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Book: Labormedizin für Grundversorger

Risch, Martin

(Therapeutische Umschau ; 72,2)

2015

Author's details	Gasthrsg. Martin Risch
Series title	Therapeutische Umschau ; 72,2
Collection
Keywords	Labormedizin
Subject	Labordiagnostik ; Medizinische Labortechnik ; Laboratoriumsdiagnostik ; Laboratoriumsmedizin
Language	German
Size	S. 73 - 136 : graph. Darst.
Publisher	Huber
Publishing place	Bern
Publishing country	Germany
Document type	Book
HBZ-ID	HT018533485
ISBN	978-3-456-85476-2 ; 3-456-85476-5
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
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Book: Nahrungsnetze im Schweizerischen Nationalpark

Schütz, Martin / Risch, Anita C. / Anderwald, Pia

Von Produzenten, Konsumenten und Destruenten

(Nationalpark-Forschung in der Schweiz ; 109)

2020

Abstract: Nahrungsnetze im Schweizerischen Nationalpark» zeigt, dass pflanzenfressende Tiere ̶ von Hirschen bis zu Schnecken und Insekten ̶ in den Weide-Ökosystemen des Nationalparks eine zentrale Rolle spielen. Fehlen sie, zerfallen Nahrungsnetze und ... ...

Series title	Nationalpark-Forschung in der Schweiz ; 109
Abstract	«Nahrungsnetze im Schweizerischen Nationalpark» zeigt, dass pflanzenfressende Tiere ̶ von Hirschen bis zu Schnecken und Insekten ̶ in den Weide-Ökosystemen des Nationalparks eine zentrale Rolle spielen. Fehlen sie, zerfallen Nahrungsnetze und Nährstoffkreisläufe werden unterbrochen. Das Ökosystem funktioniert nicht mehr. Während die grossen Tiere für eine hohe Biodiversität sorgen, halten die kleinen wirbellosen Tiere das Ökosystem am Laufen. -- In diesem Buch sind Erkenntnisse aus den ve...
Keywords	Tiere ; Nationalpark ; Ökosysteme ; Biodiversität ; Nahrungsnetz ; Tier-Pflanzen-Interaktionen
Language	German
Size	158 p.
Edition	1
Publisher	Haupt Verlag
Document type	Book
Note	Ernährungs-, Umwelt- und Agrarwissenschaften 250418
Format	170 x 240
ISBN	9783258081311 ; 325808131X
Database	PDA

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Article ; Online: Comparison of an automated DNA extraction and 16S rDNA real time PCR/sequencing diagnostic method using optimized reagents with culture during a 15-month study using specimens from sterile body sites.

Egli, Konrad / Risch, Martin / Risch, Lorenz / Bodmer, Thomas

BMC microbiology

2022 Volume 22, Issue 1, Page(s) 119

Abstract: Background: 16S rDNA-PCR for the identification of a bacterial species is an established method. However, the DNA extraction reagents as well as the PCR reagents may contain residual bacterial DNA, which consequently generates false-positive PCR results. ...

Abstract	Background: 16S rDNA-PCR for the identification of a bacterial species is an established method. However, the DNA extraction reagents as well as the PCR reagents may contain residual bacterial DNA, which consequently generates false-positive PCR results. Additionally, previously used methods are frequently time-consuming. Here, we describe the results obtained with a new technology that uses DNA-free reagents for automated DNA extraction and subsequent real time PCR using sterile clinical specimens. Results: In total, we compared 803 clinical specimens using real time PCR and culturing. The clinical specimens were mainly of orthopedic origin received at our diagnostic laboratory. In 595 (74.1%) samples, the results were concordant negative, and in 102 (12.7%) the results were concordant positive. A total of 170 (21.2%) clinical specimens were PCR-positive, of which 62 (36.5% from PCR positive, 7.7% in total) gave an additional benefit to the patient since only the PCR result was positive. Many of these 62 positive specimens were strongly positive based on crossingpoint values (54% < Cp 30), and these 62 positive clinical specimens were diagnosed as medically relevant as well. Thirty-eight (4.2%) clinical specimens were culture-positive (25 of them were only enrichment culture positive) but PCR-negative, mainly for S. epidermidis, S. aureus and C. acnes. The turnaround times for negative specimens were 4 hours (automated DNA extraction and real time PCR) and 1 working day for positive specimens (including Sanger sequencing). Melting-curve analysis of SYBR Green-PCR enables the differentiation of specific and unspecific PCR products. Using Ripseq, even mixed infections of 2 bacterial species could be resolved. Conclusions: For endocarditis cases, the added benefit of PCR is obvious. The crucial innovations of the technology enable timely reporting of explicit reliable results for adequate treatment of patients. Clinical specimens with truly PCR-positive but culture-negative results represent an additional benefit for patients. Very few results at the detection limit still have to be critically examined.
MeSH term(s)	Bacteria/genetics ; DNA, Bacterial/analysis ; DNA, Bacterial/genetics ; DNA, Ribosomal/genetics ; Humans ; Indicators and Reagents ; Real-Time Polymerase Chain Reaction ; Staphylococcus aureus/genetics
Chemical Substances	DNA, Bacterial ; DNA, Ribosomal ; Indicators and Reagents
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-022-02542-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How plant traits respond to and affect vertebrate and invertebrate herbivores-Are measurements comparable across herbivore types?

Lebbink, Gabrielle / Risch, Anita C / Schuetz, Martin / Firn, Jennifer

Plant, cell & environment

2023 Volume 47, Issue 1, Page(s) 5–23

Abstract: Despite plants realistically being affected by vertebrate and invertebrate herbivores simultaneously, fundamental differences in the ecology and evolution of these two herbivore guilds often means their impacts on plants are studied separately. A ... ...

Abstract	Despite plants realistically being affected by vertebrate and invertebrate herbivores simultaneously, fundamental differences in the ecology and evolution of these two herbivore guilds often means their impacts on plants are studied separately. A synthesis of the literature is needed to understand the types of plant traits examined and their response to, and effect on (in terms of forage selection) vertebrate and invertebrate herbivory, and to identify associated knowledge gaps. Focusing on grassland systems and species, we found 138 articles that met our criteria: 39 invertebrate, 97 vertebrate and 2 focussed on both vertebrate and invertebrate herbivores. Our study identified invertebrate focussed research, research conducted in the Southern Hemisphere and research on nondomesticated herbivores was significantly underrepresented based on our search and should be a focus of future research. Differences in study focus (trait response or trait effect), along with differences in the types of traits examined, led to limited opportunity for comparison between the two herbivore guilds. This review therefore predominantly discusses the response and effect of plant traits to each herbivore guild separately. In future studies, we suggest this review be used as a guide for trait selection, to improve comparability and the broader significance of results.
MeSH term(s)	Animals ; Herbivory/physiology ; Invertebrates/physiology ; Vertebrates ; Plants ; Ecology
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.14738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Labormedizin für die Praxis.

Risch, Martin

Therapeutische Umschau. Revue therapeutique

2015 Volume 72, Issue 2, Page(s) 75

Title translation	Laboratory medicine for the practice.
MeSH term(s)	Clinical Laboratory Services/trends ; Clinical Laboratory Techniques/trends ; Diagnostic Tests, Routine/trends ; Humans ; Practice Patterns, Physicians'/trends ; Switzerland
Language	German
Publishing date	2015-02
Publishing country	Switzerland
Document type	Editorial ; Introductory Journal Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
DOI	10.1024/0040-5930/a000646
Database	MEDical Literature Analysis and Retrieval System OnLINE

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article: S-Gene Target Failure as an Effective Tool for Tracking the Emergence of Dominant SARS-CoV-2 Variants in Switzerland and Liechtenstein, Including Alpha, Delta, and Omicron BA.1, BA.2, and BA.4/BA.5.

Hilti, Dominique / Wehrli, Faina / Berchtold, Sabine / Bigler, Susanna / Bodmer, Thomas / Seth-Smith, Helena M B / Roloff, Tim / Kohler, Philipp / Kahlert, Christian R / Kaiser, Laurent / Egli, Adrian / Risch, Lorenz / Risch, Martin / Wohlwend, Nadia

Microorganisms

2024 Volume 12, Issue 2

Abstract: During the SARS-CoV-2 pandemic, the Dr. Risch medical group employed the multiplex TaqPath ...

Abstract	During the SARS-CoV-2 pandemic, the Dr. Risch medical group employed the multiplex TaqPath
Language	English
Publishing date	2024-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020321
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 Nucleocapsid Protein Mutations Found in Switzerland Disrupt N-Gene Amplification in Commonly Used Multiplex RT-PCR Assay.

Hilti, Dominique / Wehrli, Faina / Roditscheff, Anna / Risch, Martin / Risch, Lorenz / Egli, Adrian / Bodmer, Thomas / Wohlwend, Nadia

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: At the end of 2021, we observed an increase in N-gene target failures (NGTF) with the TaqPathTM COVID-19 CE-IVD RT-PCR Kit from Thermo Fisher Scientific (TaqPath). We subsequently used whole-genome sequencing (Oxford Nanopore Technology) to identify ... ...

Abstract	At the end of 2021, we observed an increase in N-gene target failures (NGTF) with the TaqPathTM COVID-19 CE-IVD RT-PCR Kit from Thermo Fisher Scientific (TaqPath). We subsequently used whole-genome sequencing (Oxford Nanopore Technology) to identify potential issues with N-gene PCR efficacy. Among 168,101 positive samples with a cycle threshold (CT) value <30 from August 2021 to May 2022, 194 specimens without N-gene amplification by PCR were identified (0.12%). Most NGTF samples originated from a wave of infection attributable to the Delta variant (B.1.617.2) and its sublineages. Sequencing revealed the nucleotide substitution G28922T (A217S) in 151 samples (88.8%). The substitution G215C, a hallmark mutation for Delta lineages, was concurrently present in all of these samples. Ten samples (5.9%) carried the deletion 28,913-28,918 (del214/215), eight samples (4.7%) the deletion 28,913-28,915 (del214) and one sample (0.6%) the deletion 28,892-28,930 (del207-219). Samples showing intact N-gene amplification by PCR lacked these specific mutations, but delayed-type amplification (i.e., partial or pNGTF) was attributable to the exclusive presence of A217S. As the N gene is a common target in many RT-PCR methods for SARS-CoV-2, an in-depth analysis of single-target failures using a combination with viral whole genome sequencing may allow for the identification of diagnostic flaws and eventual new variants.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12121383
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Association of suPAR with Cardiovascular Risk Factors in Young and Healthy Adults.

Wohlwend, Niklas Fabio / Grossmann, Kirsten / Aeschbacher, Stefanie / Weideli, Ornella C / Telser, Julia / Risch, Martin / Conen, David / Risch, Lorenz

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 18

Abstract: The soluble urokinase plasminogen activator receptor (suPAR), as a correlate of chronic low-grade inflammation, may be used to predict individual cardiovascular risk. Since chronic low-grade inflammation is thought to be associated with the development ... ...

Abstract	The soluble urokinase plasminogen activator receptor (suPAR), as a correlate of chronic low-grade inflammation, may be used to predict individual cardiovascular risk. Since chronic low-grade inflammation is thought to be associated with the development of cardiovascular disease, this study aimed to evaluate if suPAR plasma levels are correlated with cardiovascular risk factors in young and healthy adults (aged 25-41 years). Consequently, data from the GAPP (genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors) study were used to investigate suPAR plasma levels in relation to the following cardiovascular risk factors and laboratory parameters: BMI, physical activity, alcohol consumption, smoking status, blood pressure parameters, glucose status, and lipid levels. Additionally, suPAR was compared to the healthy lifestyle score and the Framingham score representing the overall cardiovascular risk profile. These associations were assessed using two different statistical approaches. Firstly, all cardiovascular risk factors and scores were compared amongst sex-specific suPAR plasma levels with ANOVA analysis. Secondly, sex-specific multivariable linear regressions were performed. Female participants had higher plasma suPAR levels than male participants (1.73 ng/mL versus 1.50 ng/mL;
Language	English
Publishing date	2023-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13182938
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mortality risk factors in community-dwelling, subjectively healthy, Swiss older adults: update after 8-years follow-up.

Gutzwiller, Jean-Pierre / Müller-Bolla, Krisztina / Ferrari, Carlo / Stanga, Zeno / Nydegger, Urs E / Risch, Lorenz / Risch, Martin

BMC geriatrics

2023 Volume 23, Issue 1, Page(s) 303

Abstract: Background: Worldwide population is ageing, but little is known regarding risk factors associated with increased mortality in subjectively healthy, community-dwelling older adults. We present the updated results of the longest follow-up carried out on ... ...

Abstract	Background: Worldwide population is ageing, but little is known regarding risk factors associated with increased mortality in subjectively healthy, community-dwelling older adults. We present the updated results of the longest follow-up carried out on Swiss pensioners and we provide results on potential risk factors associated with mortality before the onset of the COVID-19 pandemic. Materials and methods: Within the SENIORLAB study, we collected demographic data, anthropometric measures, medical history, and laboratory parameters of 1467 subjectively healthy, community-dwelling, Swiss adults aged ≥ 60 years over a median follow-up of 8.79 years. The variables considered in the multivariable Cox-proportional hazard model for mortality during follow-up were selected based on prior knowledge. Two separate models for males and females were calculated; moreover, we fitted the old model obtained in 2018 to the complete follow-up data to highlight differences and similarities. Results: The population sample included 680 males and 787 females. Age of participants ranged between 60 and 99 years. We experienced 208 deaths throughout the entire follow-up period; no patients were lost at follow-up. The Cox-proportional hazard regression model included female gender, age, albumin levels, smoking status, hypertension, osteoporosis and history of cancer within predictors of mortality over the follow-up period. Consistent findings were obtained also after gender stratification. After fitting the old model, female gender, hypertension, and osteoporosis still showed statistically significant independent associations with all-cause mortality. Conclusions: Understanding the predictors of a healthy survival can improve the overall quality of life of the ageing population and simultaneously reduce their global economic burden. Trial registration: The present study was registered in the International Standard Randomized Controlled Trial Number registry: https://www.isrctn.com/ISRCTN53778569 (registration date: 27/05/2015).
MeSH term(s)	Male ; Humans ; Female ; Aged ; Independent Living ; Follow-Up Studies ; Quality of Life ; Switzerland/epidemiology ; Pandemics ; COVID-19 ; Risk Factors ; Hypertension ; Osteoporosis
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-03959-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID-Results from the Prospective Population-Based COVI-GAPP Study.

Telser, Julia / Grossmann, Kirsten / Weideli, Ornella C / Hillmann, Dorothea / Aeschbacher, Stefanie / Wohlwend, Niklas / Velez, Laura / Kuhle, Jens / Maleska, Aleksandra / Benkert, Pascal / Risch, Corina / Conen, David / Risch, Martin / Risch, Lorenz

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 13

Abstract: It is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (sNfL) and glial ...

Abstract	It is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) can be used to elucidate neuro-axonal and astroglial injuries. We investigated whether these biomarkers are associated with COVID-19 infection status, associated symptoms and Long-COVID. From 146 individuals of the general population with a post-acute, mild-to-moderate SARS-CoV-2 infection, sNfL and sGFAP were measured before, during and after (five and ten months) the infection. Individual symptoms and Long-COVID status were assessed using questionnaires. Neurological associated symptoms were described for individuals after a mild and moderate COVID-19 infection; however, sNfL (
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13132167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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