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  1. Article: Ba(OH)2 Equilibria in the System Ba-O-H-F, With Application to the Formation of Ba2YCu3O6.5 + x From BaF2-Precursors.

    Cook, L P / Wong-Ng, W / Feenstra, R

    Journal of research of the National Institute of Standards and Technology

    2005  Volume 110, Issue 2, Page(s) 115–126

    Abstract: ... in which essentially all F at the surface was replaced by O. It is therefore possible that processing routes exist ...

    Abstract The ex situ process for fabricating Ba2YCu3O6.5 + x superconducting tapes from BaF2- based precursors involves a hydration/oxidation reaction at ≈730 °C to 750 °C generally written as: [Formula: see text] However, microscopic observations of partially processed films suggest the presence of a transient liquid phase during conversion. Alternatively, the conversion reaction can be rewritten as the sum of several intermediate steps, including the formation of a barium hydroxide liquid: [Formula: see text] To evaluate the possibility of a hydroxide liquid conversion step, thermodynamic calculations on the stability of Ba(OH)2(liq) have been completed from 500 °C to 900 °C at 0.1 MPa p total. Based on currently available data, the calculated phase diagrams suggest that a viable hydroxide reaction path exists in the higher part of this temperature range. The calculations indicate that Ba(OH)2(liq) may be stable at log [Formula: see text] (Pa) values from ≈4 to 5, provided log p HF (Pa) values can be maintained below 0 to -1. Limited experimental confirmation is provided by results of an experiment on BaF2(s) at 815 °C, 0.1 MPa [Formula: see text], in which essentially all F at the surface was replaced by O. It is therefore possible that processing routes exist for producing Ba2YCu3O6.5 + x based on the presence of a Ba(OH)2 liquid, which might have an effect on conversion rates and texturing in the superconducting film.
    Language English
    Publishing date 2005-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473724-3
    ISSN 1044-677X ; 0160-1741
    ISSN 1044-677X ; 0160-1741
    DOI 10.6028/jres.110.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tuning the regio- and stereoselectivity of C-H activation in n-octanes by cytochrome P450 BM-3 with fluorine substituents: evidence for interactions between a C-F bond and aromatic π systems.

    Wu, Li-Lan / Yang, Chung-Ling / Lo, Feng-Chun / Chiang, Chih-Hsiang / Chang, Chun-Wei / Ng, Kok Yaoh / Chou, Ho-Hsuan / Hung, Huei-Ying / Chan, Sunney I / Yu, Steve S-F

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2011  Volume 17, Issue 17, Page(s) 4774–4787

    Abstract: ... Waals interactions between a C-F substituent in the substrate and the polarizable π system ... mutation, presumably because of interactions of the C-F substituent with the π system of the porphyrin ...

    Abstract We employed the water-soluble cytochrome P450 BM-3 to study the activity and regiospecificity of oxidation of fluorinated n-octanes. Three mutations, A74G, F87V, and L188Q, were introduced into P450 BM-3 to allow the system to undergo n-octane oxidation. In addition, the alanine at residue 328 was replaced with a phenylalanine to introduce an aromatic residue into the hydrophobic pocket to examine whether or not van der Waals interactions between a C-F substituent in the substrate and the polarizable π system of the phenylalanine may be used to steer the positioning of the substrate within the active-site pocket of the enzyme and control the regioselectivity and stereoselectivity of hydroxylation. Interestingly, not only was the regioselectivity controlled when the fluorine substituent was judiciously positioned in the substrate, but the electron input into the iron-heme group became tightly coupled to the formation of product, essentially without abortive side reactions. Remarkable enhancement of the coupling efficiency between electron input and product formation was observed for a range of fluorinated octanes in the enzyme even without the A328F mutation, presumably because of interactions of the C-F substituent with the π system of the porphyrin macrocycle within the active-site pocket. Evidently, tightening the protein domain containing the heme pocket tunes the distribution of accessible enzyme conformations and the associated protein dynamics that activate the iron porphyrin for substrate hydroxylation to allow the reactions mediated by the high-valent Fe(IV)=O to become kinetically more commensurate with electron transfer from the flavin adenine dinucleotide (FAD)/flavin mononucleotide (FMN) reductase. These observations lend compelling evidence to support significant van der Waals interactions between the CF(2) group and aromatic π systems within the heme pocket when the fluorinated octane substrate is bound.
    MeSH term(s) Cytochrome P-450 Enzyme System/chemistry ; Electron Transport ; Flavin Mononucleotide/chemistry ; Flavin-Adenine Dinucleotide/chemistry ; Fluorine/chemistry ; Hydrocarbons, Fluorinated/chemistry ; Hydrogen Bonding ; Hydroxylation ; Molecular Conformation ; Mutagenesis ; Octanes/chemistry ; Oxidation-Reduction ; Solubility ; Stereoisomerism ; Water/chemistry
    Chemical Substances Hydrocarbons, Fluorinated ; Octanes ; Water (059QF0KO0R) ; Flavin-Adenine Dinucleotide (146-14-5) ; Fluorine (284SYP0193) ; Flavin Mononucleotide (7N464URE7E) ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2011-04-18
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201003631
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  3. Book ; Online: Sustainable Development Goal 3 : Health and Well-being of Ageing in Hong Kong

    Fong, Ben Y. F. / Law, Vincent T. S. / Leung, Tiffany C. H. / Lo, Man Fung / Ng, Tommy K. C. / Yee, Hilary H. L.

    2022  

    Keywords Development economics & emerging economies ; Public health & preventive medicine ; Child & developmental psychology ; Ageing and Diversity ; Healthy Ageing ; Health Equity ; Health Inequalities ; Sustainable Development Goals
    Size 1 electronic resource (104 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021232884
    ISBN 9781032115016 ; 1032115017
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Burkholderia pseudomallei

    Lau, F H C / Lin, M F / Ng, W S

    Hong Kong medical journal = Xianggang yi xue za zhi

    2024  Volume 30, Issue 2, Page(s) 167–169

    Language English
    Publishing date 2024-04-17
    Publishing country China
    Document type Case Reports
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj2310671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4347: Show issues Location:
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  5. Article: Cyclopenta[f]isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 1. Synthesis of 3-ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline.

    Kundu, N G / Wright, J A / Perlman, K L / Hallett, W / Heidelberger, C

    Journal of medicinal chemistry

    1975  Volume 18, Issue 4, Page(s) 395–399

    Abstract: By the use of space-filling models, a novel compound, 6-carbamylmethyl-8-methyl-7(5)H-cyclopenta[f ... a hydrogen bond to the N-7 of guanine. 3-Ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline (4) which constitutes ... Chain extension of 14 followed by cyclization led to 3-ethoxy-8-methyl-5,6-dihydro-7H-cyclopenta[f ...

    Abstract By the use of space-filling models, a novel compound, 6-carbamylmethyl-8-methyl-7(5)H-cyclopenta[f]isoquinolin-3-(2H)-one was devised which would be expected to hydrogen bond specifically to GC pairs in the major groove of the double helix such that (i) the amino group of the cytosine molecule donates a hydrogen bond to the C-3 carbonyl of the isoquinoline moiety and (ii) the amide proton of the side chain donates a hydrogen bond to the N-7 of guanine. 3-Ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline (4) which constitutes the basic ring system of 1 was synthesized in a multistep procedure starting from m-methyl-N-acetylbenzylamine (5). Friedel-Crafts reaction of 5 led to 2,4-bis(chloromethyl)-5-methyl-N-acetylbenzylamine (6) which on treatment with KCN, hydrolysis of the resultant nitrile, and subsequent esterification afforded 6-carbethoxymethyl-7-methyl-1,2,3,4-tetrahydroisoquinolin-3-one (9). Treatment of 9 with triethyloxonium fluoborate followed by dehydrogenation of the product gave 6-carbethoxy-methyl-3-ethoxy-7-methylisoquinoline (14). Chain extension of 14 followed by cyclization led to 3-ethoxy-8-methyl-5,6-dihydro-7H-cyclopenta[f]isoquinolin-5-one (19) which on reduction and subsequent dehydration yielded 3-ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline (4).
    MeSH term(s) Binding Sites ; Cells, Cultured ; Cyclopentanes/analogs & derivatives ; Cyclopentanes/chemical synthesis ; Cyclopentanes/pharmacology ; DNA ; HeLa Cells ; Isoquinolines/chemical synthesis ; Isoquinolines/pharmacology ; Lymphoma/metabolism ; Magnetic Resonance Spectroscopy ; Models, Structural ; Neoplasms, Experimental/metabolism ; Nucleic Acid Conformation ; Spectrophotometry, Ultraviolet
    Chemical Substances Cyclopentanes ; Isoquinolines ; DNA (9007-49-2)
    Language English
    Publishing date 1975-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm00238a015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 151: Show issues Location:
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  6. Article: Genome-wide DNA methylation profiling for central nervous system embryonal tumours in children: abridged secondary publication.

    Liu, A P Y / Chan, G C F / Chung, B H Y / Yang, W / Ng, H K

    Hong Kong medical journal = Xianggang yi xue za zhi

    2024  Volume 30 Suppl 1, Issue 1, Page(s) 29–33

    MeSH term(s) Child ; Humans ; DNA Methylation ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/pathology ; Neoplasms, Germ Cell and Embryonal/genetics ; Central Nervous System/pathology
    Language English
    Publishing date 2024-02-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
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  7. Article: Cyclopenta[f]isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 2. Synthesis of 6-carbamylmethyl-8-methyl-7(5)H-cyclopenta[f]isoquinolin-3(2H)-one and its interaction with deoxyribonucleic acids and poly(deoxyribonucleotides).

    Kundu, N G / Hallett, W / Heidelberger, C

    Journal of medicinal chemistry

    1975  Volume 18, Issue 4, Page(s) 399–403

    Abstract: ... subsequent dehydration yielded 6-carbamylmethyl-3-ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline (9 ... subsequent dehydration afforded the desired compound, 6-car-bamylmethyl-8-methyl-7(5)H-cyclopental[f ... 3-Ethoxy-8-methyl-5,6-dihydro-7H-cyclopenta[f]isoquinolin-5-one (2) was converted to 6 ...

    Abstract 3-Ethoxy-8-methyl-5,6-dihydro-7H-cyclopenta[f]isoquinolin-5-one (2) was converted to 6-carbethoxymethyl-3-ethoxy-8-methyl-5,6-dihydro-7H-cyclopenta[f]isoquinolin-5-one (6) through an oxalyl derivative. Treatment of 6 with ammonia gave the corresponding amide 7 which on sodium borohydride reduction and subsequent dehydration yielded 6-carbamylmethyl-3-ethoxy-8-methyl-7(5)H-cyclopenta[f]isoquinoline (9). The analogous ester 10 was similarly obtained from 6. Numerous attempts to dealkylate the 3-ethoxy group of 9 or 10 failed. However, 6 coould easily be dealkylated on heating with 25% hydrochloric acid in a sealed tube.The ester, 6-carbethoxymethyl-8-methyl-5,6-dihydro-7H-cyclopenta[f]isoquinoline-3(2H),5-dione (11), so obtained was converted to the corresponding amide 12 which on reduction with sodium borohydride and subsequent dehydration afforded the desired compound, 6-car-bamylmethyl-8-methyl-7(5)H-cyclopental[f]isoquinolin-3-(2H)-one (1). 1 was found to be mildly cytotoxic againstL5178Y mouse leukemia cells in culture.1 was also found to bind to native calf thymus DNA. 1 inhibited RNA synthesis by a DNA-dependent RNA polymerase and a higher inhibition of RNA synthesis was observed when poly(dG-dC) was used as a template than when poly(dA-dT) was used. A significant increase of thermal transition temperature of calf thymus DNA and poly(dG)-poly(dC) was observed in the presence of 1. The accumulated evidence demonstrates that 1 interacts weakly with calf thymus DNA and interacts preferentially with poly(deoxyribonucleotides)-containing GC pairs.
    MeSH term(s) Animals ; Binding Sites ; Cattle ; Cyclopentanes/analogs & derivatives ; Cyclopentanes/chemical synthesis ; Cyclopentanes/pharmacology ; DNA ; DNA Nucleotidyltransferases/metabolism ; Deoxyribonucleotides ; Depression, Chemical ; Escherichia coli/enzymology ; Hot Temperature ; Isoquinolines/chemical synthesis ; Isoquinolines/pharmacology ; Nucleic Acid Denaturation ; Polynucleotides ; Spectrophotometry, Ultraviolet ; Templates, Genetic
    Chemical Substances Cyclopentanes ; Deoxyribonucleotides ; Isoquinolines ; Polynucleotides ; DNA (9007-49-2) ; DNA Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 1975-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm00238a016
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  8. Article ; Online: A new genus and species of Scirtothrips genus-group (Thysanoptera, Thripidae), with two new species of Scirtothrips, from Dipterocarp Forest canopy in Malaysia.

    Ng, Y F / Ain, N / Rafti, N S / Lau, K H

    Zootaxa

    2023  Volume 5306, Issue 5, Page(s) 586–594

    Abstract: A new genus and three new species are described from the canopy of Dipterocarp forest in Pasoh Forest Research in Malaysia: Daunothrips gen. n., D. striatus sp. n., Scirtothrips convexum sp. n. and Scirtothrips longifacies sp. n. The morphological ... ...

    Abstract A new genus and three new species are described from the canopy of Dipterocarp forest in Pasoh Forest Research in Malaysia: Daunothrips gen. n., D. striatus sp. n., Scirtothrips convexum sp. n. and Scirtothrips longifacies sp. n. The morphological characters of these new members of the Scirtothrips genus-group are discussed and illustrated.
    MeSH term(s) Animals ; Thysanoptera ; Malaysia ; Forests
    Language English
    Publishing date 2023-06-23
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5306.5.6
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  9. Article ; Online: Correction to: Optimizing non‑invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non‑invasive PGT‑A results.

    Chow, Judy F C / Lam, Kevin K W / Cheng, Heidi H Y / Lai, Shui Fan / Yeung, William S B / Ng, Ernest H Y

    Journal of assisted reproduction and genetics

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1112577-9
    ISSN 1573-7330 ; 1058-0468
    ISSN (online) 1573-7330
    ISSN 1058-0468
    DOI 10.1007/s10815-024-03082-0
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    Zs.A 1985: Show issues Location:
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  10. Article: Outcome of Endoprosthesis used in Limb Salvage Surgery in a Malaysian Orthopaedic Oncology Centre.

    Ng, Y H / Chai, Y C / Mazli, N / Jaafar, N F / Ibrahim, S

    Malaysian orthopaedic journal

    2024  Volume 18, Issue 1, Page(s) 60–65

    Abstract: Introduction: To describe the duration of survival among bone tumour patients with endoprosthesis reconstruction and to determine frequency of implant failure, revision of surgery, and amputation after endoprosthesis reconstruction.: Materials and ... ...

    Abstract Introduction: To describe the duration of survival among bone tumour patients with endoprosthesis reconstruction and to determine frequency of implant failure, revision of surgery, and amputation after endoprosthesis reconstruction.
    Materials and methods: A retrospective cross-sectional review of all patients with either primary bone tumour or secondary bone metastases treated with en bloc resection and endoprosthesis reconstruction from January 2008 to December 2020.
    Results: A total of 35 failures were recorded among the 27 (48.2%) patients with endoprostheses. Some of the patients suffered from one to three types of modes of failure on different timelines during the course of the disease. Up to eight patients suffered from more than one type of failure throughout the course of the disease. Out of all modes of failure, local recurrence (type 5 failure) was the most common, accounting for 25.0% of all failure cases. Four patients (7.1%) eventually underwent amputation, which were either due to infection (2 patients) or disease progression causing local recurrence (2 patients).
    Conclusion: The overall result of endoprosthesis reconstruction performed in our centre was compatible with other centres around the world. Moreover, limb salvage surgery should be performed carefully in a selected patient group to maximise the benefits of surgery.
    Language English
    Publishing date 2024-03-13
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 2621480-5
    ISSN 1985-2533
    ISSN 1985-2533
    DOI 10.5704/MOJ.2403.008
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