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  1. Article ; Online: The "telomereless" erythrocytes and telomere-length dependent erythropoiesis.

    Aviv, Abraham

    Aging cell

    2023  Volume 22, Issue 12, Page(s) e13997

    Abstract: Approximately 25 trillion erythrocytes (red blood cells) circulate in the bloodstream of an adult human, surpassing the number of circulating leukocytes (white blood cells) by a factor of about 1000. Moreover, the erythrocyte turnover rate accounts for ... ...

    Abstract Approximately 25 trillion erythrocytes (red blood cells) circulate in the bloodstream of an adult human, surpassing the number of circulating leukocytes (white blood cells) by a factor of about 1000. Moreover, the erythrocyte turnover rate accounts for approximately 76% of the turnover rate of all circulating blood cells. This simple math shows that the hematopoietic system principally spends its telomere length-dependent replicative capacity on building and maintaining the erythrocyte blood pool. Erythropoiesis (red blood cell production) is thus the principal cause of telomere shortening with age in hematopoietic cells (HCs), a conclusion that holds significant implications for linking telomere length dynamics in HCs to health and lifespan of modern humans.
    MeSH term(s) Adult ; Humans ; Erythropoiesis/genetics ; Erythrocytes ; Leukocytes ; Longevity ; Telomere
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13997
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    Zs.A 6581: Show issues Location:
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  2. Article ; Online: The telomere tumult: meaning and metrics in population studies.

    Aviv, Abraham

    The Lancet. Healthy longevity

    2022  Volume 3, Issue 5, Page(s) e308–e309

    MeSH term(s) Benchmarking ; Biological Specimen Banks ; Health Behavior ; Leukocytes ; Telomere/genetics ; United Kingdom
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/s2666-7568(22)00094-0
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  3. Article ; Online: The bullwhip effect, T-cell telomeres, and SARS-CoV-2.

    Aviv, Abraham

    The Lancet. Healthy longevity

    2022  Volume 3, Issue 10, Page(s) e715–e721

    Abstract: Both myeloid cells, which contribute to innate immunity, and lymphoid cells, which dominate adaptive immunity, partake in defending against SARS-CoV-2. In response to the virus, the otherwise slow haematopoietic production supply chain quickly unleashes ... ...

    Abstract Both myeloid cells, which contribute to innate immunity, and lymphoid cells, which dominate adaptive immunity, partake in defending against SARS-CoV-2. In response to the virus, the otherwise slow haematopoietic production supply chain quickly unleashes its preconfigured myeloid element, which largely resists a bullwhip-like effect. By contrast, the lymphoid element risks a bullwhip-like effect when it produces T cells and B cells that are specifically designed to clear the virus. As T-cell production is telomere-length dependent and telomeres shorten with age, older adults are at higher risk of a T-cell shortfall when contracting SARS-CoV-2 than are younger adults. A poorly calibrated adaptive immune response, stemming from a bullwhip-like effect, compounded by a T-cell deficit, might thus contribute to the propensity of people with inherently short T-cell telomeres to develop severe COVID-19. The immune systems of these individuals might also generate an inadequate T-cell response to anti-SARS-CoV-2 vaccination.
    MeSH term(s) Adaptive Immunity ; Aged ; COVID-19 ; Humans ; SARS-CoV-2/genetics ; T-Lymphocytes ; Telomere/genetics
    Language English
    Publishing date 2022-10-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(22)00190-8
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  4. Article ; Online: Short telomeres and severe COVID-19: The connection conundrum.

    Aviv, Abraham

    EBioMedicine

    2021  Volume 70, Page(s) 103513

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Telomere ; Telomere Shortening
    Language English
    Publishing date 2021-07-29
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103513
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  5. Article ; Online: Short telomeres and severe COVID-19

    Abraham Aviv

    EBioMedicine, Vol 70, Iss , Pp 103513- (2021)

    The connection conundrum

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Telomeres and COVID-19.

    Aviv, Abraham

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 34, Issue 6, Page(s) 7247–7252

    Abstract: The medical, public health, and scientific communities are grappling with monumental imperatives to contain COVID-19, develop effective vaccines, identify efficacious treatments for the infection and its complications, and find biomarkers that detect ... ...

    Abstract The medical, public health, and scientific communities are grappling with monumental imperatives to contain COVID-19, develop effective vaccines, identify efficacious treatments for the infection and its complications, and find biomarkers that detect patients at risk of severe disease. The focus of this communication is on a potential biomarker, short telomere length (TL), that might serve to identify patients more likely to die from the SARS-CoV-2 infection, regardless of age. The common thread linking these patients is lymphopenia, which largely reflects a decline in the numbers of CD4/CD8 T cells but not B cells. These findings are consistent with data that lymphocyte TL dynamics impose a limit on T-cell proliferation. They suggest that T-cell lymphopoiesis might stall in individuals with short TL who are infected with SARS-CoV-2.
    MeSH term(s) Betacoronavirus ; Biomarkers ; Bone Marrow/pathology ; COVID-19 ; Cell Division ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Disease Progression ; Hematopoietic Stem Cells/pathology ; Humans ; Lymphocyte Activation ; Lymphocyte Count ; Lymphopenia/etiology ; Lymphopenia/pathology ; Lymphopoiesis ; Models, Biological ; Pandemics ; Pneumonia, Viral/genetics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; Prognosis ; Risk ; SARS-CoV-2 ; T-Lymphocyte Subsets/ultrastructure ; Telomere/ultrastructure ; Telomere Shortening
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202001025
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    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  7. Article ; Online: Clonal Hematopoiesis Confers Predisposition to Both Cardiovascular Disease and Cancer.

    Aviv, Abraham

    Annals of internal medicine

    2019  Volume 170, Issue 5, Page(s) 356

    MeSH term(s) Cardiovascular Diseases ; Genotype ; Hematopoiesis ; Humans ; Neoplasms
    Language English
    Publishing date 2019-02-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L18-0637
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    Ua VI Zs.178/2: Show issues Location:
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  8. Article ; Online: Telomeres and COVID‐19

    Aviv, Abraham

    The FASEB Journal

    2020  Volume 34, Issue 6, Page(s) 7247–7252

    Keywords Biotechnology ; Genetics ; Biochemistry ; Molecular Biology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202001025
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  9. Article ; Online: The mitochondrial genome, paternal age and telomere length in humans.

    Aviv, Abraham

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2018  Volume 373, Issue 1741

    Abstract: Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres ... ...

    Abstract Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres become longer with age. This puzzling phenomenon might explain why TL in the offspring correlates positively with paternal age. The present communication proposes that mitochondrial DNA polymorphisms and heteroplasmy cause variation in the production of reactive oxygen species, which, in turn, mediate age-dependent selection of germ stem cells with long telomeres and hence sperm with long telomeres. These long telomeres are then inherited by the offspring. The effect of paternal age on the offspring TL might be an evolutionarily driven mechanism that helps regulate TL across the human population.This article is part of the theme issue 'Understanding diversity in telomere dynamics'.
    MeSH term(s) Biological Evolution ; Genome, Mitochondrial ; Humans ; Male ; Paternal Age ; Polymorphism, Genetic ; Reactive Oxygen Species/metabolism ; Spermatozoa/metabolism ; Stem Cells ; Telomere/metabolism ; Telomere Homeostasis
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2018-01-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2017.0210
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    Einzelsignatur: Show issues

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  10. Article: Telomeres and COVID-19

    Aviv, Abraham

    FASEB J

    Abstract: The medical, public health, and scientific communities are grappling with monumental imperatives to contain COVID-19, develop effective vaccines, identify efficacious treatments for the infection and its complications, and find biomarkers that detect ... ...

    Abstract The medical, public health, and scientific communities are grappling with monumental imperatives to contain COVID-19, develop effective vaccines, identify efficacious treatments for the infection and its complications, and find biomarkers that detect patients at risk of severe disease. The focus of this communication is on a potential biomarker, short telomere length (TL), that might serve to identify patients more likely to die from the SARS-CoV-2 infection, regardless of age. The common thread linking these patients is lymphopenia, which largely reflects a decline in the numbers of CD4/CD8 T cells but not B cells. These findings are consistent with data that lymphocyte TL dynamics impose a limit on T-cell proliferation. They suggest that T-cell lymphopoiesis might stall in individuals with short TL who are infected with SARS-CoV-2.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #306321
    Database COVID19

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