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Article ; Online: Deep Fuzzy Min-Max Neural Network: Analysis and Design.

Huang, Wei / Sun, Mingxi / Zhu, Liehuang / Oh, Sung-Kwun / Pedrycz, Witold

IEEE transactions on neural networks and learning systems

2022 Volume PP

Abstract: Fuzzy min-max neural network (FMNN) is one kind of three-layer models based on hyperboxes that are ...

Abstract	Fuzzy min-max neural network (FMNN) is one kind of three-layer models based on hyperboxes that are constructed in a sequential way. Such a sequential mechanism inevitably leads to the input order and overlap region problem. In this study, we propose a deep FMNN (DFMNN) based on initialization and optimization operation to overcome these limitations. Initialization operation that can solve the input order problem is to design hyperboxes in a simultaneous way, and side parameters have been proposed to control the size of hyperboxes. Optimization operation that can eliminate overlap region problem is realized by means of deep layers, where the number of layers is immediately determined when the overlap among hyperboxes is eliminated. In the optimization process, each layer consists of three sections, namely, the partition section, combination section, and union section. The partition section aims to divide the hyperboxes into a nonoverlapping hyperbox set and an overlapping hyperbox set. The combination section eliminates the overlap problem of overlapping hyperbox set. The union section obtains the optimized hyperbox set in the current layer. DFMNN is evaluated based on a series of benchmark datasets. A comparative analysis illustrates that the proposed DFMNN model outperforms several models previously reported in the literature.
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3226040
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Article ; Online: Winnie- APC Min/+ Mice

Stefania De Santis / Giulio Verna / Grazia Serino / Raffaele Armentano / Elisabetta Cavalcanti / Marina Liso / Manuela Dicarlo / Sergio Coletta / Mauro Mastronardi / Antonio Lippolis / Angela Tafaro / Angelo Santino / Aldo Pinto / Pietro Campiglia / Alex Y. Huang / Fabio Cominelli / Theresa T. Pizarro / Marcello Chieppa

International Journal of Molecular Sciences, Vol 21, Iss 2972, p

A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation

2020 Volume 2972

Abstract: ... by crossing Mucin 2 mutated mice (Winnie) with Apc Min/+ mice. (3) Results: The resulting Winnie- Apc Min ... Winnie- Apc Min/+ mice show an early occurrence of inflammatory signs and dysplastic lesions ... in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie- Apc Min/+ model is ...

Abstract	(1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with Apc Min/+ mice. (3) Results: The resulting Winnie- Apc Min/+ model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie- Apc Min/+ mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie- Apc Min/+ model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC.
Keywords	colorectal cancer ; murine model ; inflammation ; Aberrant Crypt Foci ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of 5-min mindfulness of love on suffering and spiritual quality of life of palliative care patients: A randomized controlled study.

Lim, Min Ai / Ang, Bin Ting / Lam, Chee Loong / Loh, Ee Chin / Zainuddin, Sheriza Izwa / Capelle, David Paul / Ng, Chong Guan / Lim, Poh Khuen / Khor, Pei Yi / Lim, Jia Yu / Huang, See Yong / Low, Gladys Qiao Jyn / Gan, Xhi Yan / Tan, Seng Beng

European journal of cancer care

2021 Volume 30, Issue 5, Page(s) e13456

Abstract: ... to determine the effect of 5-min mindfulness of love on suffering and the spiritual quality of life ... recruited and randomly assigned to either the 5-min mindfulness of love group (N = 30) or the 5-min ... group compared to the control group.: Conclusion: The results provided evidence that 5-min ...

Abstract	Objective: Suffering is a common experience in palliative care. In our study, we aimed to determine the effect of 5-min mindfulness of love on suffering and the spiritual quality of life of palliative care patients. Methods: We conducted a parallel-group, blinded, randomized controlled study at the University of Malaya Medical Centre (UMMC), Malaysia from February 2019 to April 2019. Sixty adult palliative care patients with an overall suffering score of 4/10 or above based on the Suffering Pictogram were recruited and randomly assigned to either the 5-min mindfulness of love group (N = 30) or the 5-min supportive listening group (N = 30). Results: There were statistically significant improvements in the overall suffering score (mean difference = -2.9, CI = -3.7 to -2.1, t = -7.268, p = 0.000) and the total FACIT-Sp-12 score (mean difference = 2.9, CI = 1.5 to 4.3, t = 4.124, p = 0.000) in the intervention group compared to the control group. Conclusion: The results provided evidence that 5-min mindfulness of love could affect the actual state of suffering and the spiritual quality of life of palliative care patients.
MeSH term(s)	Adult ; Hospice and Palliative Care Nursing ; Humans ; Love ; Mindfulness ; Palliative Care ; Quality of Life
Language	English
Publishing date	2021-04-28
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1303114-4
ISSN	1365-2354 ; 0961-5423 ; 1360-5801
ISSN (online)	1365-2354
ISSN	0961-5423 ; 1360-5801
DOI	10.1111/ecc.13456
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Article ; Online: Active Transport of Membrane Components by Self-Organization of the Min Proteins.

Shih, Yu-Ling / Huang, Ling-Ting / Tu, Yu-Ming / Lee, Bo-Fan / Bau, Yu-Chiuan / Hong, Chia Yee / Lee, Hsiao-Lin / Shih, Yan-Ping / Hsu, Min-Feng / Lu, Zheng-Xin / Chen, Jui-Szu / Chao, Ling

Biophysical journal

2019 Volume 116, Issue 8, Page(s) 1469–1482

Abstract: ... Min proteins can impose steric pressure on the membrane, resulting in transport and directional ... of binding and dissociation of the Min proteins in the propagating waves on the membrane surface ... of the membrane component. Thus, transportation of the membrane component by the Min proteins follows a simple ...

Abstract	Heterogeneous distribution of components in the biological membrane is critical in the process of cell polarization. However, little is known about the mechanisms that can generate and maintain the heterogeneous distribution of the membrane components. Here, we report that the propagating wave patterns of the bacterial Min proteins can impose steric pressure on the membrane, resulting in transport and directional accumulation of the component in the membrane. Therefore, the membrane component waves represent transport of the component in the membrane that is caused by the steric pressure gradient induced by the differential levels of binding and dissociation of the Min proteins in the propagating waves on the membrane surface. The diffusivity, majorly influenced by the membrane anchor of the component, and the repulsed ability, majorly influenced by the steric property of the membrane component, determine the differential spatial distribution of the membrane component. Thus, transportation of the membrane component by the Min proteins follows a simple physical principle, which resembles a linear peristaltic pumping process, to selectively segregate and maintain heterogeneous distribution of materials in the membrane. VIDEO ABSTRACT.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Biological Transport, Active ; Cell Membrane/metabolism ; Kinetics ; Models, Biological
Chemical Substances	Bacterial Proteins
Language	English
Publishing date	2019-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2019.03.011
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Article ; Online: DMMG: Dual Min-Max Games for Self-Supervised Skeleton-Based Action Recognition.

Guan, Shannan / Yu, Xin / Huang, Wei / Fang, Gengfa / Lu, Haiyan

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2023 Volume 33, Page(s) 395–407

Abstract: In this work, we propose a new Dual Min-Max Games (DMMG) based self-supervised skeleton action ... of a viewpoint variation min-max game and an edge perturbation min-max game. These two min-max games adopt ... respectively. Our viewpoint variation min-max game focuses on constructing various hard contrastive pairs ...

Abstract	In this work, we propose a new Dual Min-Max Games (DMMG) based self-supervised skeleton action recognition method by augmenting unlabeled data in a contrastive learning framework. Our DMMG consists of a viewpoint variation min-max game and an edge perturbation min-max game. These two min-max games adopt an adversarial paradigm to perform data augmentation on the skeleton sequences and graph-structured body joints, respectively. Our viewpoint variation min-max game focuses on constructing various hard contrastive pairs by generating skeleton sequences from various viewpoints. These hard contrastive pairs help our model learn representative action features, thus facilitating model transfer to downstream tasks. Moreover, our edge perturbation min-max game specializes in building diverse hard contrastive samples through perturbing connectivity strength among graph-based body joints. The connectivity-strength varying contrastive pairs enable the model to capture minimal sufficient information of different actions, such as representative gestures for an action while preventing the model from overfitting. By fully exploiting the proposed DMMG, we can generate sufficient challenging contrastive pairs and thus achieve discriminative action feature representations from unlabeled skeleton data in a self-supervised manner. Extensive experiments demonstrate that our method achieves superior results under various evaluation protocols on widely-used NTU-RGB+D, NTU120-RGB+D and PKU-MMD datasets.
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2023.3338410
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Article ; Online: Immediate analgesic effect of acupuncture intervention within 10 min during acute migraine attacks: protocol of a randomised controlled trial.

Huang, Ya / Li, Qifu / Huang, Gaoyangzi / Pei, Xianmei / Chen, Ziwen / Tang, Xing / Zhang, Renrui / Zhao, Si-Wen / Liu, Zili / Sun, Jinbo / Guo, Taipin / Liang, Fan-Rong

BMJ open

2023 Volume 13, Issue 9, Page(s) e075715

Abstract: ... analgesic effect of acupuncture for 10 min during acute migraine attacks.: Methods and analysis ... group with an allocation ratio of 1:1. Each group will receive 10 min of treatment, and ... the post-treatment evaluation will be performed after 0, 0-2, 4, 6, 8 and 10 min of acupuncture. The primary outcome ...

Abstract	Introduction: Migraine is a widespread neurological disorder characterised by recurrent moderate-to-severe headaches. These headaches can seriously affect patients' daily life and work, especially during acute attacks when patients often need immediate pain relief. This study aims to assess the immediate analgesic effect of acupuncture for 10 min during acute migraine attacks. Methods and analysis: The study will randomly divide 80 participants into either the acupuncture group or the sham acupuncture group with an allocation ratio of 1:1. Each group will receive 10 min of treatment, and the post-treatment evaluation will be performed after 0, 0-2, 4, 6, 8 and 10 min of acupuncture. The primary outcome is the pain Visual Analogue Scale (VAS) score assessed before and after treatment at 10 min. Additionally, secondary outcomes include the pain VAS score assessed at 0-2, 4, 6 and 8 min, blinding assessment and treatment effectiveness expectations scale. Data will be collected at baseline time and the end of treatment (after 10 min). Adverse events during each treatment period will be collected and recorded. Ethics and dissemination: Ethics approval was obtained from the Ethics Committee of the Second Affiliated Hospital of Yunnan University of Chinese Medicine (2022-008). All participants will provide written informed consent before randomisation. The results of this study will be published in a peer-reviewed journal and presented at conferences. Trial registration number: Chinese Clinical Trial Registration Center (ChiCTR2200066976).
MeSH term(s)	Humans ; China ; Acupuncture Therapy ; Migraine Disorders/therapy ; Headache ; Analgesics ; Randomized Controlled Trials as Topic
Chemical Substances	Analgesics
Language	English
Publishing date	2023-09-18
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075715
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Article ; Online: Detecting Submicromolar Analytes in Mixtures with a 5 min Acquisition on 600 MHz NMR Spectrometers.

Zhang, Congcong / Xu, Li / Huang, Qingxia / Wang, Yulan / Tang, Huiru

Journal of the American Chemical Society

2023 Volume 145, Issue 47, Page(s) 25513–25517

Abstract: Amino compounds are widely present in complex mixtures in chemistry, biology, medicine, food, and environmental sciences involving drug impurities and metabolisms of proteins, biogenic amines, neurotransmitters, and pyrimidine in biological systems. ... ...

Abstract	Amino compounds are widely present in complex mixtures in chemistry, biology, medicine, food, and environmental sciences involving drug impurities and metabolisms of proteins, biogenic amines, neurotransmitters, and pyrimidine in biological systems. Nuclear magnetic resonance (NMR) spectroscopy is an excellent tool for simultaneously identifying and quantifying these in-mixture compounds but has a limit-of-detection (LOD) over several micromolarities (>5 μM). To break such a sensitivity barrier, we developed a sensitive and rapid method by combining the probe-induced sensitivity enhancement and nonuniform-sampling-based
MeSH term(s)	Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Imaging ; Proteins ; Metabolomics/methods ; Complex Mixtures
Chemical Substances	Proteins ; Complex Mixtures
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c07861
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Article ; Online: Preoperative dexamethasone administration in hepatectomy of 25-min intermittent Pringle's maneuver for hepatocellular carcinoma: a randomized controlled trial.

Huang, Yang / Xu, Liangliang / Wang, Ning / Wei, Yonggang / Wang, Wentao / Xu, Mingqing / Jiang, Li

International journal of surgery (London, England)

2023 Volume 109, Issue 11, Page(s) 3354–3364

Abstract: ... maneuver (IPM) with a 25-min ischemic interval could be applied safely and efficiently in hepatectomy ... of prophylactic dexamethasone on alleviating surgical stress for HCC patients with a 25-min ischemic interval ... patients when applying IPM with a 25-min ischemic interval in hepatectomy. ...

Abstract	Background: A previous randomized controlled trial demonstrated that intermittent Pringle's maneuver (IPM) with a 25-min ischemic interval could be applied safely and efficiently in hepatectomy for patients with hepatocellular carcinoma (HCC). But prolonging the hepatic inflow clamping time will inevitably aggravate the ischemia-reperfusion injury. Therefore, we aimed to evaluate the effect of prophylactic dexamethasone on alleviating surgical stress for HCC patients with a 25-min ischemic interval. Methods: From December 2022 to April 2023, patients who met the inclusion criteria were randomly assigned to the dexamethasone group or control group. Perioperative data and short-term survival outcomes between the two groups were recorded and compared, and subgroup analysis was performed. Results: Two hundred and seventy patients were allocated to the dexamethasone group ( n =135) and control group ( n =135). Patients in the dexamethasone group had lower area under the curve of serial alanine aminotransferase (AUC ALT ) ( P =0.043) and aspartate aminotransferase (AUC AST ) ( P =0.009), total bilirubin (TB) ( P =0.018), procalcitonin (PCT) ( P =0.012), interleukin-6 (IL-6) ( P =0.006), incidence of major complication ( P =0.031) and shorter postoperative hospital stay ( P =0.046) than those in the control group. Subgroup analysis showed that the dexamethasone group experienced milder hepatocellular injury than the control group for patients with cirrhosis, and for patients without cirrhosis, the dexamethasone group experienced milder inflammatory response. Moreover, the dexamethasone group preserved better liver function and experienced milder inflammatory response for patients undergoing major hepatectomy, although the hepatocellular injury was not significantly improved. Conclusion: Preoperative dexamethasone administration can help improve perioperative outcomes for HCC patients when applying IPM with a 25-min ischemic interval in hepatectomy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Hepatectomy/adverse effects ; Liver Neoplasms/pathology ; Ischemia/etiology ; Dexamethasone/therapeutic use
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000622
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Article ; Online: Preoperative dexamethasone administration in hepatectomy of 25-min intermittent Pringle's maneuver for hepatocellular carcinoma: protocol for a randomized controlled trial.

Huang, Yang / Xu, Liangliang / Wang, Ning / Pu, Xingyu / Wang, Wentao / Wen, Tianfu / Xu, Mingqing / Jiang, Li

Trials

2023 Volume 24, Issue 1, Page(s) 774

Abstract: ... Pringle's maneuver (IPM) with a 25-min ischemic interval can be applied safely and efficiently in open or ... outcomes among HCC patients undergoing liver resection with 25-min hepatic inflow occlusion.: Methods and ... the surgical stress response in order to follow securely 25-min hepatic inflow occlusion. Therefore, the trial ...

Abstract	Background: Our previous randomized controlled trial (RCT) have demonstrated that intermittent Pringle's maneuver (IPM) with a 25-min ischemic interval can be applied safely and efficiently in open or laparoscopic hepatectomy in patients with hepatocellular carcinoma (HCC) patients. But prolonging the hepatic inflow blocking time will inevitably aggravate the ischemia-reperfusion injury (IRI) caused by systemic response. This RCT aims to evaluate the effect of administration of dexamethasone versus placebo before clamping the hilar pedicle on postoperative liver function, inflammatory response, and perioperative outcomes among HCC patients undergoing liver resection with 25-min hepatic inflow occlusion. Methods and analysis: This will be a randomized, dual-arm, parallel-group, double-blinded trial. All eligible and consecutive patients are coming from a regional medical center who are diagnosed with HCC and underwent radical R0/R1 resection. All participates are randomly allocated in dexamethasone group or placebo group. All surgeons, anesthesiologists, and outcome assessors will be blinded to allocation status. Primary endpoints are transaminase-based postoperative hepatic injury on seven consecutive days after surgery and assessed by their peak values as well as area under the curve (AUC) of the postoperative course of aminotransferases. Secondary endpoints are postoperative total bilirubin (TBil), coagulation function, inflammatory cytokines and their respective peaks, intraoperative blood loss, postoperative hospital stay, morbidity, and mortality. The above parameters will be compared using the corresponding statistical approach. Subgroup analysis will be performed according to the liver cirrhosis and major hepatectomy. Discussion: Based on our previous study, we will explore further the effect of glucocorticoid administration on attenuating the surgical stress response in order to follow securely 25-min hepatic inflow occlusion. Therefore, the trial protocol is reasonable and the results of the trial may be clinically significant. Trial registration: This trial was registered on 3 December 2022, in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn ), ChiCTR2200066381. The protocol version is V1.0 (20221104).
MeSH term(s)	Humans ; Blood Loss, Surgical ; Carcinoma, Hepatocellular/surgery ; Dexamethasone/therapeutic use ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Liver Neoplasms/surgery ; Randomized Controlled Trials as Topic
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07820-0
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Article: Transcriptomics yields valuable information regarding the response mechanisms of Chinese Min pigs infected with PEDV.

Li, Huihui / Zhou, Chunxiang / Zhang, Meimei / Yuan, Na / Huang, Xiaoyu / Xiang, Jiaojiao / Wang, Lixian / Shi, Lijun

Frontiers in veterinary science

2023 Volume 10, Page(s) 1295723

Abstract: ... and immune responses of pigs infected with PEDV.In this study, 12 Min pigs were randomly selected ... sections, and transcriptomics. The phenotypes of Min piglets infected with PEDV showed that the viral copy ...

Abstract	Porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea (PED), a highly infectious disease, which has resulted in huge economic losses for the pig industry. To date, the pathogenic and immune response mechanism was not particularly clear. The purpose of this study was to investigate the pathogenic and immune responses of pigs infected with PEDV.In this study, 12 Min pigs were randomly selected without taking colostrum. At 3 days old, eight piglets were infected with 1 mL of PEDV solution (10 TCID50/ml), and the remaining four piglets were handled by 1 mL of 0.9% normal saline. Within the age of 7 days old, four piglets died and were considered as the death group. Correspondingly, four alive individuals were classified into the resistance group. Tissues of the duodenum, jejunum, ileum, colon, cecum, and rectum of piglets in the three groups were collected to measure the PEDV content. Additionally, the jejunum was used for the measurements and analyses of Hematoxylin-eosinstaining (HE), immunohistochemical sections, and transcriptomics. The phenotypes of Min piglets infected with PEDV showed that the viral copy numbers and jejunal damage had significant differences between the death and resistance groups. We also observed the transcriptome of the jejunum, and the differentially expressed (DE) analysis observed 6,585 DE protein-coding genes (PCGs), 3,188 DE long non-coding RNAs (lncRNAs), and 350 DE microRNAs (miRNAs), which were mainly involved in immune response and metabolic pathways. Furthermore, the specific expressed molecules for each group were identified, and 97 PCGs,108 lncRNAs, and 51 miRNAs were included in the ceRNA-regulated networks. By weighted gene co-expression network analysis (WGCNA) and transcription factor (TF) prediction, 27 significant modules and 32 significant motifs (
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1295723
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