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Article: Tomato Processing By-Products Valorisation through Ohmic Heating Approach.

Coelho, Marta C / Ghalamara, Soudabeh / Campos, Débora / Ribeiro, Tânia Bragança / Pereira, Ricardo / Rodrigues, António S / Teixeira, José A / Pintado, Manuela

Foods (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: ... such as phene-di-hexane and N-acethyl-D-tryptophan. According to the results, the OH boosts the potential ...

Abstract	Tomato by-products from processing industries have a higher potential to be reused as a source of bioactive compounds. Reliable national data on tomato by-products and physicochemical characterisation that will inform and find effective planning on tomato waste management in Portugal is absent. To help obtain this knowledge, selected Portugal companies were recruited to obtain representative samples of by-products generation, and physicochemical composition was evaluated. Furthermore, an environmental-friendly method (the ohmic heating (OH) method, which allows the recovery of bioactive compounds in absence of hazardous reagents) was also used and compared with conventional methods to explore new safe value-added ingredients. Total antioxidant capacity and total and individual phenolic compounds were also evaluated by spectrophotometric and high-performance liquid chromatography (HPLC), respectively. Tomato processing by-products have revealed a higher potential since both collected samples from companies were rich in protein (between 16.3 to 19.4 g/100 g DW, with fibre content ranging from 57.8 to 59.0 g/100 g DW). In addition, these samples contain 17.0 g/100 g of fatty acids (mainly polyunsaturated, monounsaturated and saturated, such as linoleic, oleic, and palmitic acid, respectively). Also, they present mainly chlorogenic acid and rutin as phenolic compounds. After understanding its composition, the OH was applied to determine added-value solutions to tomato by-products. With extractions, two types of fractions were obtained, namely liquid fraction rich in phenols, free sugars, and carotenoids and a solid fraction rich in fibre bound to phenols and carotenoids. This treatment has been shown to have the ability to preserve carotenoids, such as lycopene relative to conventional methods. Nevertheless, new molecules were identified by LC-ESI-UHR-OqTOF-MS analysis, such as phene-di-hexane and N-acethyl-D-tryptophan. According to the results, the OH boosts the potential of tomato by-products and can be directly introduced into the process, contributing to the circular economy and zero by-products.
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12040818
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Article: Wide-Awake Local Anesthesia No Tourniquet for Rhizarthrosis Surgery: Technique and Experience for 16 Consecutive Cases.

Castelo, Filipe / Santos, Cláudia / Costa, Bárbara / Sousa, Ricardo / Ricardo, Raquel / Batista, Pedro / Ribeiro, Daniel

Cureus

2023 Volume 15, Issue 9, Page(s) e45705

Abstract: Since it was described, wide-awake local anaesthesia no tourniquet (WALANT) has gained popularity. Our department has started using WALANT for hand surgery with increasing complexity. We present our results with WALANT rhizarthrosis surgery, including ... ...

Abstract	Since it was described, wide-awake local anaesthesia no tourniquet (WALANT) has gained popularity. Our department has started using WALANT for hand surgery with increasing complexity. We present our results with WALANT rhizarthrosis surgery, including prosthetic replacement, trapeziectomy with suture button suspensionplasty and revision surgery. A retrospective review of all rhizarthrosis procedures under WALANT was performed from April 2021 to July 2022. We included patients who fulfilled inclusion criteria and had adequate imaging and clinical follow-up. A satisfaction survey was performed by telephone. Surgical time, complications, conversion to conventional anesthesia, pain, anxiety and global satisfaction were recorded. Tumescent anesthesia is performed 20-25 minutes before surgery, and is performed in four or five strategic locations that allow adequate anesthesia and vasoconstriction for the procedure to be comfortably carried out. We observed a series of 16 sequential surgeries involving 14 patients. All were female with a mean age of 65 years. Fourteen cases were performed due to primary rhizarthrosis, eight trapeziectomies with suture button suspensionplasty, six prosthetic replacements, and two revision surgeries. One patient needed to be converted to conventional anaesthesia due to anxiety during the procedure. Mean procedure time was 73 minutes. There were no WALANT-related complications. Mean patient-reported satisfaction with the anesthetic technique was a 9 (on a scale from 1 to 10) and 100% of patients would choose to undergo surgery with WALANT anesthesia for a future procedure. We find it useful to actively engage the patients during surgery to keep them comfortable and also help the surgeons assess stability and functional results. After wound closure, the hand is shown to the patient and he performs various tasks. There is somewhat of a learning curve for rhizarthrosis surgery under WALANT; patient comfort can be achieved through an adequate anesthetic technique and reassurance before and during surgery. We recommend that the first few cases be done in the presence of an anesthesiologist and a fasting patient in case there is a need to convert to conventional anesthesia. Wide awake rhizarthrosis surgery, even revision surgery, is safe and pain-free. Patient-reported satisfaction is also high. The authors find that including patient participation in their own surgery might be promising for post-op rehabilitation. There are limitations in this study such as the absence of a control conventional anesthesia group, the satisfaction questionnaire was not done immediately post-operatively, as such, a memory bias cannot be excluded, and it is not yet validated for the Portuguese population.
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45705
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Article: Mechanical Pruning and Soil Organic Amending in Two Terroirs. Effects on Wine Chemical Composition and Sensory Profile

Botelho, M. / Ribeiro, H. / Cruz, A. / Duarte, D. F. / Faria, D. L. / Khairnar, K. S. / Pardal, R. / Susini, M. / Correia, C. / Catarino, S. / Cadima, J. / de Castro, R. / Ricardo-da-Silva, J. M.

American journal of enology and viticulture

2022 Volume 73, Issue 1, Page(s) 26

Document type	Article
ZDB-ID	407380-0
ISSN	0002-9254
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Impact of radiotherapy on adverse events of self-expanding metallic stents in patients with esophageal cancer.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2023 Volume 36, Issue 10

Abstract: Self-expanding metallic stents (SEMS) are considered the treatment of choice for the palliation of dysphagia and fistulas in inoperable esophageal neoplasms. However, the safety of SEMSs in patients who received or who will be submitted to radiotherapy ( ... ...

Abstract	Self-expanding metallic stents (SEMS) are considered the treatment of choice for the palliation of dysphagia and fistulas in inoperable esophageal neoplasms. However, the safety of SEMSs in patients who received or who will be submitted to radiotherapy (RT) is uncertain. The study aimed to evaluate the impact of RT on adverse events (AEs) in patients with esophageal cancer with SEMSs. This is a retrospective study conducted at a tertiary cancer hospital from 2009 to 2018. We collected information regarding RT, the histological type of the tumor, the model of SEMSs and AEs after stent placement. Three hundred twenty-three patients with malignant stenosis or fistula were treated with SEMSs. The predominant histological type was squamous cell carcinoma (79.6%). A total of 282 partially covered and 41 fully covered SEMSs were inserted. Of the 323 patients, 182 did not received RT, 118 received RT before SEMS placement and 23 after. Comparing the group that received RT before stent insertion with the group that did not, the first one presented a higher frequency of severe pain (9/118 7.6% vs. 3/182 1.6%; P = 0.02). The group treated with RT after stent placement had a higher risk of global AEs (13/23 56.5% vs. 63/182 34.6%; P = 0.019), ingrowth/overgrowth (6/23 26.1% vs. 21/182 11.5%; P = 0.045) and gastroesophageal reflux (2/23 8.7% vs. 2/182 1.1%; P = 0.034). Treatment with RT before stent placement in patients with inoperable esophageal neoplasm prolongs survival and is associated with an increased risk of severe chest pain. Treatment with RT of patients with an esophageal stent increases the frequency of minor, not life-threatening AEs.
MeSH term(s)	Humans ; Retrospective Studies ; Treatment Outcome ; Stents/adverse effects ; Esophageal Neoplasms/therapy ; Esophageal Neoplasms/complications ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Palliative Care ; Self Expandable Metallic Stents/adverse effects ; Esophageal Stenosis/therapy
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/doad019
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Article ; Online: Sarcopenia in Children With Wilms Tumor: A Marker of Undernutrition Which May Impact Adversely on Clinical Outcomes.

de Oliveira, Wilson E / Murra, Mariana S / Tufi, Leticia M B / Cavalcante, Carlos E B / de Oliveira, Marco A / da Costa, Ricardo F A / Rosa, Bianca R / da Silva, Roberta Z M / Ribeiro, Rodrigo C / Ladas, Elena J / Barr, Ronald D

Journal of pediatric hematology/oncology

2023 Volume 45, Issue 7, Page(s) e817–e822

Abstract: The therapeutic approach to Wilms tumor (WT) is multidisciplinary and leads to significant patient impairment, increasing the risk of nutritional compromise and malnutrition. Children with cancer are vulnerable to sarcopenia which has been recognized as ... ...

Abstract	The therapeutic approach to Wilms tumor (WT) is multidisciplinary and leads to significant patient impairment, increasing the risk of nutritional compromise and malnutrition. Children with cancer are vulnerable to sarcopenia which has been recognized as a negative impact of anticancer therapy. Recent studies have highlighted the reduction in the total psoas muscle area (TPMA) to be associated with a poor prognosis in many pediatric diseases, including cancer. This study aims to evaluate changes in the TPMA compartment during the treatment of children with WT. An observational, longitudinal, and retrospective study was undertaken in a single institution evaluating children (1 to 14 y, n=38) with WT between 2014 and 2020. TPMA was assessed by the analysis of previously collected, electronically stored computed tomography images of the abdomen obtained at 3 time points: diagnosis, preoperatively, and 1 year after surgery. For all patients, TPMA/age were calculated with a specific online calculator. Our data show a high incidence of sarcopenia (55.3%) at diagnosis which increased after 4 to 6 weeks of neoadjuvant chemotherapy (73.7%) and remained high (78.9%) 1 year after the surgical procedure. Using TPMA/age Z-score curves we have found significant and rapid muscle loss in children with WT, with little or no recovery in the study period.
MeSH term(s)	Child ; Humans ; Kidney Neoplasms/complications ; Malnutrition/complications ; Prognosis ; Retrospective Studies ; Sarcopenia/diagnosis ; Sarcopenia/etiology ; Wilms Tumor/complications ; Wilms Tumor/therapy ; Longitudinal Studies
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002732
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Article ; Online: Guide catheter extension use are associated with higher procedural success in chronic total occlusion percutaneous coronary interventions.

Filho, Evandro M / Araujo, Gustavo N / Machado, Guilherme P / Padilla, Lucio / de Paula, João E T / Botelho, Antonio C / Campos, Carlos M / Quesada, Franklin L H / Alcantara, Marco / Santiago, Ricardo / de Los Santos, Félix D / Oliveira, Marcos D / Ribeiro, Marcelo H / Perez, Luiz / Pinto, Mauro E / Côrtes, Leandro A / Piccaro, Pedro / Brilakis, Emmanouil S / Quadros, Alexandre S

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2024 Volume 103, Issue 4, Page(s) 539–547

Abstract: Background: Guide catheter extensions (GCEs) increase support and facilitate equipment delivery, but aggressive instrumentation may be associated with a higher risk of complications.: Aim: Our aim was to assess the impact of GCEs on procedural ... ...

Abstract	Background: Guide catheter extensions (GCEs) increase support and facilitate equipment delivery, but aggressive instrumentation may be associated with a higher risk of complications. Aim: Our aim was to assess the impact of GCEs on procedural success and complications in patients submitted to chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Methods: We analyzed data from the multicenter LATAM CTO Registry. Procedural success was defined as <30% residual stenosis and TIMI 3 distal flow. Major adverse cardiac and cerebrovascular events (MACCE) was defined as the composite of all-cause death, myocardial infarction, target vessel revascularization, and stroke. Propensity score matching (PSM) was used to compare outcomes with and without GCE use. Results: From August 2010 to August 2021, 3049 patients were included. GCEs were used in 438 patients (14.5%). In unadjusted analysis, patients in the GCE group were older and had more comorbidities. The median J-CTO score and its components were higher in the GCE group. After PSM, procedural success was higher with GCE use (87.7% vs. 80.5%, p = 0.007). The incidence of coronary perforation (odds ratio [OR]: 1.46, 95% confidence interval [CI]: 0.78-2.71, p = 0.230), bleeding (OR: 1.99, 95% CI: 0.41-2.41, p = 0.986), in-hospital death (OR: 1.39, 95% CI: 0.54-3.62, p = 0.495) and MACCE (OR: 1.07, 95% CI: 0.52-2.19, p = 0.850) were similar in both groups. Conclusion: In a contemporary, multicenter cohort of patients undergoing CTO PCI, GCEs were used in older patients, with more comorbidities and complex anatomy. After PSM, GCE use was associated with higher procedural success, and similar incidence of adverse outcomes.
MeSH term(s)	Aged ; Humans ; Catheters ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/therapy ; Coronary Occlusion/etiology ; Hospital Mortality ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30987
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Article ; Online: Disparities in early initiation of breast feeding and prelacteal feeding: A study of low- and middle-income countries.

Neves, Paulo Augusto Ribeiro / Vaz, Juliana S / Ricardo, Luiza I C / Armenta-Paulino, Nancy N / Barros, Aluísio J D / Richter, Linda / Rollins, Nigel / Peréz-Escamilla, Rafael

Paediatric and perinatal epidemiology

2022 Volume 36, Issue 5, Page(s) 741–749

Abstract: Background: Early initiation of breast feeding (EIBF) reduces the risk of neonatal mortality. However, only 45% of newborns are breast-fed within the first hour after birth and prelacteal feeding (PLF) is widely prevalent in low- and middle-income ... ...

Abstract	Background: Early initiation of breast feeding (EIBF) reduces the risk of neonatal mortality. However, only 45% of newborns are breast-fed within the first hour after birth and prelacteal feeding (PLF) is widely prevalent in low- and middle-income countries (LMICs). Objective: To assess within- and between-country disparities in EIBF and PLF practices by household wealth and place of birth and to investigate the national-level correlation between these feeding indicators in LMICs. Methods: Data from Demographic Health Surveys and Multiple Indicator Cluster Surveys (2010-2019) in 76 LMICs were used to investigate within-country disparities in EIBF, any PLF, milk-based prelacteal feeding (MPLF), and water-based prelacteal feeding (WPLF) by wealth quintiles and place of childbirth (institutional [private or public sector] or in-home) for children under two years. We examined the between-country Pearson's correlation between EIBF and types of PLF, later adjusted for per capita gross domestic product (GDP). Results: No clear wealth-related differences were found for EIBF and WPLF; however, any PLF and MPLF were significantly higher in children belonging to the richest 20% of households but are also prevalent among lower income groups. Prevalence of any PLF was higher among institutional births in all LMICs, but especially for MPLF in private sector deliveries in East Asia & the Pacific, Eastern Europe & Central Asia, and Latin America & the Caribbean. WPLF was more common in all African regions. EIBF was inversely correlated with any PLF (r = -0.59, 95% CI -0.72, -0.42), MPLF (r = -0.41, 95% CI -0.58, -0.21) and WPLF (r = -0.34, 95% CI -0.53, -0.13). Adjustment for log-GDP did not affect the magnitude and direction of the results. Conclusion: Clear prorich disparities exist in the prevalence of PLF, especially MPLF. Children born in private sector facilities are more likely to receive MPLF. EIBF is negatively associated with PLF practices in LMICs. The promotion of better early feeding practices is urgent to achieve the Sustainable Development Goal to reduce neonatal mortality to 12 deaths per 1000 live births.
MeSH term(s)	Breast Feeding ; Child ; Developing Countries ; Female ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Postnatal Care ; Pregnancy ; Socioeconomic Factors
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	639089-4
ISSN	1365-3016 ; 0269-5022 ; 1353-663X
ISSN (online)	1365-3016
ISSN	0269-5022 ; 1353-663X
DOI	10.1111/ppe.12871
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Article ; Online: Amblyomma sculptum

Costa, Gabriel Cerqueira Alves / Ribeiro, Izabela Cosso Tavares / Melo-Junior, Otoni / Gontijo, Nelder F / Sant'Anna, Mauricio R V / Pereira, Marcos H / Pessoa, Grasielle C D / Koerich, Leonardo B / Oliveira, Fabiano / Valenzuela, Jesus G / Giunchetti, Rodolfo Cordeiro / Fujiwara, Ricardo Toshio / Bartholomeu, Daniella Castanheira / Araujo, Ricardo N

Frontiers in immunology

2021 Volume 11, Page(s) 611104

Abstract: Amblyomma ... ...

Abstract	Amblyomma sculptum
MeSH term(s)	Amblyomma/genetics ; Amblyomma/immunology ; Animals ; Arthropod Proteins/administration & dosage ; Arthropod Proteins/genetics ; Arthropod Proteins/immunology ; Disease Models, Animal ; Host-Parasite Interactions ; Immunization ; Mice ; Parasite Egg Count ; Saliva/immunology ; Tick Infestations/immunology ; Tick Infestations/parasitology ; Tick Infestations/prevention & control ; Vaccines/administration & dosage ; Vaccines/genetics ; Vaccines/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology
Chemical Substances	Arthropod Proteins ; Vaccines ; Vaccines, Synthetic
Language	English
Publishing date	2021-02-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.611104
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Article ; Online: Ecological modeling, biogeography, and phenotypic analyses setting the tiger cats' hyperdimensional niches reveal a new species.

de Oliveira, Tadeu G / Fox-Rosales, Lester A / Ramírez-Fernández, José D / Cepeda-Duque, Juan C / Zug, Rebecca / Sanchez-Lalinde, Catalina / Oliveira, Marcelo J R / Marinho, Paulo H D / Bonilla-Sánchez, Alejandra / Marques, Mara C / Cassaro, Katia / Moreno, Ricardo / Rumiz, Damián / Peters, Felipe B / Ortega, Josué / Cavalcanti, Gitana / Mooring, Michael S / Blankenship, Steven R / Brenes-Mora, Esteban /

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2395

Abstract: Recently, the tiger-cat species complex was split into Leopardus tigrinus and Leopardus guttulus, along with other proposed schemes. We performed a detailed analysis integrating ecological modeling, biogeography, and phenotype of the four originally ... ...

Abstract	Recently, the tiger-cat species complex was split into Leopardus tigrinus and Leopardus guttulus, along with other proposed schemes. We performed a detailed analysis integrating ecological modeling, biogeography, and phenotype of the four originally recognized subspecies-tigrinus, oncilla, pardinoides, guttulus-and presented a new multidimensional niche depiction of the species. Species distribution models used > 1400 records from museums and photographs, all checked for species accuracy. Morphological data were obtained from institutional/personal archives. Spotting patterns were established by integrating museum and photographic/camera-trap records. Principal component analysis showed three clearly distinct groups, with the Central American specimens (oncilla) clustering entirely within those of the Andes, namely the pardinoides group of the cloud forests of the southern Central-American and Andean mountain chains (clouded tiger-cat); the tigrinus group of the savannas of the Guiana Shield and central/northeastern Brazil (savanna tiger-cat); and the guttulus group in the lowland forests of the Atlantic Forest domain (Atlantic Forest tiger-cat). This scheme is supported by recent genetic analyses. All species displayed different spotting patterns, with some significant differences in body measurements/proportions. The new distribution presented alarming reductions from the historic range of - 50.4% to - 68.2%. This multidimensional approach revealed a new species of the elusive and threatened tiger-cat complex.
MeSH term(s)	Animals ; Tigers ; Phylogeny ; Forests ; Brazil
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52379-8
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Article: Virtual Learning Environment of the Brazilian Health System (AVASUS): Efficiency of Results, Impacts, and Contributions.

Valentim, Ricardo A M / de Oliveira, Carlos A P / Oliveira, Eloiza S G / Ribeiro, Eduardo L / da Costa, Soneide M / Morais, Ione R D / Fernandes, Felipe R Dos S / Caitano, Alexandre R / Gusmão, Cristine M G / Cunha-Oliveira, Aliete / Rêgo, Maria C F D / Coutinho, Karilany D / Barros, Daniele M S / Ceccim, Ricardo B

Frontiers in medicine

2022 Volume 9, Page(s) 896208

Abstract: The Virtual Learning Environment of the Brazilian Health System (AVASUS) is a free and open distance education platform of the Ministry of Health (MS). AVASUS is a scalable virtual learning environment that has surpassed 800,000 users, 2 million ... ...

Abstract	The Virtual Learning Environment of the Brazilian Health System (AVASUS) is a free and open distance education platform of the Ministry of Health (MS). AVASUS is a scalable virtual learning environment that has surpassed 800,000 users, 2 million enrollments, and 310 courses in its catalog. The objective of this paper was to assess the impacts of the educational offerings on health services and AVASUS course participants' professional practice. This study analyzed data from AVASUS, the Brazilian National Registry of Health Care Facilities (CNES), the Brazilian Occupational Classification (CBO), and a questionnaire applied to 720-course participants from five regions of Brazil. After acquiring and extracting data, computational methods were used for the evaluation process. Only the responses of 462 participants were considered for data analysis, as they had a formal link to CNES. The results showed that respondents recommended 76.2% of AVASUS courses to peers. Accordingly, the quality of educational offerings motivated 81.3% of such recommendations. In addition, 75.6% of course participants who answered the questionnaire also indicated that AVASUS course contents contribute to enhancing existing health services in the health facilities where they work. Finally, 24.6% of all responses mentioned that courses available in AVASUS were essential in offering new health services in such facilities.
Language	English
Publishing date	2022-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.896208
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