Article ; Online: Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond.

Tsilingiris, Dimitrios / Kokkinos, Alexander

2023 Volume 151, Page(s) 155741

Abstract: Currently, metabolic surgery (MS) constitutes the most effective means for durable weight loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non-alcoholic steatohepatitis, as well as other obesity-related comorbidities. ... ...

Abstract	Currently, metabolic surgery (MS) constitutes the most effective means for durable weight loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non-alcoholic steatohepatitis, as well as other obesity-related comorbidities. Accumulating evidence on the mechanisms through which MS exerts its actions has highlighted the altered secretion of hormonally active peptides of intestinal origin with biological actions crucial to energy metabolism as key drivers of MS clinical effects. The initial success of glucagon-like peptide-1 (GLP-1) receptor agonists regarding weight loss and metabolic amelioration have been followed by the development of unimolecular dual and triple polyagonists, additionally exploiting the effects of glucagon and/or glucose-dependent insulinotropic polypeptide (GIP) which achieves a magnitude of weight loss approximating that of common MS operations. Through the implementation of such therapies, the feasibility of a "medical bypass", namely the replication of the clinical effects of MS through non-surgical interventions may be foreseeable in the near future. Apart from weight loss, this approach ought to be put to the test also regarding other clinical outcomes, such as liver steatosis and steatohepatitis, cardiovascular disease, and overall prognosis, on which MS has a robustly demonstrated impact. Besides, a medical bypass as an alternative, salvage, or combination strategy to MS may promote precision medicine in obesity therapeutics.
MeSH term(s)	Humans ; Glucagon-Like Peptide 1/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/surgery ; Diabetes Mellitus, Type 2/metabolism ; Obesity/complications ; Obesity/drug therapy ; Obesity/surgery ; Gastric Inhibitory Polypeptide/therapeutic use ; Bariatric Surgery ; Fatty Liver/drug therapy ; Weight Loss ; Glucagon-Like Peptide-1 Receptor
Chemical Substances	Glucagon-Like Peptide 1 (89750-14-1) ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide-1 Receptor
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80230-x
ISSN	1532-8600 ; 0026-0495
ISSN (online)	1532-8600
ISSN	0026-0495
DOI	10.1016/j.metabol.2023.155741
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Article ; Online: The non-linear relationship between muscle mass and BMI calls into question the use of BMI as a major criterion for eligibility for bariatric surgery.

Liu, Junli / Tsilingiris, Dimitrios / Dalamaga, Maria

Metabolism open

2022 Volume 13, Page(s) 100164

Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Editorial
ISSN	2589-9368
ISSN (online)	2589-9368
DOI	10.1016/j.metop.2022.100164
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Article ; Online: Regression of common viral warts in an immunocompetent child and an immunosuppressed adult relative after mRNA BNT162b2 COVID-19 vaccine.

Dalamaga, Maria / Tsilingiris, Dimitrios / Katoulis, Alexandros

Journal of the European Academy of Dermatology and Venereology : JEADV

2022

Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.18577
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Article ; Online: Body composition and fat depot assessment: going supersonic to improve cardiometabolic outcomes.

Dalamaga, Maria / Stratigou, Theodora / Tsilingiris, Dimitrios

Polish archives of internal medicine

2022 Volume 132, Issue 11

MeSH term(s)	Humans ; Body Composition ; Cardiovascular Diseases/prevention & control
Language	English
Publishing date	2022-11-25
Publishing country	Poland
Document type	Editorial ; Comment
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16362
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Article ; Online: The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies.

Dalamaga, Maria / Kounatidis, Dimitrios / Tsilingiris, Dimitrios / Vallianou, Natalia G / Karampela, Irene / Psallida, Sotiria / Papavassiliou, Athanasios G

International journal of molecular sciences

2024 Volume 25, Issue 1

Abstract: Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, recent data have highlighted a possible association between ... ...

Abstract	Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology. Based on the available data from mechanistic, animal and epidemiological studies including meta-analyses, the weight of evidence points towards the contribution of EDCs to the development of obesity, associated disorders and obesity-related adipose tissue dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility to obesity; (3) influencing neuroendocrine signals responsible for appetite and satiety; (4) promoting a proinflammatory milieu in adipose tissue and inducing a state of chronic subclinical inflammation; (5) dysregulating gut microbiome and immune homeostasis; and (6) inducing dysfunction in thermogenic adipose tissue. Critical periods of exposure to obesogenic EDCs are the prenatal, neonatal, pubertal and reproductive periods. Interestingly, EDCs even at low doses may promote epigenetic transgenerational inheritance of adult obesity in subsequent generations. The aim of this review is to summarize the available evidence on the role of obesogenic EDCs, specifically BPA and phthalate plasticizers, in the development of obesity, taking into account in vitro, animal and epidemiologic studies; discuss mechanisms linking EDCs to obesity; analyze the effects of EDCs on obesity in critical chronic periods of exposure; and present interesting perspectives, challenges and preventive measures in this research area.
MeSH term(s)	Animals ; Female ; Pregnancy ; Benzhydryl Compounds ; Endocrine Disruptors/toxicity ; Obesity/chemically induced ; Phenols ; Phthalic Acids ; Weight Gain ; Humans
Chemical Substances	Benzhydryl Compounds ; bisphenol A (MLT3645I99) ; Endocrine Disruptors ; Phenols ; phthalic acid (6O7F7IX66E) ; Phthalic Acids
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010675
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Article ; Online: SARS-CoV-2 adipose tissue infection and hyperglycemia: A further step towards the understanding of severe COVID-19.

Tsilingiris, Dimitrios / Dalamaga, Maria / Liu, Junli

Metabolism open

2022 Volume 13, Page(s) 100163

Abstract: Numerous studies have highlighted the prognostic significance of hyperglycemia in the outcomes of SARS-CoV-2 infection. A number of mechanisms have been proposed as potential drivers of this association, which were, however, up until recently based ... ...

Abstract	Numerous studies have highlighted the prognostic significance of hyperglycemia in the outcomes of SARS-CoV-2 infection. A number of mechanisms have been proposed as potential drivers of this association, which were, however, up until recently based rather on speculation than on investigational evidence. It has been recently come to light that the development of insulin resistance in the frame of COVID-19 is likely the driving force behind the development of overt hyperglycemia. This results through the infectious insult of the adipose tissue, and is observed in conjunction with aberrant adipokine secretion by host adipocytes, such as decreased adiponectin, as well as a switch towards an antiviral immune secretory profile. These data could have a considerable relevance not only for the management of hyperglycemia in the course of the infection but also for the overall understanding of the pathogenesis of severe COVID-19.
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Editorial
ISSN	2589-9368
ISSN (online)	2589-9368
DOI	10.1016/j.metop.2022.100163
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Article ; Online: The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity

Maria Dalamaga / Dimitrios Kounatidis / Dimitrios Tsilingiris / Natalia G. Vallianou / Irene Karampela / Sotiria Psallida / Athanasios G. Papavassiliou

International Journal of Molecular Sciences, Vol 25, Iss 1, p

Current Evidence, Perspectives and Controversies

2024 Volume 675

Abstract	Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology. Based on the available data from mechanistic, animal and epidemiological studies including meta-analyses, the weight of evidence points towards the contribution of EDCs to the development of obesity, associated disorders and obesity-related adipose tissue dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility to obesity; (3) influencing neuroendocrine signals responsible for appetite and satiety; (4) promoting a proinflammatory milieu in adipose tissue and inducing a state of chronic subclinical inflammation; (5) dysregulating gut microbiome and immune homeostasis; and (6) inducing dysfunction in thermogenic adipose tissue. Critical periods of exposure to obesogenic EDCs are the prenatal, neonatal, pubertal and reproductive periods. Interestingly, EDCs even at low doses may promote epigenetic transgenerational inheritance of adult obesity in subsequent generations. The aim of this review is to summarize the available evidence on the role of obesogenic EDCs, specifically BPA and phthalate plasticizers, in the development of obesity, taking into account in vitro, animal and epidemiologic studies; discuss mechanisms linking EDCs to obesity; analyze the effects of EDCs on obesity in critical chronic periods of exposure; and present interesting perspectives, challenges and preventive measures in this research area.
Keywords	adiposity ; bisphenol ; body mass index ; endocrine disruptors ; endocrine-disrupting chemicals ; obesity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Utility of bioelectrical phase angle for cardiovascular risk assessment among individuals with and without diabetes mellitus.

Tsilingiris, Dimitrios / Schimpfle, Lukas / Κender, Zoltan / Sulaj, Alba / von Rauchhaupt, Ekaterina / Herzig, Stephan / Szendroedi, Julia / Kopf, Stefan

Diabetes & vascular disease research

2024 Volume 21, Issue 1, Page(s) 14791641231223701

Abstract: Purpose: Low values of bioimpedance-derived phase angle (PA) have been associated with various adverse outcomes. We investigated the association of PA with cardiovascular markers in individuals with and without diabetes mellitus (DM).: Methods: PA ... ...

Abstract	Purpose: Low values of bioimpedance-derived phase angle (PA) have been associated with various adverse outcomes. We investigated the association of PA with cardiovascular markers in individuals with and without diabetes mellitus (DM). Methods: PA was measured in 452 adults (without DM Results: PA values were lower in DM independently of age, gender, and BMI (estimated marginal means 6.21, 5.83, 5.95 for controls, T1DM, T2DM Conclusions: PA exhibits independent correlations with various parameters pertinent to cardiovascular risk and may be useful for cardiovascular assessment.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Carotid Intima-Media Thickness ; Pulse Wave Analysis ; Diabetes Mellitus, Type 1 ; Risk Factors ; Heart Disease Risk Factors ; Diabetes Mellitus, Type 2 ; Natriuretic Peptide, Brain ; Peptide Fragments ; Biomarkers
Chemical Substances	Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments ; Biomarkers
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2250793-0
ISSN	1752-8984 ; 1479-1641
ISSN (online)	1752-8984
ISSN	1479-1641
DOI	10.1177/14791641231223701
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Article ; Online: The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence.

Vallianou, Natalia G / Kounatidis, Dimitris / Psallida, Sotiria / Panagopoulos, Fotis / Stratigou, Theodora / Geladari, Eleni / Karampela, Irene / Tsilingiris, Dimitrios / Dalamaga, Maria

Current nutrition reports

2024

Abstract: Purpose of review: Choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. The aim of this review is ... ...

Abstract	Purpose of review: Choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. The aim of this review is to analyze the beneficial effects of choline and its significance in cellular metabolism and various inflammatory pathways, such as the inflammasome. We will discuss the significance of dietary choline in cardiometabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and chronic kidney disease (CKD) as well as in cognitive function and associated neuropsychiatric disorders. Recent findings: Choline deficiency has been related to the development of NAFLD and cognitive disability in the offspring as well as in adulthood. In sharp contrast, excess dietary intake of choline mediated via the increased production of trimethylamine by the gut microbiota and increased trimethylamine-N-oxide (TMAO) levels has been related to atherosclerosis in most studies. In this context, CVD and CKD through the accumulation of TMAO, p-Cresyl-sulfate (pCS), and indoxyl-sulfate (IS) in serum may be the result of the interplay between excess dietary choline, the increased production of TMAO by the gut microbiota, and the resulting activation of inflammatory responses and fibrosis. A balanced diet, with no excess nor any deficiency in dietary choline, is of outmost importance regarding the prevention of cardiometabolic disorders as well as cognitive function. Large-scale studies with the use of next-generation probiotics, especially Akkermansia muciniphila and Faecalibacterium prausnitzii, should further examine their therapeutic potential in this context.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2161-3311
ISSN (online)	2161-3311
DOI	10.1007/s13668-024-00521-3
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Article: NAFLD in the 21st Century: Current Knowledge Regarding Its Pathogenesis, Diagnosis and Therapeutics.

Kounatidis, Dimitris / Vallianou, Natalia G / Geladari, Eleni / Panoilia, Maria Paraskevi / Daskou, Anna / Stratigou, Theodora / Karampela, Irene / Tsilingiris, Dimitrios / Dalamaga, Maria

Biomedicines

2024 Volume 12, Issue 4

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. It is the most common liver disease in Western countries, andits global prevalence is estimated to be up to 35%. However, its diagnosis may be elusive, because liver ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. It is the most common liver disease in Western countries, andits global prevalence is estimated to be up to 35%. However, its diagnosis may be elusive, because liver biopsy is relatively rarely performed and usually only in advanced stages of the disease. Therefore, several non-invasive scores may be applied to more easily diagnose and monitor NAFLD. In this review, we discuss the various biomarkers and imaging scores that could be useful in diagnosing and managing NAFLD. Despite the fact that general measures, such as abstinence from alcohol and modulation of other cardiovascular disease risk factors, should be applied, the mainstay of prevention and management is weight loss. Bariatric surgery may be suggested as a means to confront NAFLD. In addition, pharmacological treatment with GLP-1 analogues or the GIP agonist tirzepatide may be advisable. In this review, we focus on the utility of GLP-1 analogues and GIP agonists in lowering body weight, their pharmaceutical potential, and their safety profile, as already evidenced inanimal and human studies. We also elaborate on other options, such as the use of vitamin E, probiotics, especially next-generation probiotics, and prebiotics in this context. Finally, we explore future perspectives regarding the administration of GLP-1 analogues, GIP agonists, and probiotics/prebiotics as a means to prevent and combat NAFLD. The newest drugs pegozafermin and resmetiron, which seem to be very promising, arealso discussed.
Language	English
Publishing date	2024-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12040826
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