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Article ; Online: Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition.

Meng, Fanbo / Dai, Liting

2023 Volume 41, Issue 2, Page(s) 71–81

Abstract: Thyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspect of transcription factor-target gene interaction. TP63 ... ...

Abstract	Thyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspect of transcription factor-target gene interaction. TP63 and KRT17 were both highly expressed in TC tissues and cells. The results of ChIP and dual-luciferase assays confirmed TP63 to bind the KRT17 promoter. Cell function assays revealed that knockdown of TP63 could repress TC cell progression. Furthermore, the rescue assay verified that TP63 could facilitate KRT17 expression to activate the AKT signaling pathway, which in turn stimulated TC cell invasion and migration, and induced EMT. All these results verified that TP63 facilitates TC malignant progression by promoting KRT17 expression and inducing EMT.
MeSH term(s)	Female ; Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Signal Transduction ; Thyroid Neoplasms/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Chemical Substances	TP63 protein, human ; Transcription Factors ; Tumor Suppressor Proteins ; KRT17 protein, human
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1035755-5
ISSN	1029-2292 ; 0897-7194
ISSN (online)	1029-2292
ISSN	0897-7194
DOI	10.1080/08977194.2023.2184656
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Zs.A 2612: Show issues

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Article ; Online: The Interconnecting Process and Sensing Performance of Stretchable Hybrid Electronic Yarn for Body Temperature Monitoring.

Meng, Fenye / Dai, Shaoqing / Zhang, Yong / Hu, Jiyong

Polymers

2024 Volume 16, Issue 2

Abstract: Flexible and stretchable electronic yarn containing electronic components (i.e., hybrid electronic yarn) are essential for manufacturing smart textile garments or fabrics. Due to their low stretchability and easy interconnection fracture, previously ... ...

Abstract	Flexible and stretchable electronic yarn containing electronic components (i.e., hybrid electronic yarn) are essential for manufacturing smart textile garments or fabrics. Due to their low stretchability and easy interconnection fracture, previously reported hybrid electronic sensing yarns have poor mechanical durability and washability. In order to address this issue, a stretchable hybrid electronic yarn for body temperature monitoring was designed and prepared using a spandex filament as the core yarn and a thin enameled copper wire connected with a thermal resistor as the wrapping fiber. The temperature sensing performance of different hybrid electronic yarn samples was evaluated using the following three types of interconnection methods: conductive adhesive bonding, melt soldering, and hot pressure bonding. The optimal interconnection method with good sensing performance was determined. Furthermore, in order to improve the mechanical durability of the hybrid electronic yarn made using the optimal interconnection method, the interconnection area was encapsulated with polymers, and the effect of polymer materials and structures on the temperature-sensing properties was evaluated. The results show that traditional wrapping combined with hot pressing interconnection followed by tube encapsulating technology is beneficial for achieving high stretchability and good temperature-sensing performance of hybrid electronic yarn.
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16020243
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Article ; Online: Choice of refractive surgery types for myopia assisted by machine learning based on doctors' surgical selection data.

Li, Jiajing / Dai, Yuanyuan / Mu, Zhicheng / Wang, Zhonghai / Meng, Juan / Meng, Tao / Wang, Jimin

BMC medical informatics and decision making

2024 Volume 24, Issue 1, Page(s) 41

Abstract: In recent years, corneal refractive surgery has been widely used in clinics as an effective means to restore vision and improve the quality of life. When choosing myopia-refractive surgery, it is necessary to comprehensively consider the differences in ... ...

Abstract	In recent years, corneal refractive surgery has been widely used in clinics as an effective means to restore vision and improve the quality of life. When choosing myopia-refractive surgery, it is necessary to comprehensively consider the differences in equipment and technology as well as the specificity of individual patients, which heavily depend on the experience of ophthalmologists. In our study, we took advantage of machine learning to learn about the experience of ophthalmologists in decision-making and assist them in the choice of corneal refractive surgery in a new case. Our study was based on the clinical data of 7,081 patients who underwent corneal refractive surgery between 2000 and 2017 at the Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences. Due to the long data period, there were data losses and errors in this dataset. First, we cleaned the data and deleted the samples of key data loss. Then, patients were divided into three groups according to the type of surgery, after which we used SMOTE technology to eliminate imbalance between groups. Six statistical machine learning models, including NBM, RF, AdaBoost, XGBoost, BP neural network, and DBN were selected, and a ten-fold cross-validation and grid search were used to determine the optimal hyperparameters for better performance. When tested on the dataset, the multi-class RF model showed the best performance, with agreement with ophthalmologist decisions as high as 0.8775 and Macro F1 as high as 0.8019. Furthermore, the results of the feature importance analysis based on the SHAP technique were consistent with an ophthalmologist's practical experience. Our research will assist ophthalmologists in choosing appropriate types of refractive surgery and will have beneficial clinical effects.
MeSH term(s)	Humans ; Visual Acuity ; Quality of Life ; Refractive Surgical Procedures ; Myopia/surgery ; Machine Learning
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2046490-3
ISSN	1472-6947 ; 1472-6947
ISSN (online)	1472-6947
ISSN	1472-6947
DOI	10.1186/s12911-024-02451-0
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Article ; Online: High-precision retinal blood vessel segmentation based on a multi-stage and dual-channel deep learning network.

Guo, Hui / Meng, Jing / Zhao, Yongfu / Zhang, Hongdong / Dai, Cuixia

Physics in medicine and biology

2024 Volume 69, Issue 4

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Algorithms ; Deep Learning ; Retinal Vessels/diagnostic imaging ; Image Enhancement ; Image Processing, Computer-Assisted/methods ; Spiro Compounds
Chemical Substances	10-methyl spiro(4.5)dec-6-en-6-carboxylic acid (132603-09-9) ; Spiro Compounds
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad1cf6
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Article ; Online: Image segmentation of mouse eye

Ma, Fei / Wang, Shengbo / Guo, Yanfei / Dai, Cuixia / Meng, Jing

Biomedizinische Technik. Biomedical engineering

2024

Abstract: Objectives: Optical coherence tomography (OCT) is a new imaging technology that uses an optical analog of ultrasound imaging for biological tissues. Image segmentation plays an important role in dealing with quantitative analysis of medical images.: ... ...

Abstract	Objectives: Optical coherence tomography (OCT) is a new imaging technology that uses an optical analog of ultrasound imaging for biological tissues. Image segmentation plays an important role in dealing with quantitative analysis of medical images. Methods: We have proposed a novel framework to deal with the low intensity problem, based on the labeled patches and Bayesian classification ( Results: In addition, we have collected a new dataset of mouse eyes Conclusions: The experimental results demonstrate the effectiveness of the LPBC method on the new MEVOCT dataset. The ROI segmentation is of great importance for the distortion correction.
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120817-2
ISSN	1862-278X ; 0013-5585
ISSN (online)	1862-278X
ISSN	0013-5585
DOI	10.1515/bmt-2023-0266
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Article ; Online: Effects of Pd atom vibration in the Sr-Te octahedral interstitial space in Zintl compound SrPdTe on lattice anharmonicity and thermoelectric properties.

Wang, Yue / Zhao, Yinchang / Meng, Sheng / Ni, Jun / Dai, Zhenhong

The Journal of chemical physics

2024 Volume 160, Issue 5

Abstract: Based on first-principles calculations, the current study deeply explores the thermoelectric properties of the Zintl compound SrPdTe. We found that the anharmonic vibration of Pd atoms plays an important role in the quartic anharmonic effect and the ... ...

Abstract	Based on first-principles calculations, the current study deeply explores the thermoelectric properties of the Zintl compound SrPdTe. We found that the anharmonic vibration of Pd atoms plays an important role in the quartic anharmonic effect and the temperature dependence of the thermal conductivity. In the crystalline structure, Sr atoms form octahedra with eight surrounding Te atoms, while Pd atoms are located in the gaps between the octahedra. This structure makes the strong atomic mean square displacement of Pd atoms the main factor leading to the ultralow thermal conductivity. The study also reveals the effects of phonon frequency renormalization and four-phonon scattering on heat transfer performance. Even considering the spin-orbit coupling effect, multiple secondary valence band tops maintain the power factor of the material at high temperatures, providing a potential opportunity for achieving excellent thermoelectric performance.
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0185762
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Article ; Online: Template-Free Self-Assembly of Hollow Microtubular Covalent Organic Frameworks for Oral Delivery of Insulin.

Dai, Lihui / Wu, Fang / Xiao, Yi / Liu, Qian / Meng, Meng / Xi, Rimo / Yin, Yongmei

ACS applied materials & interfaces

2024 Volume 16, Issue 14, Page(s) 17891–17903

Abstract: Covalent organic frameworks (COFs) have demonstrated versatile application potential since their discovery. Although the structure of COFs is orderly arranged, the synthesis of controllable macrostructures still faces challenges. Herein, we report, to ... ...

Abstract	Covalent organic frameworks (COFs) have demonstrated versatile application potential since their discovery. Although the structure of COFs is orderly arranged, the synthesis of controllable macrostructures still faces challenges. Herein, we report, to our knowledge, the first template-free self-assembled COF-18 Å hollow microtubule (MT-COF-18 Å) structure and its use for insulin delivery that exhibits high loading capacity, gastroresistance, and glucose-responsive properties. The hollow MT-COF-18 Å was achieved by a template-free method benefiting from the mixed solvents of mesitylene and dioxane. The formation mechanism and morphology changes with insulin loading and release were observed. In Caco-2 cells, the transferrin-coated system demonstrated enhanced insulin cellular uptake and transcellular transport, which indicated great potential for oral applications. Additionally, the composites presented sustained glycemic control and effective insulin blood concentrations without noticeable toxicity in diabetic rats. This work shows that hollow microtubular COFs hold great promise in loading and delivery of biomolecules.
MeSH term(s)	Animals ; Rats ; Humans ; Insulin ; Metal-Organic Frameworks ; Caco-2 Cells ; Diabetes Mellitus, Experimental/drug therapy ; Biological Transport
Chemical Substances	Insulin ; Metal-Organic Frameworks
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c01165
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Article ; Online: Exertional Rhabdomyolysis Combined with Acute Kidney Injury and Complicated by Posterior Reversible Encephalopathy Syndrome.

Dai, Ruanxian / Meng, Qiang

Internal medicine (Tokyo, Japan)

2022 Volume 61, Issue 24, Page(s) 3729–3732

Abstract: Posterior reversible encephalopathy syndrome is an uncommon syndrome in exertional rhabdomyolysis. We herein report a case of rhabdomyolysis and acute kidney injury after intense exercise. The patient also had generalized hypertension, headache, and ... ...

Abstract	Posterior reversible encephalopathy syndrome is an uncommon syndrome in exertional rhabdomyolysis. We herein report a case of rhabdomyolysis and acute kidney injury after intense exercise. The patient also had generalized hypertension, headache, and painless complete loss of vision in both eyes, which was consistent with the symptoms of posterior reversible encephalopathy syndrome detected by magnetic resonance imaging of the brain. The patient fully recovered through active fluid replacement, diuresis, blood pressure control, alkalization of urine and blood purification, and supportive measures. This case report describes an infrequent neurological complication of exertional rhabdomyolysis. Understanding the range of complications is critical for improving patient outcomes.
MeSH term(s)	Humans ; Acute Kidney Injury/complications ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Posterior Leukoencephalopathy Syndrome/complications ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Rhabdomyolysis/complications
Language	English
Publishing date	2022-05-07
Publishing country	Japan
Document type	Case Reports
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9376-22
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Article: Empirical

Li, Meng / Wang, Xiaolei / Meng, Wenting / Dai, Yun / Wang, Weihong

Therapeutic advances in gastroenterology

2023 Volume 16, Page(s) 17562848231196357

Abstract: Background: The eradication rate of : Objectives: The purpose of our study was to evaluate whether tailored therapy based on genotypic resistance is superior to empirical therapy for : Design: A systematic review and meta-analysis of randomized ... ...

Abstract	Background: The eradication rate of Objectives: The purpose of our study was to evaluate whether tailored therapy based on genotypic resistance is superior to empirical therapy for Design: A systematic review and meta-analysis of randomized controlled trials (RCTs) comparing tailored therapy based on genotypic resistance with empirical therapy was performed. Sources and methods: We retrieved relevant studies from PubMed, Embase, and the Cochrane Library. The primary outcome was Results: A total of 12 qualified RCTs containing 3940 patients were identified in our systematic review and meta-analysis. The pooled eradication rates of tailored therapy based on the detection of genotypic resistance were consistently higher than those in the empirical treatment group, with no statistical significance. In triple therapy, the eradication rate was significantly higher in the tailored group than in the empirical group by intention-to-treat analysis (ITT) and per-protocol analysis (PP) analysis ( Conclusion: In conclusion, tailored therapy based on molecular methods may offer better efficacy than empirical triple therapy, but it may not be superior to empirical quadruple therapy in eradicating Registration prospero: CRD42023408688.
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2440710-0
ISSN	1756-2848 ; 1756-283X
ISSN (online)	1756-2848
ISSN	1756-283X
DOI	10.1177/17562848231196357
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Article ; Online: [Structure and function of human-derived lysozyme: a review].

Liu, Ruwei / Meng, Qingyong / Dai, Yunping / Zhang, Yali

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2023 Volume 39, Issue 11, Page(s) 4482–4496

Abstract: Human-derived lysozyme is a general term for a group of naturally occurring alkaline proteins in the human body that are capable of lysing bacterial cell walls. Its action is characterized by its ability to cleave the β-(1,4)-glycosidic bond between N- ... ...

Abstract	Human-derived lysozyme is a general term for a group of naturally occurring alkaline proteins in the human body that are capable of lysing bacterial cell walls. Its action is characterized by its ability to cleave the β-(1,4)-glycosidic bond between N-acetylglucosamine and N-acetylmuramic acid in peptidoglycan. Human-derived lysozyme has a variety of properties such as antibacterial, anti-inflammatory, antiviral and immune enhancing, and is therefore widely used in the domestic and international pharmaceutical markets. This review summarizes the structural features, expression sites, biological functions of human-derived lysozymes and its market applications.
MeSH term(s)	Humans ; Muramidase ; Anti-Bacterial Agents
Chemical Substances	Muramidase (EC 3.2.1.17) ; Anti-Bacterial Agents
Language	Chinese
Publishing date	2023-09-15
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.230241
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