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  1. Article: Telomere regulation and function during meiosis.

    Siderakis, Manos / Tarsounas, Madalena

    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

    2007  Volume 15, Issue 5, Page(s) 667–679

    Abstract: Telomeres are essential for genomic stability and their dysfunction has been implicated in cancer and ageing. The most prominent function of the telomeres is to protect chromosome ends against degradation and fusion, which, in turn, requires maintenance ... ...

    Abstract Telomeres are essential for genomic stability and their dysfunction has been implicated in cancer and ageing. The most prominent function of the telomeres is to protect chromosome ends against degradation and fusion, which, in turn, requires maintenance of telomere DNA to a critical length that allows assembly of end-capping structures. During early meiosis, telomeres play the distinctive function of anchoring chromosomes to the inner nuclear membrane. Subsequently, as a consequence of the nuclear membrane polarization, telomeres cluster together into a bouquet configuration, which facilitates pairing and recombination of the homologous chromosomes. Here we review how the two fundamental aspects of telomere maintenance, elongation and protection, contribute to the essential functions performed by telomeres during meiosis.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Meiosis/genetics ; Meiosis/physiology ; Mice ; Models, Genetic ; Oogenesis/genetics ; Oogenesis/physiology ; Spermatogenesis/genetics ; Spermatogenesis/physiology ; Telomerase/deficiency ; Telomerase/genetics ; Telomere/genetics
    Chemical Substances Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2007-08-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1161632-5
    ISSN 1573-6849 ; 0967-3849
    ISSN (online) 1573-6849
    ISSN 0967-3849
    DOI 10.1007/s10577-007-1149-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Telomere regulation and function during meiosis

    Siderakis, Manos / Tarsounas, Madalena

    Chromosome research. 2007 July, v. 15, no. 5

    2007  

    Abstract: Telomeres are essential for genomic stability and their dysfunction has been implicated in cancer and ageing. The most prominent function of the telomeres is to protect chromosome ends against degradation and fusion, which, in turn, requires maintenance ... ...

    Abstract Telomeres are essential for genomic stability and their dysfunction has been implicated in cancer and ageing. The most prominent function of the telomeres is to protect chromosome ends against degradation and fusion, which, in turn, requires maintenance of telomere DNA to a critical length that allows assembly of end-capping structures. During early meiosis, telomeres play the distinctive function of anchoring chromosomes to the inner nuclear membrane. Subsequently, as a consequence of the nuclear membrane polarization, telomeres cluster together into a bouquet configuration, which facilitates pairing and recombination of the homologous chromosomes. Here we review how the two fundamental aspects of telomere maintenance, elongation and protection, contribute to the essential functions performed by telomeres during meiosis.
    Keywords homologous recombination ; meiosis ; telomerase ; telomeres
    Language English
    Dates of publication 2007-07
    Size p. 667-679.
    Publisher Springer Netherlands
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 1161632-5
    ISSN 1573-6849 ; 0967-3849
    ISSN (online) 1573-6849
    ISSN 0967-3849
    DOI 10.1007/s10577-007-1149-7
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Novel regulation of Smad3 oligomerization and DNA binding by its linker domain.

    Vasilaki, Eleftheria / Siderakis, Manos / Papakosta, Paraskevi / Skourti-Stathaki, Konstantina / Mavridou, Sofia / Kardassis, Dimitris

    Biochemistry

    2009  Volume 48, Issue 35, Page(s) 8366–8378

    Abstract: Smad proteins are key effectors of the transforming growth factor beta (TGFbeta) signaling pathway in mammalian cells. Smads are composed of two highly structured and conserved domains called Mad homology 1 (MH1) and 2 (MH2), which are linked together by ...

    Abstract Smad proteins are key effectors of the transforming growth factor beta (TGFbeta) signaling pathway in mammalian cells. Smads are composed of two highly structured and conserved domains called Mad homology 1 (MH1) and 2 (MH2), which are linked together by a nonconserved linker region. The recent identification of phosphorylation sites and binding sites for ubiquitin ligases in the linker regions of TGFbeta and bone morphogenetic protein (BMP) receptor-regulated Smads suggested that the linker may contribute to the regulation of Smad function by facilitating cross-talks with other signaling pathways. In the present study, we have generated and characterized novel Smad3 mutants bearing individual substitutions of conserved and nonconserved amino acid residues within a previously described transcriptionally active linker fragment. Our analysis showed that the conserved linker amino acids glutamine 222 and proline 229 play important roles in Smad functions such as homo- and hetero-oligomerization, nuclear accumulation in response to TGFbeta stimulation, and DNA binding. Furthermore, a Smad3 mutant bearing a substitution of the nonconserved amino acid asparagine 218 to alanine displayed enhanced transactivation potential relative to wild type Smad3. Finally, Smad3 P229A inhibited TGFbeta signaling when overexpressed in mammalian cells. In conclusion, our data are in line with previous studies supporting an important regulatory role of the linker region of Smads in their function as key transducers of TGFbeta signaling.
    MeSH term(s) Amino Acid Substitution ; Animals ; Bone Morphogenetic Protein 2/genetics ; Bone Morphogenetic Protein 2/metabolism ; Bone Morphogenetic Protein 4/genetics ; Bone Morphogenetic Protein 4/metabolism ; Conserved Sequence ; Mammals ; Phosphorylation ; Protein Binding ; Signal Transduction/physiology ; Smad3 Protein/genetics ; Smad3 Protein/metabolism ; Transcriptional Activation ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
    Chemical Substances Bone Morphogenetic Protein 2 ; Bone Morphogenetic Protein 4 ; Smad3 Protein ; Transforming Growth Factor beta
    Language English
    Publishing date 2009-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/bi9005489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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