Article ; Online: Functional disorders as a common motor manifestation of COVID-19 infection or vaccination.
2022 Volume 30, Issue 3, Page(s) 678–691
Abstract: Background and purpose: There have been over 500 million confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), across the globe. To date, a broad spectrum of neurological ... ...
| Abstract | Background and purpose: There have been over 500 million confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), across the globe. To date, a broad spectrum of neurological manifestations following acute infections as well as COVID-19 vaccines have been reported. The aim of this study was to describe the spectrum of neurological manifestations seen in the 'COVID-19 clinic' established in a tertiary Movement Disorders clinic. Methods: In this consecutive case-series study over the period March 2020-January 2022, clinical information regarding demographic data, clinical history and examination findings, investigation results and video recordings of outpatients with motor manifestations associated with COVID-19 infection or vaccination were reviewed. Results: Twenty-one adult patients were reviewed in this ad hoc clinic at Toronto Western Hospital. The majority of the patients were female (76%) and the mean (range) age was 50.7 ± 17.2 (21-80) years. Nine patients (43%) presented with motor manifestations following COVID-19 infection. Twelve patients (57%) developed neurological symptoms following at least one dose of the mRNA or viral vector-based COVID-19 vaccine. The most common manifestation observed was a functional movement disorder (43%). The vaccine group demonstrated a higher number of functional disorders compared to the infection group (58% vs. 22%; p = 0.08). Conclusion: Functional motor manifestations can be associated with COVID-19 and are likely to be under-reported. In view of the co-existence of functional symptoms, movement disorders and mental health conditions observed in this study, we would advocate the use of dedicated COVID-19 Neurology clinics with full access to an experienced multidisciplinary team. |
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| MeSH term(s) | Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Movement Disorders ; SARS-CoV-2 ; Vaccination/adverse effects |
| Chemical Substances | COVID-19 Vaccines |
| Language | English |
| Publishing date | 2022-12-08 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1280785-0 |
| ISSN | 1468-1331 ; 1351-5101 ; 1471-0552 |
| ISSN (online) | 1468-1331 |
| ISSN | 1351-5101 ; 1471-0552 |
| DOI | 10.1111/ene.15630 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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