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  1. Article: The other fly room: J. T. Patterson and Texas genetics.

    Wagner, R P / Crow, J F

    Genetics

    2001  Volume 157, Issue 1, Page(s) 1–5

    MeSH term(s) Animals ; Drosophila/genetics ; Genetics/history ; History, 20th Century ; Texas ; United States
    Language English
    Publishing date 2001-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/157.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Conference proceedings: Abstracts of the XIIIth Biennial Winter Workshop on Schizophrenia Research

    Crow, T. J.

    Davos, Switzerland, February 4 - 10, 2006

    (Schizophrenia research ; 81, Suppl.)

    2006  

    Event/congress Winter Workshop on Schizophrenia Research (13, 2006, Davos)
    Author's details organized by Timothy J. Crow
    Series title Schizophrenia research ; 81, Suppl.
    Collection
    Language English
    Size 367, XX S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT014643734
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2351 -81,Suppl.- not available for loan Zeitschriften-Lesesaal

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  3. Book ; Conference proceedings: Abstracts of the XIIth Biennial Winter Workshop on Schizophrenia

    Crow, T. J.

    Davos, Switzerland, February 7 - 13, 2004

    (Schizophrenia research ; 67,1, Suppl.)

    2004  

    Event/congress Winter Workshop on Schizophrenia (12, 2004, Davos)
    Author's details organized by Timothy J. Crow
    Series title Schizophrenia research ; 67,1, Suppl.
    Collection
    Language English
    Size VI, 320 S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT013926974
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2351 -67,1,Suppl.- not available for loan Zeitschriften-Lesesaal

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  4. Book: The speciation of modern Homo sapiens

    Crow, T. J.

    [the meeting that took place under the auspices of the British Academy and the Academy of Medical Sciences on 28 March 2000 at the British Academy]

    (Proceedings of the British Academy ; 106)

    2002  

    Institution British Academy
    Author's details ed. by Tim J. Crow
    Series title Proceedings of the British Academy ; 106
    Collection
    Keywords Mensch ; Entwicklungsbiologie ; Artbildung
    Subject Art ; Arten ; Speziation ; Menschen ; Homo sapiens
    Language English
    Size IV, 265 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012999474
    ISBN 0-19-726246-5 ; 978-0-19-726246-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 4115 order for loan Magazin

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  5. Article: Meloidogyne Haplanaria

    Espinoza-Lozano, Lisbeth / Joseph, S / Crow, W T / Noling, J / Mekete, T

    Journal of nematology

    2022  Volume 54, Issue 1, Page(s) 20220032

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2022-09-30
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 410426-2
    ISSN 0022-300X
    ISSN 0022-300X
    DOI 10.2478/jofnem-2022-0032
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  6. Article ; Online: Land transpiration-evaporation partitioning errors responsible for modeled summertime warm bias in the central United States.

    Dong, Jianzhi / Lei, Fangni / Crow, Wade T

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 336

    Abstract: Earth system models (ESMs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6) experiment exhibit a well-known summertime warm bias in mid-latitude land regions - most notably in the central contiguous United States (CUS). The dominant source ... ...

    Abstract Earth system models (ESMs) from the Coupled Model Intercomparison Project Phase 6 (CMIP6) experiment exhibit a well-known summertime warm bias in mid-latitude land regions - most notably in the central contiguous United States (CUS). The dominant source of this bias is still under debate. Using validated datasets and both coupled and off-line modeling, we find that the CUS summertime warm bias is driven by the incorrect partitioning of evapotranspiration (ET) into its canopy transpiration and soil evaporation components. Specifically, CMIP6 ESMs do not effectively use available rootzone soil moisture for summertime transpiration and instead rely excessively on shallow soil and canopy-intercepted water storage to supply ET. As such, expected summertime precipitation deficits in CUS induce a negative ET bias into CMIP6 ESMs and a corresponding positive temperature bias via local land-atmosphere coupling. This tendency potentially biases CMIP6 projections of regional water stress and summertime air temperature variability under elevated CO
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-27938-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: First Report of

    Bonkowski, John / Crow, William T / Habteweld, Alemayehu

    Journal of nematology

    2022  Volume 54, Issue 1, Page(s) 20220034

    Abstract: Soybeans ( ...

    Abstract Soybeans (
    Language English
    Publishing date 2022-11-12
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 410426-2
    ISSN 0022-300X
    ISSN 0022-300X
    DOI 10.2478/jofnem-2022-0034
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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: Notch intracellular domains form transcriptionally active heterodimeric complexes on sequence-paired sites.

    Gazdik, Tana R / Crow, Jacob J / Lawton, Tyler / Munroe, Chloe J / Theriault, Hannah / Wood, Travis M / Albig, Allan R

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 218

    Abstract: Notch signaling is universally conserved in metazoans where it is important for a wide variety of both normal and abnormal physiology. All four mammalian Notch receptors are activated by a conserved mechanism that releases Notch intracellular domains ( ... ...

    Abstract Notch signaling is universally conserved in metazoans where it is important for a wide variety of both normal and abnormal physiology. All four mammalian Notch receptors are activated by a conserved mechanism that releases Notch intracellular domains (NICDs) from the plasma membrane to translocate to the nucleus. Once there, NICDs interact through highly conserved ankyrin domains to form head-to-head homodimers on Notch sensitive promoters and stimulate transcription. Due to the highly conserved nature of these Notch ankyrin domains in all four mammalian Notch proteins, we hypothesized that NICDs may also engage in heterodimerization. Our results reveal the presence of two NICD dimerization states that can both engage in homo and heterodimerization. Using a Co-IP approach, we show that all NICD's can form non-transcriptionally active dimers and that the N4ICD appears to perform this function better than the other NICDs. Using a combination of ChIP analysis and transcriptional reporter assays, we also demonstrate the formation of transcriptionally active heterodimers that form on DNA. In particular, we demonstrate heterodimerization between the N2ICD and N4ICD and show that this heterodimer pair appears to exhibit differential activity on various Notch sensitive promoters. These results illustrate a new diversification of Notch signaling mechanisms which will help us better understand basic Notch function.
    MeSH term(s) Animals ; Ankyrins/genetics ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Promoter Regions, Genetic ; Mammals/metabolism
    Chemical Substances Ankyrins ; Receptors, Notch
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50763-4
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  9. Article: First Report of

    Habteweld, Alemayehu / Davidson, Wade / Desaeger, Johan / Crow, William T

    Journal of nematology

    2022  Volume 54, Issue 1, Page(s) 20220021

    Abstract: Kratom ( ...

    Abstract Kratom (
    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410426-2
    ISSN 0022-300X
    ISSN 0022-300X
    DOI 10.2478/jofnem-2022-0021
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease.

    Lepelley, Alice / Wai, Timothy / Crow, Yanick J

    Frontiers in immunology

    2021  Volume 12, Page(s) 729763

    Abstract: The immune response to viral infection involves the recognition of pathogen-derived nucleic acids by intracellular sensors, leading to type I interferon (IFN), and downstream IFN-stimulated gene, induction. Ineffective discrimination of self from non- ... ...

    Abstract The immune response to viral infection involves the recognition of pathogen-derived nucleic acids by intracellular sensors, leading to type I interferon (IFN), and downstream IFN-stimulated gene, induction. Ineffective discrimination of self from non-self nucleic acid can lead to autoinflammation, a phenomenon implicated in an increasing number of disease states, and well highlighted by the group of rare genetic disorders referred to as the type I interferonopathies. To understand the pathogenesis of these monogenic disorders, and polyfactorial diseases associated with pathogenic IFN upregulation, such as systemic lupus erythematosus and dermatomyositis, it is important to define the self-derived nucleic acid species responsible for such abnormal IFN induction. Recently, attention has focused on mitochondria as a novel source of immunogenic self nucleic acid. Best appreciated for their function in oxidative phosphorylation, metabolism and apoptosis, mitochondria are double membrane-bound organelles that represent vestigial bacteria in the cytosol of eukaryotic cells, containing their own DNA and RNA enclosed within the inner mitochondrial membrane. There is increasing recognition that a loss of mitochondrial integrity and compartmentalization can allow the release of mitochondrial nucleic acid into the cytosol, leading to IFN induction. Here, we provide recent insights into the potential of mitochondrial-derived DNA and RNA to drive IFN production in Mendelian disease. Specifically, we summarize current understanding of how nucleic acids are detected as foreign when released into the cytosol, and then consider the findings implicating mitochondrial nucleic acid in type I interferonopathy disease states. Finally, we discuss the potential for IFN-driven pathology in primary mitochondrial disorders.
    MeSH term(s) Animals ; Autoimmunity ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/immunology ; DNA, Mitochondrial/metabolism ; Humans ; Immunity, Innate ; Interferons/metabolism ; Mitochondria/genetics ; Mitochondria/immunology ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/immunology ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/pathology ; RNA, Mitochondrial/genetics ; RNA, Mitochondrial/immunology ; RNA, Mitochondrial/metabolism ; Signal Transduction ; Up-Regulation
    Chemical Substances DNA, Mitochondrial ; RNA, Mitochondrial ; Interferons (9008-11-1)
    Language English
    Publishing date 2021-08-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.729763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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